Treponema pallidum flagellins stimulate MMP-9 and MMP-13 expression via TLR5 and MAPK/NF-κB signaling pathways in human epidermal keratinocytes

Experimental Cell Research

Volumn 361, Issue 1, 2017, Pages 46-55

  Jiang, Chuanhao ^a,b   Xu, Man ^a   Kuang, Xingxing ^a   Xiao, Jinhong ^c   Tan, Manyi ^a   Xie, Yafeng ^a   Xiao, Yongjian ^a   Zhao, Feijun ^a   Wu, Yimou ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c Hunan Provincial People's Hospital   (China)

Author keywords

Flagellin; Keratinocytes; Matrix metalloproteinase; Syphilis; Treponema pallidum

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; COLLAGENASE 3; ENDOTOXIN; FLAGELLIN; FLAGELLIN B1; FLAGELLIN B2; FLAGELLIN B3; GELATINASE B; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; UNCLASSIFIED DRUG; FLAB1 PROTEIN, BACTERIA; FLAB3 PROTEIN, TREPONEMA PALLIDUM; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MMP13 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; TLR5 PROTEIN, HUMAN;

AFFINITY CHROMATOGRAPHY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GENE SILENCING; GENETIC TRANSFECTION; HACAT CELL LINE; HUMAN; HUMAN CELL; MAPK SIGNALING; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TREPONEMA PALLIDUM; WESTERN BLOTTING; ZYMOGRAPHY; CELL CULTURE; CYTOLOGY; KERATINOCYTE; METABOLISM; SIGNAL TRANSDUCTION;

CELLS, CULTURED; FLAGELLIN; HUMANS; KERATINOCYTES; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE 1; NF-KAPPA B; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 5; TREPONEMA PALLIDUM;

EID: 85031115364     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2017.09.040     Document Type: Article

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