Neratinib: An oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer

Expert Opinion on Investigational Drugs

Volumn 18, Issue 11, 2009, Pages 1735-1751

  Bose, Prithviraj ^a   Ozer, Howard ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

EGFR; HER2; HKI 272; Neratinib; Tyrosine kinase

Indexed keywords

4 [3 CHLORO 4 (2 PYRIDINYLMETHOXY)ANILINO] 3 CYANO 6 (4 DIMETHYLAMINOCROTONAMIDO) 7 ETHOXYQUINOLINE; CANERTINIB; CAPECITABINE; CETUXIMAB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; LAPATINIB; LEFLUNOMIDE; MATUZUMAB; N [4 (3 CHLORO 4 FLUOROANILINO) 7 (TETRAHYDRO 3 FURYLOXY) 6 QUINAZOLINYL] 4 DIMETHYLAMINO 2 BUTENAMIDE; NAVELBINE; NERATINIB; PACLITAXEL; PANITUMUMAB; PELITINIB; PEMETREXED; PERTUZUMAB; PF 299804; PROCARBAZINE; RAPAMYCIN; TRASTUZUMAB; UNCLASSIFIED DRUG; VANDETANIB; XL 647;

ADVANCED CANCER; ANOREXIA; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER RESISTANCE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; DIARRHEA; DRUG ACTIVITY; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG MARKETING; DRUG METABOLISM; DRUG RESPONSE; DRUG SAFETY; DRUG STRUCTURE; FATIGUE; GLIOBLASTOMA; HEAD AND NECK CANCER; HUMAN; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; MEDLINE; NAUSEA; ONCOGENE; OVARY CANCER; PHARMACODYNAMICS; PIPELINE; PROSTATE CANCER; REVIEW; SINGLE DRUG DOSE; VOMITING;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; LUNG NEOPLASMS; QUINOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 73849107114     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543780903305428     Document Type: Review

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