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Volumn 50, Issue 7, 2014, Pages 503-525

Current status of targeted therapy in non-small cell lung cancer

(1)  Parums, Dinah V a  

a NONE

Author keywords

Biomarkers; EGFR; HER2; Non small cell lung cancer; Targeted therapy

Indexed keywords

AFATINIB; ALECTINIB; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BIOSIMILAR AGENT; CERITINIB; CETUXIMAB; CRIZOTINIB; DABRAFENIB; DACOMITINIB; ERLOTINIB; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GEFITINIB; ICOTINIB; LAPATINIB; NECITUMUMAB; NERATINIB; NINTEDANIB; ONARTUZUMAB; PALBOCICLIB; RAMUCIRUMAB; SELUMETINIB; SORAFENIB; TIVANTINIB; TRAMETINIB; TRASTUZUMAB; TUMOR MARKER; VANDETANIB; VEMURAFENIB;

EID: 85047687980     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2014.50.07.2185913     Document Type: Review
Times cited : (57)

References (98)
  • 1
    • 84901982006 scopus 로고    scopus 로고
    • The state of cancer care in America, 2014: A report by the American Society of Clinical Oncology
    • The state of cancer care in America, 2014: a report by the American Society of Clinical Oncology. J Oncol Pract 2014, 10(2): 119-42.
    • (2014) J Oncol Pract , vol.10 , Issue.2 , pp. 119-142
  • 2
    • 84862577157 scopus 로고    scopus 로고
    • Management of non-small cell lung in cancer patients with stable disease
    • Grossi, F. Management of non-small cell lung in cancer patients with stable disease. Drugs 2012, 72(Suppl. 1): 20-7.
    • (2012) Drugs , vol.72 , Issue.SUPPL. 1 , pp. 20-27
    • Grossi, F.1
  • 3
    • 80053639884 scopus 로고    scopus 로고
    • Focused Update of 2009 American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer
    • 2011
    • Azzoli, C.G., Temin, S., Aliff, T. et al. 2011 Focused Update of 2009 American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer. J Clin Oncol 2011, 29(28): 3825-31.
    • (2011) J Clin Oncol , vol.29 , Issue.28 , pp. 3825-3831
    • Azzoli, C.G.1    Temin, S.2    Aliff, T.3
  • 6
    • 39749191925 scopus 로고    scopus 로고
    • Epidermal growth factor receptor immunohistochemistry: Comparison of antibodies and cutoff points to predict benefit from gefitinib in a phase 3 placebo-controlled study in advanced nonsmall-cell lung cancer
    • DOI 10.1002/cncr.23282
    • Hirsch, F.R., Dziadziuszko, R., Thatcher, N. et al. Epidermal growth factor receptor immunohistochemistry: comparison of antibodies and cutoff points to predict benefit from gefitinib in a phase 3 placebo-controlled study in advanced non-small-cell lung cancer. Cancer 2008, 112(5): 1114-21. (Pubitemid 351304597)
    • (2008) Cancer , vol.112 , Issue.5 , pp. 1114-1121
    • Hirsch, F.R.1    Dziadziuszko, R.2    Thatcher, N.3    Mann, H.4    Watkins, C.5    Parums, D.V.6    Speake, G.7    Holloway, B.8    Bunn Jr., P.A.9    Franklin, W.A.10
  • 7
    • 65249147752 scopus 로고    scopus 로고
    • A systems pathology model for predicting overall survival in patients with refractory, advanced non-small-cell lung cancer treated with gefitinib
    • Donovan, M.J., Kotsianti, A., Bayer-Zubek, V. et al. A systems pathology model for predicting overall survival in patients with refractory, advanced non-small-cell lung cancer treated with gefitinib. Eur J Cancer 2009, 45(8): 1518-26.
    • (2009) Eur J Cancer , vol.45 , Issue.8 , pp. 1518-1526
    • Donovan, M.J.1    Kotsianti, A.2    Bayer-Zubek, V.3
  • 8
    • 84896537994 scopus 로고    scopus 로고
    • FDA perspective on companion diagnostics: An evolving paradigm
    • Mansfield, E.A. FDA perspective on companion diagnostics: an evolving paradigm. Clin Cancer Res 2014, 20(6): 1453-7.
    • (2014) Clin Cancer Res , vol.20 , Issue.6 , pp. 1453-1457
    • Mansfield, E.A.1
  • 9
    • 84885021119 scopus 로고    scopus 로고
    • Considerations for the successful co-development of targeted cancer therapies and companion diagnostics
    • Fridlyand, J., Simon, R.M., Walrath, J.C. et al. Considerations for the successful co-development of targeted cancer therapies and companion diagnostics. Nat Rev Drug Discov 2013, 12(10): 743-55.
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.10 , pp. 743-755
    • Fridlyand, J.1    Simon, R.M.2    Walrath, J.C.3
  • 10
    • 84879290901 scopus 로고    scopus 로고
    • Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology
    • Lindeman, N.I., Cagle, P.T., Beasley, M.B. et al. Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J Mol Diagn 2013, 15(4): 415-53.
    • (2013) J Mol Diagn , vol.15 , Issue.4 , pp. 415-453
    • Lindeman, N.I.1    Cagle, P.T.2    Beasley, M.B.3
  • 11
    • 84879635389 scopus 로고    scopus 로고
    • Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology
    • Lindeman, N.I., Cagle, P.T., Beasley, M.B. et al. Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. Arch Pathol Lab Med 2013, 137(6): 828-60.
    • (2013) Arch Pathol Lab Med , vol.137 , Issue.6 , pp. 828-860
    • Lindeman, N.I.1    Cagle, P.T.2    Beasley, M.B.3
  • 14
    • 84876827517 scopus 로고    scopus 로고
    • Erlotinib in the first-line treatment of non-small-cell lung cancer
    • D'Arcangelo, M., Cappuzzo, F. Erlotinib in the first-line treatment of non-small-cell lung cancer. Expert Rev Anticancer Ther 2013, 13(5): 523-33.
    • (2013) Expert Rev Anticancer Ther , vol.13 , Issue.5 , pp. 523-533
    • D'Arcangelo, M.1    Cappuzzo, F.2
  • 15
    • 77954838436 scopus 로고    scopus 로고
    • Frontline gefitinib in advanced non-small cell lung cancer: Meta-analysis of published randomized trials
    • Ibrahim, E.M. Frontline gefitinib in advanced non-small cell lung cancer: Meta-analysis of published randomized trials. Ann Thorac Med 2010, 5(3): 153-60.
    • (2010) Ann Thorac Med , vol.5 , Issue.3 , pp. 153-160
    • Ibrahim, E.M.1
  • 16
    • 66249118670 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions
    • Morabito, A., Piccirillo, M.C., Falasconi, F. et al. Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions. Oncologist 2009, 14(4): 378-90.
    • (2009) Oncologist , vol.14 , Issue.4 , pp. 378-390
    • Morabito, A.1    Piccirillo, M.C.2    Falasconi, F.3
  • 17
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial
    • Herbst, R.S., Sun, Y., Eberhardt, W.E. et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol 2010, 11(7): 619-26.
    • (2010) Lancet Oncol , vol.11 , Issue.7 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3
  • 18
    • 79955891953 scopus 로고    scopus 로고
    • Vandetanib: An overview of its clinical development in NSCLC and other tumors
    • Morabito, A., Piccirillo, M.C., Costanzo, R. et al. Vandetanib: An overview of its clinical development in NSCLC and other tumors. Drugs Today (Barc) 2010, 46(9): 683-98.
    • (2010) Drugs Today (Barc) , vol.46 , Issue.9 , pp. 683-698
    • Morabito, A.1    Piccirillo, M.C.2    Costanzo, R.3
  • 19
    • 84900546256 scopus 로고    scopus 로고
    • Irreversible EGFR-TKIs: Dreaming perfection
    • Landi, L., Cappuzzo, F. Irreversible EGFR-TKIs: dreaming perfection. Transl Lung Cancer Res 2013, 2(1): 40-9.
    • (2013) Transl Lung Cancer Res , vol.2 , Issue.1 , pp. 40-49
    • Landi, L.1    Cappuzzo, F.2
  • 20
    • 84859435053 scopus 로고    scopus 로고
    • Icotinib (BPI-2009H), a novel EGFR tyrosine kinase inhibitor, displays potent efficacy in preclinical studies
    • Tan, F., Shen, X., Wang, D. et al. Icotinib (BPI-2009H), a novel EGFR tyrosine kinase inhibitor, displays potent efficacy in preclinical studies. Lung Cancer 2012, 76(2): 177-82.
    • (2012) Lung Cancer , vol.76 , Issue.2 , pp. 177-182
    • Tan, F.1    Shen, X.2    Wang, D.3
  • 21
    • 84883050731 scopus 로고    scopus 로고
    • Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): A randomised, double-blind phase 3 non-inferiority trial
    • Shi, Y., Zhang, L., Liu, X. et al. Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial. Lancet Oncol 2013, 14(10): 953-61.
    • (2013) Lancet Oncol , vol.14 , Issue.10 , pp. 953-961
    • Shi, Y.1    Zhang, L.2    Liu, X.3
  • 22
    • 84899878457 scopus 로고    scopus 로고
    • Dacomitinib for the treatment of advanced or metastatic non-small-cell lung cancer
    • Mok, T., Lee, K., Tang, M., Leung, L. Dacomitinib for the treatment of advanced or metastatic non-small-cell lung cancer. Future Oncol 2014, 10(5): 813-22.
    • (2014) Future Oncol , vol.10 , Issue.5 , pp. 813-822
    • Mok, T.1    Lee, K.2    Tang, M.3    Leung, L.4
  • 23
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg, F., Roth, G.J., Krssak, M. et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008, 68(12): 4774-82.
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 24
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): A phase 3, double-blind, randomised controlled trial
    • Reck, M., Kaiser, R., Mellemgaard, A. et al. Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial. Lancet Oncol 2014, 15(2): 143-55.
    • (2014) Lancet Oncol , vol.15 , Issue.2 , pp. 143-155
    • Reck, M.1    Kaiser, R.2    Mellemgaard, A.3
  • 25
    • 84874933609 scopus 로고    scopus 로고
    • EGFR-directed monoclonal antibodies in non-small cell lung cancer
    • Pirker, R. EGFR-directed monoclonal antibodies in non-small cell lung cancer. Target Oncol 2013, 8(1): 47-53.
    • (2013) Target Oncol , vol.8 , Issue.1 , pp. 47-53
    • Pirker, R.1
  • 26
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
    • Pirker, R., Pereira, J.R., Szczesna, A. et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 2009, 373(9674): 1525-31.
    • (2009) Lancet , vol.373 , Issue.9674 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3
  • 27
    • 84855311144 scopus 로고    scopus 로고
    • EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: Analysis of data from the phase 3 FLEX study
    • Pirker, R., Pereira, J.R., von Pawel, J. et al. EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study. Lancet Oncol 2012, 13(1): 33-42.
    • (2012) Lancet Oncol , vol.13 , Issue.1 , pp. 33-42
    • Pirker, R.1    Pereira, J.R.2    Von Pawel, J.3
  • 28
    • 84888129994 scopus 로고    scopus 로고
    • Docetaxel or pemetrexed with or without cetuximab in recurrent or progressive non-small-cell lung cancer after platinum-based therapy: A phase 3, open-label, randomised trial
    • Kim, E.S., Neubauer, M., Cohn, A. et al. Docetaxel or pemetrexed with or without cetuximab in recurrent or progressive non-small-cell lung cancer after platinum-based therapy: a phase 3, open-label, randomised trial. Lancet Oncol 2013, 14(13): 1326-36.
    • (2013) Lancet Oncol , vol.14 , Issue.13 , pp. 1326-1336
    • Kim, E.S.1    Neubauer, M.2    Cohn, A.3
  • 30
    • 80051528496 scopus 로고    scopus 로고
    • Necitumumab in the treatment of advanced non-small cell lung cancer: Translation from preclinical to clinical development
    • Dienstmann, R., Felip, E. Necitumumab in the treatment of advanced non-small cell lung cancer: translation from preclinical to clinical development. Expert Opin Biol Ther 2011, 11(9): 1223-31.
    • (2011) Expert Opin Biol Ther , vol.11 , Issue.9 , pp. 1223-1231
    • Dienstmann, R.1    Felip, E.2
  • 32
    • 84880661427 scopus 로고    scopus 로고
    • Lung cancer that harbors an HER2 mutation: Epidemiologic characteristics and therapeutic perspectives
    • Mazieres, J., Peters, S., Lepage, B. et al. Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. J Clin Oncol 2013, 31(16): 1997-2003.
    • (2013) J Clin Oncol , vol.31 , Issue.16 , pp. 1997-2003
    • Mazieres, J.1    Peters, S.2    Lepage, B.3
  • 33
    • 84866360342 scopus 로고    scopus 로고
    • Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas
    • Arcila, M.E., Chaft, J.E., Nafa, K. et al. Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin Cancer Res 2012, 18(18): 4910-8.
    • (2012) Clin Cancer Res , vol.18 , Issue.18 , pp. 4910-4918
    • Arcila, M.E.1    Chaft, J.E.2    Nafa, K.3
  • 34
    • 84899948353 scopus 로고    scopus 로고
    • HER2 aberrations in cancer: Implications for therapy
    • Yan, M., Parker, B.A., Schwab, R., Kurzrock, R. HER2 aberrations in cancer: implications for therapy. Cancer Treat Rev 2014, 40(6): 770-80.
    • (2014) Cancer Treat Rev , vol.40 , Issue.6 , pp. 770-780
    • Yan, M.1    Parker, B.A.2    Schwab, R.3    Kurzrock, R.4
  • 35
    • 84902921465 scopus 로고    scopus 로고
    • Which tyrosine kinase inhibitor should be recommended as initial treatment for non-small cell lung cancer patients with EGFR mutations?
    • Tartarone, A., Lerose, R., Lazzari, C., Gregorc, V., Aieta, M. Which tyrosine kinase inhibitor should be recommended as initial treatment for non-small cell lung cancer patients with EGFR mutations? Med Oncol 2014, 31(8): 78.
    • (2014) Med Oncol , vol.31 , Issue.8 , pp. 78
    • Tartarone, A.1    Lerose, R.2    Lazzari, C.3    Gregorc, V.4    Aieta, M.5
  • 36
    • 65249170861 scopus 로고    scopus 로고
    • A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors
    • Wong, K.K., Fracasso, P.M., Bukowski, R.M. et al. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin Cancer Res 2009, 15(7): 2552-8.
    • (2009) Clin Cancer Res , vol.15 , Issue.7 , pp. 2552-2558
    • Wong, K.K.1    Fracasso, P.M.2    Bukowski, R.M.3
  • 37
    • 73849107114 scopus 로고    scopus 로고
    • Neratinib: An oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer
    • Bose, P., Ozer, H. Neratinib: an oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer. Expert Opin Investig Drugs 2009, 18(11): 1735-51.
    • (2009) Expert Opin Investig Drugs , vol.18 , Issue.11 , pp. 1735-1751
    • Bose, P.1    Ozer, H.2
  • 38
    • 84894807977 scopus 로고    scopus 로고
    • Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors
    • Gandhi, L., Bahleda, R., Tolaney, S.M. et al. Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors. J Clin Oncol 2014, 32(2): 68-75.
    • (2014) J Clin Oncol , vol.32 , Issue.2 , pp. 68-75
    • Gandhi, L.1    Bahleda, R.2    Tolaney, S.M.3
  • 39
    • 77951956384 scopus 로고    scopus 로고
    • Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model
    • Diaz, R., Nguewa, P.A., Parrondo, R. et al. Antitumor and antiangiogenic effect of the dual EGFR and HER-2 tyrosine kinase inhibitor lapatinib in a lung cancer model. BMC Cancer 2010, 10: 188.
    • (2010) BMC Cancer , vol.10 , pp. 188
    • Diaz, R.1    Nguewa, P.A.2    Parrondo, R.3
  • 40
    • 84867621201 scopus 로고    scopus 로고
    • Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
    • Solca, F., Dahl, G., Zoephel, A. et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther 2012, 343(2): 342-50.
    • (2012) J Pharmacol Exp Ther , vol.343 , Issue.2 , pp. 342-350
    • Solca, F.1    Dahl, G.2    Zoephel, A.3
  • 41
    • 84892997539 scopus 로고    scopus 로고
    • Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): An open-label, randomised phase 3 trial
    • Wu, Y.L., Zhou, C., Hu, C.P. et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial. Lancet Oncol 2014, 15(2): 213-22.
    • (2014) Lancet Oncol , vol.15 , Issue.2 , pp. 213-222
    • Wu, Y.L.1    Zhou, C.2    Hu, C.P.3
  • 42
    • 84884605223 scopus 로고    scopus 로고
    • Symptom control and quality of life in LUX-Lung 3: A phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations
    • Yang, J.C., Hirsh, V., Schuler, M. et al. Symptom control and quality of life in LUX-Lung 3: a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations. J Clin Oncol 2013, 31(27): 3342-50.
    • (2013) J Clin Oncol , vol.31 , Issue.27 , pp. 3342-3350
    • Yang, J.C.1    Hirsh, V.2    Schuler, M.3
  • 43
    • 84895765218 scopus 로고    scopus 로고
    • Network meta-analysis of erlotinib, gefitinib, afatinib and icotinib in patients with advanced non-small-cell lung cancer harboring EGFR mutations
    • Liang, W., Wu, X., Fang, W. et al. Network meta-analysis of erlotinib, gefitinib, afatinib and icotinib in patients with advanced non-small-cell lung cancer harboring EGFR mutations. PLoS One 2014, 9(2): e85245.
    • (2014) PLoS One , vol.9 , Issue.2
    • Liang, W.1    Wu, X.2    Fang, W.3
  • 44
    • 79952376771 scopus 로고    scopus 로고
    • Treatment of non-small-cell lung cancer with erlotinib or gefitinib
    • Cataldo, V.D., Gibbons, D.L., Perez-Soler, R., Quintas-Cardama, A. Treatment of non-small-cell lung cancer with erlotinib or gefitinib. N Engl J Med 2011, 364(10): 947-55.
    • (2011) N Engl J Med , vol.364 , Issue.10 , pp. 947-955
    • Cataldo, V.D.1    Gibbons, D.L.2    Perez-Soler, R.3    Quintas-Cardama, A.4
  • 45
    • 84902297551 scopus 로고    scopus 로고
    • The use of bevacizumab in non-small cell lung cancer: An update
    • Lauro, S., Onesti, C.E., Righini, R., Marchetti, P. The use of bevacizumab in non-small cell lung cancer: an update. Anticancer Res 2014, 34(4): 1537-45.
    • (2014) Anticancer Res , vol.34 , Issue.4 , pp. 1537-1545
    • Lauro, S.1    Onesti, C.E.2    Righini, R.3    Marchetti, P.4
  • 46
    • 84859851347 scopus 로고    scopus 로고
    • Carboplatin and paclitaxel with vs without bevacizumab in older patients with advanced non-small cell lung cancer
    • Zhu, J., Sharma, D.B., Gray, S.W., Chen, A.B., Weeks, J.C., Schrag, D. Carboplatin and paclitaxel with vs without bevacizumab in older patients with advanced non-small cell lung cancer. JAMA 2012, 307(15): 1593-601.
    • (2012) JAMA , vol.307 , Issue.15 , pp. 1593-1601
    • Zhu, J.1    Sharma, D.B.2    Gray, S.W.3    Chen, A.B.4    Weeks, J.C.5    Schrag, D.6
  • 47
    • 84927597669 scopus 로고    scopus 로고
    • The top 25 best-selling drugs of 2013
    • March 3, Accessed July 22, 2014
    • The top 25 best-selling drugs of 2013. Genetic Eng & Biotech News, March 3, 2014. Accessed July 22, 2014.
    • (2014) Genetic Eng & Biotech News
  • 48
    • 84555206070 scopus 로고    scopus 로고
    • Safety and efficacy of first-line bevacizumab plus chemotherapy in elderly patients with advanced or recurrent nonsquamous non-small cell lung cancer: Safety of avastin in lung trial (MO19390)
    • Laskin, J., Crino, L., Felip, E. et al. Safety and efficacy of first-line bevacizumab plus chemotherapy in elderly patients with advanced or recurrent nonsquamous non-small cell lung cancer: safety of avastin in lung trial (MO19390). J Thorac Oncol 2012, 7(1): 203-11.
    • (2012) J Thorac Oncol , vol.7 , Issue.1 , pp. 203-211
    • Laskin, J.1    Crino, L.2    Felip, E.3
  • 49
    • 84904044814 scopus 로고    scopus 로고
    • Ramucirumab: First global approval
    • Poole, R.M., Vaidya, A. Ramucirumab: first global approval. Drugs 2014, 74(9): 1047-58.
    • (2014) Drugs , vol.74 , Issue.9 , pp. 1047-1058
    • Poole, R.M.1    Vaidya, A.2
  • 50
    • 84867503535 scopus 로고    scopus 로고
    • A randomized, double-blind, phase III study of Docetaxel and Ramucirumab versus Docetaxel and placebo in the treatment of stage IV non-small-cell lung cancer after disease progression after 1 previous platinum-based therapy (REVEL): Treatment rationale and study design
    • Garon, E.B., Cao, D., Alexandris, E., John, W.J., Yurasov, S., Perol, M. A randomized, double-blind, phase III study of Docetaxel and Ramucirumab versus Docetaxel and placebo in the treatment of stage IV non-small-cell lung cancer after disease progression after 1 previous platinum-based therapy (REVEL): treatment rationale and study design. Clin Lung Cancer 2012, 13(6): 505-9.
    • (2012) Clin Lung Cancer , vol.13 , Issue.6 , pp. 505-509
    • Garon, E.B.1    Cao, D.2    Alexandris, E.3    John, W.J.4    Yurasov, S.5    Perol, M.6
  • 51
    • 79955755025 scopus 로고    scopus 로고
    • Targeting oncogenic ALK: A promising strategy for cancer treatment
    • Grande, E., Bolos, M.V., Arriola, E. Targeting oncogenic ALK: a promising strategy for cancer treatment. Mol Cancer Ther 2011, 10(4): 569-79.
    • (2011) Mol Cancer Ther , vol.10 , Issue.4 , pp. 569-579
    • Grande, E.1    Bolos, M.V.2    Arriola, E.3
  • 52
    • 84655164310 scopus 로고    scopus 로고
    • EML4-ALK translocation predicts better outcome in lung adenocarcinoma patients with wild-type EGFR
    • Wu, S.G., Kuo, Y.W., Chang, Y.L. et al. EML4-ALK translocation predicts better outcome in lung adenocarcinoma patients with wild-type EGFR. J Thorac Oncol 2012, 7(1): 98-104.
    • (2012) J Thorac Oncol , vol.7 , Issue.1 , pp. 98-104
    • Wu, S.G.1    Kuo, Y.W.2    Chang, Y.L.3
  • 53
    • 84876482049 scopus 로고    scopus 로고
    • ALK status testing in non-small cell lung carcinoma: Correlation between ultrasensitive IHC and FISH
    • Minca, E.C., Portier, B.P., Wang, Z. et al. ALK status testing in non-small cell lung carcinoma: correlation between ultrasensitive IHC and FISH. J Mol Diagn 2013, 15(3): 341-6.
    • (2013) J Mol Diagn , vol.15 , Issue.3 , pp. 341-346
    • Minca, E.C.1    Portier, B.P.2    Wang, Z.3
  • 54
    • 80052806086 scopus 로고    scopus 로고
    • Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)
    • Cui, J.J., Tran-Dube, M., Shen, H. et al. Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem 2011, 54(18): 6342-63.
    • (2011) J Med Chem , vol.54 , Issue.18 , pp. 6342-6363
    • Cui, J.J.1    Tran-Dube, M.2    Shen, H.3
  • 55
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • Shaw, A.T., Kim, D.W., Nakagawa, K. et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013, 368(25): 2385-94.
    • (2013) N Engl J Med , vol.368 , Issue.25 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 56
    • 84903466222 scopus 로고    scopus 로고
    • The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer
    • Friboulet, L., Li, N., Katayama, R. et al. The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discov 2014, 4(6): 662-73.
    • (2014) Cancer Discov , vol.4 , Issue.6 , pp. 662-673
    • Friboulet, L.1    Li, N.2    Katayama, R.3
  • 57
    • 84896957081 scopus 로고    scopus 로고
    • Ceritinib in ALK-rearranged non-small-cell lung cancer
    • Shaw, A.T., Kim, D.W., Mehra, R. et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med 2014, 370(13): 1189-97.
    • (2014) N Engl J Med , vol.370 , Issue.13 , pp. 1189-1197
    • Shaw, A.T.1    Kim, D.W.2    Mehra, R.3
  • 58
    • 84905660513 scopus 로고    scopus 로고
    • Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib
    • Ignatius Ou, S.H., Azada, M., Hsiang, D.J. et al. Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib. J Thorac Oncol 2014, 9(4): 549-53.
    • (2014) J Thorac Oncol , vol.9 , Issue.4 , pp. 549-553
    • Ignatius Ou, S.H.1    Azada, M.2    Hsiang, D.J.3
  • 59
    • 84878347085 scopus 로고    scopus 로고
    • CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): A single-arm, open-label, phase 1-2 study
    • Seto, T., Kiura, K., Nishio, M. et al. CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study. Lancet Oncol 2013, 14(7): 590-8.
    • (2013) Lancet Oncol , vol.14 , Issue.7 , pp. 590-598
    • Seto, T.1    Kiura, K.2    Nishio, M.3
  • 60
    • 84892706604 scopus 로고    scopus 로고
    • Palbociclib (PD 0332991): Targeting the cell cycle machinery in breast cancer
    • Rocca, A., Farolfi, A., Bravaccini, S., Schirone, A., Amadori, D. Palbociclib (PD 0332991) : targeting the cell cycle machinery in breast cancer. Expert Opin Pharmacother 2014, 15(3): 407-20.
    • (2014) Expert Opin Pharmacother , vol.15 , Issue.3 , pp. 407-420
    • Rocca, A.1    Farolfi, A.2    Bravaccini, S.3    Schirone, A.4    Amadori, D.5
  • 62
    • 84865312708 scopus 로고    scopus 로고
    • Sorafenib in non-small cell lung cancer
    • Zhang, J., Gold, K.A., Kim, E. Sorafenib in non-small cell lung cancer. Expert Opin Investig Drugs 2012, 21(9): 1417-26.
    • (2012) Expert Opin Investig Drugs , vol.21 , Issue.9 , pp. 1417-1426
    • Zhang, J.1    Gold, K.A.2    Kim, E.3
  • 63
    • 84897562716 scopus 로고    scopus 로고
    • Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma
    • Imielinski, M., Greulich, H., Kaplan, B. et al. Oncogenic and sorafenib-sensitive ARAF mutations in lung adenocarcinoma. J Clin Invest 2014, 124(4): 1582-6.
    • (2014) J Clin Invest , vol.124 , Issue.4 , pp. 1582-1586
    • Imielinski, M.1    Greulich, H.2    Kaplan, B.3
  • 64
    • 84871720411 scopus 로고    scopus 로고
    • Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study
    • Janne, P.A., Shaw, A.T., Pereira, J.R. et al. Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study. Lancet Oncol 2013, 14(1): 38-47.
    • (2013) Lancet Oncol , vol.14 , Issue.1 , pp. 38-47
    • Janne, P.A.1    Shaw, A.T.2    Pereira, J.R.3
  • 65
    • 77954592048 scopus 로고    scopus 로고
    • Identification of common predictive markers of in vitro response to the Mek inhibitor selumetinib (AZD6244; ARRY-142886) in human breast cancer and non-small cell lung cancer cell lines
    • Garon, E.B., Finn, R.S., Hosmer, W. et al. Identification of common predictive markers of in vitro response to the Mek inhibitor selumetinib (AZD6244; ARRY-142886) in human breast cancer and non-small cell lung cancer cell lines. Mol Cancer Ther 2010, 9(7): 1985-94.
    • (2010) Mol Cancer Ther , vol.9 , Issue.7 , pp. 1985-1994
    • Garon, E.B.1    Finn, R.S.2    Hosmer, W.3
  • 66
    • 84880780573 scopus 로고    scopus 로고
    • Trametinib: First global approval
    • Wright, C.J., McCormack, P.L. Trametinib: first global approval. Drugs 2013, 73(11): 1245-54.
    • (2013) Drugs , vol.73 , Issue.11 , pp. 1245-1254
    • Wright, C.J.1    McCormack, P.L.2
  • 70
    • 82355191818 scopus 로고    scopus 로고
    • Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
    • Sequist, L.V., Heist, R.S., Shaw, A.T. et al. Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol 2011, 22(12): 2616-24.
    • (2011) Ann Oncol , vol.22 , Issue.12 , pp. 2616-2624
    • Sequist, L.V.1    Heist, R.S.2    Shaw, A.T.3
  • 71
    • 84864524696 scopus 로고    scopus 로고
    • Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
    • Ohashi, K., Sequist, L.V., Arcila, M.E. et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc Natl Acad Sci U S A 2012, 109(31): E2127-33.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.31
    • Ohashi, K.1    Sequist, L.V.2    Arcila, M.E.3
  • 72
    • 84883237132 scopus 로고    scopus 로고
    • Dabrafenib: First global approval
    • Ballantyne, A.D., Garnock-Jones, K.P. Dabrafenib: first global approval. Drugs 2013, 73(12): 1367-76.
    • (2013) Drugs , vol.73 , Issue.12 , pp. 1367-1376
    • Ballantyne, A.D.1    Garnock-Jones, K.P.2
  • 73
    • 84902573067 scopus 로고    scopus 로고
    • Vemurafenib: An evidence-based review of its clinical utility in the treatment of metastatic melanoma
    • Swaika, A., Crozier, J.A., Joseph, R.W. Vemurafenib: an evidence-based review of its clinical utility in the treatment of metastatic melanoma. Drug Des Devel Ther 2014, 8: 775-87.
    • (2014) Drug des Devel Ther , vol.8 , pp. 775-787
    • Swaika, A.1    Crozier, J.A.2    Joseph, R.W.3
  • 74
    • 84883879311 scopus 로고    scopus 로고
    • Dramatic response induced by vemurafenib in a BRAF V600E-mutated lung adenocarcinoma
    • Peters, S., Michielin, O., Zimmermann, S. Dramatic response induced by vemurafenib in a BRAF V600E-mutated lung adenocarcinoma. J Clin Oncol 2013, 31(20): e341-4.
    • (2013) J Clin Oncol , vol.31 , Issue.20
    • Peters, S.1    Michielin, O.2    Zimmermann, S.3
  • 75
    • 34249912683 scopus 로고    scopus 로고
    • c-Met activation in lung adenocarcinoma tissues: An immunohistochemical analysis
    • DOI 10.1111/j.1349-7006.2007.00493.x
    • Nakamura, Y., Niki, T., Goto, A., Morikawa, T., Miyazawa, K., Nakajima, J., Fukayama, M. c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis. Cancer Sci 2007, 98(7): 1006-13. (Pubitemid 46865384)
    • (2007) Cancer Science , vol.98 , Issue.7 , pp. 1006-1013
    • Nakamura, Y.1    Niki, T.2    Goto, A.3    Morikawa, T.4    Miyazawa, K.5    Nakajima, J.6    Fukayama, M.7
  • 76
    • 0029803612 scopus 로고    scopus 로고
    • Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance
    • Ichimura, E., Maeshima, A., Nakajima, T., Nakamura, T. Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance. Jpn J Cancer Res 1996, 87(10): 1063-9. (Pubitemid 26392044)
    • (1996) Japanese Journal of Cancer Research , vol.87 , Issue.10 , pp. 1063-1069
    • Ichimura, E.1    Maeshima, A.2    Nakajima, T.3    Nakamura, T.4
  • 77
    • 79955458487 scopus 로고    scopus 로고
    • Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification
    • Ou, S.H., Kwak, E.L., Siwak-Tapp, C. et al. Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification. J Thorac Oncol 2011, 6(5): 942-6.
    • (2011) J Thorac Oncol , vol.6 , Issue.5 , pp. 942-946
    • Ou, S.H.1    Kwak, E.L.2    Siwak-Tapp, C.3
  • 78
    • 84930541176 scopus 로고    scopus 로고
    • Onartuzumab. Anti-HGFR (c-Met) monoclonal antibody, Oncolytic
    • Arriola, E., Conde-Estévez, D. Onartuzumab. Anti-HGFR (c-Met) monoclonal antibody, Oncolytic. Drugs Fut 2014, 39(6): 403-8.
    • (2014) Drugs Fut , vol.39 , Issue.6 , pp. 403-408
    • Arriola, E.1    Conde-Estévez, D.2
  • 79
    • 84890108571 scopus 로고    scopus 로고
    • Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
    • Spigel, D.R., Ervin, T.J., Ramlau, R.A. et al. Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J Clin Oncol 2013, 31(32): 4105-14.
    • (2013) J Clin Oncol , vol.31 , Issue.32 , pp. 4105-4114
    • Spigel, D.R.1    Ervin, T.J.2    Ramlau, R.A.3
  • 82
    • 80051974548 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
    • Sequist, L.V., von Pawel, J., Garmey, E.G. et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol 2011, 29(24): 3307-15.
    • (2011) J Clin Oncol , vol.29 , Issue.24 , pp. 3307-3315
    • Sequist, L.V.1    Von Pawel, J.2    Garmey, E.G.3
  • 83
    • 84865506979 scopus 로고    scopus 로고
    • Rationale and design of MARQUEE: A phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer
    • Scagliotti, G.V., Novello, S., Schiller, J.H. et al. Rationale and design of MARQUEE: a phase III, randomized, double-blind study of tivantinib plus erlotinib versus placebo plus erlotinib in previously treated patients with locally advanced or metastatic, nonsquamous, non-small-cell lung cancer. Clin Lung Cancer 2012, 13(5): 391-5.
    • (2012) Clin Lung Cancer , vol.13 , Issue.5 , pp. 391-395
    • Scagliotti, G.V.1    Novello, S.2    Schiller, J.H.3
  • 85
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research, N
    • Cancer Genome Atlas Research, N. Comprehensive genomic characterization of squamous cell lung cancers. Nature 2012, 489(7417): 519-25.
    • (2012) Nature , vol.489 , Issue.7417 , pp. 519-525
  • 86
    • 84870748688 scopus 로고    scopus 로고
    • RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer
    • Wang, R., Hu, H., Pan, Y. et al. RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer. J Clin Oncol 2012, 30(35): 4352-9.
    • (2012) J Clin Oncol , vol.30 , Issue.35 , pp. 4352-4359
    • Wang, R.1    Hu, H.2    Pan, Y.3
  • 87
    • 84896493186 scopus 로고    scopus 로고
    • RET-rearranged non-small-cell lung carcinoma: A clinicopathological and molecular analysis
    • Tsuta, K., Kohno, T., Yoshida, A., Shimada, Y., Asamura, H., Furuta, K., Kushima, R. RET-rearranged non-small-cell lung carcinoma: a clinicopathological and molecular analysis. Br J Cancer 2014, 110(6): 1571-8.
    • (2014) Br J Cancer , vol.110 , Issue.6 , pp. 1571-1578
    • Tsuta, K.1    Kohno, T.2    Yoshida, A.3    Shimada, Y.4    Asamura, H.5    Furuta, K.6    Kushima, R.7
  • 88
    • 84877156527 scopus 로고    scopus 로고
    • Personalized therapy on the horizon for squamous cell carcinoma of the lung
    • Kim, H.S., Mitsudomi, T., Soo, R.A., Cho, B.C. Personalized therapy on the horizon for squamous cell carcinoma of the lung. Lung Cancer 2013, 80(3): 249-55.
    • (2013) Lung Cancer , vol.80 , Issue.3 , pp. 249-255
    • Kim, H.S.1    Mitsudomi, T.2    Soo, R.A.3    Cho, B.C.4
  • 89
    • 84874888512 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer
    • Kim, H.R., Kim, D.J., Kang, D.R. et al. Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer. J Clin Oncol 2013, 31(6): 731-7.
    • (2013) J Clin Oncol , vol.31 , Issue.6 , pp. 731-737
    • Kim, H.R.1    Kim, D.J.2    Kang, D.R.3
  • 90
    • 84905370049 scopus 로고    scopus 로고
    • Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study
    • Jamal-Hanjani, M., Hackshaw, A., Ngai, Y. et al. Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study. PLoS Biol 2014, 12(7): e1001906.
    • (2014) PLoS Biol , vol.12 , Issue.7
    • Jamal-Hanjani, M.1    Hackshaw, A.2    Ngai, Y.3
  • 91
    • 84896705821 scopus 로고    scopus 로고
    • Clinical management patterns and treatment outcomes in patients with non-small cell lung cancer (NSCLC) across Europe: EPICLIN-Lung study
    • Carrato, A., Vergnenegre, A., Thomas, M., McBride, K., Medina, J., Cruciani, G. Clinical management patterns and treatment outcomes in patients with non-small cell lung cancer (NSCLC) across Europe: EPICLIN-Lung study. Curr Med Res Opin 2014, 30(3): 447-61.
    • (2014) Curr Med Res Opin , vol.30 , Issue.3 , pp. 447-461
    • Carrato, A.1    Vergnenegre, A.2    Thomas, M.3    McBride, K.4    Medina, J.5    Cruciani, G.6
  • 92
    • 79957857433 scopus 로고    scopus 로고
    • The BATTLE trial: Personalizing therapy for lung cancer
    • Kim, E.S., Herbst, R.S., Wistuba, II et al. The BATTLE trial: personalizing therapy for lung cancer. Cancer Discov 2011, 1(1): 44-53.
    • (2011) Cancer Discov , vol.1 , Issue.1 , pp. 44-53
    • Kim, E.S.1    Herbst, R.S.2    Wistuba, I.I.3
  • 93
    • 84890663541 scopus 로고    scopus 로고
    • Comprehensive biomarker analysis and final efficacy results of sorafenib in the BATTLE trial
    • Blumenschein, G.R., Jr., Saintigny, P., Liu, S. et al. Comprehensive biomarker analysis and final efficacy results of sorafenib in the BATTLE trial. Clin Cancer Res 2013, 19(24): 6967-75.
    • (2013) Clin Cancer Res , vol.19 , Issue.24 , pp. 6967-6975
    • Blumenschein Jr., G.R.1    Saintigny, P.2    Liu, S.3
  • 94
    • 84904863374 scopus 로고    scopus 로고
    • Large personalised medicine trial in lung cancer heralds new research partnership
    • Torjesen, I. Large personalised medicine trial in lung cancer heralds new research partnership. BMJ 2014, 348: g2837.
    • (2014) BMJ , vol.348
    • Torjesen, I.1
  • 95
    • 84901835916 scopus 로고    scopus 로고
    • Trial watch: Lung cancer trial aims to bolster personalized medicine
    • Harrison, C. Trial watch: lung cancer trial aims to bolster personalized medicine. Nat Rev Drug Discov 2014, 13(6): 407.
    • (2014) Nat Rev Drug Discov , vol.13 , Issue.6 , pp. 407
    • Harrison, C.1
  • 96
    • 84900829967 scopus 로고    scopus 로고
    • Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
    • Kris, M.G., Johnson, B.E., Berry, L.D. et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA 2014, 311(19): 1998-2006.
    • (2014) JAMA , vol.311 , Issue.19 , pp. 1998-2006
    • Kris, M.G.1    Johnson, B.E.2    Berry, L.D.3
  • 97
    • 84903581591 scopus 로고    scopus 로고
    • Antibodies to watch in 2014: Mid-year update
    • Reichert, J.M. Antibodies to watch in 2014: Mid-year update. MAbs 2014, 6(4): 799-802.
    • (2014) MAbs , vol.6 , Issue.4 , pp. 799-802
    • Reichert, J.M.1
  • 98
    • 84899412968 scopus 로고    scopus 로고
    • Biosimilars in oncology: From development to clinical practice
    • Rak Tkaczuk, K.H., Jacobs, I.A. Biosimilars in oncology: from development to clinical practice. Semin Oncol 2014, 41(Suppl. 3): S3-S12.
    • (2014) Semin Oncol , vol.41 , Issue.SUPPL. 3
    • Rak Tkaczuk, K.H.1    Jacobs, I.A.2


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