PK/PD Target Attainment With Ceftolozane/Tazobactam Using Monte Carlo Simulation in Patients With Various Degrees of Renal Function, Including Augmented Renal Clearance and End-Stage Renal Disease

Infectious Diseases and Therapy

Volumn 6, Issue 1, 2017, Pages 137-148

  Xiao, Alan J ^a   Caro, Luzelena ^a   Popejoy, Myra W ^a   Huntington, Jennifer A ^a   Kullar, Ravina ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antibacterial; Ceftolozane tazobactam; Complicated intraabdominal infection; Complicated urinary tract infection; ESRD; Gram negative pathogens; Monte Carlo simulation; Renal impairment; Target attainment

Indexed keywords

CEFTOLOZANE PLUS TAZOBACTAM;

ARTICLE; BACTERICIDAL ACTIVITY; END STAGE RENAL DISEASE; ENZYME ACTIVITY; HUMAN; IC50; KIDNEY FUNCTION; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MONTE CARLO METHOD; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RENAL CLEARANCE; TREATMENT OUTCOME;

EID: 85014663078     PISSN: 21938229     EISSN: 21936382     Source Type: Journal    
DOI: 10.1007/s40121-016-0143-9     Document Type: Article

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