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Volumn 4, Issue 4, 2002, Pages

Effects of obesity on the pharmacodynamics of nitroglycerin in conscious rats

Author keywords

Dependent diabetes; Mellitus; Nitrate tolerance; Nitric oxide; Noninsulin; Obesity; Zucker

Indexed keywords

DRUG VEHICLE; GLYCERYL TRINITRATE; ORGANIC NITRATE;

EID: 85046916286     PISSN: 15221059     EISSN: None     Source Type: Journal    
DOI: 10.1208/ps040428     Document Type: Review
Times cited : (2)

References (41)
  • 1
    • 0031755436 scopus 로고    scopus 로고
    • Obesity as a chronic disease: Modern medical and lifestyle management
    • Rippe JM, Crossley S, Ringer R. Obesity as a chronic disease: modern medical and lifestyle management. J Am Diet Assoc. 1998;98:S9-15.
    • (1998) J. Am. Diet Assoc. , vol.98
    • Rippe, J.M.1    Crossley, S.2    Ringer, R.3
  • 2
    • 0034630441 scopus 로고    scopus 로고
    • Overweight, obesity, and health risk
    • National Task Force on the Prevention and Treatment of Obesity
    • National Task Force on the Prevention and Treatment of Obesity. Overweight, obesity, and health risk. Arch Intern Med. 2000;160:898-904.
    • (2000) Arch. Intern. Med. , vol.160 , pp. 898-904
  • 4
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. Obesity as a medical problem. Nature. 2000;404:635-643.
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 5
    • 0023898163 scopus 로고
    • Drug pharmacokinetics in the obese
    • Cheymol G. Drug pharmacokinetics in the obese. Fundam Clin Pharmacol. 1988;2:239-256.
    • (1988) Fundam. Clin. Pharmacol. , vol.2 , pp. 239-256
    • Cheymol, G.1
  • 6
    • 0033800745 scopus 로고    scopus 로고
    • Effects of obesity on pharmacokinetics: Implications for drug therapy
    • Cheymol G. Effects of obesity on pharmacokinetics: implications for drug therapy. Clin Pharmacokinet. 2000;39:215-231.
    • (2000) Clin. Pharmacokinet. , vol.39 , pp. 215-231
    • Cheymol, G.1
  • 7
    • 0021710085 scopus 로고
    • Phenobarbital in the genetically obese Zucker rat. I. Pharmacokinetics after acute and chronic administration
    • Brouwer KL, Kostenbauder HB, McNamara PJ, Blouin RA. Phenobarbital in the genetically obese Zucker rat. I. Pharmacokinetics after acute and chronic administration. J Pharmacol Exp Ther. 1984;231:649-653.
    • (1984) J. Pharmacol. Exp. Ther. , vol.231 , pp. 649-653
    • Brouwer, K.L.1    Kostenbauder, H.B.2    McNamara, P.J.3    Blouin, R.A.4
  • 8
    • 0021741768 scopus 로고
    • Phenobarbital in the genetically obese Zucker rat. II. In vivo and in vitro assessments of microsomal enzyme induction
    • Brouwer KL, Kostenbauder HB, McNamara PJ, Blouin RA. Phenobarbital in the genetically obese Zucker rat. II. In vivo and in vitro assessments of microsomal enzyme induction. J Pharmacol Exp Ther. 1984;231:654-659.
    • (1984) J. Pharmacol. Exp. Ther. , vol.231 , pp. 654-659
    • Brouwer, K.L.1    Kostenbauder, H.B.2    McNamara, P.J.3    Blouin, R.A.4
  • 11
    • 0022556549 scopus 로고
    • Pharmacokinetics and dynamics of (+/-)-verapamil in lean and obese Zucker rats
    • Todd EL, Abernethy DR. Pharmacokinetics and dynamics of (+/-)-verapamil in lean and obese Zucker rats. J Pharmacol Exp Ther. 1986;238:642-647.
    • (1986) J. Pharmacol. Exp. Ther. , vol.238 , pp. 642-647
    • Todd, E.L.1    Abernethy, D.R.2
  • 12
    • 0029063395 scopus 로고
    • Dyslipidemia and diabetes: Animal models
    • Mathe D. Dyslipidemia and diabetes: animal models. Diabetes Metab. 1995;21:106-111.
    • (1995) Diabetes Metab. , vol.21 , pp. 106-111
    • Mathe, D.1
  • 13
    • 0027947379 scopus 로고
    • Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
    • Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A. 1994;91:10878-10882.
    • (1994) Proc. Natl. Acad. Sci. U S A , vol.91 , pp. 10878-10882
    • Lee, Y.1    Hirose, H.2    Ohneda, M.3    Johnson, J.H.4    McGarry, J.D.5    Unger, R.H.6
  • 14
    • 0032484132 scopus 로고    scopus 로고
    • Unger RH. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats: Role of serine palmitoyltransferase overexpression
    • Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats: role of serine palmitoyltransferase overexpression. J Biol Chem. 1998;273:32487-32490.
    • (1998) J. Biol. Chem. , vol.273 , pp. 32487-32490
    • Shimabukuro, M.1    Higa, M.2    Zhou, Y.T.3    Wang, M.Y.4    Newgard, C.B.5
  • 15
    • 0034683178 scopus 로고    scopus 로고
    • Endothelial dysfunction accompanies a pro-oxidant, pro-diabetic challenge in the insulin resistant, obese Zucker rat in vivo
    • Laight DW, Desai KM, Anggard EE, Carrier MJ. Endothelial dysfunction accompanies a pro-oxidant, pro-diabetic challenge in the insulin resistant, obese Zucker rat in vivo. Eur J Pharmacol. 2000;402:95-99.
    • (2000) Eur. J. Pharmacol. , vol.402 , pp. 95-99
    • Laight, D.W.1    Desai, K.M.2    Anggard, E.E.3    Carrier, M.J.4
  • 16
    • 0035130102 scopus 로고    scopus 로고
    • Diseases of liporegulation: New perspective on obesity and related disorders
    • Unger RH, Orci L. Diseases of liporegulation: new perspective on obesity and related disorders. Faseb J. 2001;15:312-321.
    • (2001) Faseb J. , vol.15 , pp. 312-321
    • Unger, R.H.1    Orci, L.2
  • 17
    • 0026684462 scopus 로고
    • Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus
    • McVeigh GE, Brennan GM, Johnston GD, et al. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1992;35:771-776.
    • (1992) Diabetologia , vol.35 , pp. 771-776
    • McVeigh, G.E.1    Brennan, G.M.2    Johnston, G.D.3
  • 19
    • 0028799761 scopus 로고
    • Evidence for enhanced vascular superoxide anion production in nitrate tolerance: A novel mechanism underlying tolerance and cross-tolerance
    • Munzel T, Sayegh H, Freeman BA, Tarpey MM, Harrison DG. Evidence for enhanced vascular superoxide anion production in nitrate tolerance: a novel mechanism underlying tolerance and cross-tolerance. J Clin Invest. 1995;95:187-194.
    • (1995) J. Clin. Invest. , vol.95 , pp. 187-194
    • Munzel, T.1    Sayegh, H.2    Freeman, B.A.3    Tarpey, M.M.4    Harrison, D.G.5
  • 20
    • 0017865261 scopus 로고
    • Pharmacokinetics of nitroglycerin in rats
    • Yap PS, Fung HL. Pharmacokinetics of nitroglycerin in rats. J Pharm Sci. 1978;67:584-586.
    • (1978) J. Pharm. Sci. , vol.67 , pp. 584-586
    • Yap, P.S.1    Fung, H.L.2
  • 21
    • 0025977848 scopus 로고
    • Differential hemodynamic effects and tolerance properties of nitroglycerin and an S-nitrosothiol in experimental heart failure
    • Bauer JA, Fung HL. Differential hemodynamic effects and tolerance properties of nitroglycerin and an S-nitrosothiol in experimental heart failure. J Pharmacol Exp Ther. 1991;256:249-254.
    • (1991) J. Pharmacol. Exp. Ther. , vol.256 , pp. 249-254
    • Bauer, J.A.1    Fung, H.L.2
  • 22
    • 0029815891 scopus 로고    scopus 로고
    • Sustained antiplatelet properties of nitroglycerin during hemodynamic tolerance in rats
    • Booth BP, Jacob S, Bauer JA, Fung HL. Sustained antiplatelet properties of nitroglycerin during hemodynamic tolerance in rats. J Cardiovasc Pharmacol. 1996;28:432-438.
    • (1996) J. Cardiovasc. Pharmacol. , vol.28 , pp. 432-438
    • Booth, B.P.1    Jacob, S.2    Bauer, J.A.3    Fung, H.L.4
  • 23
    • 33646123927 scopus 로고    scopus 로고
    • Pharmacodynamic modeling of in vivo nitroglycerin (NTG) tolerance in conscious rats: Effects of dose and dosage regimen
    • [Abstract]
    • Wang EQ, Balthasar JP, Fung HL. Pharmacodynamic modeling of in vivo nitroglycerin (NTG) tolerance in conscious rats: effects of dose and dosage regimen [Abstract]. AAPSPharmSci. 2001;3:68.
    • (2001) AAPSPharmSci. , vol.3 , pp. 68
    • Wang, E.Q.1    Balthasar, J.P.2    Fung, H.L.3
  • 24
    • 0027437262 scopus 로고
    • Medical hazards of obesity
    • Pi-Sunyer FX. Medical hazards of obesity. Ann Intern Med. 1993;119:655-660.
    • (1993) Ann. Intern. Med. , vol.119 , pp. 655-660
    • Pi-Sunyer, F.X.1
  • 25
    • 0029893203 scopus 로고    scopus 로고
    • Nitric oxide synthase levels in obese Zucker rats
    • Morley JE, Mattammal MB. Nitric oxide synthase levels in obese Zucker rats. Neurosci Lett. 1996;209:137-139.
    • (1996) Neurosci. Lett. , vol.209 , pp. 137-139
    • Morley, J.E.1    Mattammal, M.B.2
  • 26
    • 0032867409 scopus 로고    scopus 로고
    • Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity
    • Arcaro G, Zamboni M, Rossi L, et al. Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity. Int J Obes Relat Metab Disord. 1999;23:936-942.
    • (1999) Int. J. Obes. Relat. Metab. Disord. , vol.23 , pp. 936-942
    • Arcaro, G.1    Zamboni, M.2    Rossi, L.3
  • 27
    • 0031947613 scopus 로고    scopus 로고
    • The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation
    • Hashimoto M, Akishita M, Eto M, et al. The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation. Int J Obes Relat Metab Disord. 1998;22:477-484.
    • (1998) Int. J. Obes. Relat. Metab. Disord. , vol.22 , pp. 477-484
    • Hashimoto, M.1    Akishita, M.2    Eto, M.3
  • 28
    • 0029882357 scopus 로고    scopus 로고
    • Augmented contractile function and abnormal Ca2+ handling in the aorta of Zucker obese rats with insulin resistance
    • Ouchi Y, Han SZ, Kim S, et al. Augmented contractile function and abnormal Ca2+ handling in the aorta of Zucker obese rats with insulin resistance. Diabetes. 1996;45(suppl 3):S55-58.
    • (1996) Diabetes , vol.45 , Issue.SUPPL. 3
    • Ouchi, Y.1    Han, S.Z.2    Kim, S.3
  • 30
    • 0033304535 scopus 로고    scopus 로고
    • Influence of low density lipoprotein (LDL) subfraction profile and LDL oxidation on endothelium-dependent and independent vasodilation in patients with type 2 diabetes
    • Tan KC, Ai VH, Chow WS, Chau MT, Leong L, Lam KS. Influence of low density lipoprotein (LDL) subfraction profile and LDL oxidation on endothelium-dependent and independent vasodilation in patients with type 2 diabetes. J Clin Endocrinol Metab. 1999;84:3212-3216.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3212-3216
    • Tan, K.C.1    Ai, V.H.2    Chow, W.S.3    Chau, M.T.4    Leong, L.5    Lam, K.S.6
  • 31
    • 0030034465 scopus 로고    scopus 로고
    • Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus
    • Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1996;97:22-28.
    • (1996) J. Clin. Invest. , vol.97 , pp. 22-28
    • Ting, H.H.1    Timimi, F.K.2    Boles, K.S.3    Creager, S.J.4    Ganz, P.5    Creager, M.A.6
  • 32
    • 0030007350 scopus 로고    scopus 로고
    • Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
    • Williams SB, Cusco JA, Roddy MA, Johnstone MT, Creager MA. Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1996;27:567-574.
    • (1996) J. Am. Coll. Cardiol. , vol.27 , pp. 567-574
    • Williams, S.B.1    Cusco, J.A.2    Roddy, M.A.3    Johnstone, M.T.4    Creager, M.A.5
  • 33
    • 0031728129 scopus 로고    scopus 로고
    • Investigation of oxidant stress and vasodepression to glyceryl trinitrate in the obese Zucker rat in vivo
    • Laight DW, Kengatharan KM, Gopaul NK, Anggard EE, Carrier MJ. Investigation of oxidant stress and vasodepression to glyceryl trinitrate in the obese Zucker rat in vivo. Br J Pharmacol. 1998;125:895-901.
    • (1998) Br. J. Pharmacol. , vol.125 , pp. 895-901
    • Laight, D.W.1    Kengatharan, K.M.2    Gopaul, N.K.3    Anggard, E.E.4    Carrier, M.J.5
  • 34
    • 0035152499 scopus 로고    scopus 로고
    • Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: Protective effect of vitamin C
    • Perticone F, Ceravolo R, Candigliota M, et al. Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. Diabetes. 2001;50:159-165.
    • (2001) Diabetes , vol.50 , pp. 159-165
    • Perticone, F.1    Ceravolo, R.2    Candigliota, M.3
  • 35
    • 0029977757 scopus 로고    scopus 로고
    • Obesity/insulin resistance is associated with endothelial dysfunction: Implications for the syndrome of insulin resistance
    • Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction: implications for the syndrome of insulin resistance. J Clin Invest. 1996;97:2601-2610.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2601-2610
    • Steinberg, H.O.1    Chaker, H.2    Leaming, R.3    Johnson, A.4    Brechtel, G.5    Baron, A.D.6
  • 36
    • 0029033444 scopus 로고
    • Endothelial-dependent vasodilation is preserved in non-insulin-dependent Zucker fatty diabetic rats
    • Bohlen HG, Lash JM. Endothelial-dependent vasodilation is preserved in non-insulin-dependent Zucker fatty diabetic rats. Am J Physiol. 1995;268:H2366-2374.
    • (1995) Am. J. Physiol. , vol.268
    • Bohlen, H.G.1    Lash, J.M.2
  • 37
    • 0030953203 scopus 로고    scopus 로고
    • Forearm nitric oxide balance, vascular relaxation, and glucose metabolism in NIDDM patients
    • Avogaro A, Piarulli F, Valerio A, et al. Forearm nitric oxide balance, vascular relaxation, and glucose metabolism in NIDDM patients. Diabetes. 1997;46:1040-1046.
    • (1997) Diabetes , vol.46 , pp. 1040-1046
    • Avogaro, A.1    Piarulli, F.2    Valerio, A.3
  • 38
    • 0033600533 scopus 로고    scopus 로고
    • Effects of autonomic neuropathy on coronary blood flow in patients with diabetes mellitus
    • Di Carli MF, Bianco-Batlles D, Landa ME, et al. Effects of autonomic neuropathy on coronary blood flow in patients with diabetes mellitus. Circulation. 1999;100:813-819.
    • (1999) Circulation , vol.100 , pp. 813-819
    • Di Carli, M.F.1    Bianco-Batlles, D.2    Landa, M.E.3
  • 40
    • 0032588412 scopus 로고    scopus 로고
    • F2-isoprostane evidence of oxidant stress in the insulin resistant, obese Zucker rat: Effects of vitamin E
    • Laight DW, Desai KM, Gopaul NK, Anggard EE, Carrier MJ. F2-isoprostane evidence of oxidant stress in the insulin resistant, obese Zucker rat: effects of vitamin E. Eur J Pharmacol. 1999;377:89-92.
    • (1999) Eur. J. Pharmacol. , vol.377 , pp. 89-92
    • Laight, D.W.1    Desai, K.M.2    Gopaul, N.K.3    Anggard, E.E.4    Carrier, M.J.5
  • 41
    • 0029156223 scopus 로고
    • Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants
    • Giugliano D, Marfella R, Verrazzo G, et al. Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants. Ann Intern Med. 1995;123:338-343.
    • (1995) Ann. Intern. Med. , vol.123 , pp. 338-343
    • Giugliano, D.1    Marfella, R.2    Verrazzo, G.3


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