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Volumn 16, Issue 8, 1996, Pages 2829-2838

Impaired classical eyeblink conditioning in cerebellar-lesioned and Purkinje cell degeneration (pcd) mutant mice

Author keywords

cerebellum; eyeblink conditioning; interpositus nucleus; learning; long term depression; memory; mutant mice; Purkinje cells

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CEREBELLUM CORTEX; CONDITIONING; CONTROLLED STUDY; ELECTROMYOGRAM; EYELID REFLEX; HISTOLOGY; MALE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL;

EID: 0029986150     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-08-02829.1996     Document Type: Article
Times cited : (193)

References (61)
  • 2
    • 0022514981 scopus 로고
    • Cerebellar Purkinje cell activity related to the classically conditioned nictitating membrane response
    • Berthier NE, Moore JW (1986) Cerebellar Purkinje cell activity related to the classically conditioned nictitating membrane response. Exp Brain Res 63:341-350.
    • (1986) Exp Brain Res , vol.63 , pp. 341-350
    • Berthier, N.E.1    Moore, J.W.2
  • 4
    • 0029294806 scopus 로고
    • Temporal specificity of long-term depression in parallel fiber-Purkinje synapses in rat cerebellar slice
    • Chen C, Thompson RF (1995) Temporal specificity of long-term depression in parallel fiber-Purkinje synapses in rat cerebellar slice. Learn and Mem 2:185-198.
    • (1995) Learn and Mem , vol.2 , pp. 185-198
    • Chen, C.1    Thompson, R.F.2
  • 5
    • 0029620817 scopus 로고
    • Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCy mutant mice
    • Chen C, Kano M, Abeliovich A, Chen L, Bao S, Kim JJ, Hashimoto K, Thompson RF, Tonegawa S (1995) Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCy mutant mice. Cell 83:1233-1242.
    • (1995) Cell , vol.83 , pp. 1233-1242
    • Chen, C.1    Kano, M.2    Abeliovich, A.3    Chen, L.4    Bao, S.5    Kim, J.J.6    Hashimoto, K.7    Thompson, R.F.8    Tonegawa, S.9
  • 6
    • 0021364012 scopus 로고
    • Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses
    • Clark GA, McCormick DA, Lavond DG, Thompson RF (1984) Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses. Brain Res 291:125-136.
    • (1984) Brain Res , vol.291 , pp. 125-136
    • Clark, G.A.1    McCormick, D.A.2    Lavond, D.G.3    Thompson, R.F.4
  • 7
    • 0027092543 scopus 로고
    • Reversible lesions of the cerebellar interpositus nucleus during acquisition and retention of a classically conditioned behavior
    • Clark RE, Zhang AA, Lavond DG (1993) Reversible lesions of the cerebellar interpositus nucleus during acquisition and retention of a classically conditioned behavior. Behav Neurosci 106:879-888.
    • (1993) Behav Neurosci , vol.106 , pp. 879-888
    • Clark, R.E.1    Zhang, A.A.2    Lavond, D.G.3
  • 8
    • 0017748104 scopus 로고
    • Projections from the inferior olive to the cerebellar nuclei in the cat demonstrated by retrograde transport of horseradish peroxidase
    • Courville J, Augustine JR, Martel P (1977) Projections from the inferior olive to the cerebellar nuclei in the cat demonstrated by retrograde transport of horseradish peroxidase. Brain Res 130:405-419.
    • (1977) Brain Res , vol.130 , pp. 405-419
    • Courville, J.1    Augustine, J.R.2    Martel, P.3
  • 11
    • 0022374029 scopus 로고
    • Long-term depression of parallel fibre synapses following stimulation of climbing fibres
    • Ekerot CF, Kano M (1985) Long-term depression of parallel fibre synapses following stimulation of climbing fibres. Brain Res 342:357-360.
    • (1985) Brain Res , vol.342 , pp. 357-360
    • Ekerot, C.F.1    Kano, M.2
  • 12
    • 0028804826 scopus 로고
    • Disruption of cerebellar maturation by an antimitotic agent impairs the ontogeny of eyeblink conditioning in rats
    • Freeman JH, Barone S, Stanton ME (1995) Disruption of cerebellar maturation by an antimitotic agent impairs the ontogeny of eyeblink conditioning in rats. J Neurosci 15:7301-7314.
    • (1995) J Neurosci , vol.15 , pp. 7301-7314
    • Freeman, J.H.1    Barone, S.2    Stanton, M.E.3
  • 13
    • 0021369741 scopus 로고
    • An anterograde neuroanatomical tracing method that shows detailed morphology of neurons, their axons and terminals: Immunohistochemical localization of an axonally transported plant lectin, Phaseolus vulgaris leucoagglutinin (PHA-L)
    • Gerfen CR, Sawchenko PE (1984) An anterograde neuroanatomical tracing method that shows detailed morphology of neurons, their axons and terminals: immunohistochemical localization of an axonally transported plant lectin, Phaseolus vulgaris leucoagglutinin (PHA-L). Brain Res 290:219-238.
    • (1984) Brain Res , vol.290 , pp. 219-238
    • Gerfen, C.R.1    Sawchenko, P.E.2
  • 15
    • 0026503499 scopus 로고
    • Dissociation of spatial navigation and visual guidance performance in Purkinje cell degeneration (pcd) mutant mice
    • Goodlett CR, Hamre KM, West JR (1992) Dissociation of spatial navigation and visual guidance performance in Purkinje cell degeneration (pcd) mutant mice. Behav Brain Res 47:129-141.
    • (1992) Behav Brain Res , vol.47 , pp. 129-141
    • Goodlett, C.R.1    Hamre, K.M.2    West, J.R.3
  • 18
    • 0024520759 scopus 로고
    • Long-term depression
    • Ito M (1989) Long-term depression. Annu Rev Neurosci 12:85-102.
    • (1989) Annu Rev Neurosci , vol.12 , pp. 85-102
    • Ito, M.1
  • 19
    • 0020005065 scopus 로고
    • Climbing fibre induced depression of both mossy fiber responsiveness and glutamate sensitivity of cerebellar Purkinje cells
    • Lond
    • Ito M, Sakurai M, Tongroach P (1982) Climbing fibre induced depression of both mossy fiber responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J Physiol (Lond) 324:113-134.
    • (1982) J Physiol , vol.324 , pp. 113-134
    • Ito, M.1    Sakurai, M.2    Tongroach, P.3
  • 20
    • 0017344942 scopus 로고
    • Electrophysiological and horseradish peroxidase studies of precerebellar afferents to the nucleus interpositus anterior. I. Climbing fiber system
    • Kitai ST, McCrea RA, Preston RJ, Bishop GA (1977) Electrophysiological and horseradish peroxidase studies of precerebellar afferents to the nucleus interpositus anterior. I. Climbing fiber system. Brain Res 122:197-214.
    • (1977) Brain Res , vol.122 , pp. 197-214
    • Kitai, S.T.1    McCrea, R.A.2    Preston, R.J.3    Bishop, G.A.4
  • 21
    • 0027257377 scopus 로고
    • Localization of a memory trace in the mammalian brain
    • Krupa DJ, Thompson JK, Thompson RF (1993) Localization of a memory trace in the mammalian brain. Science 260:989-991.
    • (1993) Science , vol.260 , pp. 989-991
    • Krupa, D.J.1    Thompson, J.K.2    Thompson, R.F.3
  • 22
    • 0022504754 scopus 로고
    • Spontaneous alternation and habituation in a t-maze in nervous mutant mice
    • Lalonde R, Botez MI, Boivin D (1986) Spontaneous alternation and habituation in a t-maze in nervous mutant mice. Behav Neurosci 100:350-352.
    • (1986) Behav Neurosci , vol.100 , pp. 350-352
    • Lalonde, R.1    Botez, M.I.2    Boivin, D.3
  • 23
    • 0023227210 scopus 로고
    • Spontaneous alternation and habituation in Purkinje cell degeneration mutant mice
    • Lalonde R, Manseau M, Botez MI (1987) Spontaneous alternation and habituation in Purkinje cell degeneration mutant mice. Brain Res 411:187-189.
    • (1987) Brain Res , vol.411 , pp. 187-189
    • Lalonde, R.1    Manseau, M.2    Botez, M.I.3
  • 24
    • 0023859072 scopus 로고
    • Spontaneous alternation and exploration in staggerer mutant mice
    • Lalonde R, Manseau M, Botez MI (1988a) Spontaneous alternation and exploration in staggerer mutant mice. Behav Brain Res 27:273-276.
    • (1988) Behav Brain Res , vol.27 , pp. 273-276
    • Lalonde, R.1    Manseau, M.2    Botez, M.I.3
  • 25
    • 0023736367 scopus 로고
    • Spontaneous alternation and exploration in weaver mutant mice
    • Lalonde R, Manseau M, Botez MI (1988b) Spontaneous alternation and exploration in weaver mutant mice. Behav Brain Res 31:111-114.
    • (1988) Behav Brain Res , vol.31 , pp. 111-114
    • Lalonde, R.1    Manseau, M.2    Botez, M.I.3
  • 26
    • 0017927928 scopus 로고
    • The development and degeneration of Purkinje cells in pcd mutant mice
    • Landis SC, Mullen RJ (1978) The development and degeneration of Purkinje cells in pcd mutant mice. J Comp Neurol 177:125-144.
    • (1978) J Comp Neurol , vol.177 , pp. 125-144
    • Landis, S.C.1    Mullen, R.J.2
  • 27
    • 0024321954 scopus 로고
    • Acquisition of classical conditioning without cerebellar cortex
    • Lavond DG, Steinmetz JE (1989) Acquisition of classical conditioning without cerebellar cortex. Behav Brain Res 33:113-164.
    • (1989) Behav Brain Res , vol.33 , pp. 113-164
    • Lavond, D.G.1    Steinmetz, J.E.2
  • 28
    • 0021958255 scopus 로고
    • Effects of kainic acid lesions of the cerebellar interpositus nucleus on eyelid conditioning in the rabbit
    • Lavond DG, Hembree TL, Thompson RF (1985) Effects of kainic acid lesions of the cerebellar interpositus nucleus on eyelid conditioning in the rabbit. Brain Res 326:179-182.
    • (1985) Brain Res , vol.326 , pp. 179-182
    • Lavond, D.G.1    Hembree, T.L.2    Thompson, R.F.3
  • 29
    • 0027344055 scopus 로고
    • Mammalian brain substrates of aversive classical conditioning
    • Lavond DG, Kim JJ, Thompson RF (1993) Mammalian brain substrates of aversive classical conditioning. Annu Rev Psychol 44:317-342.
    • (1993) Annu Rev Psychol , vol.44 , pp. 317-342
    • Lavond, D.G.1    Kim, J.J.2    Thompson, R.F.3
  • 30
    • 0023232529 scopus 로고
    • Reacquisition of classical conditioning after removal of cerebellar cortex
    • Lavond DG, Steinmetz JE, Yokaitis MH, Thompson RF (1987) Reacquisition of classical conditioning after removal of cerebellar cortex. Exp Brain Res 67:569-593.
    • (1987) Exp Brain Res , vol.67 , pp. 569-593
    • Lavond, D.G.1    Steinmetz, J.E.2    Yokaitis, M.H.3    Thompson, R.F.4
  • 31
    • 9244222247 scopus 로고
    • Ipsilateral cerebellar lesions prevent learning of the classically conditioned nictitating membrane/eyelid response
    • Lincoln JS, McCormick DA, Thompson RF (1982) Ipsilateral cerebellar lesions prevent learning of the classically conditioned nictitating membrane/eyelid response. Brain Res 67:569-593.
    • (1982) Brain Res , vol.67 , pp. 569-593
    • Lincoln, J.S.1    McCormick, D.A.2    Thompson, R.F.3
  • 32
    • 0028208421 scopus 로고
    • Long-term synaptic depression in the mammalian brain
    • Linden DJ (1994) Long-term synaptic depression in the mammalian brain. Neuron 12:457-472.
    • (1994) Neuron , vol.12 , pp. 457-472
    • Linden, D.J.1
  • 34
    • 0022748136 scopus 로고
    • Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus
    • Mauk MD, Steinmetz JE, Thompson RF (1986) Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus. Proc Natl Acad Sci USA 83:5349-5353.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 5349-5353
    • Mauk, M.D.1    Steinmetz, J.E.2    Thompson, R.F.3
  • 35
    • 0021344334 scopus 로고
    • Cerebellum: Essential involvement in the classically conditioned eyelid response
    • McCormick DA, Thompson RF (1984a) Cerebellum: essential involvement in the classically conditioned eyelid response. Science 223:296-299.
    • (1984) Science , vol.223 , pp. 296-299
    • McCormick, D.A.1    Thompson, R.F.2
  • 36
    • 0021686453 scopus 로고
    • Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response
    • McCormick DA, Thompson RF (1984b) Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response. J Neurosci 4:2811-2822.
    • (1984) J Neurosci , vol.4 , pp. 2811-2822
    • McCormick, D.A.1    Thompson, R.F.2
  • 38
    • 0022401974 scopus 로고
    • Lesions of the inferior olivary complex cause extinction of the classically conditioned eyeblink response
    • McCormick DA, Steinmetz JE, Thompson RF (1985) Lesions of the inferior olivary complex cause extinction of the classically conditioned eyeblink response. Brain Res 359:120-130.
    • (1985) Brain Res , vol.359 , pp. 120-130
    • McCormick, D.A.1    Steinmetz, J.E.2    Thompson, R.F.3
  • 39
    • 0028341070 scopus 로고
    • Identification of pontocerebellar axon collateral synaptic boutons in the rat cerebellar nuclei
    • Mihailoff GA (1994) Identification of pontocerebellar axon collateral synaptic boutons in the rat cerebellar nuclei. Brain Res 648:313-318.
    • (1994) Brain Res , vol.648 , pp. 313-318
    • Mihailoff, G.A.1
  • 41
    • 0016588264 scopus 로고
    • Two new types of retinal degeneration in cerebellar mutant mice
    • Mullen RJ, La Vail MM (1975) Two new types of retinal degeneration in cerebellar mutant mice. Nature 258:528-530.
    • (1975) Nature , vol.258 , pp. 528-530
    • Mullen, R.J.1    La Vail, M.M.2
  • 42
    • 2042422363 scopus 로고
    • Purkinje cell degeneration, a new neurological mutation in the mouse
    • Mullen RJ, Eicher EM, Sidman RL (1976) Purkinje cell degeneration, a new neurological mutation in the mouse. Proc Natl Acad Sci USA 73:208-212.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 208-212
    • Mullen, R.J.1    Eicher, E.M.2    Sidman, R.L.3
  • 43
    • 0027370317 scopus 로고
    • Lidocaine infusion in a critical region of cerebellum completely prevents learning of the conditioned eyeblink response
    • Nordholm AF, Thompson JK, Dersarkissian C, Thompson RF (1993) Lidocaine infusion in a critical region of cerebellum completely prevents learning of the conditioned eyeblink response. Behav Neurosci 107:882-886.
    • (1993) Behav Neurosci , vol.107 , pp. 882-886
    • Nordholm, A.F.1    Thompson, J.K.2    Dersarkissian, C.3    Thompson, R.F.4
  • 44
    • 0028952239 scopus 로고
    • Extinction of conditioned eyelid responses requires the anterior lobe of cerebellar cortex
    • Perrett SP, Mauk MD (1995) Extinction of conditioned eyelid responses requires the anterior lobe of cerebellar cortex. J Neurosci 15: 2074-2080.
    • (1995) J Neurosci , vol.15 , pp. 2074-2080
    • Perrett, S.P.1    Mauk, M.D.2
  • 45
    • 0027456994 scopus 로고
    • Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses
    • Perrett SP, Ruiz BP, Mauk MD (1993) Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses. J Neurosci 13:1708-1718.
    • (1993) J Neurosci , vol.13 , pp. 1708-1718
    • Perrett, S.P.1    Ruiz, B.P.2    Mauk, M.D.3
  • 46
    • 0022469966 scopus 로고
    • Long-term potentiation in the interpositus and vestibular nuclei in the rat
    • Racine RJ, Wilson DA, Gingell R, Sunderland D (1986) Long-term potentiation in the interpositus and vestibular nuclei in the rat. Exp Brain Res 63:158-162.
    • (1986) Exp Brain Res , vol.63 , pp. 158-162
    • Racine, R.J.1    Wilson, D.A.2    Gingell, R.3    Sunderland, D.4
  • 47
    • 0025809342 scopus 로고
    • Learning-specific differences in Purkinje-cell dendrites of lobule HVI (Lobulus simplex): Intracellular recording in a rabbit cerebellar slice
    • Schreurs BG, Sanchez-Andres JV, Alkon DL (1991) Learning-specific differences in Purkinje-cell dendrites of lobule HVI (Lobulus simplex): intracellular recording in a rabbit cerebellar slice. Brain Res 548:18-22.
    • (1991) Brain Res , vol.548 , pp. 18-22
    • Schreurs, B.G.1    Sanchez-Andres, J.V.2    Alkon, D.L.3
  • 49
    • 0026546488 scopus 로고
    • Axon collaterals of mossy fibers from the pontine nucleus in the cerebellar dentate nucleus
    • Shinoda Y, Suguichi Y, Futami T, Izawa R (1992) Axon collaterals of mossy fibers from the pontine nucleus in the cerebellar dentate nucleus. J Neurophysiol 67:547-560.
    • (1992) J Neurophysiol , vol.67 , pp. 547-560
    • Shinoda, Y.1    Suguichi, Y.2    Futami, T.3    Izawa, R.4
  • 50
    • 0023782337 scopus 로고
    • Bilateral cerebellar lesions disrupt conditioned eyelid responses in unrestrained rats
    • Skelton RW (1988) Bilateral cerebellar lesions disrupt conditioned eyelid responses in unrestrained rats. Behav Neurosci 102:586-590.
    • (1988) Behav Neurosci , vol.102 , pp. 586-590
    • Skelton, R.W.1
  • 51
    • 0026562096 scopus 로고
    • Possible conditioned stimulus pathway for classical eyelid conditioning in rabbits. I. Anatomical evidence for direct projections from the pontine nuclei to the cerebellar interpositus nucleus
    • Steinmetz JE, Sengelaub DR (1992) Possible conditioned stimulus pathway for classical eyelid conditioning in rabbits. I. Anatomical evidence for direct projections from the pontine nuclei to the cerebellar interpositus nucleus. Behav Neural Biol 57:103-115.
    • (1992) Behav Neural Biol , vol.57 , pp. 103-115
    • Steinmetz, J.E.1    Sengelaub, D.R.2
  • 52
    • 0022905497 scopus 로고
    • Classical conditioning of the rabbit eyelid response with a mossy fiber stimulation CS. I. Pontine nuclei and middle cerebellar peduncle stimulation
    • Steinmetz JE, Rosen DJ, Chapman PF, Lavond DG, Thompson RF (1986) Classical conditioning of the rabbit eyelid response with a mossy fiber stimulation CS. I. Pontine nuclei and middle cerebellar peduncle stimulation. Behav Neurosci 100:871-880.
    • (1986) Behav Neurosci , vol.100 , pp. 871-880
    • Steinmetz, J.E.1    Rosen, D.J.2    Chapman, P.F.3    Lavond, D.G.4    Thompson, R.F.5
  • 53
    • 0024559713 scopus 로고
    • Classical conditioning in rabbits using pontine nucleus stimulation as a conditioned stimulus and inferior olive stimulation as an unconditioned stimulus
    • Steinmetz JE, Lavond DG, Thompson RF (1989) Classical conditioning in rabbits using pontine nucleus stimulation as a conditioned stimulus and inferior olive stimulation as an unconditioned stimulus. Synapse 3:225-233.
    • (1989) Synapse , vol.3 , pp. 225-233
    • Steinmetz, J.E.1    Lavond, D.G.2    Thompson, R.F.3
  • 54
    • 0022500985 scopus 로고
    • The neurobiology of learning and memory
    • Thompson RF (1986) The neurobiology of learning and memory. Science 233:941-947.
    • (1986) Science , vol.233 , pp. 941-947
    • Thompson, R.F.1
  • 55
    • 0025716057 scopus 로고
    • Neural mechanisms of classical conditioning in mammals
    • Thompson RF (1990) Neural mechanisms of classical conditioning in mammals. Philos Trans R Soc Lond [Biol] 329:161-170.
    • (1990) Philos Trans R Soc Lond [Biol] , vol.329 , pp. 161-170
    • Thompson, R.F.1
  • 56
    • 0025798978 scopus 로고
    • Stabilisation of neurone number in the inferior olivary complex of aged "Purkinje cell degeneration" mutant mice
    • Berl
    • Triarhou LC, Ghetti B (1991) Stabilisation of neurone number in the inferior olivary complex of aged "Purkinje cell degeneration" mutant mice. Acta Neurophathol (Berl) 81:597-602.
    • (1991) Acta Neurophathol , vol.81 , pp. 597-602
    • Triarhou, L.C.1    Ghetti, B.2
  • 57
    • 0020370446 scopus 로고
    • The olivocerebellar projection in the cat
    • (Palay SL, Chan-Palay V, eds). New York: Springer
    • Voogd J (1982) The olivocerebellar projection in the cat. In: The cerebellum (Palay SL, Chan-Palay V, eds), pp 134-161. New York: Springer.
    • (1982) The Cerebellum , pp. 134-161
    • Voogd, J.1
  • 58
    • 0025613199 scopus 로고
    • Purkinje cell number related to rate of classical conditioning
    • Woodruff-Pak DS, Cronholm JF, Sheffield JB (1990) Purkinje cell number related to rate of classical conditioning. NeuroReport 1:165-168.
    • (1990) NeuroReport , vol.1 , pp. 165-168
    • Woodruff-Pak, D.S.1    Cronholm, J.F.2    Sheffield, J.B.3
  • 59
    • 0021680192 scopus 로고
    • Discrete lesions of the cerebellar cortex abolish the classically conditioned nictitating membrane response of the rabbit
    • Yeo CH, Hardiman MJ, Glickstein M (1984) Discrete lesions of the cerebellar cortex abolish the classically conditioned nictitating membrane response of the rabbit. Behav Brain Res 13:261-266.
    • (1984) Behav Brain Res , vol.13 , pp. 261-266
    • Yeo, C.H.1    Hardiman, M.J.2    Glickstein, M.3
  • 60
    • 0022196617 scopus 로고
    • Classical conditioning of the nictitating membrane response of the rabbit. II. Lesions of the cerebellar cortex
    • Yeo CH, Hardiman MJ, Glickstein M (1985) Classical conditioning of the nictitating membrane response of the rabbit. II. Lesions of the cerebellar cortex. Exp Brain Res 60:99-113.
    • (1985) Exp Brain Res , vol.60 , pp. 99-113
    • Yeo, C.H.1    Hardiman, M.J.2    Glickstein, M.3
  • 61
    • 0022542066 scopus 로고
    • Classical conditioning of the nictitating membrane response of the rabbit. IV. Lesions of the inferior olive
    • Yeo CH, Hardiman MJ. Glickstein M (1986) Classical conditioning of the nictitating membrane response of the rabbit. IV. Lesions of the inferior olive. Exp Brain Res 63:81-92.
    • (1986) Exp Brain Res , vol.63 , pp. 81-92
    • Yeo, C.H.1    Hardiman, M.J.2    Glickstein, M.3


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