Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 9, 2013, Pages 3327-3332

  Barthelme, Dominik ^a   Sauer, Robert T ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

AAA+ protease; P97

Indexed keywords

20S PEPTIDASE; ADENOSINE TRIPHOSPHATASE; ATPASE ASSOCIATED WITH A VARIETY OF CELLULAR ACTIVITIES; BACTERIAL ENZYME; CDC48 ENZYME; PEPTIDASE; UNCLASSIFIED DRUG;

ARTICLE; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; THERMOPLASMA ACIDOPHILUM;

ADENOSINE TRIPHOSPHATASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ARCHAEAL PROTEINS; CELL CYCLE PROTEINS; EVOLUTION, MOLECULAR; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEOLYSIS; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY; THERMOPLASMA;

EID: 84874452437     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300408110     Document Type: Article

References (28)

1. Hanson PI, Whiteheart SW (2005) AAA+ proteins: Have engine, will work. Nat Rev Mol Cell Biol 6(7): 519-529.
2. Sauer RT, Baker TA (2011) AAA+ proteases: ATP-fueled machines of protein destruction. Annu Rev Biochem 80: 587-612.
3. Smith DM, et al. (2005) ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell 20(5): 687-698.
4. Barthelme D, Sauer RT (2012) Identification of the Cdc48·20S proteasome as an ancient AAA+ proteolytic machine. Science 337(6096): 843-846.
5. Voges D, Zwickl P, Baumeister W (1999) The 26S proteasome: A molecular machine designed for controlled proteolysis. Annu Rev Biochem 68: 1015-1068.
6. Wang T, et al. (2009) Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure 17(10): 1377-1385.
7. Groll M, et al. (2000) A gated channel into the proteasome core particle. Nat Struct Biol 7(11): 1062-1067.
8. Löwe J, et al. (1995) Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution. Science 268(5210): 533-539.
9. Stadtmueller BM, Hill CP (2011) Proteasome activators. Mol Cell 41(1): 8-19.
10. Smith DM, et al. (2007) Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell 27(5): 731-744.
11. Meyer H, Bug M, Bremer S (2012) Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat Cell Biol 14(2): 117-123.
12. Hirsch C, Gauss R, Horn SC, Neuber O, Sommer T (2009) The ubiquitylation machinery of the endoplasmic reticulum. Nature 458(7237): 453-460.
13. Davies JM, Brunger AT, Weis WI (2008) Improved structures of full-length p97, an AAA ATPase: Implications for mechanisms of nucleotide-dependent conformational change. Structure 16(5): 715-726.
14. Braun S, Matuschewski K, Rape M, Thoms S, Jentsch S (2002) Role of the ubiquitinselective CDC48(UFD1/NPL4) chaperone (segregase) in ERAD of OLE1 and other substrates. EMBO J 21(4): 615-621.
15. Rape M, et al. (2001) Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell 107(5): 667-677.
16. Verma R, Oania R, Fang R, Smith GT, Deshaies RJ (2011) Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. Mol Cell 41(1): 82-92.
17. Förster A, Masters EI, Whitby FG, Robinson H, Hill CP (2005) The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions. Mol Cell 18(5): 589-599.
18. Zhang F, et al. (2009) Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell 34(4): 473-484.
19. Kumar B, Kim YC, DeMartino GN (2010) The C terminus of Rpt3, an ATPase subunit of PA700 (19 S) regulatory complex, is essential for 26 S proteasome assembly but not for activation. J Biol Chem 285(50): 39523-39535.
20. Rabl J, et al. (2008) Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell 30(3): 360-368.
21. Tian G, et al. (2011) An asymmetric interface between the regulatory and core particles of the proteasome. Nat Struct Mol Biol 18(11): 1259-1267.
22. Rothballer A, Tzvetkov N, Zwickl P (2007) Mutations in p97/VCP induce unfolding activity. FEBS Lett 581(6): 1197-1201.
23. Isakov E, Stanhill A (2011) Stalled proteasomes are directly relieved by P97 recruitment. J Biol Chem 286(35): 30274-30283.
24. Matouschek A, Finley D (2012) Cell biology. An ancient portal to proteolysis. Science 337(6096): 813-814.
25. Martin A, Baker TA, Sauer RT (2007) Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease. Mol Cell 27(1): 41-52.
26. Lander GC, et al. (2012) Complete subunit architecture of the proteasome regulatory particle. Nature 482(7384): 186-191.
27. Verma R, et al. (2000) Proteasomal proteomics: Identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes. Mol Biol Cell 11(10): 3425-3439.
28. Crooks GE, Hon G, Chandonia JM, Brenner SE (2004) WebLogo: A sequence logo generator. Genome Res 14(6): 1188-1190.