A Mixed-Effects Model for Powerful Association Tests in Integrative Functional Genomics

American Journal of Human Genetics

Volumn 102, Issue 5, 2018, Pages 904-919

  Su, Yu Ru ^a   Di, Chongzhi ^a   Bien, Stephanie ^a   Huang, Licai ^a   Dong, Xinyuan ^b   Abecasis, Goncalo ^c   Berndt, Sonja ^d   Bezieau, Stephane ^e   Brenner, Hermann ^f   Caan, Bette ^g   Casey, Graham ^h   Chang Claude, Jenny ^f   Chanock, Stephen ^d   Chen, Sai ^c   Connolly, Charles ^a   Curtis, Keith ^a   Figueiredo, Jane ^q   Gala, Manish ⁱ   Gallinger, Steven ^j   Harrison, Tabitha ^a   Hoffmeister, Michael ^f   Hopper, John ^k   Huyghe, Jeroen R ^a   Jenkins, Mark ^k   Joshi, Amit ^l   Le Marchand, Loic ^m   Newcomb, Polly ^a,b   Nickerson, Deborah ^b   Potter, John ^a,b   Schoen, Robert ⁿ   Slattery, Martha ^o   White, Emily ^a,b   Zanke, Brent ^p   Peters, Ulrike ^a,b   Hsu, Li ^a,b   more..

^a USA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e NANTES UNIVERSITY HOSPITAL   (France)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^g DIVISION OF RESEARCH   (United States)

^h UNIVERSITY OF VIRGINIA   (United States)

ⁱ MASSACHUSETTS GENERAL HOSPITAL   (United States)

^j MOUNT SINAI HOSPITAL   (Canada)

^k UNIVERSITY OF MELBOURNE   (Australia)

^l HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^m UNIVERSITY OF HAWAII CANCER CENTER   (United States)

ⁿ UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^o UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^p UNIVERSITY OF OTTAWA   (Canada)

^q CEDARS SINAI MEDICAL CENTER   (United States)

more..

Author keywords

data adaptive weight; expression quantitative trait locus; functional annotation; genome wide association study; mixed effects score test; set based association; variance component test

Indexed keywords

ARTICLE; ATF1 GENE; COLORECTAL CANCER; FUNCTIONAL GENOMICS; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; PHENOTYPE; POU5F1B GENE; PRIORITY JOURNAL; SIMULATION; TRANSCRIPTOMICS; TUMOR GENE; BIOLOGICAL MODEL; BIOLOGY; COLORECTAL TUMOR; COMPUTER SIMULATION; GENETICS; GENOMICS; HUMAN; MATHEMATICAL COMPUTING; SOFTWARE;

COLORECTAL NEOPLASMS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; GENES, NEOPLASM; GENOME-WIDE ASSOCIATION STUDY; GENOMICS; HUMANS; MODELS, GENETIC; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; SOFTWARE;

EID: 85046162380     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2018.03.019     Document Type: Article

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