-
1
-
-
2342624080
-
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
-
Paez JG, Jänne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Jänne, P.A.2
Lee, J.C.3
-
2
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004;101:13306-11.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
-
3
-
-
84861203302
-
EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects
-
Soria JC, Mok TS, Cappuzzo F, et al. EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects. Cancer Treat Rev 2012;38:416-30.
-
(2012)
Cancer Treat Rev
, vol.38
, pp. 416-430
-
-
Soria, J.C.1
Mok, T.S.2
Cappuzzo, F.3
-
4
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-57.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
5
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
-
Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239-46.
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
6
-
-
84877926687
-
Biomarkers analyses and overall survival (OS) from the randomized, placebocontrolled, phase 3, FASTACT-2 study of intercalated erlotinib with first-line chemotherapy in advanced nonsmall cell lung cancer (NSCLC)
-
Mok TS, Lee JS, Zhang L, et al. Biomarkers analyses and overall survival (OS) from the randomized, placebocontrolled, phase 3, FASTACT-2 study of intercalated erlotinib with first-line chemotherapy in advanced nonsmall cell lung cancer (NSCLC). Ann Oncol 2012;29:ix 400;abstr 12260.
-
(2012)
Ann Oncol
, vol.29
-
-
Mok, T.S.1
Lee, J.S.2
Zhang, L.3
-
7
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-smallcell lung cancer
-
Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-smallcell lung cancer. N Engl J Med 2002;346:92-8.
-
(2002)
N Engl J Med
, vol.346
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
-
8
-
-
84861976809
-
First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung
-
Han JY, Park K, Kim SW, et al. First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung. J Clin Oncol 2012;30:1122-8.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1122-1128
-
-
Han, J.Y.1
Park, K.2
Kim, S.W.3
-
9
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
-
Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010;11:121-8.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
10
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010;362:2380-8.
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
11
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
-
Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011;12:735-42.
-
(2011)
Lancet Oncol
, vol.12
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
12
-
-
84866655838
-
LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations
-
Yang JC, Schuler MH, Yamamoto N, et al. LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin as first-line treatment for patients with advanced adenocarcinoma of the lung harboring EGFR-activating mutations. J Clin Oncol 2012;30:abstr LBA7500.
-
(2012)
J Clin Oncol
, vol.30
-
-
Yang, J.C.1
Schuler, M.H.2
Yamamoto, N.3
-
13
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123-32.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
14
-
-
77649222572
-
Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial
-
Douillard JY, Shepherd FA, Hirsh V, et al. Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial. J Clin Oncol 2010;28:744-52.
-
(2010)
J Clin Oncol
, vol.28
, pp. 744-752
-
-
Douillard, J.Y.1
Shepherd, F.A.2
Hirsh, V.3
-
15
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study
-
Cappuzzo F, Ciuleanu T, Stelmakh L, et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 2010;11:521-9.
-
(2010)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
-
16
-
-
84860479704
-
Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial
-
Zhang L, Ma S, Song X, et al. Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial. Lancet Oncol 2012;13:466-75.
-
(2012)
Lancet Oncol
, vol.13
, pp. 466-475
-
-
Zhang, L.1
Ma, S.2
Song, X.3
-
17
-
-
60549110433
-
MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
-
Cappuzzo F, Jänne PA, Skokan M, et al. MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients. Ann Oncol 2009;20:298-304.
-
(2009)
Ann Oncol
, vol.20
, pp. 298-304
-
-
Cappuzzo, F.1
Jänne, P.A.2
Skokan, M.3
-
18
-
-
33846187218
-
Update on epidermal growth factor receptor mutations in non-small cell lung cancer
-
Riely GJ, Politi KA, Miller VA, et al. Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin Cancer Res 2006;12:7232-41.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7232-7241
-
-
Riely, G.J.1
Politi, K.A.2
Miller, V.A.3
-
19
-
-
47549104067
-
EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids
-
Chen Z, Feng J, Saldivar JS, et al. EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids. Oncogene 2008;27:4336-43.
-
(2008)
Oncogene
, vol.27
, pp. 4336-4343
-
-
Chen, Z.1
Feng, J.2
Saldivar, J.S.3
-
20
-
-
79957916527
-
Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer
-
Wu JY, Yu CJ, Chang YC, et al. Effectiveness of tyrosine kinase inhibitors on "uncommon" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer. Clin Cancer Res 2011;17:3812-21.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 3812-3821
-
-
Wu, J.Y.1
Yu, C.J.2
Chang, Y.C.3
-
21
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005;352:786-92.
-
(2005)
N Engl J Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
-
22
-
-
84863410315
-
EGFR-TKI resistant nonsmall cell lung cancer (NSCLC): new developments and implications for future treatment
-
Brugger W, Thomas M. EGFR-TKI resistant nonsmall cell lung cancer (NSCLC): new developments and implications for future treatment. Lung Cancer 2012;77:2-8.
-
(2012)
Lung Cancer
, vol.77
, pp. 2-8
-
-
Brugger, W.1
Thomas, M.2
-
23
-
-
49649127657
-
Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
-
Engelman JA, Jänne PA. Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 2008;14:2895-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2895-2899
-
-
Engelman, J.A.1
Jänne, P.A.2
-
24
-
-
74949110711
-
Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
-
Jackman D, Pao W, Riely GJ, et al. Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. J Clin Oncol 2010;28:357-60.
-
(2010)
J Clin Oncol
, vol.28
, pp. 357-360
-
-
Jackman, D.1
Pao, W.2
Riely, G.J.3
-
25
-
-
84866601770
-
Timing of epidermal growth factor receptor tyrosine kinase inhibitor therapy in patients with lung cancer with EGFR mutations
-
Moran T, Sequist LV. Timing of epidermal growth factor receptor tyrosine kinase inhibitor therapy in patients with lung cancer with EGFR mutations. J Clin Oncol 2012;30:3330-6.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3330-3336
-
-
Moran, T.1
Sequist, L.V.2
-
26
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011;3:75ra26.
-
(2011)
Sci Transl Med
, vol.3
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
-
27
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007;316:1039-43.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
28
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 2007;104:20932-7.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
-
29
-
-
75049083402
-
Clinicopathologic and molecular features of epidermal growth factor receptor T790M mutation and c-MET amplification in tyrosine kinase inhibitor-resistant Chinese non-small cell lung cancer
-
Chen HJ, Mok TS, Chen ZH, et al. Clinicopathologic and molecular features of epidermal growth factor receptor T790M mutation and c-MET amplification in tyrosine kinase inhibitor-resistant Chinese non-small cell lung cancer. Pathol Oncol Res 2009;15:651-8.
-
(2009)
Pathol Oncol Res
, vol.15
, pp. 651-658
-
-
Chen, H.J.1
Mok, T.S.2
Chen, Z.H.3
-
30
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005;2:e73.
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
-
31
-
-
84872214179
-
Phase Ib study of ficlatuzumab (formerly AV-299), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb) in combination with gefitinib (G) in Asian patients (pts) with NSCLC
-
Tan E, Park K, Lim WT, et al. Phase Ib study of ficlatuzumab (formerly AV-299), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb) in combination with gefitinib (G) in Asian patients (pts) with NSCLC. J Clin Oncol 2011;29:abstr 7571.
-
(2011)
J Clin Oncol
, vol.29
-
-
Tan, E.1
Park, K.2
Lim, W.T.3
-
32
-
-
84873624178
-
A Randomized Phase 2 Study with Exploratory Biomarker Analysis of Ficlatuzumab, a Humanized Hepatocyte Growth Factor (HGF) Inhibitory Monoclonal Antibody, in Combination with Gefitinib versus Gefitinib Alone in Asian Patients With Lung Adenocarcinoma
-
abstr
-
Mok TS, Park K, Geater SL, et al. A Randomized Phase 2 Study with Exploratory Biomarker Analysis of Ficlatuzumab, a Humanized Hepatocyte Growth Factor (HGF) Inhibitory Monoclonal Antibody, in Combination with Gefitinib versus Gefitinib Alone in Asian Patients With Lung Adenocarcinoma. Ann Oncol 2012;23:abstr.
-
(2012)
Ann Oncol
, vol.23
-
-
Mok, T.S.1
Park, K.2
Geater, S.L.3
-
33
-
-
80052511675
-
Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC
-
Spigel DR, Ervin TJ, Ramlau R, et al. Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC. J Clin Oncol 2011;29:abstr 7505.
-
(2011)
J Clin Oncol
, vol.29
-
-
Spigel, D.R.1
Ervin, T.J.2
Ramlau, R.3
-
34
-
-
80051974548
-
Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
-
Sequist LV, von Pawel J, Garmey EG, et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol 2011;29:3307-15.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3307-3315
-
-
Sequist, L.V.1
von Pawel, J.2
Garmey, E.G.3
-
35
-
-
84866594844
-
Targeting the hepatocyte growth factor-cMET axis in cancer therapy
-
Blumenschein GR Jr, Mills GB, Gonzalez-Angulo AM. Targeting the hepatocyte growth factor-cMET axis in cancer therapy. J Clin Oncol 2012;30:3287-96.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3287-3296
-
-
Blumenschein, G.R.1
Mills, G.B.2
Gonzalez-Angulo, A.M.3
-
36
-
-
84555202728
-
MET signaling pathway: a rational target for cancer therapy
-
Appleman LJ. MET signaling pathway: a rational target for cancer therapy. J Clin Oncol 2011;29:4837-8.
-
(2011)
J Clin Oncol
, vol.29
, pp. 4837-4838
-
-
Appleman, L.J.1
-
37
-
-
77952519096
-
Clinical implications of MET gene copy number in lung cancer
-
Toschi L, Cappuzzo F. Clinical implications of MET gene copy number in lung cancer. Future Oncol 2010;6:239-47.
-
(2010)
Future Oncol
, vol.6
, pp. 239-247
-
-
Toschi, L.1
Cappuzzo, F.2
-
38
-
-
79952711946
-
Acquired resistance to EGFR tyrosine kinase inhibitors in EGFRmutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation
-
Oxnard GR, Arcila ME, Sima CS, et al. Acquired resistance to EGFR tyrosine kinase inhibitors in EGFRmutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation. Clin Cancer Res 2011;17:1616-22.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1616-1622
-
-
Oxnard, G.R.1
Arcila, M.E.2
Sima, C.S.3
-
39
-
-
79952259564
-
Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
-
Arcila ME, Oxnard GR, Nafa K, et al. Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res 2011;17:1169-80.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1169-1180
-
-
Arcila, M.E.1
Oxnard, G.R.2
Nafa, K.3
-
40
-
-
40049099220
-
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
-
Yun CH, Mengwasser KE, Toms AV, et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A 2008;105:2070-5.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2070-2075
-
-
Yun, C.H.1
Mengwasser, K.E.2
Toms, A.V.3
-
41
-
-
61549108338
-
EGFR T790M mutation: a double role in lung cancer cell survival?
-
Suda K, Onozato R, Yatabe Y, et al. EGFR T790M mutation: a double role in lung cancer cell survival? J Thorac Oncol 2009;4:1-4.
-
(2009)
J Thorac Oncol
, vol.4
, pp. 1-4
-
-
Suda, K.1
Onozato, R.2
Yatabe, Y.3
-
42
-
-
21144439000
-
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
-
Kwak EL, Sordella R, Bell DW, et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci U S A 2005;102:7665-70.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 7665-7670
-
-
Kwak, E.L.1
Sordella, R.2
Bell, D.W.3
-
43
-
-
77949884661
-
Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
-
Blackwell KL, Burstein HJ, Storniolo AM, et al. Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol 2010;28:1124-30.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1124-1130
-
-
Blackwell, K.L.1
Burstein, H.J.2
Storniolo, A.M.3
-
44
-
-
70349684791
-
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
-
Regales L, Gong Y, Shen R, et al. Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer. J Clin Invest 2009;119:3000-10.
-
(2009)
J Clin Invest
, vol.119
, pp. 3000-3010
-
-
Regales, L.1
Gong, Y.2
Shen, R.3
-
45
-
-
80052441453
-
Activity and tolerability of afatinib (BIBW2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib
-
Janjigian YY, Groen HJ, Horn L, et al. Activity and tolerability of afatinib (BIBW2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib. J Clin Oncol 2011; 29:abstr 7525.
-
(2011)
J Clin Oncol
, vol.29
-
-
Janjigian, Y.Y.1
Groen, H.J.2
Horn, L.3
-
46
-
-
84873677937
-
Activity of afatinib/cetuximab in patients with EGFR mutant non-small cell lung cancer and acquired resistance to EGFR inhibitors
-
Janjigian YY, Smith EE, Horn L, et al. Activity of afatinib/cetuximab in patients with EGFR mutant non-small cell lung cancer and acquired resistance to EGFR inhibitors. Ann Oncol 2012;23:ix 401.
-
(2012)
Ann Oncol
, vol.23
-
-
Janjigian, Y.Y.1
Smith, E.E.2
Horn, L.3
-
47
-
-
49149118719
-
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
-
Li D, Ambrogio L, Shimamura T, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008;27:4702-11.
-
(2008)
Oncogene
, vol.27
, pp. 4702-4711
-
-
Li, D.1
Ambrogio, L.2
Shimamura, T.3
-
49
-
-
37549061078
-
PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib
-
Engelman JA, Zejnullahu K, Gale CM, et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res 2007;67:11924-32.
-
(2007)
Cancer Res
, vol.67
, pp. 11924-11932
-
-
Engelman, J.A.1
Zejnullahu, K.2
Gale, C.M.3
-
50
-
-
77957585027
-
Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors
-
Yap TA, Vidal L, Adam J, et al. Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors. J Clin Oncol 2010;28:3965-72.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3965-3972
-
-
Yap, T.A.1
Vidal, L.2
Adam, J.3
-
51
-
-
84862785051
-
Afatinib versus placebo for patients with advanced, metastatic nonsmall-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUXLung 1): a phase 2b/3 randomised trial
-
Miller VA, Hirsh V, Cadranel J, et al. Afatinib versus placebo for patients with advanced, metastatic nonsmall-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUXLung 1): a phase 2b/3 randomised trial. Lancet Oncol 2012;13:528-38.
-
(2012)
Lancet Oncol
, vol.13
, pp. 528-538
-
-
Miller, V.A.1
Hirsh, V.2
Cadranel, J.3
-
52
-
-
84881665623
-
LUX Lung 4: a phase II of Afatinib (BIBW2992) in advanced NSCLC patients previously treated with erlotinib or gefitinib
-
Atagi S, Katakami N, Hida T, et al. LUX Lung 4: a phase II of Afatinib (BIBW2992) in advanced NSCLC patients previously treated with erlotinib or gefitinib. J Thor Oncol 2011;6:abstr O19.06.
-
(2011)
J Thor Oncol
, vol.6
-
-
Atagi, S.1
Katakami, N.2
Hida, T.3
-
53
-
-
84862819699
-
Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial
-
Yang JC, Shih JY, Su WC, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol 2012;13:539-48.
-
(2012)
Lancet Oncol
, vol.13
, pp. 539-548
-
-
Yang, J.C.1
Shih, J.Y.2
Su, W.C.3
-
54
-
-
56349167837
-
Preliminary activity and safety results from a phase I clinical trial of PF-00299804, an Irreversible pan-HER inhibitor in patients with NSCLC
-
Janne PA, Schellenns JH, Engelman JA, et al. Preliminary activity and safety results from a phase I clinical trial of PF-00299804, an Irreversible pan-HER inhibitor in patients with NSCLC. J Clin Oncol 2008;26:abstr 8027.
-
(2008)
J Clin Oncol
, vol.26
-
-
Janne, P.A.1
Schellenns, J.H.2
Engelman, J.A.3
-
55
-
-
77349106710
-
A phase 2 trial of PF-00299804, an oral irreversible HER kinase inhibitor (TKI) in patients with advanced NSCLC after failure of prior chemotherapy: preliminary efficacy and safety results
-
Janne PA, Reckamp K, Koczywas M, et al. A phase 2 trial of PF-00299804, an oral irreversible HER kinase inhibitor (TKI) in patients with advanced NSCLC after failure of prior chemotherapy: preliminary efficacy and safety results. J Thorac Oncol 2009;4:S293-94.
-
(2009)
J Thorac Oncol
, vol.4
, pp. S293-S294
-
-
Janne, P.A.1
Reckamp, K.2
Koczywas, M.3
-
56
-
-
79952535822
-
PF299804 in Asian patients with non-small-cell lung cancer refractory to chemotherapy and erlotinib or gefitinib: aphase I/II study
-
Park K, Heo DS, Cho BC, et al. PF299804 in Asian patients with non-small-cell lung cancer refractory to chemotherapy and erlotinib or gefitinib: aphase I/II study. J Clin Oncol 2010;28:abstr 7599.
-
(2010)
J Clin Oncol
, vol.28
-
-
Park, K.1
Heo, D.S.2
Cho, B.C.3
-
57
-
-
84942601355
-
Dacomitinib (PF-00299804), an Irreversible pan-HER Tyrosine Kinase Inhibitor, for First-Line Treatment of EGFR-Mutant or HER2-Mutant or-Amplified Lung Cancers
-
Kris MG, Mok T, Ou SH, et al. Dacomitinib (PF-00299804), an Irreversible pan-HER Tyrosine Kinase Inhibitor, for First-Line Treatment of EGFR-Mutant or HER2-Mutant or-Amplified Lung Cancers. J Clin Oncol 2012;30:abstr 7530.
-
(2012)
J Clin Oncol
, vol.30
-
-
Kris, M.G.1
Mok, T.2
Ou, S.H.3
-
58
-
-
65249170861
-
A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors
-
Wong KK, Fracasso PM, Bukowski RM, et al. A phase I study with neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin Cancer Res 2009;15:2552-8.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2552-2558
-
-
Wong, K.K.1
Fracasso, P.M.2
Bukowski, R.M.3
-
59
-
-
84866255620
-
Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer
-
Ramalingam SS, Blackhall F, Krzakowski M, et al. Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer. J Clin Oncol 2012;30:3337-44.
-
(2012)
J Clin Oncol
, vol.30
, pp. 3337-3344
-
-
Ramalingam, S.S.1
Blackhall, F.2
Krzakowski, M.3
-
60
-
-
77954584507
-
Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced nonsmall-cell lung cancer
-
Sequist LV, Besse B, Lynch TJ, et al. Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced nonsmall-cell lung cancer. J Clin Oncol 2010;28:3076-83.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3076-3083
-
-
Sequist, L.V.1
Besse, B.2
Lynch, T.J.3
-
61
-
-
84863892117
-
Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial
-
Jänne PA, Wang X, Socinski MA, et al. Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial. J Clin Oncol 2012;30:2063-9.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2063-2069
-
-
Jänne, P.A.1
Wang, X.2
Socinski, M.A.3
-
62
-
-
45149084723
-
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
-
Sequist LV, Martins RG, Spigel D, et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008;26:2442-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2442-2449
-
-
Sequist, L.V.1
Martins, R.G.2
Spigel, D.3
-
63
-
-
84879888935
-
Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations in LUX-Lung 3, a phase III trial of afatinib or cisplatin/pemetrexed in EGFR mutationpositive lung cancer
-
Yang JC, Schuler M, Yamamoto N, et al. Activity of afatinib in uncommon epidermal growth factor receptor (EGFR) mutations in LUX-Lung 3, a phase III trial of afatinib or cisplatin/pemetrexed in EGFR mutationpositive lung cancer. Ann Oncol 2012;23:ix410, abstr 1256p.
-
(2012)
Ann Oncol
, vol.23
, pp. ix410
-
-
Yang, J.C.1
Schuler, M.2
Yamamoto, N.3
-
64
-
-
84959904533
-
Efficacy of the irreversible EGFR-HER2 dual inhibitor afatinib in pretreated lung adenocarcinoma
-
Landi L, Galetta D, Bennati C, et al. Efficacy of the irreversible EGFR-HER2 dual inhibitor afatinib in pretreated lung adenocarcinoma. Ann Oncol 2012;23:ix423, abstr 1288P.
-
(2012)
Ann Oncol
, vol.23
, pp. ix423
-
-
Landi, L.1
Galetta, D.2
Bennati, C.3
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