-
1
-
-
84898729879
-
Cleaning up in the endoplasmic reticulum: ubiquitin in charge
-
Christianson, J.C., Ye, Y., Cleaning up in the endoplasmic reticulum: ubiquitin in charge. Nat Struct Mol Biol 21 (2014), 325–335.
-
(2014)
Nat Struct Mol Biol
, vol.21
, pp. 325-335
-
-
Christianson, J.C.1
Ye, Y.2
-
2
-
-
33746228127
-
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins
-
Carvalho, P., Goder, V., Rapoport, T.A., Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 126 (2006), 361–373.
-
(2006)
Cell
, vol.126
, pp. 361-373
-
-
Carvalho, P.1
Goder, V.2
Rapoport, T.A.3
-
3
-
-
2442451126
-
Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control
-
Vashist, S., Ng, D.T.W., Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control. J Cell Biol 165 (2004), 41–52.
-
(2004)
J Cell Biol
, vol.165
, pp. 41-52
-
-
Vashist, S.1
Ng, D.T.W.2
-
4
-
-
4444355303
-
Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein
-
Huyer, G., Piluek, W.F., Fansler, Z., Kreft, S.G., Hochstrasser, M., Brodsky, J.L., Michaelis, S., Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. J Biol Chem 279 (2004), 38369–38378.
-
(2004)
J Biol Chem
, vol.279
, pp. 38369-38378
-
-
Huyer, G.1
Piluek, W.F.2
Fansler, Z.3
Kreft, S.G.4
Hochstrasser, M.5
Brodsky, J.L.6
Michaelis, S.7
-
5
-
-
0035144199
-
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation
-
Bays, N.W., Gardner, R.G., Seelig, L.P., Joazeiro, C.A., Hampton, R.Y., Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 3 (2001), 24–29.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 24-29
-
-
Bays, N.W.1
Gardner, R.G.2
Seelig, L.P.3
Joazeiro, C.A.4
Hampton, R.Y.5
-
6
-
-
0031885043
-
Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins
-
Bordallo, J., Plemper, R.K., Finger, A., Wolf, D.H., Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell 9 (1998), 209–222.
-
(1998)
Mol Biol Cell
, vol.9
, pp. 209-222
-
-
Bordallo, J.1
Plemper, R.K.2
Finger, A.3
Wolf, D.H.4
-
7
-
-
71149100878
-
Usa1 functions as a scaffold of the HRD-ubiquitin ligase
-
Horn, S.C., Hanna, J., Hirsch, C., Volkwein, C., Schutz, A., Heinemann, U., Sommer, T., Jarosch, E., Usa1 functions as a scaffold of the HRD-ubiquitin ligase. Mol Cell 36 (2009), 782–793.
-
(2009)
Mol Cell
, vol.36
, pp. 782-793
-
-
Horn, S.C.1
Hanna, J.2
Hirsch, C.3
Volkwein, C.4
Schutz, A.5
Heinemann, U.6
Sommer, T.7
Jarosch, E.8
-
8
-
-
0035887277
-
A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation
-
Swanson, R., Locher, M., Hochstrasser, M., A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. Genes Dev 15 (2001), 2660–2674.
-
(2001)
Genes Dev
, vol.15
, pp. 2660-2674
-
-
Swanson, R.1
Locher, M.2
Hochstrasser, M.3
-
9
-
-
84980051722
-
The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron
-
Habeck, G., Ebner, F.A., Shimada-Kreft, H., Kreft, S.G., The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron. J Cell Biol 209 (2015), 261–273.
-
(2015)
J Cell Biol
, vol.209
, pp. 261-273
-
-
Habeck, G.1
Ebner, F.A.2
Shimada-Kreft, H.3
Kreft, S.G.4
-
10
-
-
84909962081
-
Quality control of inner nuclear membrane proteins by the Asi complex
-
Foresti, O., Rodriguez-Vaello, V., Funaya, C., Carvalho, P., Quality control of inner nuclear membrane proteins by the Asi complex. Science 346 (2014), 751–755.
-
(2014)
Science
, vol.346
, pp. 751-755
-
-
Foresti, O.1
Rodriguez-Vaello, V.2
Funaya, C.3
Carvalho, P.4
-
11
-
-
84922218720
-
Protein quality control at the inner nuclear membrane
-
Khmelinskii, A., Blaszczak, E., Pantazopoulou, M., Fischer, B., Omnus, D.J., Le Dez, G., Brossard, A., Gunnarsson, A., Barry, J.D., Meurer, M., et al. Protein quality control at the inner nuclear membrane. Nature 516 (2014), 410–413.
-
(2014)
Nature
, vol.516
, pp. 410-413
-
-
Khmelinskii, A.1
Blaszczak, E.2
Pantazopoulou, M.3
Fischer, B.4
Omnus, D.J.5
Le Dez, G.6
Brossard, A.7
Gunnarsson, A.8
Barry, J.D.9
Meurer, M.10
-
12
-
-
0035658442
-
HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins
-
Bays, N.W., Wilhovsky, S.K., Goradia, A., Hodgkiss-Harlow, K., Hampton, R.Y., HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Mol Biol Cell 12 (2001), 4114–4128.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 4114-4128
-
-
Bays, N.W.1
Wilhovsky, S.K.2
Goradia, A.3
Hodgkiss-Harlow, K.4
Hampton, R.Y.5
-
13
-
-
0037084028
-
Role of the ubiquitin-selective CDC48(UFD1/NPL4)chaperone (segregase) in ERAD of OLE1 and other substrates
-
Braun, S., Matuschewski, K., Rape, M., Thoms, S., Jentsch, S., Role of the ubiquitin-selective CDC48(UFD1/NPL4)chaperone (segregase) in ERAD of OLE1 and other substrates. EMBO J 21 (2002), 615–621.
-
(2002)
EMBO J
, vol.21
, pp. 615-621
-
-
Braun, S.1
Matuschewski, K.2
Rape, M.3
Thoms, S.4
Jentsch, S.5
-
14
-
-
0036173013
-
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48
-
Jarosch, E., Taxis, C., Volkwein, C., Bordallo, J., Finley, D., Wolf, D.H., Sommer, T., Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol 4 (2002), 134–139.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 134-139
-
-
Jarosch, E.1
Taxis, C.2
Volkwein, C.3
Bordallo, J.4
Finley, D.5
Wolf, D.H.6
Sommer, T.7
-
15
-
-
0036136901
-
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation
-
Rabinovich, E., Kerem, A., Frohlich, K.U., Diamant, N., Bar-Nun, S., AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. Mol Cell Biol 22 (2002), 626–634.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 626-634
-
-
Rabinovich, E.1
Kerem, A.2
Frohlich, K.U.3
Diamant, N.4
Bar-Nun, S.5
-
16
-
-
0035818999
-
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
-
Ye, Y., Meyer, H.H., Rapoport, T.A., The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature 414 (2001), 652–656.
-
(2001)
Nature
, vol.414
, pp. 652-656
-
-
Ye, Y.1
Meyer, H.H.2
Rapoport, T.A.3
-
17
-
-
0038487228
-
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
-
Ye, Y., Meyer, H.H., Rapoport, T.A., Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol 162 (2003), 71–84.
-
(2003)
J Cell Biol
, vol.162
, pp. 71-84
-
-
Ye, Y.1
Meyer, H.H.2
Rapoport, T.A.3
-
18
-
-
77952555674
-
ERAD substrate recognition in budding yeast
-
Xie, W., Ng, D.T., ERAD substrate recognition in budding yeast. Semin Cell Dev Biol 5 (2010), 533–539, 10.1016/j.semcdb.2010.02.007.
-
(2010)
Semin Cell Dev Biol
, vol.5
, pp. 533-539
-
-
Xie, W.1
Ng, D.T.2
-
19
-
-
33746208871
-
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation
-
Denic, V., Quan, E.M., Weissman, J.S., A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Cell 126 (2006), 349–359.
-
(2006)
Cell
, vol.126
, pp. 349-359
-
-
Denic, V.1
Quan, E.M.2
Weissman, J.S.3
-
20
-
-
33746587049
-
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery
-
Gauss, R., Jarosch, E., Sommer, T., Hirsch, C., A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery. Nat Cell Biol 8 (2006), 849–854.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 849-854
-
-
Gauss, R.1
Jarosch, E.2
Sommer, T.3
Hirsch, C.4
-
21
-
-
0030041781
-
Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast
-
Knop, M., Finger, A., Braun, T., Hellmuth, K., Wolf, D.H., Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J 15 (1996), 753–763.
-
(1996)
EMBO J
, vol.15
, pp. 753-763
-
-
Knop, M.1
Finger, A.2
Braun, T.3
Hellmuth, K.4
Wolf, D.H.5
-
22
-
-
84891347210
-
Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane
-
Mehnert, M., Sommer, T., Jarosch, E., Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane. Nat Cell Biol 16 (2014), 77–86.
-
(2014)
Nat Cell Biol
, vol.16
, pp. 77-86
-
-
Mehnert, M.1
Sommer, T.2
Jarosch, E.3
-
23
-
-
27144535945
-
Ubx2 links the Cdc48 complex to ER-associated protein degradation
-
Neuber, O., Jarosch, E., Volkwein, C., Walter, J., Sommer, T., Ubx2 links the Cdc48 complex to ER-associated protein degradation. Nat Cell Biol 7 (2005), 993–998.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 993-998
-
-
Neuber, O.1
Jarosch, E.2
Volkwein, C.3
Walter, J.4
Sommer, T.5
-
24
-
-
27144539523
-
Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation
-
Schuberth, C., Buchberger, A., Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation. Nat Cell Biol 7 (2005), 999–1006.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 999-1006
-
-
Schuberth, C.1
Buchberger, A.2
-
25
-
-
85018732290
-
Molecular mechanism of substrate processing by the Cdc48 ATPase complex
-
This paper elucidates how the Cdc48 ATPase complex processes its substrates. Substrates are first bound through the attached polyubiquitin chain to the UN cofactor and then pulled through the central pore of the hexameric ATPase ring. The ubiquitin chain is trimmed by a DUB, and the remaining oligoubiquitin chain then follows the substrate through the pore. This paper and Ref. [49] show that the ATPase exerts a pulling force that leads to substrate unfolding.
-
Bodnar, N.O., Rapoport, T.A., Molecular mechanism of substrate processing by the Cdc48 ATPase complex. Cell 169 (2017), 722–735.e9 This paper elucidates how the Cdc48 ATPase complex processes its substrates. Substrates are first bound through the attached polyubiquitin chain to the UN cofactor and then pulled through the central pore of the hexameric ATPase ring. The ubiquitin chain is trimmed by a DUB, and the remaining oligoubiquitin chain then follows the substrate through the pore. This paper and Ref. [49] show that the ATPase exerts a pulling force that leads to substrate unfolding.
-
(2017)
Cell
, vol.169
, pp. 722-735.e9
-
-
Bodnar, N.O.1
Rapoport, T.A.2
-
26
-
-
84908072286
-
Key steps in ERAD of luminal ER proteins reconstituted with purified components
-
Stein, A., Ruggiano, A., Carvalho, P., Rapoport, T.A., Key steps in ERAD of luminal ER proteins reconstituted with purified components. Cell 158 (2014), 1375–1388.
-
(2014)
Cell
, vol.158
, pp. 1375-1388
-
-
Stein, A.1
Ruggiano, A.2
Carvalho, P.3
Rapoport, T.A.4
-
27
-
-
85007586487
-
A case for Sec61 channel involvement in ERAD
-
Römisch, K., A case for Sec61 channel involvement in ERAD. Trends Biochem Sci 42 (2017), 171–179.
-
(2017)
Trends Biochem Sci
, vol.42
, pp. 171-179
-
-
Römisch, K.1
-
28
-
-
78149482323
-
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p
-
Carvalho, P., Stanley, A.M., Rapoport, T.A., Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell 143 (2010), 579–591.
-
(2010)
Cell
, vol.143
, pp. 579-591
-
-
Carvalho, P.1
Stanley, A.M.2
Rapoport, T.A.3
-
29
-
-
0347192985
-
X-ray structure of a protein-conducting channel
-
van den Berg, B., Clemons, W.M.J., Collinson, I., Modis, Y., Hartmann, E., Harrison, S.C., Rapoport, T.A., X-ray structure of a protein-conducting channel. Nature 427 (2004), 36–44.
-
(2004)
Nature
, vol.427
, pp. 36-44
-
-
van den Berg, B.1
Clemons, W.M.J.2
Collinson, I.3
Modis, Y.4
Hartmann, E.5
Harrison, S.C.6
Rapoport, T.A.7
-
30
-
-
84903310310
-
Structure of the mammalian ribosome-Sec61 complex to 3.4 A resolution
-
Voorhees, R.M., Fernandez, I.S., Scheres, S.H., Hegde, R.S., Structure of the mammalian ribosome-Sec61 complex to 3.4 A resolution. Cell 157 (2014), 1632–1643.
-
(2014)
Cell
, vol.157
, pp. 1632-1643
-
-
Voorhees, R.M.1
Fernandez, I.S.2
Scheres, S.H.3
Hegde, R.S.4
-
31
-
-
3042616595
-
A membrane protein required for dislocation of misfolded proteins from the ER
-
Lilley, B.N., Ploegh, H.L., A membrane protein required for dislocation of misfolded proteins from the ER. Nature 429 (2004), 834–840.
-
(2004)
Nature
, vol.429
, pp. 834-840
-
-
Lilley, B.N.1
Ploegh, H.L.2
-
32
-
-
3042677637
-
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
-
Ye, Y., Shibata, Y., Yun, C., Ron, D., Rapoport, T.A., A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol. Nature 429 (2004), 841–847.
-
(2004)
Nature
, vol.429
, pp. 841-847
-
-
Ye, Y.1
Shibata, Y.2
Yun, C.3
Ron, D.4
Rapoport, T.A.5
-
33
-
-
0034597161
-
Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p
-
Gardner, R.G., Swarbrick, G.M., Bays, N.W., Cronin, S.R., Wilhovsky, S., Seelig, L., Kim, C., Hampton, R.Y., Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151 (2000), 69–82.
-
(2000)
J Cell Biol
, vol.151
, pp. 69-82
-
-
Gardner, R.G.1
Swarbrick, G.M.2
Bays, N.W.3
Cronin, S.R.4
Wilhovsky, S.5
Seelig, L.6
Kim, C.7
Hampton, R.Y.8
-
34
-
-
0033492290
-
Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation
-
Plemper, R.K., Bordallo, J., Deak, P.M., Taxis, C., Hitt, R., Wolf, D.H., Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation. J Cell Sci 112 (1999), 4123–4134.
-
(1999)
J Cell Sci
, vol.112
, pp. 4123-4134
-
-
Plemper, R.K.1
Bordallo, J.2
Deak, P.M.3
Taxis, C.4
Hitt, R.5
Wolf, D.H.6
-
35
-
-
84978435047
-
Autoubiquitination of the Hrd1 ligase triggers protein retrotranslocation in ERAD
-
This paper shows that membrane translocation of a polypeptide during ERAD-L can be recapitulated with proteoliposomes containing purified Hrd1 ubiquitin ligase. Hrd1 seems to form a ubiquitin-gated protein-conducting channel.
-
Baldridge, R.D., Rapoport, T.A., Autoubiquitination of the Hrd1 ligase triggers protein retrotranslocation in ERAD. Cell 166 (2016), 394–407 This paper shows that membrane translocation of a polypeptide during ERAD-L can be recapitulated with proteoliposomes containing purified Hrd1 ubiquitin ligase. Hrd1 seems to form a ubiquitin-gated protein-conducting channel.
-
(2016)
Cell
, vol.166
, pp. 394-407
-
-
Baldridge, R.D.1
Rapoport, T.A.2
-
36
-
-
33749569154
-
Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11
-
Hassink, G.C., Barel, M.T., Van Voorden, S.B., Kikkert, M., Wiertz, E.J., Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11. J Biol Chem 281 (2006), 30063–30071.
-
(2006)
J Biol Chem
, vol.281
, pp. 30063-30071
-
-
Hassink, G.C.1
Barel, M.T.2
Van Voorden, S.B.3
Kikkert, M.4
Wiertz, E.J.5
-
37
-
-
84881398313
-
Decoupling the role of ubiquitination for the dislocation versus degradation of major histocompatibility complex (MHC) class I proteins during endoplasmic reticulum-associated degradation (ERAD)
-
Wang, X., Yu, Y.Y., Myers, N., Hansen, T.H., Decoupling the role of ubiquitination for the dislocation versus degradation of major histocompatibility complex (MHC) class I proteins during endoplasmic reticulum-associated degradation (ERAD). J Biol Chem 288 (2013), 23295–23306.
-
(2013)
J Biol Chem
, vol.288
, pp. 23295-23306
-
-
Wang, X.1
Yu, Y.Y.2
Myers, N.3
Hansen, T.H.4
-
38
-
-
0033601349
-
The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor
-
Yu, H., Kopito, R.R., The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor. J Biol Chem 274 (1999), 36852–36858.
-
(1999)
J Biol Chem
, vol.274
, pp. 36852-36858
-
-
Yu, H.1
Kopito, R.R.2
-
39
-
-
85027840068
-
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
-
This paper reports a cryo-EM structure of a complex of the Hrd1 ligase and its luminal binding partner Hrd3. Hrd1 has a deep cytoplasmic cavity, reminiscent of other protein-conducting channels.
-
Schoebel, S., Mi, W., Stein, A., Ovchinnikov, S., Pavlovicz, R., DiMaio, F., Baker, D., Chambers, M.G., Su, H., Li, D., et al. Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. Nature 548 (2017), 352–355 This paper reports a cryo-EM structure of a complex of the Hrd1 ligase and its luminal binding partner Hrd3. Hrd1 has a deep cytoplasmic cavity, reminiscent of other protein-conducting channels.
-
(2017)
Nature
, vol.548
, pp. 352-355
-
-
Schoebel, S.1
Mi, W.2
Stein, A.3
Ovchinnikov, S.4
Pavlovicz, R.5
DiMaio, F.6
Baker, D.7
Chambers, M.G.8
Su, H.9
Li, D.10
-
40
-
-
0035815754
-
Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation
-
Deak, P.M., Wolf, D.H., Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 276 (2001), 10663–10669.
-
(2001)
J Biol Chem
, vol.276
, pp. 10663-10669
-
-
Deak, P.M.1
Wolf, D.H.2
-
41
-
-
84901259411
-
Structural basis of Sec-independent membrane protein insertion by YidC
-
Kumazaki, K., Chiba, S., Takemoto, M., Furukawa, A., Nishiyama, K.-I., Sugano, Y., Mori, T., Dohmae, N., Hirata, K., Nakada-Nakura, Y., et al. Structural basis of Sec-independent membrane protein insertion by YidC. Nature 509 (2014), 516–520.
-
(2014)
Nature
, vol.509
, pp. 516-520
-
-
Kumazaki, K.1
Chiba, S.2
Takemoto, M.3
Furukawa, A.4
Nishiyama, K.-I.5
Sugano, Y.6
Mori, T.7
Dohmae, N.8
Hirata, K.9
Nakada-Nakura, Y.10
-
42
-
-
84946753354
-
Membrane insertases are present in all three domains of life
-
Dalbey, R.E., Kuhn, A., Membrane insertases are present in all three domains of life. Structure 23 (2015), 1559–1560.
-
(2015)
Structure
, vol.23
, pp. 1559-1560
-
-
Dalbey, R.E.1
Kuhn, A.2
-
43
-
-
80455164551
-
Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum
-
Greenblatt, E.J., Olzmann, J.A., Kopito, R.R., Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum. Nat Struct Mol Biol 18 (2011), 1147–1152.
-
(2011)
Nat Struct Mol Biol
, vol.18
, pp. 1147-1152
-
-
Greenblatt, E.J.1
Olzmann, J.A.2
Kopito, R.R.3
-
44
-
-
84969749567
-
Direct and essential function for Hrd3 in ER-associated degradation
-
This paper shows that Hrd3 regulates the enzymatic activity of Hrd1 and is an integral part of the retro-translocation machinery.
-
Vashistha, N., Neal, S.E., Singh, A., Carroll, S.M., Hampton, R.Y., Direct and essential function for Hrd3 in ER-associated degradation. Proc Natl Acad Sci USA 113 (2016), 5934–5939 This paper shows that Hrd3 regulates the enzymatic activity of Hrd1 and is an integral part of the retro-translocation machinery.
-
(2016)
Proc Natl Acad Sci USA
, vol.113
, pp. 5934-5939
-
-
Vashistha, N.1
Neal, S.E.2
Singh, A.3
Carroll, S.M.4
Hampton, R.Y.5
-
45
-
-
0027936633
-
Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane
-
Mothes, W., Prehn, S., Rapoport, T.A., Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane. EMBO J 13 (1994), 3937–3982.
-
(1994)
EMBO J
, vol.13
, pp. 3937-3982
-
-
Mothes, W.1
Prehn, S.2
Rapoport, T.A.3
-
46
-
-
0141507032
-
Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains
-
DeLaBarre, B., Brunger, A.T., Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains. Nat Struct Biol 10 (2003), 856–863.
-
(2003)
Nat Struct Biol
, vol.10
, pp. 856-863
-
-
DeLaBarre, B.1
Brunger, A.T.2
-
47
-
-
84958883175
-
2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition
-
This paper reports high-resolution cryo-EM structures of the p97 ATPase, which demonstrate that the N-terminal domains move up and down in response to the nucleotide state of the ATPase.
-
Banerjee, S., Bartesaghi, A., Merk, A., Rao, P., Bulfer, S.L., Yan, Y., Green, N., Mroczkowski, B., Neitz, R.J., Wipf, P., et al. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science 351 (2016), 871–875 This paper reports high-resolution cryo-EM structures of the p97 ATPase, which demonstrate that the N-terminal domains move up and down in response to the nucleotide state of the ATPase.
-
(2016)
Science
, vol.351
, pp. 871-875
-
-
Banerjee, S.1
Bartesaghi, A.2
Merk, A.3
Rao, P.4
Bulfer, S.L.5
Yan, Y.6
Green, N.7
Mroczkowski, B.8
Neitz, R.J.9
Wipf, P.10
-
48
-
-
84863020783
-
Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy
-
Bebeacua, C., Förster, A., McKeown, C., Meyer, H.H., Zhang, X., Freemont, P.S., Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy. Proc Natl Acad Sci USA 109 (2012), 1098–1103.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 1098-1103
-
-
Bebeacua, C.1
Förster, A.2
McKeown, C.3
Meyer, H.H.4
Zhang, X.5
Freemont, P.S.6
-
49
-
-
85019969049
-
Ubiquitin and ATP_dependent unfoldase activity of p97/VCP-NPLOC4-UFD1L1 is enhanced by a mutation that causes mutlisystem proteinopathy
-
• ], shows that the p97/Cdc48 ATPase exerts a pulling force on its substrates, thereby leading to their unfolding.
-
• ], shows that the p97/Cdc48 ATPase exerts a pulling force on its substrates, thereby leading to their unfolding.
-
(2017)
Proc Natl Acad Sci USA
, vol.114
, pp. E4380-E4388
-
-
Blyth, E.1
Olson, K.2
Chau, V.3
Deshaies, R.4
-
50
-
-
85019969049
-
Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy
-
Blythe, E.E., Olson, K.C., Chau, V., Deshaies, R.J., Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy. Proc Natl Acad Sci USA 114 (2017), E4380–E4388.
-
(2017)
Proc Natl Acad Sci USA
, vol.114
, pp. E4380-E4388
-
-
Blythe, E.E.1
Olson, K.C.2
Chau, V.3
Deshaies, R.J.4
-
51
-
-
33744817103
-
The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor
-
Li, G., Zhao, G., Zhou, X., Schindelin, H., Lennarz, W.J., The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Proc Natl Acad Sci USA 103 (2006), 8348–8353.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 8348-8353
-
-
Li, G.1
Zhao, G.2
Zhou, X.3
Schindelin, H.4
Lennarz, W.J.5
-
52
-
-
0034602845
-
Recognition of the polyubiquitin proteolytic signal
-
Thrower, J.S., Hoffman, L., Rechsteiner, M., Pickart, C.M., Recognition of the polyubiquitin proteolytic signal. EMBO J 19 (2000), 94–102.
-
(2000)
EMBO J
, vol.19
, pp. 94-102
-
-
Thrower, J.S.1
Hoffman, L.2
Rechsteiner, M.3
Pickart, C.M.4
-
53
-
-
4444320698
-
A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation
-
Medicherla, B., Kostova, Z., Schaefer, A., Wolf, D.H., A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation. EMBO Rep 5 (2004), 692–697.
-
(2004)
EMBO Rep
, vol.5
, pp. 692-697
-
-
Medicherla, B.1
Kostova, Z.2
Schaefer, A.3
Wolf, D.H.4
-
54
-
-
3042764201
-
Multiple interactions of rad23 suggest a mechanism for ubiquitylated substrate delivery important in proteolysis
-
Kim, I., Mi, K., Rao, H., Multiple interactions of rad23 suggest a mechanism for ubiquitylated substrate delivery important in proteolysis. Mol Biol Cell 15 (2004), 3357–3365.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 3357-3365
-
-
Kim, I.1
Mi, K.2
Rao, H.3
-
55
-
-
84865094127
-
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine
-
Barthelme, D., Sauer, R.T., Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine. Science 337 (2012), 843–846.
-
(2012)
Science
, vol.337
, pp. 843-846
-
-
Barthelme, D.1
Sauer, R.T.2
-
56
-
-
84874452437
-
Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase
-
Barthelme, D., Sauer, R.T., Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase. Proc Natl Acad Sci USA 110 (2013), 3327–3332.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 3327-3332
-
-
Barthelme, D.1
Sauer, R.T.2
-
57
-
-
79953771687
-
Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding
-
Böhm, S., Lamberti, G., Fernández-Sáiz, V., Stapf, C., Buchberger, A., Cellular functions of Ufd2 and Ufd3 in proteasomal protein degradation depend on Cdc48 binding. Mol Cell Biol 31 (2011), 1528–1539.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 1528-1539
-
-
Böhm, S.1
Lamberti, G.2
Fernández-Sáiz, V.3
Stapf, C.4
Buchberger, A.5
-
58
-
-
0029119522
-
A proteolytic pathway that recognizes ubiquitin as a degradation signal
-
Johnson, E.S., Ma, P.C., Ota, I.M., Varshavsky, A., A proteolytic pathway that recognizes ubiquitin as a degradation signal. J Biol Chem 270 (1995), 17442–17456.
-
(1995)
J Biol Chem
, vol.270
, pp. 17442-17456
-
-
Johnson, E.S.1
Ma, P.C.2
Ota, I.M.3
Varshavsky, A.4
-
59
-
-
0033525589
-
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
-
Koegl, M., Hoppe, T., Schlenker, S., Ulrich, H.D., Mayer, T.U., Jentsch, S., A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 96 (1999), 635–644.
-
(1999)
Cell
, vol.96
, pp. 635-644
-
-
Koegl, M.1
Hoppe, T.2
Schlenker, S.3
Ulrich, H.D.4
Mayer, T.U.5
Jentsch, S.6
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