메뉴 건너뛰기




Volumn 16, Issue 4, 2018, Pages 307-320

Ceftolozane/tazobactam: place in therapy

Author keywords

Antimicrobial resistance; carbapenem sparing; ceftolozane; Enterobacteriaceae; ESBL; MDR; Pseudomonas; tazobactam

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CEFTOLOZANE; CEFTOLOZANE PLUS TAZOBACTAM; GAMMA GLUTAMYLTRANSFERASE; ANTIINFECTIVE AGENT; CEFTOLOZANE, TAZOBACTAM DRUG COMBINATION; CEPHALOSPORIN DERIVATIVE; TAZOBACTAM;

EID: 85045662944     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1080/14787210.2018.1447381     Document Type: Review
Times cited : (101)

References (114)
  • 1
    • 39049128343 scopus 로고    scopus 로고
    • Extended-spectrum b-lactamase-producing Enterobacteriaceae: an emerging public-health concern
    • Pitout JD, Laupland KB., Extended-spectrum b-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect Dis. 2008;8:159–166.
    • (2008) Lancet Infect Dis , vol.8 , pp. 159-166
    • Pitout, J.D.1    Laupland, K.B.2
  • 2
    • 0242322614 scopus 로고    scopus 로고
    • International Klebsiella Study Group. Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases
    • Paterson DL, Hujer KM, Hujer AM, et al. International Klebsiella Study Group. Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases. Antimicrob Agents Chemother. 2003;47:3554–3560.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 3554-3560
    • Paterson, D.L.1    Hujer, K.M.2    Hujer, A.M.3
  • 3
    • 80053563514 scopus 로고    scopus 로고
    • Multidrug-resistant Pseudomonas aeruginosa bloodstream infections: risk factors and mortality
    • Tumbarello M, Repetto E, Trecarichi EM, et al. Multidrug-resistant Pseudomonas aeruginosa bloodstream infections: risk factors and mortality. Epidemiol Infect. 2011;139:1740–1749.
    • (2011) Epidemiol Infect , vol.139 , pp. 1740-1749
    • Tumbarello, M.1    Repetto, E.2    Trecarichi, E.M.3
  • 4
    • 85045641499 scopus 로고    scopus 로고
    • Atlanta (GA): Centers for Disease Control and Prevention, [cited 2017 Oct30], Available from
    • Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States. 2016. Atlanta (GA): Centers for Disease Control and Prevention. [cited 2017 Oct30]. Available from: http://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf
    • (2016)
  • 5
    • 85025477641 scopus 로고    scopus 로고
    • Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach
    • Bassetti M, Poulakou G, Ruppe E, et al. Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach. Intensive Care Med. 2017;43:1464–1475. DOI: 10.1007/s00134-017-4878-x.
    • (2017) Intensive Care Med , vol.43 , pp. 1464-1475
    • Bassetti, M.1    Poulakou, G.2    Ruppe, E.3
  • 6
    • 84926343938 scopus 로고    scopus 로고
    • Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study
    • Zilberberg MD, Shorr AF, Micek ST, et al. Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study. Crit Care. 2014;18:596.
    • (2014) Crit Care , vol.18 , pp. 596
    • Zilberberg, M.D.1    Shorr, A.F.2    Micek, S.T.3
  • 7
    • 84998694455 scopus 로고    scopus 로고
    • Antimicrobial resistance
    • Marston HD, Dixon DM, Knisely JM, et al. Antimicrobial resistance. JAMA. 2016;316:1193–1204.
    • (2016) JAMA , vol.316 , pp. 1193-1204
    • Marston, H.D.1    Dixon, D.M.2    Knisely, J.M.3
  • 8
    • 84941662888 scopus 로고    scopus 로고
    • Risk factors for bloodstream infections due to colistin-resistant KPC-producing Klebsiella pneumoniae: results from a multicenter case-control-control study
    • Giacobbe DR, Del Bono V, Trecarichi EM, et al. Risk factors for bloodstream infections due to colistin-resistant KPC-producing Klebsiella pneumoniae: results from a multicenter case-control-control study. Clin Microbiol Infect. 2015;21:1106.e1–8.
    • (2015) Clin Microbiol Infect , vol.21
    • Giacobbe, D.R.1    Del Bono, V.2    Trecarichi, E.M.3
  • 9
    • 85018263644 scopus 로고    scopus 로고
    • The use of noncarbapenem β-lactams for the treatment of extended-spectrum β-lactamase infections
    • Tamma PD, Rodriguez-Bano J., The use of noncarbapenem β-lactams for the treatment of extended-spectrum β-lactamase infections. Clin Infect Dis. 2017;64:972–980.
    • (2017) Clin Infect Dis , vol.64 , pp. 972-980
    • Tamma, P.D.1    Rodriguez-Bano, J.2
  • 10
    • 85029688287 scopus 로고    scopus 로고
    • New agents for the treatment of infections with Gram-negative bacteria: restoring the miracle or false dawn?
    • Wright H, Bonomo RA, Paterson DL. New agents for the treatment of infections with Gram-negative bacteria: restoring the miracle or false dawn? Clin Microbiol Infect. 2017;23:704–712.
    • (2017) Clin Microbiol Infect , vol.23 , pp. 704-712
    • Wright, H.1    Bonomo, R.A.2    Paterson, D.L.3
  • 11
    • 84939265322 scopus 로고    scopus 로고
    • [cited 2017 Oct30], Available from
    • U.S. Food and Drug Administration. Zerbaxa ®. Full prescribing information. [cited 2017 Oct30]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206829lbl.pdf
    • Zerbaxa ®. Full prescribing information
  • 12
    • 84873424242 scopus 로고    scopus 로고
    • [cited 2017 Oct30], Available from
    • European Medicines Agency. Zerbaxa ®. Annex I. Summary of product characteristics. [cited 2017 Oct30]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/003772/WC500194595.pdf
    • Zerbaxa ®. Annex I. Summary of product characteristics
  • 13
    • 77956123209 scopus 로고    scopus 로고
    • Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa
    • Moya B, Zamorano L, Juan C, et al. Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2010;54:3933–3937.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3933-3937
    • Moya, B.1    Zamorano, L.2    Juan, C.3
  • 14
    • 40749147150 scopus 로고    scopus 로고
    • Structural requirements for the stability of novel cephalosporins to AmpC beta-lactamase based on 3D-structure
    • Murano K, Yamanaka T, Toda A, et al. Structural requirements for the stability of novel cephalosporins to AmpC beta-lactamase based on 3D-structure. Bioorg Med Chem. 2008;16:2261–2275.
    • (2008) Bioorg Med Chem , vol.16 , pp. 2261-2275
    • Murano, K.1    Yamanaka, T.2    Toda, A.3
  • 15
    • 34848844055 scopus 로고    scopus 로고
    • Stability of FR264205 against AmpC beta-lactamase of Pseudomonas aeruginosa
    • Takeda S, Ishii Y, Hatano K, et al. Stability of FR264205 against AmpC beta-lactamase of Pseudomonas aeruginosa. Int J Antimicrob Agents. 2007;30:443–445.
    • (2007) Int J Antimicrob Agents , vol.30 , pp. 443-445
    • Takeda, S.1    Ishii, Y.2    Hatano, K.3
  • 16
    • 84865413973 scopus 로고    scopus 로고
    • Pan-β-lactam resistance development in Pseudomonas aeruginosa clinical strains: molecular mechanisms, penicillin-binding protein profiles, and binding affinities
    • Moyá B, Beceiro A, Cabot G, et al. Pan-β-lactam resistance development in Pseudomonas aeruginosa clinical strains: molecular mechanisms, penicillin-binding protein profiles, and binding affinities. Antimicrob Agents Chemother. 2012;56:4771–4778.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 4771-4778
    • Moyá, B.1    Beceiro, A.2    Cabot, G.3
  • 17
    • 84908582594 scopus 로고    scopus 로고
    • Mutation-driven β-lactam resistance mechanisms among contemporary ceftazidime-nonsusceptible Pseudomonas aeruginosa isolates from U.S. hospitals
    • Castanheira M, Mills JC, Farrell DJ, et al. Mutation-driven β-lactam resistance mechanisms among contemporary ceftazidime-nonsusceptible Pseudomonas aeruginosa isolates from U.S. hospitals. Antimicrob Agents Chemother. 2014;58:6844–6850.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 6844-6850
    • Castanheira, M.1    Mills, J.C.2    Farrell, D.J.3
  • 18
    • 77149179342 scopus 로고    scopus 로고
    • Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients
    • Moyá B, Zamorano L, Juan C, et al. Activity of a new cephalosporin, CXA-101 (FR264205), against beta-lactam-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of intensive care unit patients. Antimicrob Agents Chemother. 2010;54:1213–1217.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1213-1217
    • Moyá, B.1    Zamorano, L.2    Juan, C.3
  • 19
    • 77954180134 scopus 로고    scopus 로고
    • Anti-biofilm and resistance suppression activities of CXA-101 against chronic respiratory infection phenotypes of Pseudomonas aeruginosa strain PAO1
    • Riera E, Macià MD, Mena A, et al. Anti-biofilm and resistance suppression activities of CXA-101 against chronic respiratory infection phenotypes of Pseudomonas aeruginosa strain PAO1. J Antimicrob Chemother. 2010;65:1399–1404.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 1399-1404
    • Riera, E.1    Macià, M.D.2    Mena, A.3
  • 20
    • 84964597352 scopus 로고    scopus 로고
    • In vitro activity of ceftolozane/tazobactam against clinical isolates of Pseudomonas aeruginosa in the planktonic and biofilm states
    • Velez Perez AL, Schmidt-Malan SM, Kohner PC, et al. In vitro activity of ceftolozane/tazobactam against clinical isolates of Pseudomonas aeruginosa in the planktonic and biofilm states. Diagn Microbiol Infect Dis. 2016;85:356–359.
    • (2016) Diagn Microbiol Infect Dis , vol.85 , pp. 356-359
    • Velez Perez, A.L.1    Schmidt-Malan, S.M.2    Kohner, P.C.3
  • 21
    • 77955618992 scopus 로고    scopus 로고
    • Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase producing Enterobacteriaceae
    • Livermore DM, Mushtaq S, Ge Y. Chequerboard titration of cephalosporin CXA-101 (FR264205) and tazobactam versus beta-lactamase producing Enterobacteriaceae. J Antimicrob Chemother. 2010;65:1972–1974.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 1972-1974
    • Livermore, D.M.1    Mushtaq, S.2    Ge, Y.3
  • 22
    • 79955536362 scopus 로고    scopus 로고
    • Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes
    • Sader HS, Rhomberg PR, Farrell DJ, et al. Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes. Antimicrob Agents Chemother. 2011;55:2390–2394.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2390-2394
    • Sader, H.S.1    Rhomberg, P.R.2    Farrell, D.J.3
  • 23
    • 84893029558 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli
    • Zhanel GG, Chung P, Adam H, et al. Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli. Drugs. 2014;74:31–51.
    • (2014) Drugs , vol.74 , pp. 31-51
    • Zhanel, G.G.1    Chung, P.2    Adam, H.3
  • 24
    • 85028357426 scopus 로고    scopus 로고
    • In vitro activity of ceftolozane-tazobactam and other antimicrobial agents against Burkholderia cepacia complex and Burkholderia gladioli
    • Mazer DM, Young C, Kalikin LM, et al. In vitro activity of ceftolozane-tazobactam and other antimicrobial agents against Burkholderia cepacia complex and Burkholderia gladioli. Antimicrob Agents Chemother. 2017;61:e00766–17.
    • (2017) Antimicrob Agents Chemother , vol.61
    • Mazer, D.M.1    Young, C.2    Kalikin, L.M.3
  • 25
    • 85027156348 scopus 로고    scopus 로고
    • Activity of ceftolozane/tazobactam against surveillance and ‘problem’ Enterobacteriaceae, Pseudomonas aeruginosa and non-fermenters from the British Isles
    • Livermore DM, Mushtaq S, Meunier D, et al. Activity of ceftolozane/tazobactam against surveillance and ‘problem’ Enterobacteriaceae, Pseudomonas aeruginosa and non-fermenters from the British Isles. J Antimicrob Chemother. 2017;72:2278–2289.
    • (2017) J Antimicrob Chemother , vol.72 , pp. 2278-2289
    • Livermore, D.M.1    Mushtaq, S.2    Meunier, D.3
  • 26
    • 84957928522 scopus 로고    scopus 로고
    • In vitro activity of ceftolozane-tazobactam against anaerobic organisms identified during the ASPECT-cIAI Study
    • Armstrong ES, Farrell DJ, Palchak M, et al. In vitro activity of ceftolozane-tazobactam against anaerobic organisms identified during the ASPECT-cIAI Study. Antimicrob Agents Chemother. 2015;60:666–668.
    • (2015) Antimicrob Agents Chemother , vol.60 , pp. 666-668
    • Armstrong, E.S.1    Farrell, D.J.2    Palchak, M.3
  • 27
    • 84946234354 scopus 로고    scopus 로고
    • Ceftolozane-tazobactam activity against phylogenetically diverse Clostridium difficile strains
    • Gonzalez MD, Wallace MA, Hink T, et al. Ceftolozane-tazobactam activity against phylogenetically diverse Clostridium difficile strains. Antimicrob Agents Chemother. 2015;59:7084–7085.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 7084-7085
    • Gonzalez, M.D.1    Wallace, M.A.2    Hink, T.3
  • 28
    • 85021913699 scopus 로고    scopus 로고
    • Ceftolozane-tazobactam activity against Pseudomonas aeruginosa clinical isolates from U.S. hospitals: report from the PACTS antimicrobial surveillance program, 2012 to 2015
    • Shortridge D, Castanheira M, Pfaller MA, et al. Ceftolozane-tazobactam activity against Pseudomonas aeruginosa clinical isolates from U.S. hospitals: report from the PACTS antimicrobial surveillance program, 2012 to 2015. Antimicrob Agents Chemother. 2017;61:e00465–17.
    • (2017) Antimicrob Agents Chemother , vol.61
    • Shortridge, D.1    Castanheira, M.2    Pfaller, M.A.3
  • 29
    • 85019081486 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam activity against drug-resistant enterobacteriaceae and Pseudomonas aeruginosa causing urinary tract and intraabdominal infections in Europe: report from an antimicrobial surveillance programme (2012–15)
    • Pfaller MA, Bassetti M, Duncan LR, et al. Ceftolozane/tazobactam activity against drug-resistant enterobacteriaceae and Pseudomonas aeruginosa causing urinary tract and intraabdominal infections in Europe: report from an antimicrobial surveillance programme (2012–15). J Antimicrob Chemother. 2017;72:1386–1395.
    • (2017) J Antimicrob Chemother , vol.72 , pp. 1386-1395
    • Pfaller, M.A.1    Bassetti, M.2    Duncan, L.R.3
  • 30
    • 85031669554 scopus 로고    scopus 로고
    • Ceftolozane-tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing healthcare-associated infections in Latin America: report from an antimicrobial surveillance program (2013–2015)
    • Pfaller MA, Shortridge D, Sader HS, et al. Ceftolozane-tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing healthcare-associated infections in Latin America: report from an antimicrobial surveillance program (2013–2015). Braz J Infect Dis. 2017;21:627–637.
    • (2017) Braz J Infect Dis , vol.21 , pp. 627-637
    • Pfaller, M.A.1    Shortridge, D.2    Sader, H.S.3
  • 31
    • 85026386066 scopus 로고    scopus 로고
    • Ceftolozane-tazobactam activity against drug-resistant enterobacteriaceae and Pseudomonas aeruginosa causing healthcare-associated infections in Australia and New Zealand: report from an antimicrobial surveillance program (2013–2015)
    • Pfaller MA, Shortridge D, Sader HS, et al. Ceftolozane-tazobactam activity against drug-resistant enterobacteriaceae and Pseudomonas aeruginosa causing healthcare-associated infections in Australia and New Zealand: report from an antimicrobial surveillance program (2013–2015). J Glob Antimicrob Resist. 2017;10:186–194.
    • (2017) J Glob Antimicrob Resist , vol.10 , pp. 186-194
    • Pfaller, M.A.1    Shortridge, D.2    Sader, H.S.3
  • 32
    • 85033803624 scopus 로고    scopus 로고
    • In-vitro activity of ceftolozane/tazobactam against Pseudomonas aeruginosa and enterobacteriaceae isolates recovered from hospitalized patients in Germany
    • Seifert H, Körber-Irrgang B, Kresken M. In-vitro activity of ceftolozane/tazobactam against Pseudomonas aeruginosa and enterobacteriaceae isolates recovered from hospitalized patients in Germany. Int J Antimicrob Agents. 2017. DOI:10.1016/j.ijantimicag.2017.06.024
    • (2017) Int J Antimicrob Agents
    • Seifert, H.1    Körber-Irrgang, B.2    Kresken, M.3
  • 33
    • 85043350586 scopus 로고    scopus 로고
    • Italian nationwide survey on Pseudomonas aeruginosa from invasive infections: activity of ceftolozane/tazobactam and comparators, and molecular epidemiology of carbapenemase producers
    • Giani T, Arena F, Pollini S, et al. Italian nationwide survey on Pseudomonas aeruginosa from invasive infections: activity of ceftolozane/tazobactam and comparators, and molecular epidemiology of carbapenemase producers. J Antimicrob Chemother. 2017;73:664–671.
    • (2017) J Antimicrob Chemother , vol.73 , pp. 664-671
    • Giani, T.1    Arena, F.2    Pollini, S.3
  • 34
    • 85029744649 scopus 로고    scopus 로고
    • Multicenter evaluation of ceftazidime-avibactam and ceftolozane-tazobactam inhibitory activity against meropenem-nonsusceptible Pseudomonas aeruginosa from blood, respiratory tract, and wounds
    • Grupper M, Sutherland C, Nicolau DP. Multicenter evaluation of ceftazidime-avibactam and ceftolozane-tazobactam inhibitory activity against meropenem-nonsusceptible Pseudomonas aeruginosa from blood, respiratory tract, and wounds. Antimicrob Agents Chemother. 2017;61:e00875–17.
    • (2017) Antimicrob Agents Chemother , vol.61
    • Grupper, M.1    Sutherland, C.2    Nicolau, D.P.3
  • 35
    • 77955637131 scopus 로고    scopus 로고
    • Activity of the new cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa isolates from chronically-infected cystic fibrosis patients
    • Zamorano L, Juan C, Fernández-Olmos A, et al. Activity of the new cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa isolates from chronically-infected cystic fibrosis patients. Clin Microbiol Infect. 2010;16:1482–1487.
    • (2010) Clin Microbiol Infect , vol.16 , pp. 1482-1487
    • Zamorano, L.1    Juan, C.2    Fernández-Olmos, A.3
  • 36
    • 84938739520 scopus 로고    scopus 로고
    • Microbiological activity of ceftolozane/tazobactam, ceftazidime, meropenem, and piperacillin/tazobactam against Pseudomonas aeruginosa isolated from children with cystic fibrosis
    • Kuti JL, Pettit RS, Neu N, et al. Microbiological activity of ceftolozane/tazobactam, ceftazidime, meropenem, and piperacillin/tazobactam against Pseudomonas aeruginosa isolated from children with cystic fibrosis. Diagn Microbiol Infect Dis. 2015;83:53–55.
    • (2015) Diagn Microbiol Infect Dis , vol.83 , pp. 53-55
    • Kuti, J.L.1    Pettit, R.S.2    Neu, N.3
  • 37
    • 85016978400 scopus 로고    scopus 로고
    • VitroActivity of ceftolozane-tazobactam against multidrug-resistant nonfermenting gram-negative bacilli Isolated from patients with cystic fibrosis
    • Grohs P, Taieb G, Morand P, et al. VitroActivity of ceftolozane-tazobactam against multidrug-resistant nonfermenting gram-negative bacilli Isolated from patients with cystic fibrosis. Antimicrob Agents Chemother. 2017;61:e02688–16.
    • (2017) Antimicrob Agents Chemother , vol.61
    • Grohs, P.1    Taieb, G.2    Morand, P.3
  • 38
    • 85045639617 scopus 로고    scopus 로고
    • Antimicrobial activity of ceftolozane-tazobactam tested against enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in U.S. hospitals (2013–2016) as part of the surveillance program: program to assess ceftolozane-tazobactam susceptibility
    • Shortridge D, Pfaller MA, Castanheira M, et al. Antimicrobial activity of ceftolozane-tazobactam tested against enterobacteriaceae and Pseudomonas aeruginosa with various resistance patterns isolated in U.S. hospitals (2013–2016) as part of the surveillance program: program to assess ceftolozane-tazobactam susceptibility. Microb Drug Resist. 2017. DOI:10.1089/mdr.2017.0266
    • (2017) Microb Drug Resist
    • Shortridge, D.1    Pfaller, M.A.2    Castanheira, M.3
  • 39
    • 85028309763 scopus 로고    scopus 로고
    • In vivo emergence of resistance to novel cephalosporin-β-Lactamase inhibitor combinations through the duplication of amino acid D149 from OXA-2 β-lactamase (OXA-539) in sequence type 235 Pseudomonas aeruginosa
    • Fraile-Ribot PA, Mulet X, Cabot G, et al. In vivo emergence of resistance to novel cephalosporin-β-Lactamase inhibitor combinations through the duplication of amino acid D149 from OXA-2 β-lactamase (OXA-539) in sequence type 235 Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2017;61:e01117–17.
    • (2017) Antimicrob Agents Chemother , vol.61
    • Fraile-Ribot, P.A.1    Mulet, X.2    Cabot, G.3
  • 40
    • 85041036384 scopus 로고    scopus 로고
    • Susceptibility of MDR Pseudomonas aeruginosa to ceftolozane/tazobactam and comparison of different susceptibility testing methods
    • Schaumburg F, Bletz S, Mellmann A, et al. Susceptibility of MDR Pseudomonas aeruginosa to ceftolozane/tazobactam and comparison of different susceptibility testing methods. J Antimicrob Chemother. 2017;72:3079–3084.
    • (2017) J Antimicrob Chemother , vol.72 , pp. 3079-3084
    • Schaumburg, F.1    Bletz, S.2    Mellmann, A.3
  • 41
    • 84901280909 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC
    • Cabot G, Bruchmann S, Mulet X, et al. Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC. Antimicrob Agents Chemother. 2014;58:3091–3099.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 3091-3099
    • Cabot, G.1    Bruchmann, S.2    Mulet, X.3
  • 42
    • 84941168496 scopus 로고    scopus 로고
    • Mutations in β-lactamase AmpC increase resistance of Pseudomonas aeruginosa isolates to antipseudomonal cephalosporins
    • Berrazeg M, Jeannot K, Ntsogo Enguéné VY, et al. Mutations in β-lactamase AmpC increase resistance of Pseudomonas aeruginosa isolates to antipseudomonal cephalosporins. Antimicrob Agents Chemother. 2015;59:6248–6255.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 6248-6255
    • Berrazeg, M.1    Jeannot, K.2    Ntsogo Enguéné, V.Y.3
  • 43
    • 85021827336 scopus 로고    scopus 로고
    • Ceftolozane-tazobactam for the treatment of multidrug-resistant Pseudomonas aeruginosa infections: clinical effectiveness and evolution of resistance
    • Haidar G, Philips NJ, Shields RK, et al. Ceftolozane-tazobactam for the treatment of multidrug-resistant Pseudomonas aeruginosa infections: clinical effectiveness and evolution of resistance. Clin Infect Dis. 2017;65:110–120.
    • (2017) Clin Infect Dis , vol.65 , pp. 110-120
    • Haidar, G.1    Philips, N.J.2    Shields, R.K.3
  • 44
    • 85035049407 scopus 로고    scopus 로고
    • Emergence of ceftolozane-tazobactam resistant Pseudomonas aeruginosa during treatment is mediated by a single AmpC structural mutation
    • MacVane SH, Pandey R, Steed LL, et al. Emergence of ceftolozane-tazobactam resistant Pseudomonas aeruginosa during treatment is mediated by a single AmpC structural mutation. Antimicrob Agents Chemother. 2017;61:e01183–17.
    • (2017) Antimicrob Agents Chemother , vol.61
    • MacVane, S.H.1    Pandey, R.2    Steed, L.L.3
  • 47
    • 85008350884 scopus 로고    scopus 로고
    • Comparison of Etest to broth microdilution for testing of susceptibility of Pseudomonas aeruginosa to ceftolozane-tazobactam
    • Flynt LK, Veve MP, Samuel LP, et al. Comparison of Etest to broth microdilution for testing of susceptibility of Pseudomonas aeruginosa to ceftolozane-tazobactam. J Clin Microbiol. 2017;55:334–335.
    • (2017) J Clin Microbiol , vol.55 , pp. 334-335
    • Flynt, L.K.1    Veve, M.P.2    Samuel, L.P.3
  • 48
    • 84937515119 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam: a novel cephalosporin/beta-lactamase inhibitor combination
    • Cho JC, Fiorenza MA, Estrada SJ. Ceftolozane/tazobactam: a novel cephalosporin/beta-lactamase inhibitor combination. Pharmacotherapy. 2015;35:701–715.
    • (2015) Pharmacotherapy , vol.35 , pp. 701-715
    • Cho, J.C.1    Fiorenza, M.A.2    Estrada, S.J.3
  • 49
    • 84940199623 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam: a new cephalosporin and beta-lactamase inhibitor combination
    • Sucher AJ, Chahine EB, Cogan P, et al. Ceftolozane/tazobactam: a new cephalosporin and beta-lactamase inhibitor combination. Ann Pharmacother. 2015;49:1046–1056.
    • (2015) Ann Pharmacother , vol.49 , pp. 1046-1056
    • Sucher, A.J.1    Chahine, E.B.2    Cogan, P.3
  • 50
    • 0025774926 scopus 로고
    • Pharmacokinetics and tissue penetration of tazobactam administered alone and with piperacillin
    • Wise R, Logan M, Cooper M, et al. Pharmacokinetics and tissue penetration of tazobactam administered alone and with piperacillin. Antimicrob Agents Chemother. 1991;35:1081–1084.
    • (1991) Antimicrob Agents Chemother , vol.35 , pp. 1081-1084
    • Wise, R.1    Logan, M.2    Cooper, M.3
  • 51
    • 84896914754 scopus 로고    scopus 로고
    • Impact of renal function on the pharmacokinetics and safety of ceftolozane-tazobactam
    • Wooley M, Miller B, Krishna G, et al. Impact of renal function on the pharmacokinetics and safety of ceftolozane-tazobactam. Antimicrob Agents Chemother. 2014;58:2249–2255.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 2249-2255
    • Wooley, M.1    Miller, B.2    Krishna, G.3
  • 52
    • 84940449628 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam and ceftazidime/avibactam: two novel beta-lactam/beta-lactamase inhibitor combination agents for the treatment of resistant Gram-negative bacterial infections
    • Liscio JL, Mahoney MV, Hirsch EB. Ceftolozane/tazobactam and ceftazidime/avibactam: two novel beta-lactam/beta-lactamase inhibitor combination agents for the treatment of resistant Gram-negative bacterial infections. Int J Antimicrob Agents. 2015;46:266–271.
    • (2015) Int J Antimicrob Agents , vol.46 , pp. 266-271
    • Liscio, J.L.1    Mahoney, M.V.2    Hirsch, E.B.3
  • 53
    • 85034738414 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue penetration of ceftolozane/tazobactam in diabetic patients with lower limb infections and healthy adult volunteers
    • Monogue ML, Stainton SM, Baummer-Carr A, et al. Pharmacokinetics and tissue penetration of ceftolozane/tazobactam in diabetic patients with lower limb infections and healthy adult volunteers. Antimicrob Agents Chemother. 2017;61:e01449–17.
    • (2017) Antimicrob Agents Chemother , vol.61
    • Monogue, M.L.1    Stainton, S.M.2    Baummer-Carr, A.3
  • 54
    • 84964765576 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam pharmacokinetics in a critically ill adult receiving continuous renal replacement therapy
    • Bremmer DN, Nicolau DP, Burcham P, et al. Ceftolozane/tazobactam pharmacokinetics in a critically ill adult receiving continuous renal replacement therapy. Pharmacotherapy. 2016;36:e30–e33.
    • (2016) Pharmacotherapy , vol.36 , pp. e30-e33
    • Bremmer, D.N.1    Nicolau, D.P.2    Burcham, P.3
  • 55
    • 84978865098 scopus 로고    scopus 로고
    • Treatment of multidrug-resistant Pseudomonas aeruginosa with ceftolozane/tazobactam in a critically ill patient receiving continuous venovenous haemodiafiltration
    • Kuti JL, Ghazi IM, Quintiliani R, Jr, et al. Treatment of multidrug-resistant Pseudomonas aeruginosa with ceftolozane/tazobactam in a critically ill patient receiving continuous venovenous haemodiafiltration. Int J Antimicrob Agents. 2016;48:342–343.
    • (2016) Int J Antimicrob Agents , vol.48 , pp. 342-343
    • Kuti, J.L.1    Ghazi, I.M.2    Quintiliani, R.3
  • 56
    • 84875175772 scopus 로고    scopus 로고
    • In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum beta-lactamases, in the thighs of neutropenic mice
    • Craig WA, Andes DR. In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum beta-lactamases, in the thighs of neutropenic mice. Antimicrob Agents Chemother. 2013;57:1577–1582.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 1577-1582
    • Craig, W.A.1    Andes, D.R.2
  • 57
    • 84957928059 scopus 로고    scopus 로고
    • Pharmacodynamics of ceftolozane plus tazobactam studied in an in vitro pharmacokinetic model of infection
    • MacGowan AP, Noel AR, Tomaselli SG, et al. Pharmacodynamics of ceftolozane plus tazobactam studied in an in vitro pharmacokinetic model of infection. Antimicrob Agents Chemother. 2015;60:515–521.
    • (2015) Antimicrob Agents Chemother , vol.60 , pp. 515-521
    • MacGowan, A.P.1    Noel, A.R.2    Tomaselli, S.G.3
  • 58
    • 84877867715 scopus 로고    scopus 로고
    • Pharmacokinetics-pharmacodynamics of tazobactam in combination with ceftolozane in an in vitro infection model
    • VanScoy B, Mendes RE, Nicasio AM, et al. Pharmacokinetics-pharmacodynamics of tazobactam in combination with ceftolozane in an in vitro infection model. Antimicrob Agents Chemother. 2013;57:2809–2814.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 2809-2814
    • VanScoy, B.1    Mendes, R.E.2    Nicasio, A.M.3
  • 59
    • 84887432368 scopus 로고    scopus 로고
    • Pharmacological basis of beta-lactamase inhibitor therapeutics: tazobactam in combination with Ceftolozane
    • VanScoy B, Mendes RE, McCauley J, et al. Pharmacological basis of beta-lactamase inhibitor therapeutics: tazobactam in combination with Ceftolozane. Antimicrob Agents Chemother. 2013;57:5924–5930.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 5924-5930
    • VanScoy, B.1    Mendes, R.E.2    McCauley, J.3
  • 60
    • 84963600221 scopus 로고    scopus 로고
    • Combinatorial pharmacodynamics of ceftolozane-tazobactam against genotypically defined beta-lactamase-producing escherichia coli: insights into the pharmacokinetics/pharmacodynamics of beta-lactam-beta-lactamase inhibitor combinations
    • Soon RL, Lenhard JR, Bulman ZP, et al. Combinatorial pharmacodynamics of ceftolozane-tazobactam against genotypically defined beta-lactamase-producing escherichia coli: insights into the pharmacokinetics/pharmacodynamics of beta-lactam-beta-lactamase inhibitor combinations. Antimicrob Agents Chemother. 2016;60:1967–1973.
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 1967-1973
    • Soon, R.L.1    Lenhard, J.R.2    Bulman, Z.P.3
  • 61
    • 84996567043 scopus 로고    scopus 로고
    • Pharmacodynamics of ceftolozane combined with tazobactam against enterobacteriaceae in a neutropenic mouse thigh model
    • Melchers MJ, Mavridou E, van Mil AC, et al. Pharmacodynamics of ceftolozane combined with tazobactam against enterobacteriaceae in a neutropenic mouse thigh model. Antimicrob Agents Chemother. 2016;60:7272–7279.
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 7272-7279
    • Melchers, M.J.1    Mavridou, E.2    van Mil, A.C.3
  • 62
    • 84921018804 scopus 로고    scopus 로고
    • Population pharmacokinetics of ceftolozane/tazobactam in healthy volunteers, subjects with varying degrees of renal function and patients with bacterial infections
    • Chandorkar G, Xiao A, Mouksassi MS, et al. Population pharmacokinetics of ceftolozane/tazobactam in healthy volunteers, subjects with varying degrees of renal function and patients with bacterial infections. J Clin Pharmacol. 2015;55:230–239.
    • (2015) J Clin Pharmacol , vol.55 , pp. 230-239
    • Chandorkar, G.1    Xiao, A.2    Mouksassi, M.S.3
  • 63
    • 85014663078 scopus 로고    scopus 로고
    • PK/PD target attainment with ceftolozane/tazobactam using monte carlo simulation in patients with various degrees of renal function, including augmented renal clearance and end-stage renal disease
    • Xiao AJ, Caro L, Popejoy MW, et al. PK/PD target attainment with ceftolozane/tazobactam using monte carlo simulation in patients with various degrees of renal function, including augmented renal clearance and end-stage renal disease. Infect Dis Ther. 2017;6:137–148.
    • (2017) Infect Dis Ther , vol.6 , pp. 137-148
    • Xiao, A.J.1    Caro, L.2    Popejoy, M.W.3
  • 64
    • 84954153001 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam pharmacokinetic/pharmacodynamic-derived dose justification for phase 3 studies in patients with nosocomial pneumonia
    • Xiao AJ, Miller BW, Huntington JA, et al. Ceftolozane/tazobactam pharmacokinetic/pharmacodynamic-derived dose justification for phase 3 studies in patients with nosocomial pneumonia. J Clin Pharmacol. 2016;56:56–66.
    • (2016) J Clin Pharmacol , vol.56 , pp. 56-66
    • Xiao, A.J.1    Miller, B.W.2    Huntington, J.A.3
  • 65
    • 84866599592 scopus 로고    scopus 로고
    • Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects
    • Chandorkar G, Huntington JA, Gotfried MH, et al. Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects. J Antimicrob Chemother. 2012;67:2463–2469.
    • (2012) J Antimicrob Chemother , vol.67 , pp. 2463-2469
    • Chandorkar, G.1    Huntington, J.A.2    Gotfried, M.H.3
  • 66
    • 84994494386 scopus 로고    scopus 로고
    • Population pharmacokinetics and safety of ceftolozane-tazobactam in adult cystic fibrosis patients admitted with acute pulmonary exacerbation
    • Monogue ML, Pettit RS, Muhlebach M, et al. Population pharmacokinetics and safety of ceftolozane-tazobactam in adult cystic fibrosis patients admitted with acute pulmonary exacerbation. Antimicrob Agents Chemother. 2016;60:6578–6584.
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 6578-6584
    • Monogue, M.L.1    Pettit, R.S.2    Muhlebach, M.3
  • 67
    • 84907445421 scopus 로고    scopus 로고
    • Relationship between ceftolozane-tazobactam exposure and selection for Pseudomonas aeruginosa resistance in a hollow-fiber infection model
    • VanScoy BD, Mendes RE, Castanheira M, et al. Relationship between ceftolozane-tazobactam exposure and selection for Pseudomonas aeruginosa resistance in a hollow-fiber infection model. Antimicrob Agents Chemother. 2014;58:6024–6031.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 6024-6031
    • VanScoy, B.D.1    Mendes, R.E.2    Castanheira, M.3
  • 68
    • 85007006802 scopus 로고    scopus 로고
    • In vitro pharmacodynamic evaluation of ceftolozane/tazobactam against beta-lactamase-producing Escherichia coli in a hollow-fibre infection model
    • Soon RL, Lenhard JR, Bulman ZP, et al. In vitro pharmacodynamic evaluation of ceftolozane/tazobactam against beta-lactamase-producing Escherichia coli in a hollow-fibre infection model. Int J Antimicrob Agents. 2017;49:25–30.
    • (2017) Int J Antimicrob Agents , vol.49 , pp. 25-30
    • Soon, R.L.1    Lenhard, J.R.2    Bulman, Z.P.3
  • 69
    • 85030723349 scopus 로고    scopus 로고
    • Determination of alternative ceftolozane/tazobactam dosing regimens for patients with infections due to Pseudomonas aeruginosa with MIC values between 4 and 32 mg/L
    • Natesan S, Pai MP, Lodise TP. Determination of alternative ceftolozane/tazobactam dosing regimens for patients with infections due to Pseudomonas aeruginosa with MIC values between 4 and 32 mg/L. J Antimicrob Chemother. 2017;72:2813–2816.
    • (2017) J Antimicrob Chemother , vol.72 , pp. 2813-2816
    • Natesan, S.1    Pai, M.P.2    Lodise, T.P.3
  • 70
    • 85007228604 scopus 로고    scopus 로고
    • Physical compatibility of ceftolozane-tazobactam with selected i.v. drugs during simulated Y-site administration
    • Thabit AK, Hamada Y, Nicolau DP. Physical compatibility of ceftolozane-tazobactam with selected i.v. drugs during simulated Y-site administration. Am J Health Syst Pharm. 2017;74:e47–e54.
    • (2017) Am J Health Syst Pharm , vol.74 , pp. e47-e54
    • Thabit, A.K.1    Hamada, Y.2    Nicolau, D.P.3
  • 71
    • 84929206762 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: results from a randomized, double-blind, phase 3 trial (ASPECT-cIAI)
    • Solomkin J, Hershberger E, Miller B, et al. Ceftolozane/tazobactam plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: results from a randomized, double-blind, phase 3 trial (ASPECT-cIAI). Clin Infect Dis. 2015;60:1462–1471.
    • (2015) Clin Infect Dis , vol.60 , pp. 1462-1471
    • Solomkin, J.1    Hershberger, E.2    Miller, B.3
  • 72
    • 84929606496 scopus 로고    scopus 로고
    • Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI)
    • Wagenlehner FM, Umeh O, Steenbergen J, et al. Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI). Lancet. 2015;385:1949–1956.
    • (2015) Lancet , vol.385 , pp. 1949-1956
    • Wagenlehner, F.M.1    Umeh, O.2    Steenbergen, J.3
  • 73
    • 84906085321 scopus 로고    scopus 로고
    • Multicenter, double-blind, randomized, phase II trial to assess the safety and efficacy of ceftolozane-tazobactam plus metronidazole compared with meropenem in adult patients with complicated intra-abdominal infections
    • Lucasti C, Hershberger E, Miller B, et al. Multicenter, double-blind, randomized, phase II trial to assess the safety and efficacy of ceftolozane-tazobactam plus metronidazole compared with meropenem in adult patients with complicated intra-abdominal infections. Antimicrob Agents Chemother. 2014;58:5350–5357.
    • (2014) Antimicrob Agents Chemother , vol.58 , pp. 5350-5357
    • Lucasti, C.1    Hershberger, E.2    Miller, B.3
  • 74
    • 84976892814 scopus 로고    scopus 로고
    • Characteristics and outcomes of complicated intra-abdominal infections involving Pseudomonas aeruginosa from a randomized, double-blind, phase 3 ceftolozane-tazobactam study
    • Miller B, Popejoy MW, Hershberger E, et al. Characteristics and outcomes of complicated intra-abdominal infections involving Pseudomonas aeruginosa from a randomized, double-blind, phase 3 ceftolozane-tazobactam study. Antimicrob Agents Chemother. 2016;60:4387–4390.
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 4387-4390
    • Miller, B.1    Popejoy, M.W.2    Hershberger, E.3
  • 75
    • 84979072369 scopus 로고    scopus 로고
    • Efficacy of ceftolozane/tazobactam versus levofloxacin in the treatment of complicated urinary tract infections (cUTIs) caused by levofloxacin-resistant pathogens: results from the ASPECT-cUTI trial
    • Huntington JA, Sakoulas G, Umeh O, et al. Efficacy of ceftolozane/tazobactam versus levofloxacin in the treatment of complicated urinary tract infections (cUTIs) caused by levofloxacin-resistant pathogens: results from the ASPECT-cUTI trial. J Antimicrob Chemother. 2016;71:2014–2021.
    • (2016) J Antimicrob Chemother , vol.71 , pp. 2014-2021
    • Huntington, J.A.1    Sakoulas, G.2    Umeh, O.3
  • 76
    • 85014538017 scopus 로고    scopus 로고
    • Efficacy of ceftolozane/tazobactam against urinary tract and intra-abdominal infections caused by ESBL-producing E.coli and K. pneumoniae: a pooled analysis of Phase 3 clinical trials
    • Popejoy MW, Paterson DL, Cloutier D, et al. Efficacy of ceftolozane/tazobactam against urinary tract and intra-abdominal infections caused by ESBL-producing E.coli and K. pneumoniae: a pooled analysis of Phase 3 clinical trials. J Antimicrob Chemother. 2017;72:268–272.
    • (2017) J Antimicrob Chemother , vol.72 , pp. 268-272
    • Popejoy, M.W.1    Paterson, D.L.2    Cloutier, D.3
  • 77
    • 85018758809 scopus 로고    scopus 로고
    • Analysis of patients with diabetes and complicated intra-abdominal infection or complicated urinary tract infection in phase 3 trials of ceftolozane/tazobactam
    • Popejoy MW, Long J, Huntington JA. Analysis of patients with diabetes and complicated intra-abdominal infection or complicated urinary tract infection in phase 3 trials of ceftolozane/tazobactam. BMC Infect Dis. 2017;17:316.
    • (2017) BMC Infect Dis , vol.17 , pp. 316
    • Popejoy, M.W.1    Long, J.2    Huntington, J.A.3
  • 78
    • 85030986851 scopus 로고    scopus 로고
    • Does moderate renal impairment affect clinical outcomes in complicated intra-abdominal and complicated urinary tract infections? Analysis of two randomized controlled trials with ceftolozane/tazobactam
    • Kullar R, Wagenlehner FM, Popejoy MW, et al. Does moderate renal impairment affect clinical outcomes in complicated intra-abdominal and complicated urinary tract infections? Analysis of two randomized controlled trials with ceftolozane/tazobactam. J Antimicrob Chemother. 2017;72:900–905.
    • (2017) J Antimicrob Chemother , vol.72 , pp. 900-905
    • Kullar, R.1    Wagenlehner, F.M.2    Popejoy, M.W.3
  • 79
    • 85045668175 scopus 로고    scopus 로고
    • [cited 2017 Oct15], Available from
    • FDA Drug Safety Communication: FDA cautions about dose confusion and medication errors for antibacterial drug Zerbaxa (ceftolozane and tazobactam). [cited 2017 Oct15]. Available from: https://www.fda.gov/Drugs/DrugSafety/ucm445919.htm
  • 80
    • 85021792400 scopus 로고    scopus 로고
    • Multicenter evaluation of ceftolozane/tazobactam for serious infections caused by carbapenem-resistant Pseudomonas aeruginosa
    • Munita JM, Aitken SL, Miller WR, et al. Multicenter evaluation of ceftolozane/tazobactam for serious infections caused by carbapenem-resistant Pseudomonas aeruginosa. Clin Infect Dis. 2017;65:158–161.
    • (2017) Clin Infect Dis , vol.65 , pp. 158-161
    • Munita, J.M.1    Aitken, S.L.2    Miller, W.R.3
  • 81
    • 85028592748 scopus 로고    scopus 로고
    • Impact of a mixed educational and semi-restrictive antimicrobial stewardship project in a large teaching hospital in Northern Italy
    • Giacobbe DR, Del Bono V, Mikulska M, et al. Impact of a mixed educational and semi-restrictive antimicrobial stewardship project in a large teaching hospital in Northern Italy. Infection. 2017;45:849–856.
    • (2017) Infection , vol.45 , pp. 849-856
    • Giacobbe, D.R.1    Del Bono, V.2    Mikulska, M.3
  • 82
    • 85029701701 scopus 로고    scopus 로고
    • Using β-lactam/β-lactamase inhibitors for infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae to slow the emergence of carbapenem-resistant Enterobacteriaceae
    • Watkins RR, Deresinski S. Using β-lactam/β-lactamase inhibitors for infections due to extended-spectrum β-lactamase-producing Enterobacteriaceae to slow the emergence of carbapenem-resistant Enterobacteriaceae. Expert Rev Anti Infect Ther. 2017;15:893–895.
    • (2017) Expert Rev Anti Infect Ther , vol.15 , pp. 893-895
    • Watkins, R.R.1    Deresinski, S.2
  • 83
    • 84977072761 scopus 로고    scopus 로고
    • A multinational, preregistered cohort study of beta-lactam/beta-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-spectrum-beta-lactamase-producing enterobacteriaceae
    • Gutierrez-Gutierrez B, Perez-Galera S, Salamanca E, et al. A multinational, preregistered cohort study of beta-lactam/beta-lactamase inhibitor combinations for treatment of bloodstream infections due to extended-spectrum-beta-lactamase-producing enterobacteriaceae. Antimicrob Agents Chemother. 2016;60:4159–4169.
    • (2016) Antimicrob Agents Chemother , vol.60 , pp. 4159-4169
    • Gutierrez-Gutierrez, B.1    Perez-Galera, S.2    Salamanca, E.3
  • 84
    • 35848946597 scopus 로고    scopus 로고
    • Optimal dosing of piperacillin-tazobactam for the treatment of Pseudomonas aeruginosa infections: prolonged or continuous infusion?
    • Kim A, Sutherland CA, Kuti JL, et al. Optimal dosing of piperacillin-tazobactam for the treatment of Pseudomonas aeruginosa infections: prolonged or continuous infusion? Pharmacotherapy. 2007;27:1490–1497.
    • (2007) Pharmacotherapy , vol.27 , pp. 1490-1497
    • Kim, A.1    Sutherland, C.A.2    Kuti, J.L.3
  • 85
    • 84928879624 scopus 로고    scopus 로고
    • Carbapenem therapy is associated with improved survival compared with piperacillin-tazobactam for patients with extended-spectrum β-lactamase bacteremia
    • Tamma PD, Han JH, Rock C, et al. Carbapenem therapy is associated with improved survival compared with piperacillin-tazobactam for patients with extended-spectrum β-lactamase bacteremia. Clin Infect Dis. 2015;60:1319–1325.
    • (2015) Clin Infect Dis , vol.60 , pp. 1319-1325
    • Tamma, P.D.1    Han, J.H.2    Rock, C.3
  • 86
    • 84988847909 scopus 로고    scopus 로고
    • Carbapenems versus piperacillin-tazobactam for bloodstream infections of nonurinary source caused by extended- spectrum beta-lactamase-producing Enterobacteriaceae
    • Ofer-Friedman H, Shefler C, Sharma S, et al. Carbapenems versus piperacillin-tazobactam for bloodstream infections of nonurinary source caused by extended- spectrum beta-lactamase-producing Enterobacteriaceae. Infect Control Hosp Epidemiol. 2015;36:981–985.
    • (2015) Infect Control Hosp Epidemiol , vol.36 , pp. 981-985
    • Ofer-Friedman, H.1    Shefler, C.2    Sharma, S.3
  • 87
    • 85018457636 scopus 로고    scopus 로고
    • Cost-effectiveness of ceftolozane/tazobactam compared with piperacillin/tazobactam as empiric therapy based on the in-vitro surveillance of bacterial isolates in the United States for the treatment of complicated urinary tract infections
    • Kauf TL, Prabhu VS, Medic G, et al. Cost-effectiveness of ceftolozane/tazobactam compared with piperacillin/tazobactam as empiric therapy based on the in-vitro surveillance of bacterial isolates in the United States for the treatment of complicated urinary tract infections. BMC Infect Dis. 2017;17:314.
    • (2017) BMC Infect Dis , vol.17 , pp. 314
    • Kauf, T.L.1    Prabhu, V.S.2    Medic, G.3
  • 88
    • 85020461086 scopus 로고    scopus 로고
    • Cost-effectiveness of ceftolozane/tazobactam plus metronidazole compared with piperacillin/tazobactam as empiric therapy for the treatment of complicated intra-abdominal infections based on the in-vitro surveillance of bacterial isolates in the UK
    • Prabhu V, Foo J, Ahir H, et al. Cost-effectiveness of ceftolozane/tazobactam plus metronidazole compared with piperacillin/tazobactam as empiric therapy for the treatment of complicated intra-abdominal infections based on the in-vitro surveillance of bacterial isolates in the UK. J Med Econ. 2017;20:840–849.
    • (2017) J Med Econ , vol.20 , pp. 840-849
    • Prabhu, V.1    Foo, J.2    Ahir, H.3
  • 89
    • 84964837459 scopus 로고    scopus 로고
    • Cancer drugs approved on the basis of a surrogate end point and subsequent overall survival: an analysis of 5 years of US Food and Drug Administration approvals
    • Kim C, Prasad V. Cancer drugs approved on the basis of a surrogate end point and subsequent overall survival: an analysis of 5 years of US Food and Drug Administration approvals. JAMA Intern Med. 2015;175:1992–1994.
    • (2015) JAMA Intern Med , vol.175 , pp. 1992-1994
    • Kim, C.1    Prasad, V.2
  • 90
    • 85030646958 scopus 로고    scopus 로고
    • Availability of evidence on overall survival and quality of life benefits of cancer drugs approved by the European Medicines Agency: retrospective cohort study of drug approvals from 2009–2013
    • Davis C, Naci H, Gurpinar E, et al. Availability of evidence on overall survival and quality of life benefits of cancer drugs approved by the European Medicines Agency: retrospective cohort study of drug approvals from 2009–2013. BMJ. 2017;359:j4530.
    • (2017) BMJ , vol.359 , pp. j4530
    • Davis, C.1    Naci, H.2    Gurpinar, E.3
  • 91
    • 85021899864 scopus 로고    scopus 로고
    • Stockholm: ECDC, [cited 2017 Oct30], Available from
    • Antimicrobial resistance surveillance in Europe. Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net) 2015. Stockholm: ECDC; 2017 [cited 2017 Oct30]. Available from: https://ecdc.europa.eu/sites/portal/files/media/en/publications/Publications/antimicrobial-resistance-europe-2015.pdf
    • (2017) Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net) 2015
  • 92
    • 85014124690 scopus 로고    scopus 로고
    • Salvage therapy with ceftolozane-tazobactam for multidrug-resistant Pseudomonas aeruginosa infections
    • Castón JJ, De la Torre Á, Ruiz-Camps I, et al. Salvage therapy with ceftolozane-tazobactam for multidrug-resistant Pseudomonas aeruginosa infections. Antimicrob Agents Chemother. 2017;61:e02136–16.
    • (2017) Antimicrob Agents Chemother , vol.61
    • Castón, J.J.1    De la Torre, Á.2    Ruiz-Camps, I.3
  • 93
    • 85034060966 scopus 로고    scopus 로고
    • Successful treatment of three severe MDR or XDR Pseudomonas aeruginosa infections with ceftolozane/tazobactam
    • Xipell M, Bodro M, Marco F, et al. Successful treatment of three severe MDR or XDR Pseudomonas aeruginosa infections with ceftolozane/tazobactam. Future Microbiol. 2017;12:1323–1326.
    • (2017) Future Microbiol , vol.12 , pp. 1323-1326
    • Xipell, M.1    Bodro, M.2    Marco, F.3
  • 94
    • 85031015450 scopus 로고    scopus 로고
    • Successful treatment of post-surgical osteomyelitis caused by XDR Pseudomonas aeruginosa with ceftolozane/tazobactam monotherapy
    • Gentile I, Buonomo AR, Maraolo AE, et al. Successful treatment of post-surgical osteomyelitis caused by XDR Pseudomonas aeruginosa with ceftolozane/tazobactam monotherapy. J Antimicrob Chemother. 2017;72:2678–2679.
    • (2017) J Antimicrob Chemother , vol.72 , pp. 2678-2679
    • Gentile, I.1    Buonomo, A.R.2    Maraolo, A.E.3
  • 95
    • 85040797532 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam for febrile UTI due to multidrug-resistant Pseudomonas aeruginosa in a patient with neurogenic bladder
    • Dinh A, Davido B, Calin R, et al. Ceftolozane/tazobactam for febrile UTI due to multidrug-resistant Pseudomonas aeruginosa in a patient with neurogenic bladder. Spinal Cord Ser Cases. 2017;3:17019.
    • (2017) Spinal Cord Ser Cases , vol.3 , pp. 17019
    • Dinh, A.1    Davido, B.2    Calin, R.3
  • 96
    • 85019134830 scopus 로고    scopus 로고
    • Multidrug-resistant Pseudomonas aeruginosa skin and soft-tissue infection successfully treated with ceftolozane/tazobactam
    • Castaldo N, Givone F, Peghin M, et al. Multidrug-resistant Pseudomonas aeruginosa skin and soft-tissue infection successfully treated with ceftolozane/tazobactam. J Glob Antimicrob Resist. 2017;9:100–102.
    • (2017) J Glob Antimicrob Resist , vol.9 , pp. 100-102
    • Castaldo, N.1    Givone, F.2    Peghin, M.3
  • 97
    • 85018867531 scopus 로고    scopus 로고
    • Use of ceftolozane/tazobactam as salvage therapy for infections due to extensively drug-resistant Pseudomonas aeruginosa
    • Dinh A, Wyplosz B, Kernéis S, et al. Use of ceftolozane/tazobactam as salvage therapy for infections due to extensively drug-resistant Pseudomonas aeruginosa. Int J Antimicrob Agents. 2017;49:782–783.
    • (2017) Int J Antimicrob Agents , vol.49 , pp. 782-783
    • Dinh, A.1    Wyplosz, B.2    Kernéis, S.3
  • 98
    • 85048184078 scopus 로고    scopus 로고
    • Multidrug resistant pseudomonas mycotic pseudoaneurysm following cardiac transplant bridged by ventricular assistant device
    • Aye C, Williams M, Horvath R. Multidrug resistant pseudomonas mycotic pseudoaneurysm following cardiac transplant bridged by ventricular assistant device. Case Rep Infect Dis. 2017;2017:1402320.
    • (2017) Case Rep Infect Dis , vol.2017 , pp. 1402320
    • Aye, C.1    Williams, M.2    Horvath, R.3
  • 99
    • 85016570969 scopus 로고    scopus 로고
    • Successful treatment of multidrug-resistant Pseudomonas aeruginosa pubic symphysis osteomyelitis with ceftolozane/tazobactam
    • Kurtzhalts KE, Mergenhagen KA, Manohar A, et al. Successful treatment of multidrug-resistant Pseudomonas aeruginosa pubic symphysis osteomyelitis with ceftolozane/tazobactam. BMJ Case Rep. 2017 Mar 31;2017. pii: bcr2016217005. doi: 10.1136/bcr-2016-217005.
    • (2017) BMJ Case Rep
    • Kurtzhalts, K.E.1    Mergenhagen, K.A.2    Manohar, A.3
  • 100
    • 85040075066 scopus 로고    scopus 로고
    • Ceftolozane-tazobactam for the treatment of ventilator-associated infections by colistin-resistant Pseudomonas aeruginosa
    • Álvarez Lerma F, Muñoz Bermudez R, Grau S, et al. Ceftolozane-tazobactam for the treatment of ventilator-associated infections by colistin-resistant Pseudomonas aeruginosa. Rev Esp Quimioter. 2017;30:224–228.
    • (2017) Rev Esp Quimioter , vol.30 , pp. 224-228
    • Álvarez Lerma, F.1    Muñoz Bermudez, R.2    Grau, S.3
  • 101
    • 85024093319 scopus 로고    scopus 로고
    • Use of continuous-infusion ceftolozane/tazobactam in a multidrug-resistant pseudomonas aeruginosa urinary tract infection in the outpatient setting
    • Jones BM, Smith B, Bland CM. Use of continuous-infusion ceftolozane/tazobactam in a multidrug-resistant pseudomonas aeruginosa urinary tract infection in the outpatient setting. Ann Pharmacother. 2017;51:715–716.
    • (2017) Ann Pharmacother , vol.51 , pp. 715-716
    • Jones, B.M.1    Smith, B.2    Bland, C.M.3
  • 102
    • 85018289904 scopus 로고    scopus 로고
    • Successful treatment of MDR Pseudomonas aeruginosa skin and soft-tissue infection with ceftolozane/tazobactam
    • Sousa Dominguez A, Perez-Rodríguez MT, Nodar A, et al. Successful treatment of MDR Pseudomonas aeruginosa skin and soft-tissue infection with ceftolozane/tazobactam. J Antimicrob Chemother. 2017;72:1262–1263.
    • (2017) J Antimicrob Chemother , vol.72 , pp. 1262-1263
    • Sousa Dominguez, A.1    Perez-Rodríguez, M.T.2    Nodar, A.3
  • 103
    • 85040058844 scopus 로고    scopus 로고
    • Persistent bacteremia from Pseudomonas aeruginosa with in vitro resistance to the novel antibiotics ceftolozane-tazobactam and ceftazidime-avibactam
    • Gangcuangco LM, Clark P, Stewart C, et al. Persistent bacteremia from Pseudomonas aeruginosa with in vitro resistance to the novel antibiotics ceftolozane-tazobactam and ceftazidime-avibactam. Case Rep Infect Dis. 2016;2016:1520404.
    • (2016) Case Rep Infect Dis , vol.2016 , pp. 1520404
    • Gangcuangco, L.M.1    Clark, P.2    Stewart, C.3
  • 104
    • 84991338328 scopus 로고    scopus 로고
    • Successful treatment of multidrug-resistant Pseudomonas aeruginosa breakthrough bacteremia with ceftolozane/tazobactam
    • Hernández-Tejedor A, Merino-Vega CD, Martín-Vivas A, et al. Successful treatment of multidrug-resistant Pseudomonas aeruginosa breakthrough bacteremia with ceftolozane/tazobactam. Infection. 2017;45:115–117.
    • (2017) Infection , vol.45 , pp. 115-117
    • Hernández-Tejedor, A.1    Merino-Vega, C.D.2    Martín-Vivas, A.3
  • 105
    • 84990849773 scopus 로고    scopus 로고
    • Successful use of ceftolozane-tazobactam to treat a pulmonary exacerbation of cystic fibrosis caused by multidrug-resistant Pseudomonas aeruginosa
    • Vickery SB, McClain D, Wargo KA. Successful use of ceftolozane-tazobactam to treat a pulmonary exacerbation of cystic fibrosis caused by multidrug-resistant Pseudomonas aeruginosa. Pharmacotherapy. 2016;36:e154–e159.
    • (2016) Pharmacotherapy , vol.36 , pp. e154-e159
    • Vickery, S.B.1    McClain, D.2    Wargo, K.A.3
  • 106
    • 85016618904 scopus 로고    scopus 로고
    • Treatment of polymicrobial osteomyelitis with ceftolozane-tazobactam: case report and sensitivity testing of isolates
    • Jolliff JC, Ho J, Joson J, et al. Treatment of polymicrobial osteomyelitis with ceftolozane-tazobactam: case report and sensitivity testing of isolates. Case Rep Infect Dis. 2016;2016:1628932.
    • (2016) Case Rep Infect Dis , vol.2016 , pp. 1628932
    • Jolliff, J.C.1    Ho, J.2    Joson, J.3
  • 107
    • 84973151729 scopus 로고    scopus 로고
    • Use of ceftolozane/tazobactam in the treatment of multidrug-resistant Pseudomonas aeruginosa bloodstream infection in a pediatric leukemia patient
    • Aitken SL, Kontoyiannis DP, DePombo AM, et al. Use of ceftolozane/tazobactam in the treatment of multidrug-resistant Pseudomonas aeruginosa bloodstream infection in a pediatric leukemia patient. Pediatr Infect Dis J. 2016;35:1040–1042.
    • (2016) Pediatr Infect Dis J , vol.35 , pp. 1040-1042
    • Aitken, S.L.1    Kontoyiannis, D.P.2    DePombo, A.M.3
  • 108
    • 84977091066 scopus 로고    scopus 로고
    • Successful treatment of multi-drug resistant pseudomonas aeruginosa bacteremia with the recommended renally adjusted ceftolozane/tazobactam regimen
    • Patel UC, Nicolau DP, Sabzwari RK. Successful treatment of multi-drug resistant pseudomonas aeruginosa bacteremia with the recommended renally adjusted ceftolozane/tazobactam regimen. Infect Dis Ther. 2016;5:73–79.
    • (2016) Infect Dis Ther , vol.5 , pp. 73-79
    • Patel, U.C.1    Nicolau, D.P.2    Sabzwari, R.K.3
  • 109
    • 84942018581 scopus 로고    scopus 로고
    • Ceftolozane/Tazobactam therapy of respiratory infections due to multidrug-resistant Pseudomonas aeruginosa
    • Gelfand MS, Cleveland KO. Ceftolozane/Tazobactam therapy of respiratory infections due to multidrug-resistant Pseudomonas aeruginosa. Clin Infect Dis. 2015;61:853–855.
    • (2015) Clin Infect Dis , vol.61 , pp. 853-855
    • Gelfand, M.S.1    Cleveland, K.O.2
  • 110
    • 85032667796 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam for the treatment of MDR Pseudomonas aeruginosa left ventricular assist device infection as a bridge to heart transplant
    • Peghin M, Maiani M, Castaldo N, et al. Ceftolozane/tazobactam for the treatment of MDR Pseudomonas aeruginosa left ventricular assist device infection as a bridge to heart transplant. Infection. 2017. DOI:10.1007/s15010-017-1086-0
    • (2017) Infection
    • Peghin, M.1    Maiani, M.2    Castaldo, N.3
  • 111
    • 85033213540 scopus 로고    scopus 로고
    • Use of ceftolozane-tazobactam in a cystic fibrosis patient with multidrug-resistant Pseudomonas infection and renal insufficiency
    • Stokem K, Zuckerman JB, Nicolau DP, et al. Use of ceftolozane-tazobactam in a cystic fibrosis patient with multidrug-resistant Pseudomonas infection and renal insufficiency. Respir Med Case Rep. 2017;23:8–9.
    • (2017) Respir Med Case Rep , vol.23 , pp. 8-9
    • Stokem, K.1    Zuckerman, J.B.2    Nicolau, D.P.3
  • 112
    • 85041690585 scopus 로고    scopus 로고
    • Ceftolozane/tazobactam in the treatment of osteomyelitis and skin and soft tissue infections due to extensively drug-resistant Pseudomonas aeruginosa: clinical and microbiological outcomes
    • Dietl B, Sánchez I, Arcenillas P, et al. Ceftolozane/tazobactam in the treatment of osteomyelitis and skin and soft tissue infections due to extensively drug-resistant Pseudomonas aeruginosa: clinical and microbiological outcomes. Int J Antimicrob Agents. 2017. DOI:10.1016/j.ijantimicag.2017.11.003
    • (2017) Int J Antimicrob Agents
    • Dietl, B.1    Sánchez, I.2    Arcenillas, P.3
  • 113
    • 85056371178 scopus 로고    scopus 로고
    • Real-world evaluation of Ceftolozane/Tazobactam (C/T) use and clinical outcomes at an academic medical center in las vegas
    • Leuthner KD, Kullar R, Jayakumar B, et al. Real-world evaluation of Ceftolozane/Tazobactam (C/T) use and clinical outcomes at an academic medical center in las vegas. Open Forum Infect Dis. 2017;4:S296–S297.
    • (2017) Open Forum Infect Dis , vol.4 , pp. S296-S297
    • Leuthner, K.D.1    Kullar, R.2    Jayakumar, B.3
  • 114
    • 85056370852 scopus 로고    scopus 로고
    • Real-world analysis of prescribing patterns and susceptibility of Ceftolozane/Tazobactam (C/T) treatment using an Electronic Medical Record (EMR) database in the United States
    • Pogue JM, Puzniak L, Merchant S, et al. Real-world analysis of prescribing patterns and susceptibility of Ceftolozane/Tazobactam (C/T) treatment using an Electronic Medical Record (EMR) database in the United States. Open Forum Infect Dis. 2017;4:S287–S288.
    • (2017) Open Forum Infect Dis , vol.4 , pp. S287-S288
    • Pogue, J.M.1    Puzniak, L.2    Merchant, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.