In vitro classical conditioning of the turtle eyeblink reflex: Approaching cellular mechanisms of acquisition

Cerebellum

Volumn 2, Issue 1, 2003, Pages 55-61

  Keifer, Joyce ^a  

^a UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

Classical conditioning; Eyeblink; In vitro; NMDA receptors; Turtle

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; N METHYLASPARTIC ACID;

ABDUCENS NERVE; ANIMAL CELL; BRAIN STEM; CELL FUNCTION; CEREBELLUM; COCHLEAR NERVE; CONDITIONING; CONTROLLED STUDY; CORRELATION ANALYSIS; EYELID REFLEX; FEEDBACK SYSTEM; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LEARNING; MEMORY; MOTONEURON NUCLEUS; NERVE CELL NETWORK; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RED NUCLEUS; REVIEW; SIGNAL TRANSDUCTION; TRIGEMINAL NERVE; TURTLE; ANIMAL; ARTICLE; BLINKING; CONDITIONED REFLEX; DRUG EFFECT; PHYSIOLOGY; SYNAPSE;

ANIMALS; BLINKING; CEREBELLUM; CONDITIONING, CLASSICAL; N-METHYLASPARTATE; SYNAPSES; TURTLES;

EID: 85047689631     PISSN: 14734222     EISSN: None     Source Type: Journal    
DOI: 10.1080/14734220310015610     Document Type: Review

References (42)

1. Bloedel JR, Bracha V. On the cerebellum, cutaneomuscular reflexes, movements control and the elusive engrams of memory. Behav Brain Res 1995; 68: 1-44.
2. Kim JJ, Thompson RF. Cerebellar circuits and synaptic mechanisms involved in classical eyeblink conditioning. Trends Neurosci 1997; 20: 177-181.
3. Keifer, J. In vitro eye-blink reflex model: role of excitatory amino acids and labeling of network activity with sulforhodamine. Exp Brain Res 1993; 97: 239-253.
4. Powers, AS, Evinger C. Characterization of the blink response in turtles. Second International Behavior and Neuroscience Society Conference, Clearwater, FL, 1993.
5. Pellegrini, JJ, Horn AKE, Evinger C. The trigeminally evoked blink reflex. I. Neuronal circuits. Exp Brain Res 1995; 107: 166-180.
6. Keifer J, Armstrong KE, Houk JC. In vitro classical conditioning of abducens nerve discharge. J Neurosci 1995; 15: 5036-5048.
7. Canli T, Donegan NH. Conditioned diminution of the unconditioned response in rabbit eyeblink conditioning: identifying neural substrates in the cerebellum and brainstem. Behav Neurosci 1995; 109: 874-892.
8. Anderson CW, Keifer J. The cerebellum and red nucleus are not required for in vitro classical conditioning of the turtle abducens nerve response. J Neurosci 1997; 17: 9736-9745.
9. Herrick JL, Keifer J. Central trigeminal and posterior eighth nerve projections in the turtle Chrysemys picta studied in vitro. Brain Behav Evol 1998; 51: 183-201.
10. Norman RJ, Buchwald JS, Villablanca JR. Classical conditioning with auditory discrimination of the eye blink in decerebrate cats. Science 1977; 196: 551-553.
11. Kelly TM, Zuo C, Bloedel JR. Classical conditioning of the eyeblink reflex in the decerebrate-decerebellate rabbit. Behav Brain Res 1990; 38: 7-18.
12. Yeo CH. Cerebellum and classical conditioning of motor responses. PNAS 1991; 627: 292-304.
13. Gruart A, Blazquez P, Delgado-Garcia JM. Kinematic analyses of classically-conditioned eyelid movements in the cat suggest a brain stem site for motor learning. Neurosci Lett 1994; 175: 81-84.
14. Chen L, Bao S, Lockard JM, Kim JJ, Thompson RF. Impaired classical conditioning in cerebellar-lesioned and Purkinje cell degeneration (pcd) mutant mice. J Neurosci 1996; 16: 2829-2838.
15. Perrett SP, Ruiz BP, Mauk MD. Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses. J Neurosci 1993; 13: 1708-1718.
16. Anderson CW, Keifer J. Properties of conditioned abducens nerve responses in a highly reduced in vitro brain stem preparation from the turtle. J Neurophysiol 1999; 81: 1242-1250.
17. Bi G-Q, Poo M-M. Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type. J Neurosci 1998; 18: 10464-10472.
18. Bell CC, Han VZ, Sugawara Y, Grant K. Synaptic plasticity in a cerebellum-like structure depends on temporal order. Nature 1997; 387: 278-281.
19. Keifer, J. In vitro eye-blink classical conditioning is NMDA receptor-dependent and involves redistribution of AMPA receptor subunit GluR4. J Neurosci 2001; 21: 2434-2441.
20. Malenka RC. Synaptic plasticity in the hippocampus: LTP and LTD. Cell 1994; 78: 535-538.
21. Soderling TR, Derkach VA. Postsynaptic protein phosphorylation and LTP. Trends Neurosci 2000; 23: 75-80.
22. Servatius RJ, Shors TJ. Early acquisition, but not retention, of the classically conditioned eyeblink response is N-methyl-D-aspartate (NMDA) receptor dependent. Behav Neurosci 1996; 110: 1040-1048.
23. Kishimoto Y, Kawahara S, Kirino Y, Kadotani H, Nakamura Y, Ikeda M, Yoshioka T. Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A. NeuroReport 1997; 8: 3717-3721.
24. Liao D, Hessler NA, Malinow R. Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 1995; 375: 400-404.
25. Barria A, Muller D, Derkach V, Griffith LC, Soderling TR. Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science 1997; 276: 2042-2045.
26. Hayashi Y, Shi S-H, Esteban JA, Piccini A, Poncer J-C, Malinow R. Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Science 2000; 287: 2262-2267.
27. Tocco G, Devgan KK, Hauge SA, Weiss C, Baudry M, Thompson RF. Classical conditioning selectively increases AMPA receptor binding in rabbit hippocampus. Brain Res 1991; 559: 331-336.
28. Liao D, Zhang X, O'Brien R, Ehlers MD, Huganir RL. Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons. Nature Neurosci 1999; 2: 37-43.
29. Lissin DV, Carroll RC, Nicoll RA, Malenka RC, von Zastrow M. Rapid, activation-induced redistribution of ionotropic glutamate receptors in cultured hippocampal neurons. J Neurosci 1999; 19: 1263-1272.
30. Shi S-H, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 1999; 284: 1811-1816.
31. Mosbacher J, Schoepfer R, Monyer H, Burnashev N, Seeburg PH, Rupersberg JP. A molecular determinant for submillisecond desensitization in glutamate receptors. Science 1994; 266: 1059-1062.
32. Jouvenceau A, Potier B, Battini R, Ferrari S, Dutar P, Billard J-M. Glutamatergic synaptic responses and long-term potentiation are impaired in the CA1 hippocampal area of calbindin D28K-deficient mice. Synapse 1999; 33: 172-180.
33. Molinari S, Battini R, Ferrari, S, Pozzi L, Killcross AS, Robbins TW, Jouvenceau A, Billard J-M, Dutur P, Lamour Y, Baker WA, Cox H, Emson PC. Deficits in memory and hippocampal long-term potentiation in mice with reduced calbindin D28K expression. PNAS 1996; 93: 8028-8033.
34. Keifer J, Brewer BT. Evidence that the expression of in vitro eyeblink conditioned responses in turtles is not mediated by CaMKII. Soc Neurosci Abs 2001; 27: 316.22.
35. Zhu JJ, Esteban JA, Hayashi Y, Malinow R. Postnatal synaptic potentiation: delivery of GluR4-containing AMPA receptors by spontaneous activity. Nature Neurosci 2000; 3: 1098-1106.
36. Keifer J, Carr MT. Immunocytochemical localization of glutamate receptor subunits in the brain stem and cerebellum of the turtle Chrysemys picta. J Comp Neurol 2000; 427: 455-468.
37. Keifer, J. Enhanced synaptic clustering of GluR4-containing AMPA receptors after in vitro classical conditioning. Soc Neurosci Abs, in press.
38. Crump FT, Dillman KS, Craig AM. cAMP-dependent protein kinase mediates activity-regulated synaptic targeting of NMDA receptors. J Neurosci 2001; 21: 5079-5088.
39. Lan J-Y, Skeberdis VA, Jover T, Grooms SY, Lin Y, Araneda RC, Zheng X, Bennett MVL, Zukin RS. Protein kinase C modulates NMDA receptor trafficking and gating. Nat Neurosci 2001; 4: 382-390.
40. Keifer J. Effects of red nucleus inactivation on burst discharge in turtle cerebellum in vitro: evidence for positive feedback. J Neurophysiol 1996; 76: 2200-2210.
41. Bracha V, Bloedel JR. The multiple pathway model of circuits subserving the classical conditioning of withdrawal reflexes. In: Bloedel JR, Ebner TJ, Wise SP, editors. Acquisition of Motor Behavior in Vertebrates. Cambridge, MIT Press, 1996: 175-204.
42. Houk JC, Keifer J, Barto A. Distributed motor commands in the limb premotor network. TINS 1993; 16: 27-33.