Structural requirements for the stability of novel cephalosporins to AmpC β-lactamase based on 3D-structure

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2261-2275

  Murano, Kenji ^a   Yamanaka, Toshio ^a   Toda, Ayako ^a   Ohki, Hidenori ^a   Okuda, Shinya ^a   Kawabata, Kohji ^a   Hatano, Kazuo ^a   Takeda, Shinobu ^a   Akamatsu, Hisashi ^b   Itoh, Kenji ^b   Misumi, Keiji ^b   Inoue, Satoshi ^b   Takagi, Tatsuya ^c  

^a ASTELLAS PHARMA INC   (Japan)

^b WAKUNAGA PHARMACEUTICAL CO LTD   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

AmpC lactamase; Cephalosporin; Conformational studies; Pseudomonas aeruginosa

Indexed keywords

7BETA [2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 2 (1 CARBOXY 1 METHYLETHOXYIMINO)ACETAMIDO] 3 [3 (2 AMINOETHYL) 2 METHYL 1 PYRAZOLIO]METHYL 3 CEPHEM 4 CARBOXYLIC ACID HYDROGEN SULFATE; 7BETA [2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 2 (1 CARBOXY 1 METHYLETHOXYIMINO)ACETAMIDO] 3 [3 AMINO 2 METHYL 4 (1 PROPYL) 1 PYRAZOLIO]METHYL 3 CEPHEM 4 CARBOXYLIC ACID; 7BETA [2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 2 (1 CARBOXY 1 METHYLETHOXYIMINO)ACETAMIDO] 3 [3 AMINO 4 (4 AMINOBUTYL) 2 METHYL 1 PYRAZOLIO]METHYL 3 CEPHEM 4 CARBOXYLIC ACID; 7BETA [2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 2 (1 CARBOXY 1 METHYLETHOXYIMINO)ACETAMIDO] 3 [3 AMINO 4 (5 AMINOPENTYL) 2 METHYL 1 PYRAZOLIO]METHYL 3 CEPHEM 4 CARBOXYLIC ACID; 7BETA [2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 2 (1 CARBOXY 1 METHYLETHOXYIMINO)ACETAMIDO] 3 [3 AMINO 4 AMINOMETHYL 2 METHYL 1 PYRAZOLIO]METHYL 3 CEPHEM 4 CARBOXYLIC ACID; 7BETA [2 (5 AMINO 1,2,4 THIADIAZOL 3 YL) 2 (1 CARBOXY 1 METHYLETHOXYIMINO)ACETAMIDO] 3 [3,4 DIAMINO 2 METHYL 1 PYRAZOLIO]METHYL 3 CEPHEM 4 CARBOXYLIC ACID; BETA LACTAMASE AMPC; CARBOXYLIC ACID DERIVATIVE; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; FK 518; FR 259647; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER SIMULATION; DRUG DESIGN; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; PSEUDOMONAS AERUGINOSA;

BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CEPHALOSPORINS; ENZYME STABILITY; IMAGING, THREE-DIMENSIONAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA;

PSEUDOMONAS AERUGINOSA;

EID: 40749147150     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.074     Document Type: Article

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