A 3D human airway model enables prediction of respiratory toxicity of inhaled drugs in vitro

Toxicological Sciences

Volumn 162, Issue 1, 2018, Pages 301-308

  Sivars, Kinga Balogh ^a,f   Sivars, Ulf ^b,f   Hornberg, Ellinor ^b,f   Zhang, Hui ^c,f   Brändeń, Lena ^c,f   Bonfante, Rosy ^d   Huang, Song ^d   Constant, Samuel ^d   Robinson, Ian ^e,g   Betts, Catherine J ^c,g   Aberg, Per M ^b,e  

^a Drug Safety and Metabolism   (Sweden)

^b Respiratory Inflammation and Autoimmunity Innovative Medicines Drug MetabolismPharmacokinetics   (Sweden)

^c Pathology Aleris Medilab   (Sweden)

^d Epithelix   (Switzerland)

^e Drug Safety and Metabolism   (Switzerland)

^f ASTRAZENECA R AND D   (Sweden)

^g ASTRAZENECA   (United Kingdom)

Author keywords

3D in vitro model; Airway epithelium; Inhalation toxicology; Predictive toxicology; Respiratory toxicology

Indexed keywords

AIRWAY CELL; ARTICLE; CELL CULTURE; CELL MEMBRANE; CELL VIABILITY; CYTOKINE RELEASE; CYTOTOXICITY; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG TOXICITY; MUCOCILIARY CLEARANCE; PREDICTIVE VALUE; RECEIVER OPERATING CHARACTERISTIC; RESAZURIN ASSAY; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; THREE DIMENSIONAL PRINTING; TOXIC INHALATION; BIOLOGICAL MODEL; CELL SURVIVAL; DRUG EFFECT; EPITHELIUM CELL; EXPOSURE; IMPEDANCE; PATHOLOGY; PRECLINICAL STUDY; RESPIRATORY SYSTEM;

NEW DRUG;

CELL SURVIVAL; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; DRUGS, INVESTIGATIONAL; ELECTRIC IMPEDANCE; EPITHELIAL CELLS; HUMANS; INHALATION EXPOSURE; MODELS, BIOLOGICAL; PREDICTIVE VALUE OF TESTS; RESPIRATORY SYSTEM;

EID: 85047411511     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfx255     Document Type: Article

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