메뉴 건너뛰기




Volumn 46, Issue 9, 2010, Pages 683-698

Vandetanib: An overview of its clinical development in NSCLC and other tumors

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BORTEZOMIB; CALCITONIN; CARBOPLATIN; CARCINOEMBRYONIC ANTIGEN; CYTOKINE; DOCETAXEL; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; FULVESTRANT; GEFITINIB; GELATINASE B; GEMCITABINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 12; INTERLEUKIN 8; IRINOTECAN; MONOCYTE CHEMOTACTIC PROTEIN 1; OXALIPLATIN; PACLITAXEL; PEMETREXED; PREDNISOLONE; TAXANE DERIVATIVE; UNINDEXED DRUG; VANDETANIB;

EID: 79955891953     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2010.46.9.1516989     Document Type: Review
Times cited : (33)

References (59)
  • 4
    • 0032852528 scopus 로고    scopus 로고
    • Molecular and biological properties of vascular endothelial growth factor
    • Ferrara, N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med 1999, 77(7): 527-43.
    • (1999) J Mol Med , vol.77 , Issue.7 , pp. 527-543
    • Ferrara, N.1
  • 5
    • 0035793623 scopus 로고    scopus 로고
    • Analysis of biological effects and signalling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2)
    • Gille, H., Kowalski, J., Li, B. et al. Analysis of biological effects and signalling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). J Biol Chem 2001, 276(5): 3222-30.
    • (2001) J Biol Chem , vol.276 , Issue.5 , pp. 3222-3230
    • Gille, H.1    Kowalski, J.2    Li, B.3
  • 6
    • 0032999409 scopus 로고    scopus 로고
    • EGF receptors
    • Wells, A. EGF receptors. Int J Biochem Cell Biol 1999, 31(6): 637-43.
    • (1999) Int J Biochem Cell Biol , vol.31 , Issue.6 , pp. 637-643
    • Wells, A.1
  • 8
    • 43049161065 scopus 로고    scopus 로고
    • RET oncogene in MEN2, MEN2B, MTC and other forms of thyroid cancer
    • DOI 10.1586/14737140.8.4.625
    • Lodish, M.B., Stratakis, C.A. RET oncogene in MEN2, MEN2B, MTC and other forms of thyroid cancer. Expert Rev Anticancer Ther 2008, 8(4): 625-32. (Pubitemid 351818356)
    • (2008) Expert Review of Anticancer Therapy , vol.8 , Issue.4 , pp. 625-632
    • Lodish, M.B.1    Stratakis, C.A.2
  • 9
    • 33646227448 scopus 로고    scopus 로고
    • Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy
    • Tonra, J.R., Deevi, D.S., Corcoran, E., Li, H., Wang, S., Carrick, F.E., Hicklin, D.J. Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapy. Clin Cancer Res 2006, 12(7, Pt. 1): 2197-207.
    • (2006) Clin Cancer Res , vol.12 , Issue.7 PART 1 , pp. 2197-2207
    • Tonra, J.R.1    Deevi, D.S.2    Corcoran, E.3    Li, H.4    Wang, S.5    Carrick, F.E.6    Hicklin, D.J.7
  • 10
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, anglogenesis, and tumor growth following oral administration
    • Wedge, S.R., Ogilvie, D.J., Dukes, M. et al. ZD6474 inhibits vascular endothelial growth factor signaling, anglogenesis, and tumor growth following oral administration. Cancer Res 2002, 62(16): 4645-55.
    • (2002) Cancer Res , vol.62 , Issue.16 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 12
    • 4644359863 scopus 로고    scopus 로고
    • ZD6474 a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and anglogenesis of gastric cancer
    • McCarty, M.F., Wey, J., Stoeltzing, O. et al. ZD6474 a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and anglogenesis of gastric cancer. Mol Cancer Ther 2004, 3(9): 1042-8.
    • (2004) Mol Cancer Ther , vol.3 , Issue.9 , pp. 1042-1048
    • McCarty, M.F.1    Wey, J.2    Stoeltzing, O.3
  • 14
    • 20044375036 scopus 로고    scopus 로고
    • The VEGF receptor tyrosine kinase inhibitor, ZD6474, inhibits angiogenesis and affects microvascular architecture within an orthotopically implanted renal cell carcinoma
    • DOI 10.1007/s10456-005-1394-3
    • Drevs, J., Konerding, M.A., Wolloscheck, T. et al. The VEGF receptor tyrosine kinase inhibitor, ZD6474, inhibits angiogenesis and affects microvasculature architecture within an orthotopically implanted renal cell carcinoma. Angiogenesis 2004, 7(4): 347-54. (Pubitemid 40767936)
    • (2004) Angiogenesis , vol.7 , Issue.4 , pp. 347-354
    • Drevs, J.1    Konerding, M.A.2    Wolloscheck, T.3    Wedge, S.R.4    Ryan, A.J.5    Ogilvie, D.J.6    Esser, N.7
  • 15
    • 0346752528 scopus 로고    scopus 로고
    • Use of dynamic contrast-enhanced MRI to evaluate acute treatment with ZD6474, a VEGF signalling inhibitor, in PC-3 prostate tumours
    • DOI 10.1038/sj.bjc.6601386
    • Checkley, D., Tessier, J.J., Kendrew, J. et al. Use of dynamic contrast-enhanced MRI to evaluate acute treatment with ZD6474, a VEGF signalling inhibitor, in PC-3 prostate tumors. Br J Cancer 2003, 89(10): 1889-95. (Pubitemid 37533265)
    • (2003) British Journal of Cancer , vol.89 , Issue.10 , pp. 1889-1895
    • Checkley, D.1    Tessier, J.J.2    Kendrew, J.3    Waterton, J.C.4    Wedge, S.R.5
  • 16
    • 21244502653 scopus 로고    scopus 로고
    • The VEGF signaling inhibitors ZD6474 and AZD2171 compromise hemodynamic parameters in an SW620 human colon tumor model: An analysis using perfusion-permeability dynamic contrast-enhanced magnetic resonance imaging (pp-DCE-MRI)
    • Abst 4552
    • Bradley, D.P., Tessier, J.T., Checkley, D. et al. The VEGF signaling inhibitors ZD6474 and AZD2171 compromise hemodynamic parameters in an SW620 human colon tumor model: An analysis using perfusion-permeability dynamic contrast-enhanced magnetic resonance imaging (pp-DCE-MRI). Proc Amer Assoc Cancer Res 2004, 45: Abst 4552.
    • (2004) Proc Amer Assoc Cancer Res , vol.45
    • Bradley, D.P.1    Tessier, J.T.2    Checkley, D.3
  • 17
    • 0842289982 scopus 로고    scopus 로고
    • Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy
    • DOI 10.1158/1078-0432.CCR-1100-03
    • Ciardiello, F., Bianco, R., Caputo, R. et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin Cancer Res 2004, 10(2): 784-93. (Pubitemid 38174017)
    • (2004) Clinical Cancer Research , vol.10 , Issue.2 , pp. 784-793
    • Ciardiello, F.1    Bianco, R.2    Caputo, R.3    Caputo, R.4    Damiano, V.5    Troiani, T.6    Melisi, D.7    De Vita, F.8    De Placido, S.9    Bianco, A.R.10    Tortora, G.11
  • 18
    • 10844285939 scopus 로고    scopus 로고
    • Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib (Iressa)-sensitive and resistant xenograft models
    • DOI 10.1111/j.1349-7006.2004.tb03187.x
    • Taguchi, F., Koh, Y., Koizumi, F., Tamura, T., Saijo, N., Nishio, K. Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib-sensitive and -resistant xenograft models. Cancer Sci 2004, 95(12): 984-9. (Pubitemid 40089591)
    • (2004) Cancer Science , vol.95 , Issue.12 , pp. 984-989
    • Taguchi, F.1    Koh, Y.2    Koizumi, F.3    Tamura, T.4    Saijo, N.5    Nishio, K.6
  • 19
    • 33748310873 scopus 로고    scopus 로고
    • Sequence-dependent inhibition of human colon cancer cell growth and of prosurvival pathways by oxaliplatin in combination with ZD6474 (Zactima), an inhibitor of VEGFR and EGFR tyrosine kinases
    • DOI 10.1158/1535-7163.MCT-06-0055
    • Troiani, T., Lockerbie, O., Morrow, M. et al. Sequence-dependent inhibition of human colon cancer cell growth and of prosurvival pathways by oxaliplatin in combination with ZD6474 (Zactima), an inhibitor of VEGFR and EGFR tyrosine kinases. Mol Cancer Ther. 2006, 5(7): 1883-94. (Pubitemid 44323257)
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.7 , pp. 1883-1894
    • Troiani, T.1    Lockerbie, O.2    Morrow, M.3    Ciardiello, F.4    Eckhardt, S.G.5
  • 20
    • 21244449289 scopus 로고    scopus 로고
    • Augmentation of radiation response with the VEGFR-tyrosine kinase inhibitor ZD6474
    • Abst 955
    • Hoang, T., Huang, S.M., Armstrong, E.A. et al. Augmentation of radiation response with the VEGFR-tyrosine kinase inhibitor ZD6474. Proc Am Assoc Cancer Res 2004, 45: Abst 955.
    • (2004) Proc Am Assoc Cancer Res , vol.45
    • Hoang, T.1    Huang, S.M.2    Armstrong, E.A.3
  • 21
    • 11144223542 scopus 로고    scopus 로고
    • ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: Schedule-dependent enhancement of antitumor activity
    • DOI 10.1158/1078-0432.CCR-04-1147
    • Williams, K.J., Telfer, B.A., Brave, S. et al. ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: schedule dependent enhancement of antitumor activity. Clin Cancer Res 2004, 10(24): 8587-93. (Pubitemid 40053426)
    • (2004) Clinical Cancer Research , vol.10 , Issue.24 , pp. 8587-8593
    • Williams, K.J.1    Telfer, B.A.2    Brave, S.3    Kendrew, J.4    Whittaker, L.5    Stratford, I.J.6    Wedge, S.R.7
  • 22
    • 33845789166 scopus 로고    scopus 로고
    • Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer
    • Bianco, C., Giovannetti, E., Ciardiello, F. et al. Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer. Clin Cancer Res 2006, 12(23): 7099-107.
    • (2006) Clin Cancer Res , vol.12 , Issue.23 , pp. 7099-7107
    • Bianco, C.1    Giovannetti, E.2    Ciardiello, F.3
  • 25
    • 61649116935 scopus 로고    scopus 로고
    • An open-label study of vandetanib with pemetrexed in patients with previously treated non-small cell lung cancer
    • De Boer, R., Humblet, Y., Wolf, J. et al. An open-label study of vandetanib with pemetrexed in patients with previously treated non-small cell lung cancer. Ann Oncol 2009, 20(3): 486-91.
    • (2009) Ann Oncol , vol.20 , Issue.3 , pp. 486-491
    • De Boer, R.1    Humblet, Y.2    Wolf, J.3
  • 26
    • 68149172828 scopus 로고    scopus 로고
    • Vandetanib with FOLFIRI in patients with advanced colorectal adenocarcinoma: Results from an open-label, multicentre phase I study
    • Saunders, M.P., Wilson, R., Peeters, M., Smith, R., Godwood, A., Oliver, S., Van Cutsem, E. Vandetanib with FOLFIRI in patients with advanced colorectal adenocarcinoma: Results from an open-label, multicentre phase I study. Cancer Chemother Pharmacol 2009, 64(4): 665-72.
    • (2009) Cancer Chemother Pharmacol , vol.64 , Issue.4 , pp. 665-672
    • Saunders, M.P.1    Wilson, R.2    Peeters, M.3    Smith, R.4    Godwood, A.5    Oliver, S.6    Van Cutsem, E.7
  • 27
    • 64649096230 scopus 로고    scopus 로고
    • Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer
    • Michael, M., Gibbs, P., Smith, R., Godwood, A., Oliver, S., Tebbutt, N. Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer. Invest New Drugs 2009, 27(3): 253-61.
    • (2009) Invest New Drugs , vol.27 , Issue.3 , pp. 253-261
    • Michael, M.1    Gibbs, P.2    Smith, R.3    Godwood, A.4    Oliver, S.5    Tebbutt, N.6
  • 28
    • 66249118670 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions
    • Morabito, A., Piccirillo, M.C., Falasconi, F. et al. Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions. Oncologist 2009, 14(4): 378-90.
    • (2009) Oncologist , vol.14 , Issue.4 , pp. 378-390
    • Morabito, A.1    Piccirillo, M.C.2    Falasconi, F.3
  • 30
    • 56749102822 scopus 로고    scopus 로고
    • Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
    • Heymach, J.V., Paz-Ares, L., De Braud, F. et al. Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2008, 26(33): 5407-15.
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5407-5415
    • Heymach, J.V.1    Paz-Ares, L.2    De Braud, F.3
  • 32
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results from a two-part, double-blind, randomized phase II study
    • Natale, R.B., Bodkin, D., Govindan, R. et al. Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results from a two-part, double-blind, randomized phase II study. J Clin Oncol 2009, 27(15): 2523-9.
    • (2009) J Clin Oncol , vol.27 , Issue.15 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 33
    • 74949090109 scopus 로고    scopus 로고
    • Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer
    • Hanrahan, E.O., Lin, H.Y., Kim, E.S. et al. Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. J Clin Oncol 2010, 28(2): 193-201.
    • (2010) J Clin Oncol , vol.28 , Issue.2 , pp. 193-201
    • Hanrahan, E.O.1    Lin, H.Y.2    Kim, E.S.3
  • 34
    • 66149188254 scopus 로고    scopus 로고
    • Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer
    • Hanrahan, E.O., Ryan, A.J., Mann, H. et al. Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer. Clin Cancer Res 2009, 15(10): 3600-9.
    • (2009) Clin Cancer Res , vol.15 , Issue.10 , pp. 3600-3609
    • Hanrahan, E.O.1    Ryan, A.J.2    Mann, H.3
  • 35
    • 70349476412 scopus 로고    scopus 로고
    • Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST)
    • Abst 8009
    • Natale, R.B., Thongprasert, S., Greco, F.A. et al. Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST). J Clin Oncol 2009, 27(15, Suppl.): Abst 8009.
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3
  • 36
    • 78049395323 scopus 로고    scopus 로고
    • Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): A randomized, double-blind phase III trial (ZEPHYR)
    • Abst 7525
    • Lee, J., Hirsh, V., Park, K. et al. Vandetanib versus placebo in patients with advanced non-small cell lung cancer (NSCLC) after prior therapy with an EGFR tyrosine kinase inhibitor (TKI): A randomized, double-blind phase III trial (ZEPHYR). J Clin Oncol 2010, 28(7, Suppl.): Abst 7525.
    • (2010) J Clin Oncol , vol.28 , Issue.7 SUPPL.
    • Lee, J.1    Hirsh, V.2    Park, K.3
  • 37
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (ZODIAC): A double-blind, randomized, phase 3 trial
    • Herbst, R.S., Sun, Y., Eberhardt, W.E.E. et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (ZODIAC): A double-blind, randomized, phase 3 trial. Lancet Oncol 2010, 11(7): 619-26.
    • (2010) Lancet Oncol , vol.11 , Issue.7 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.E.3
  • 38
    • 70349474058 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL)
    • Abst 8010
    • De Boer, R., Arrieta, O., Gottfried, M. et al. Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL). J Clin Oncol 2009, 27(15, Suppl.): Abst 8010.
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • De Boer, R.1    Arrieta, O.2    Gottfried, M.3
  • 39
    • 79959371861 scopus 로고    scopus 로고
    • Tumor biomarker analyses from the phase III ZODIAC study of docetaxel + vandetanib in 2nd-line advanced NSCLC
    • Abst 7516
    • Johnson, B.E., Ryan, A.J., Heymach, J.V. et al. Tumor biomarker analyses from the phase III ZODIAC study of docetaxel + vandetanib in 2nd-line advanced NSCLC. J Clin Oncol 2010, 28(7, Suppl.): Abst 7516.
    • (2010) J Clin Oncol , vol.28 , Issue.7 SUPPL.
    • Johnson, B.E.1    Ryan, A.J.2    Heymach, J.V.3
  • 40
    • 77649214078 scopus 로고    scopus 로고
    • Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Wells, S.A. Jr., Gosnell, J.E., Gagel, R.F. et al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol 2010, 28(5): 767-72.
    • (2010) J Clin Oncol , vol.28 , Issue.5 , pp. 767-772
    • Wells Jr., S.A.1    Gosnell, J.E.2    Gagel, R.F.3
  • 41
    • 77954478933 scopus 로고    scopus 로고
    • Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Robinson, B.G., Paz-Ares, L., Krebs, A., Vasselli, J., Haddad, R. Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab 2010, 95(6): 2664-71.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.6 , pp. 2664-2671
    • Robinson, B.G.1    Paz-Ares, L.2    Krebs, A.3    Vasselli, J.4    Haddad, R.5
  • 42
    • 78650408242 scopus 로고    scopus 로고
    • Vandetanib (VAN) in locally advanced or metastatic medullary thyroid cancer (MTC): A randomized, double-blind phase III trial (ZETA)
    • Abst 5503
    • Wells, S.A., Robinson, B.G., Gagel, R.F. et al. Vandetanib (VAN) in locally advanced or metastatic medullary thyroid cancer (MTC): A randomized, double-blind phase III trial (ZETA). J Clin Oncol 2010, 28(15, Suppl.): Abst 5503.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Wells, S.A.1    Robinson, B.G.2    Gagel, R.F.3
  • 43
    • 18244387980 scopus 로고    scopus 로고
    • A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer
    • DOI 10.1158/1078-0432.CCR-04-1923
    • Miller, K.D., Trigo, J.M., Wheeler, C., Barge, A., Rowbottom, .J, Sledge, G., Baselga, J. A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer. Clin Cancer Res 2005, 11(9): 3369-76. (Pubitemid 40627889)
    • (2005) Clinical Cancer Research , vol.11 , Issue.9 , pp. 3369-3376
    • Miller, K.D.1    Trigo, J.M.2    Wheeler, C.3    Barge, A.4    Rowbottom, J.5    Sledge, G.6    Baselga, J.7
  • 46
    • 74549205168 scopus 로고    scopus 로고
    • Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2
    • Annunziata, C.M., Walker, A.J., Minasian, L. et al. Vandetanib, designed to inhibit VEGFR2 and EGFR signaling, had no clinical activity as monotherapy for recurrent ovarian cancer and no detectable modulation of VEGFR2. Clin Cancer Res 2010, 16(2): 664-72.
    • (2010) Clin Cancer Res , vol.16 , Issue.2 , pp. 664-672
    • Annunziata, C.M.1    Walker, A.J.2    Minasian, L.3
  • 47
    • 66249113517 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled phase II study of vandetanib plus docetaxel/prednisolone in patients with hormone-refractory prostate cancer
    • Horti, J., Widmark, A., Stenzl, A. et al. A randomized, double-blind, placebo-controlled phase II study of vandetanib plus docetaxel/prednisolone in patients with hormone-refractory prostate cancer. Cancer Biother Radiopharm 2009, 24(2): 175-80.
    • (2009) Cancer Biother Radiopharm , vol.24 , Issue.2 , pp. 175-180
    • Horti, J.1    Widmark, A.2    Stenzl, A.3
  • 48
    • 33747644424 scopus 로고    scopus 로고
    • A phase II study of ZD6474 Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma - NCIC CTG IND.145
    • Kovacs, M.J., Reece, D.E., Marcellus, D., Meyer, R.M., Mathews, S., Dong, R.P., Eisenhauer, E. A phase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma - NCIC CTG IND.145. Invest New Drugs 2006, 24(6): 529-35.
    • (2006) Invest New Drugs , vol.24 , Issue.6 , pp. 529-535
    • Kovacs, M.J.1    Reece, D.E.2    Marcellus, D.3    Meyer, R.M.4    Mathews, S.5    Dong, R.P.6    Eisenhauer, E.7
  • 49
    • 79955882203 scopus 로고    scopus 로고
    • Vandetanib plus mFOLFOX6 in patients with advanced colorectal cancer (CRC): A randomized, double-blind, placebo-controlled phase II study
    • Abst 4084
    • Yang, T.S., Oh, D.Y., Guimbaud, R. et al. Vandetanib plus mFOLFOX6 in patients with advanced colorectal cancer (CRC): A randomized, double-blind, placebo-controlled phase II study. J Clin Oncol 2009, 27(15, Suppl.): Abst 4084.
    • (2009) J Clin Oncol , vol.27 , Issue.15 SUPPL.
    • Yang, T.S.1    Oh, D.Y.2    Guimbaud, R.3
  • 50
    • 79955924546 scopus 로고    scopus 로고
    • Phase I/II study of vandetanib for patients with recurrent malignant gliomas
    • Abst 2083
    • Mcnicol, K.A., Kreisl, T.N., Iwamoto, F.M., Sul, J., Fine, H.A. Phase I/II study of vandetanib for patients with recurrent malignant gliomas. J Clin Oncol 2010, 28(15, Suppl.): Abst 2083.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL.
    • Mcnicol, K.A.1    Kreisl, T.N.2    Iwamoto, F.M.3    Sul, J.4    Fine, H.A.5
  • 51
    • 77954785198 scopus 로고    scopus 로고
    • A phase I study of two different schedules of nab-paclitaxel (Nab-p) with ascending doses of vandetanib (V) in patients (pts) with advanced solid tumors
    • Abst 3059
    • El-Khoueiry, A.B., Iqbal, S., Lenz, H. et al. A phase I study of two different schedules of nab-paclitaxel (Nab-p) with ascending doses of vandetanib (V) in patients (pts) with advanced solid tumors. J Clin Oncol 2010, 28(7, Suppl.): Abst 3059.
    • (2010) J Clin Oncol , vol.28 , Issue.7 SUPPL.
    • El-Khoueiry, A.B.1    Iqbal, S.2    Lenz, H.3
  • 52
    • 29144460234 scopus 로고    scopus 로고
    • Is tailored therapy feasible in oncology?
    • Gasparini, G., Longo, R., Torino, F. et al. Is tailored therapy feasible in oncology? Crit Rev Oncol Hematol 2006, 57(1): 79-101.
    • (2006) Crit Rev Oncol Hematol , vol.57 , Issue.1 , pp. 79-101
    • Gasparini, G.1    Longo, R.2    Torino, F.3
  • 53
    • 14544305077 scopus 로고    scopus 로고
    • Combination of antiangiogenic therapy with other anticancer therapies: Results, challenges, and open questions
    • DOI 10.1200/JCO.2005.10.022
    • Gasparini, G., Longo, R., Fanelli, M. et al. Combination of antiangiogenic therapy with other anticancer therapies: Results, challenges, and open questions. J Clin Oncol 2005, 23(6): 1295-311. (Pubitemid 46202288)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.6 , pp. 1295-1311
    • Gasparini, G.1    Longo, R.2    Fanelli, M.3    Teicher, B.A.4
  • 54
    • 33745612994 scopus 로고    scopus 로고
    • Methodology of clinical trials with new molecular-targeted agents: Where do we stand?
    • Morabito, A., Di Maio, M., De Maio, E. et al. Methodology of clinical trials with new molecular-targeted agents: Where do we stand? Ann Oncol 2006, 17(Suppl. 7): vii128-31.
    • (2006) Ann Oncol , vol.17 , Issue.SUPPL. 7
    • Morabito, A.1    Di Maio, M.2    De Maio, E.3
  • 55
    • 33746591262 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: Current status and future directions
    • DOI 10.1634/theoncologist.11-7-753
    • Morabito, A., De Maio, E., Di Maio, M., Normanno, N., Perrone, F. Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: Current status and future directions. The Oncologist 2006, 11(7): 753-64. (Pubitemid 44157563)
    • (2006) Oncologist , vol.11 , Issue.7 , pp. 753-764
    • Morabito, A.1    De Maio, E.2    Di, M.M.3    Normanno, N.4    Perrone, F.5
  • 56
    • 27744534956 scopus 로고    scopus 로고
    • Trying to compose the puzzle with all the pieces: Epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • DOI 10.1002/jcp.20402
    • Di Maio, M., Gridelli, C., Normanno, N. et al. Trying to compose the puzzle with all the pieces: Epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. J Cell Physiol 2005, 205(3): 355-63. (Pubitemid 41598849)
    • (2005) Journal of Cellular Physiology , vol.205 , Issue.3 , pp. 355-363
    • Di, M.M.1    Gridelli, C.2    Normanno, N.3    Perrone, F.4    Ciardiello, F.5
  • 57
    • 34249294557 scopus 로고    scopus 로고
    • Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
    • DOI 10.1038/nrc2152, PII NRC2152
    • Verheul, H.M.W., Pinedo, H.M. Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev 2007, 7(6): 475-85. (Pubitemid 46809172)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.6 , pp. 475-485
    • Verheul, H.M.W.1    Pinedo, H.M.2
  • 58
    • 0009737358 scopus 로고    scopus 로고
    • The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: Clinical and regulatory implications
    • Haverkamp, W., Breithardt, G., Camm, A.J. et al. The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: Clinical and regulatory implications. Cardiovasc Res 2000, 47(2): 219-33.
    • (2000) Cardiovasc Res , vol.47 , Issue.2 , pp. 219-233
    • Haverkamp, W.1    Breithardt, G.2    Camm, A.J.3
  • 59
    • 34548276036 scopus 로고    scopus 로고
    • Molecularly targeted oncology therapeutics and prolongation of the QT interval
    • DOI 10.1200/JCO.2006.09.6925
    • Strevel, E.L., Ing, D.J., Siu, LL. Molecularly targeted oncology therapeutics and prolongation of the QT interval. J Clin Oncol 2007, 25(22): 3362-71. (Pubitemid 47325624)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.22 , pp. 3362-3371
    • Strevel, E.L.1    Ing, D.J.2    Siu, L.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.