A 26-week toxicity assessment of AIR001 (sodium nitrite) by inhalation exposure in rats and by intravenous administration in dogs

International Journal of Toxicology

Volumn 33, Issue 3, 2014, Pages 162-174

  Tepper, Jeffrey ^a   Ochoa, Ricardo ^b   Rix, Peter ^c   Elliott, Gary ^d   Hoglen, Niel ^e   Poulin, Dominic ^f   Parsley, Ed ^g   Masamune, Hiroko ^g  

^a Tepper Nonclinical Consulting   (United States)

^b Pre Clinical Safety Inc   (United States)

^c Vector Preclinical Solutions   (United States)

^d Galenic Strategies LLC   (United States)

^e Hoglen Consulting   (United States)

^f Former ITR Laboratories   (Canada)

^g Aires Pharmaceuticals Inc   (United States)

Author keywords

chronic; inhalation; intravenous; sodium nitrite; toxicity

Indexed keywords

AIR 001; HEMOGLOBIN; METHEMOGLOBIN; OXYGEN; SODIUM NITRITE; UNCLASSIFIED DRUG; ANTIHYPERTENSIVE AGENT; NEW DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BASOPHIL; BODY WEIGHT; CHRONIC TOXICITY; CONTROLLED STUDY; DOG; DRUG DOSE REDUCTION; DRUG EXPOSURE; DRUG HALF LIFE; DRUG MEGADOSE; FEMALE; HEMOGLOBIN DETERMINATION; HISTOPATHOLOGY; LEUKOCYTE DIFFERENTIAL COUNT; LIMIT OF QUANTITATION; LONG TERM EXPOSURE; LYMPHOCYTE; LYMPHOCYTE COUNT; MALE; MAXIMUM PLASMA CONCENTRATION; MONOCYTE; NONHUMAN; OXYGEN SATURATION; RAT; RETICULOCYTE COUNT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TOXICITY TESTING; ANIMAL; BLOOD; CHEMICALLY INDUCED; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; HYPOTENSION; IMMUNOLOGY; INBRED STRAIN; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; METHEMOGLOBINEMIA; NO-OBSERVED-ADVERSE-EFFECT LEVEL; NOSE CAVITY; NOSE MUCOSA; PATHOLOGY; PRECLINICAL STUDY; PULMONARY HYPERTENSION; RISK ASSESSMENT; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT;

ADMINISTRATION, INHALATION; ANIMALS; ANIMALS, INBRED STRAINS; ANTIHYPERTENSIVE AGENTS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUGS, INVESTIGATIONAL; FEMALE; HYPERTENSION, PULMONARY; HYPOTENSION; INFUSIONS, INTRAVENOUS; MALE; METHEMOGLOBINEMIA; NASAL CAVITY; NASAL MUCOSA; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; SODIUM NITRITE; SPECIES SPECIFICITY; TOXICITY TESTS, CHRONIC;

EID: 84900991955     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581814531801     Document Type: Article

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