Nuclear factor-κB p50 is required for tumor necrosis factor-α-induced colony-stimulating factor-1 gene expression in osteoblasts

Endocrinology

Volumn 141, Issue 8, 2000, Pages 2914-2922

  Yao, Gang Qing ^a   Sun, Ben Hua ^a   Insogna, Karl L ^a   Weir, Eleanor C ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b IQVIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; ANTISERUM; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NORTHERN BLOTTING; OSTEOBLAST; OSTEOLYSIS; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; ANIMAL; BINDING SITE; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; PROMOTER REGION;

ANIMALS; BINDING SITES; GENE EXPRESSION; HUMANS; IMMUNE SERA; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; MICE, KNOCKOUT; NF-KAPPA B; OSTEOBLASTS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85047684355     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.8.7592     Document Type: Article

References (53)

1. The granulocyte-macrophage colony-stimulating factors
2. The human hematopoietic colony-stimulating factors
3. Hematopoietic growth factors
4. Hematopoietic growth factors. Biology and clinical applications
5. Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse
6. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
7. Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse
8. Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse
9. Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors
10. Role of colony-stimulating factors in osteoclast development
11. Effect of macrophage colony-stimulating factor on in vitro osteoclast generation and bone resorption
12. Macrophage colony-stimulating factor release and receptor expression in bone cells
13. Detection of transcripts for the receptor for macrophage colony-stimulating factor, c-fms, in murine osteoclasts
14. The cell-surface form of colony-stimulating factor-1 is regulated by osteotropic agents and supports formation of multinucleated osteoclast-like cells
15. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors
16. Tumors producing human tumor necrosis factor induced hypercalcemia and osteoclastic bone resorption in nude mice
17. Tumor necrosis factor-alpha (cachectin) stimulates bone resorption in mouse calvaria via a prostaglandin-mediated mechanism
18. Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption
19. Two distinct effects of recombinant human tumor necrosis factor-alpha on osteoclast development and subsequent resorption of mineralized matrix
20. Tumor necrosis factor-alpha induces transcription of the colony-stimulating factor-1 gene in murine osteoblasts
21. Involvement of a nuclear factor-kappa B-like protein in induction of the macrophage colony-stimulating factor gene by tumor necrosis factor
22. Characterization of a tumor necrosis factor-responsive element which down-regulates the human osteocalcin gene
23. Embryonic lethality and liver degeneration in mice lacking the RelA component of NFkappa B
24. Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells
25. An essential role for NF-kappa B in preventing TNF-alpha-induced cell death
26. Requirement for NF-kappa B in osteoclast and B-cell development
27. Osteopetrosis in mice lacking NF-kappa B1 and NF-kappa B2
28. Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production
29. Reporter system using chloramphenicol acetyltransferase
30. Nucleotide sequence of a cDNA encoding murine CSF-1 (macrophage-CSF)
31. Human CSF-1: Gene structure and alternative splicing of mRNA precursors
32. The I kappa B proteins: Members of a multifunctional family
33. Estrogen receptor impairs interleukin-6 expression by preventing protein binding on NF- B site
34. Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclast-like cells in vitro
35. Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency
36. The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice
37. Cytokine-induced prostaglandin E2 synthesis and cyclooxygenase-2 activity are regulated both by a nitric oxide-dependent and -independent mechanism in rat osteoblasts in vitro
38. Production of virious cytokindes by normal human osteoblast-like cells in response to interleukin-1 beta and tumor necrosis factor-alpha: Lack of regulation by 17β-estradiol
39. Evidence for interleukin-1 beta production by cultured normal human osteoblast-like cells
40. Molecular mechanisms governing tumor-necrosis-factor-mediated regulation of plasminogen-activator inhibitor type-2 gene expression
41. An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta
42. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
43. Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome
44. The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B
45. Mechanistic aspects of NF-kappa B regulation: The emerging role of phosphorylation and proteolysis
46. NF-κB p105 is a target of IκB kinases and controls signal induction of Bcl-3-50 complexes
47. Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-κB/Rel family
48. Cloning and characterization of the murine promoter for the colony-stimulating factor-1-encoding gene
49. Role of NFB in the regulation of macrophage colony stimulating factor by tumor necrosis factor- in ST2 bone stromal cells
50. Function and activation of NF-kappa B in the immune system
51. Activation of interleukin-6 gene transcription by interleukin-1 in MC3T3-E1 cells is mediated by NF-kB
52. Proinflammatory cytokines tumor necrosis factoralpha and IL-6, but not IL-1, down-regulate the osteocalcin gene promoter
53. IKK-1 and IKK-2: Cytokine-activated I kappa B kinases essential for NF-kappa B activation