Low-dose nocturnal dexmedetomidine prevents ICU delirium a randomized, placebo-controlled trial

American Journal of Respiratory and Critical Care Medicine

Volumn 197, Issue 9, 2018, Pages 1147-1156

  Skrobik, Yoanna ^a,b   Duprey, Matthew S ^c,d   Hill, Nicholas S ^d   Devlin, John W ^c,d  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b Regroupement Stratégique Politiques Publiques et Santé des Populations   (Canada)

^c NORTHEASTERN UNIVERSITY   (United States)

^d TUFTS MEDICAL CENTER   (United States)

Author keywords

Delirium; Dexmedetomidine; Intensive care; Randomized controlled trial; Sleep

Indexed keywords

ANALGESIC AGENT; BENZODIAZEPINE DERIVATIVE; CORTICOSTEROID; DEXMEDETOMIDINE; FENTANYL; LORAZEPAM; MIDAZOLAM; NEUROLEPTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PARACETAMOL; PLACEBO; PROPOFOL; HYPNOTIC SEDATIVE AGENT;

ADULT; ARTICLE; BRADYCARDIA; CHECKLIST; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DELIRIUM; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; DRUG MEGADOSE; FEMALE; HUMAN; HYPOTENSION; INTENSIVE CARE DELIRIUM SCREENING CHECKLIST; LEEDS SLEEP EVALUATION QUESTIONNAIRE; MALE; PAIN; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RICHMOND AGITATION AND SEDATION SCALE SCORE; SLEEP; AGED; COMPARATIVE STUDY; CRITICAL ILLNESS; DOSE RESPONSE; INTENSIVE CARE; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; NIGHT CARE; PLACEBO EFFECT; PROCEDURES; TIME FACTOR; VERY ELDERLY;

ADMINISTRATION, INTRAVENOUS; ADULT; AGED; AGED, 80 AND OVER; BENZODIAZEPINES; CRITICAL CARE; CRITICAL ILLNESS; DELIRIUM; DEXMEDETOMIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; NIGHT CARE; PLACEBO EFFECT; PROPOFOL; TIME FACTORS;

EID: 85046530239     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201710-1995OC     Document Type: Article

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