-
1
-
-
39049128343
-
Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern
-
Pitout, J.D., Laupland, K.B., Extended-spectrum β-lactamase-producing Enterobacteriaceae: an emerging public-health concern. Lancet Infect Dis 8 (2008), 159–166.
-
(2008)
Lancet Infect Dis
, vol.8
, pp. 159-166
-
-
Pitout, J.D.1
Laupland, K.B.2
-
2
-
-
84901809320
-
Antimicrobial resistance global report on surveillance
-
World Health Organization Geneva
-
WHO, Antimicrobial resistance global report on surveillance., 2014, World Health Organization, Geneva.
-
(2014)
-
-
WHO1
-
3
-
-
79952897858
-
Risk factors and outcomes of carbapenem-nonsusceptible Escherichia coli bacteremia: a matched case-control study
-
Chang, H.J., Hsu, P.C., Yang, C.C., Kuo, A.J., Chia, J.H., Wu, T.L., et al. Risk factors and outcomes of carbapenem-nonsusceptible Escherichia coli bacteremia: a matched case-control study. J Microbiol Immunol Infect 44 (2011), 125–130.
-
(2011)
J Microbiol Immunol Infect
, vol.44
, pp. 125-130
-
-
Chang, H.J.1
Hsu, P.C.2
Yang, C.C.3
Kuo, A.J.4
Chia, J.H.5
Wu, T.L.6
-
4
-
-
84902781573
-
Deaths attributable to carbapenem-resistant Enterobacteriaceae infections
-
Falagas, M.E., Tansarli, G.S., Karageorgopoulos, D.E., Vardakas, K.Z., Deaths attributable to carbapenem-resistant Enterobacteriaceae infections. Emerg Infect Dis 20 (2014), 1170–1175.
-
(2014)
Emerg Infect Dis
, vol.20
, pp. 1170-1175
-
-
Falagas, M.E.1
Tansarli, G.S.2
Karageorgopoulos, D.E.3
Vardakas, K.Z.4
-
5
-
-
25444462811
-
Outcome of infections due to pandrug-resistant (PDR) Gram-negative bacteria
-
Falagas, M.E., Bliziotis, I.A., Kasiakou, S.K., Samonis, G., Athanassopoulou, P., Michalopoulos, A., Outcome of infections due to pandrug-resistant (PDR) Gram-negative bacteria. BMC Infect Dis, 5, 2005, 24.
-
(2005)
BMC Infect Dis
, vol.5
, pp. 24
-
-
Falagas, M.E.1
Bliziotis, I.A.2
Kasiakou, S.K.3
Samonis, G.4
Athanassopoulou, P.5
Michalopoulos, A.6
-
6
-
-
85021887585
-
Multi-hospital occurrence of pan-resistant Klebsiella pneumoniae ST147 with an ISEcp1-directed blaOXA-181 insertion into the mgrB gene in the United Arab Emirates
-
Sonnevend, A., Ghazawi, A., Hashmey, R., Haidermota, A., Girgis, S., Alfaresi, M., et al. Multi-hospital occurrence of pan-resistant Klebsiella pneumoniae ST147 with an ISEcp1-directed blaOXA-181 insertion into the mgrB gene in the United Arab Emirates. Antimicrob Agents Chemother, 61(7), 2017 Jun 27.
-
(2017)
Antimicrob Agents Chemother
, vol.61
, Issue.7
-
-
Sonnevend, A.1
Ghazawi, A.2
Hashmey, R.3
Haidermota, A.4
Girgis, S.5
Alfaresi, M.6
-
7
-
-
84937974069
-
An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread
-
Weterings, V., Zhou, K., Rossen, J.W., van Stenis, D., Thewessen, E., Kluytmans, J., et al. An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread. Eur J Clin Microbiol Infect Dis 34 (2015), 1647–1655.
-
(2015)
Eur J Clin Microbiol Infect Dis
, vol.34
, pp. 1647-1655
-
-
Weterings, V.1
Zhou, K.2
Rossen, J.W.3
van Stenis, D.4
Thewessen, E.5
Kluytmans, J.6
-
8
-
-
84880613363
-
Critically important antimicrobials for human medicine
-
3rd ed. World Health Organization Geneva Available at
-
WHO, Critically important antimicrobials for human medicine. 3rd ed., 2011, World Health Organization, Geneva Available at: http://apps.who.int/iris/ bitstream/10665/77376/1/9789241504485_eng.pdf?ua=1&ua=1.
-
(2011)
-
-
WHO1
-
9
-
-
84927786050
-
Options for treating carbapenem-resistant Enterobacteriaceae
-
Rafailidis, P.I., Falagas, M.E., Options for treating carbapenem-resistant Enterobacteriaceae. Curr Opin Infect Dis 27 (2014), 479–483.
-
(2014)
Curr Opin Infect Dis
, vol.27
, pp. 479-483
-
-
Rafailidis, P.I.1
Falagas, M.E.2
-
10
-
-
85030689744
-
-
Multicenter open-label randomized controlled trial (RCT) to compare colistin alone versus colistin plus meropenem. Available at: accessed February
-
ClinicalTrials.gov Multicenter open-label randomized controlled trial (RCT) to compare colistin alone versus colistin plus meropenem. Available at: https://clinicaltrials.gov/ct2/show/NCT01732250; accessed February 2017.
-
(2017)
-
-
-
11
-
-
84960191949
-
Dosing guidance for intravenous colistin in critically ill patients
-
Nation, R.L., Garonzik, S.M., Thamlikitkul, V., Giamarellos-Bourboulis, E.J., Forrest, A., Paterson, D.L., et al. Dosing guidance for intravenous colistin in critically ill patients. Clin Infect Dis 62 (2016), 552–558.
-
(2016)
Clin Infect Dis
, vol.62
, pp. 552-558
-
-
Nation, R.L.1
Garonzik, S.M.2
Thamlikitkul, V.3
Giamarellos-Bourboulis, E.J.4
Forrest, A.5
Paterson, D.L.6
-
12
-
-
84960432068
-
Fosfomycin
-
Falagas, M.E., Vouloumanou, E.K., Samonis, G., Vardakas, K.Z., Fosfomycin. Clin Microbiol Rev 29 (2016), 321–347.
-
(2016)
Clin Microbiol Rev
, vol.29
, pp. 321-347
-
-
Falagas, M.E.1
Vouloumanou, E.K.2
Samonis, G.3
Vardakas, K.Z.4
-
13
-
-
84867608673
-
Emergence of resistance to fosfomycin used as adjunct therapy in KPC Klebsiella pneumoniae bacteraemia: report of three cases
-
Karageorgopoulos, D.E., Miriagou, V., Tzouvelkis, L.S., Spyridopoulou, K., Daikos, G.L., Emergence of resistance to fosfomycin used as adjunct therapy in KPC Klebsiella pneumoniae bacteraemia: report of three cases. J Antimicrob Chemother 67 (2012), 2777–2779.
-
(2012)
J Antimicrob Chemother
, vol.67
, pp. 2777-2779
-
-
Karageorgopoulos, D.E.1
Miriagou, V.2
Tzouvelkis, L.S.3
Spyridopoulou, K.4
Daikos, G.L.5
-
14
-
-
85011664717
-
What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles
-
Bush, K., Page, M.G., What we may expect from novel antibacterial agents in the pipeline with respect to resistance and pharmacodynamic principles. J Pharmacokinet Pharmacodyn 44 (2017), 113–132.
-
(2017)
J Pharmacokinet Pharmacodyn
, vol.44
, pp. 113-132
-
-
Bush, K.1
Page, M.G.2
-
15
-
-
85027375562
-
WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases
-
Sader, H., Rhomberg, P., Flamm, R., Jones, R., Castanheira, M., WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram-negative organisms producing clinically relevant β-lactamases. J Antimicrob Chemother 72 (2017), 1696–1703.
-
(2017)
J Antimicrob Chemother
, vol.72
, pp. 1696-1703
-
-
Sader, H.1
Rhomberg, P.2
Flamm, R.3
Jones, R.4
Castanheira, M.5
-
16
-
-
84872732888
-
Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor combination
-
Zhanel, G.G., Lawson, C.D., Adam, H., Schweizer, F., Zelenitsky, S., Lagace-Wiens, P.R., et al. Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor combination. Drugs 73 (2013), 159–177.
-
(2013)
Drugs
, vol.73
, pp. 159-177
-
-
Zhanel, G.G.1
Lawson, C.D.2
Adam, H.3
Schweizer, F.4
Zelenitsky, S.5
Lagace-Wiens, P.R.6
-
17
-
-
84896968084
-
New β-lactamase inhibitors: a therapeutic renaissance in an MDR world
-
Drawz, S.M., Papp-Wallace, K.M., Bonomo, R.A., New β-lactamase inhibitors: a therapeutic renaissance in an MDR world. Antimicrob Agents Chemother 58 (2014), 1835–1846.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 1835-1846
-
-
Drawz, S.M.1
Papp-Wallace, K.M.2
Bonomo, R.A.3
-
18
-
-
84863905057
-
Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor
-
Ehmann, D.E., Jahic, H., Ross, P.L., Gu, R.F., Hu, J., Kern, G., et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A 109 (2012), 11663–11668.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 11663-11668
-
-
Ehmann, D.E.1
Jahic, H.2
Ross, P.L.3
Gu, R.F.4
Hu, J.5
Kern, G.6
-
19
-
-
84946567642
-
A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens
-
Bush, K., A resurgence of β-lactamase inhibitor combinations effective against multidrug-resistant Gram-negative pathogens. Int J Antimicrob Agents 46 (2015), 483–493.
-
(2015)
Int J Antimicrob Agents
, vol.46
, pp. 483-493
-
-
Bush, K.1
-
20
-
-
84929587395
-
Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U.S. hospitals (2011 to 2013) and characterization of β-lactamase-producing strains
-
Castanheira, M., Mills, J.C., Costello, S.E., Jones, R.N., Sader, H.S., Ceftazidime-avibactam activity tested against Enterobacteriaceae isolates from U.S. hospitals (2011 to 2013) and characterization of β-lactamase-producing strains. Antimicrob Agents Chemother 59 (2015), 3509–3517.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 3509-3517
-
-
Castanheira, M.1
Mills, J.C.2
Costello, S.E.3
Jones, R.N.4
Sader, H.S.5
-
21
-
-
84947026302
-
Ceftazidime-avibactam activity when tested against ceftazidime-nonsusceptible Citrobacter spp., Enterobacter spp., Serratia marcescens, and Pseudomonas aeruginosa from Unites States medical centers (2011–2014)
-
Sader, H.S., Castanheira, M., Farrell, D.J., Flamm, R.K., Jones, R.N., Ceftazidime-avibactam activity when tested against ceftazidime-nonsusceptible Citrobacter spp., Enterobacter spp., Serratia marcescens, and Pseudomonas aeruginosa from Unites States medical centers (2011–2014). Diagn Microbiol Infect Dis 83 (2015), 389–394.
-
(2015)
Diagn Microbiol Infect Dis
, vol.83
, pp. 389-394
-
-
Sader, H.S.1
Castanheira, M.2
Farrell, D.J.3
Flamm, R.K.4
Jones, R.N.5
-
22
-
-
84920099992
-
Avibactam reverts the ceftazidime MIC90 of European Gram-negative bacterial clinical isolates to the epidemiological cut-off value
-
Flamm, R.K., Stone, G.G., Sader, H.S., Jones, R.N., Nichols, W.W., Avibactam reverts the ceftazidime MIC90 of European Gram-negative bacterial clinical isolates to the epidemiological cut-off value. J Chemother 26 (2014), 333–338.
-
(2014)
J Chemother
, vol.26
, pp. 333-338
-
-
Flamm, R.K.1
Stone, G.G.2
Sader, H.S.3
Jones, R.N.4
Nichols, W.W.5
-
23
-
-
79956326529
-
In vitro activity of ceftazidime combined with NXL104 versus Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals (CANWARD 2009 study)
-
Walkty, A., DeCorby, M., Lagace-Wiens, P.R., Karlowsky, J.A., Hoban, D.J., Zhanel, G.G., In vitro activity of ceftazidime combined with NXL104 versus Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals (CANWARD 2009 study). Antimicrob Agents Chemother 55 (2011), 2992–2994.
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 2992-2994
-
-
Walkty, A.1
DeCorby, M.2
Lagace-Wiens, P.R.3
Karlowsky, J.A.4
Hoban, D.J.5
Zhanel, G.G.6
-
24
-
-
84896832898
-
In vitro activities of ceftazidime-avibactam and aztreonam-avibactam against 372 Gram-negative bacilli collected in 2011 and 2012 from 11 teaching hospitals in China
-
Wang, X., Zhang, F., Zhao, C., Wang, Z., Nichols, W.W., Testa, R., et al. In vitro activities of ceftazidime-avibactam and aztreonam-avibactam against 372 Gram-negative bacilli collected in 2011 and 2012 from 11 teaching hospitals in China. Antimicrob Agents Chemother 58 (2014), 1774–1778.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 1774-1778
-
-
Wang, X.1
Zhang, F.2
Zhao, C.3
Wang, Z.4
Nichols, W.W.5
Testa, R.6
-
25
-
-
84927574043
-
Ceftazidime-avibactam and comparator agents tested against urinary tract isolates from a global surveillance program (2011)
-
Flamm, R.K., Sader, H.S., Farrell, D.J., Jones, R.N., Ceftazidime-avibactam and comparator agents tested against urinary tract isolates from a global surveillance program (2011). Diagn Microbiol Infect Dis 80 (2014), 233–238.
-
(2014)
Diagn Microbiol Infect Dis
, vol.80
, pp. 233-238
-
-
Flamm, R.K.1
Sader, H.S.2
Farrell, D.J.3
Jones, R.N.4
-
26
-
-
84923240983
-
In vitro susceptibility of characterized β-lactamase-producing strains tested with avibactam combinations
-
Li, H., Estabrook, M., Jacoby, G.A., Nichols, W.W., Testa, R.T., Bush, K., In vitro susceptibility of characterized β-lactamase-producing strains tested with avibactam combinations. Antimicrob Agents Chemother 59 (2015), 1789–1793.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 1789-1793
-
-
Li, H.1
Estabrook, M.2
Jacoby, G.A.3
Nichols, W.W.4
Testa, R.T.5
Bush, K.6
-
27
-
-
84954494697
-
In vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli
-
Vasoo, S., Cunningham, S.A., Cole, N.C., Kohner, P.C., Menon, S.R., Krause, K.M., et al. In vitro activities of ceftazidime-avibactam, aztreonam-avibactam, and a panel of older and contemporary antimicrobial agents against carbapenemase-producing gram-negative bacilli. Antimicrob Agents Chemother 59 (2015), 7842–7846.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 7842-7846
-
-
Vasoo, S.1
Cunningham, S.A.2
Cole, N.C.3
Kohner, P.C.4
Menon, S.R.5
Krause, K.M.6
-
28
-
-
84942903035
-
First report of ceftazidime-avibactam resistance in a KPC-3-expressing Klebsiella pneumoniae isolate
-
Humphries, R.M., Yang, S., Hemarajata, P., Ward, K.W., Hindler, J.A., Miller, S.A., et al. First report of ceftazidime-avibactam resistance in a KPC-3-expressing Klebsiella pneumoniae isolate. Antimicrob Agents Chemother 59 (2015), 6605–6607.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 6605-6607
-
-
Humphries, R.M.1
Yang, S.2
Hemarajata, P.3
Ward, K.W.4
Hindler, J.A.5
Miller, S.A.6
-
29
-
-
84940937491
-
Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae
-
Shields, R.K., Clancy, C.J., Hao, B., Chen, L., Press, E.G., Iovine, N.M., et al. Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae. Antimicrob Agents Chemother 59 (2015), 5793–5797.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 5793-5797
-
-
Shields, R.K.1
Clancy, C.J.2
Hao, B.3
Chen, L.4
Press, E.G.5
Iovine, N.M.6
-
30
-
-
84857173233
-
In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates
-
Levasseur, P., Girard, A.M., Claudon, M., Goossens, H., Black, M.T., Coleman, K., et al. In vitro antibacterial activity of the ceftazidime-avibactam (NXL104) combination against Pseudomonas aeruginosa clinical isolates. Antimicrob Agents Chemother 56 (2012), 1606–1608.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 1606-1608
-
-
Levasseur, P.1
Girard, A.M.2
Claudon, M.3
Goossens, H.4
Black, M.T.5
Coleman, K.6
-
31
-
-
84929583498
-
Ceftazidime-avibactam activity against multidrug-resistant Pseudomonas aeruginosa isolated in U.S. medical centers in 2012 and 2013
-
Sader, H.S., Castanheira, M., Mendes, R.E., Flamm, R.K., Farrell, D.J., Jones, R.N., Ceftazidime-avibactam activity against multidrug-resistant Pseudomonas aeruginosa isolated in U.S. medical centers in 2012 and 2013. Antimicrob Agents Chemother 59 (2015), 3656–3659.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 3656-3659
-
-
Sader, H.S.1
Castanheira, M.2
Mendes, R.E.3
Flamm, R.K.4
Farrell, D.J.5
Jones, R.N.6
-
32
-
-
84934963355
-
Ceftazidime/avibactam tested against Gram-negative bacteria from intensive care unit (ICU) and non-ICU patients, including those with ventilator-associated pneumonia
-
Sader, H.S., Castanheira, M., Flamm, R.K., Mendes, R.E., Farrell, D.J., Jones, R.N., Ceftazidime/avibactam tested against Gram-negative bacteria from intensive care unit (ICU) and non-ICU patients, including those with ventilator-associated pneumonia. Int J Antimicrob Agents 46910 (2015), 53–59.
-
(2015)
Int J Antimicrob Agents
, vol.46910
, pp. 53-59
-
-
Sader, H.S.1
Castanheira, M.2
Flamm, R.K.3
Mendes, R.E.4
Farrell, D.J.5
Jones, R.N.6
-
33
-
-
82955187694
-
In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negative bacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae
-
Aktas, Z., Kayacan, C., Oncul, O., In vitro activity of avibactam (NXL104) in combination with β-lactams against Gram-negative bacteria, including OXA-48 β-lactamase-producing Klebsiella pneumoniae. Int J Antimicrob Agents 39 (2012), 86–89.
-
(2012)
Int J Antimicrob Agents
, vol.39
, pp. 86-89
-
-
Aktas, Z.1
Kayacan, C.2
Oncul, O.3
-
34
-
-
84971578709
-
Efficacy and safety of ceftazidime-avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infection: results from a randomized, controlled, double-blind, phase 3 program
-
Mazuski, J.E., Gasink, L.B., Armstrong, J., Broadhurst, H., Stone, G.G., Rank, D., et al. Efficacy and safety of ceftazidime-avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infection: results from a randomized, controlled, double-blind, phase 3 program. Clin Infect Dis 62 (2016), 1380–1389.
-
(2016)
Clin Infect Dis
, vol.62
, pp. 1380-1389
-
-
Mazuski, J.E.1
Gasink, L.B.2
Armstrong, J.3
Broadhurst, H.4
Stone, G.G.5
Rank, D.6
-
35
-
-
84995390345
-
Ceftazidime-avibactam versus doripenem for the treatment of complicated urinary tract infections, including acute pyelonephritis: RECAPTURE, a phase 3 randomized trial program
-
Wagenlehner, F.M., Sobel, J.D., Newell, P., Armstrong, J., Huang, X., Stone, G.G., et al. Ceftazidime-avibactam versus doripenem for the treatment of complicated urinary tract infections, including acute pyelonephritis: RECAPTURE, a phase 3 randomized trial program. Clin Infect Dis 63 (2016), 754–762.
-
(2016)
Clin Infect Dis
, vol.63
, pp. 754-762
-
-
Wagenlehner, F.M.1
Sobel, J.D.2
Newell, P.3
Armstrong, J.4
Huang, X.5
Stone, G.G.6
-
36
-
-
84963954564
-
Ceftazidime-avibactam or best available therapy in patients with ceftazidime-resistant Enterobacteriaceae and Pseudomonas aeruginosa complicated urinary tract infections or complicated intra-abdominal infections (REPRISE): a randomised, pathogen-directed, phase 3 study
-
Carmeli, Y., Armstrong, J., Laud, P.J., Newell, P., Stone, G., Wardman, A., et al. Ceftazidime-avibactam or best available therapy in patients with ceftazidime-resistant Enterobacteriaceae and Pseudomonas aeruginosa complicated urinary tract infections or complicated intra-abdominal infections (REPRISE): a randomised, pathogen-directed, phase 3 study. Lancet Infect Dis 16 (2016), 661–673.
-
(2016)
Lancet Infect Dis
, vol.16
, pp. 661-673
-
-
Carmeli, Y.1
Armstrong, J.2
Laud, P.J.3
Newell, P.4
Stone, G.5
Wardman, A.6
-
37
-
-
84995524184
-
Clinical outcomes, drug toxicity, and emergence of ceftazidime-avibactam resistance among patients treated for carbapenem-resistant Enterobacteriaceae infections
-
Shields, R.K., Potoski, B.A., Haidar, G., Hao, B., Doi, Y., Chen, L., et al. Clinical outcomes, drug toxicity, and emergence of ceftazidime-avibactam resistance among patients treated for carbapenem-resistant Enterobacteriaceae infections. Clin Infect Dis 63 (2016), 1615–1618.
-
(2016)
Clin Infect Dis
, vol.63
, pp. 1615-1618
-
-
Shields, R.K.1
Potoski, B.A.2
Haidar, G.3
Hao, B.4
Doi, Y.5
Chen, L.6
-
38
-
-
85030659013
-
Compassionate use of ceftazidime/avibactam (Cazavi) for carbapenem-resistant (Cr) Gram-negative rod infections. Abst 428. Abst ASM Microbe
-
Boston MA, USA
-
Gallagher, J.C., McKinnell, J., CAZAVI Compassionate Use Research Group. Compassionate use of ceftazidime/avibactam (Cazavi) for carbapenem-resistant (Cr) Gram-negative rod infections. Abst 428. Abst ASM Microbe. Am Soc Microbiol, June 17, 2016 Boston MA, USA.
-
(2016)
Am Soc Microbiol
-
-
Gallagher, J.C.1
McKinnell, J.2
-
39
-
-
85011085656
-
Ceftazidime-avibactam as salvage therapy for infections caused by carbapenem-resistant organisms
-
Temkin, E., Torre-Cisneros, J., Beovic, B., Benito, N., Giannella, M., Gilarranz, R., et al. Ceftazidime-avibactam as salvage therapy for infections caused by carbapenem-resistant organisms. Antimicrob Agents Chemother, 61(2), 2017.
-
(2017)
Antimicrob Agents Chemother
, vol.61
, Issue.2
-
-
Temkin, E.1
Torre-Cisneros, J.2
Beovic, B.3
Benito, N.4
Giannella, M.5
Gilarranz, R.6
-
40
-
-
85026380424
-
Ceftazidime-avibactam is superior to other treatment regimens against carbapenem-resistant Klebsiella pneumoniae bacteremia
-
e00883–e17
-
Shields, R.K., Nguyen, M.H., Chen, L., Press, E.G., Potoski, B.A., Marini, R.V., et al. Ceftazidime-avibactam is superior to other treatment regimens against carbapenem-resistant Klebsiella pneumoniae bacteremia. Antimicrob Agents Chemother, 61, 2017 e00883–e17.
-
(2017)
Antimicrob Agents Chemother
, vol.61
-
-
Shields, R.K.1
Nguyen, M.H.2
Chen, L.3
Press, E.G.4
Potoski, B.A.5
Marini, R.V.6
-
41
-
-
84888787952
-
Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa
-
Livermore, D.M., Warner, M., Mushtaq, S., Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa. J Antimicrob Chemother 68 (2013), 2286–2290.
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 2286-2290
-
-
Livermore, D.M.1
Warner, M.2
Mushtaq, S.3
-
42
-
-
84939785073
-
Activity of imipenem with relebactam against Gram-negative pathogens from New York City
-
Lapuebla, A., Abdallah, M., Olafisoye, O., Cortes, C., Urban, C., Landman, D., et al. Activity of imipenem with relebactam against Gram-negative pathogens from New York City. Antimicrob Agents Chemother 59 (2015), 5029–5031.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 5029-5031
-
-
Lapuebla, A.1
Abdallah, M.2
Olafisoye, O.3
Cortes, C.4
Urban, C.5
Landman, D.6
-
43
-
-
85020336654
-
Role of newer and re-emerging older agents in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae
-
Thaden, J.T., Poque, J.M., Kaye, K.S., Role of newer and re-emerging older agents in the treatment of infections caused by carbapenem-resistant Enterobacteriaceae. Virulence 6 (2016), 1–14.
-
(2016)
Virulence
, vol.6
, pp. 1-14
-
-
Thaden, J.T.1
Poque, J.M.2
Kaye, K.S.3
-
44
-
-
84992360092
-
Phase 2, Dose-ranging study of relebactam with imipenem-cilastatin in subjects with complicated intra-abdominal infection
-
Lucasti, C., Vasile, L., Sandesc, D., Venskutonis, D., McLeroth, P., Lala, M., et al. Phase 2, Dose-ranging study of relebactam with imipenem-cilastatin in subjects with complicated intra-abdominal infection. Antimicrob Agents Chemother 60 (2016), 6234–6243.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, pp. 6234-6243
-
-
Lucasti, C.1
Vasile, L.2
Sandesc, D.3
Venskutonis, D.4
McLeroth, P.5
Lala, M.6
-
45
-
-
85030686054
-
-
Imipenem/relebactam/cilastatin versus piperacillin/tazobactam for treatment of participants with bacterial pneumonia (MK-7655A-014) (RESTORE-IMI 2). Available at: accessed February
-
ClinicalTrials.gov. Imipenem/relebactam/cilastatin versus piperacillin/tazobactam for treatment of participants with bacterial pneumonia (MK-7655A-014) (RESTORE-IMI 2). Available at: https://clinicaltrials.gov/ct2/show/NCT02493764; accessed February 2017.
-
(2017)
-
-
-
46
-
-
85030679311
-
-
Efficacy and safety of imipenem+cilastatin/relebactam (mk-7655a) versus colistimethate sodium + imipenem+cilastatin in imipenem-resistant bacterial infection (MK-7655A-013) (RESTORE-IMI 1). Available at: accessed February
-
ClinicalTrials.gov. Efficacy and safety of imipenem+cilastatin/relebactam (mk-7655a) versus colistimethate sodium + imipenem+cilastatin in imipenem-resistant bacterial infection (MK-7655A-013) (RESTORE-IMI 1). Available at: https://clinicaltrials.gov/ct2/show/NCT02452047 accessed February 2017.
-
(2017)
-
-
-
47
-
-
84929340109
-
Discovery of a cyclic boronic acid β-lactamase inhibitor (RPX7009) with utility vs class a serine carbapenemases
-
Hecker, S.J., Reddy, K.R., Totrov, M., Hirst, G.C., Lomovskaya, O., Griffith, D.C., et al. Discovery of a cyclic boronic acid β-lactamase inhibitor (RPX7009) with utility vs class a serine carbapenemases. J Med Chem 58 (2015), 3682–3692.
-
(2015)
J Med Chem
, vol.58
, pp. 3682-3692
-
-
Hecker, S.J.1
Reddy, K.R.2
Totrov, M.3
Hirst, G.C.4
Lomovskaya, O.5
Griffith, D.C.6
-
48
-
-
84939812571
-
Activity of meropenem combined with RPX7009, a novel β-lactamase inhibitor, against Gram-negative clinical isolates in New York City
-
Lapuebla, A., Abdallah, M., Olafisoye, O., Cortes, C., Urban, C., Quale, J., et al. Activity of meropenem combined with RPX7009, a novel β-lactamase inhibitor, against Gram-negative clinical isolates in New York City. Antimicrob Agents Chemother 59 (2015), 4856–4860.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 4856-4860
-
-
Lapuebla, A.1
Abdallah, M.2
Olafisoye, O.3
Cortes, C.4
Urban, C.5
Quale, J.6
-
49
-
-
84880714408
-
Activity of biapenem (RPX2003) combined with the boronate β-lactamase inhibitor RPX7009 against carbapenem-resistant Enterobacteriaceae
-
Livermore, D.M., Mushtaq, S., Activity of biapenem (RPX2003) combined with the boronate β-lactamase inhibitor RPX7009 against carbapenem-resistant Enterobacteriaceae. J Antimicrob Chemother 68 (2013), 1825–1831.
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 1825-1831
-
-
Livermore, D.M.1
Mushtaq, S.2
-
50
-
-
85030665651
-
-
Meropenem-vaborbactam (M-V) versus piperacillin-tazobactam (P-T) in the treatment of adults with complicated urinary tract infections (cUTI), including acute pyelonephritis (AP) in TANGO 1, a phase 3 randomized, double-blind, double-dummy trial. Presented at 27th European Congress of Clinical Microbiology and Infectious Diseases, Vienna April
-
Stus V, Sagan O, Bidair M, Loutit J, Dudley M et al. Meropenem-vaborbactam (M-V) versus piperacillin-tazobactam (P-T) in the treatment of adults with complicated urinary tract infections (cUTI), including acute pyelonephritis (AP) in TANGO 1, a phase 3 randomized, double-blind, double-dummy trial. Presented at 27th European Congress of Clinical Microbiology and Infectious Diseases, Vienna April 2017.
-
(2017)
-
-
Stus, V.1
Sagan, O.2
Bidair, M.3
Loutit, J.4
Dudley, M.5
-
51
-
-
85030661343
-
ClinicalTrials.gov. Efficacy, Safety, Tolerability of Carbavance Compared to Best Available Therapy in Serious Infections Due to Carbapenem Resistant Enterobacteriaceae
-
in Adults. Available at: accessed February
-
ClinicalTrials.gov. Efficacy, Safety, Tolerability of Carbavance Compared to Best Available Therapy in Serious Infections Due to Carbapenem Resistant Enterobacteriaceae, in Adults. Available at: https://clinicaltrials.gov/ct2/show/NCT02168946; accessed February 2017.
-
(2017)
-
-
-
52
-
-
85030696086
-
-
accessed August
-
http://www.themedicinescompany.com/investors/news/medicines-company-announces-tango-2-trial-meropenem-vaborbactam-formerly-carbavance accessed August 2017.
-
(2017)
-
-
-
53
-
-
0029879460
-
Detection of extended-spectrum β-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli
-
Jacoby, G.A., Han, P., Detection of extended-spectrum β-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli. J Clin Microbiol 34 (1996), 908–911.
-
(1996)
J Clin Microbiol
, vol.34
, pp. 908-911
-
-
Jacoby, G.A.1
Han, P.2
-
54
-
-
0344443208
-
Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing β-lactamase KPC-2
-
Yigit, H., Queenan, A.M., Rasheed, J.K., Biddle, J.W., Domenech-Sanchez, A., Alberti, S., et al. Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing β-lactamase KPC-2. Antimicrob Agents Chemother 47 (2003), 3881–3889.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 3881-3889
-
-
Yigit, H.1
Queenan, A.M.2
Rasheed, J.K.3
Biddle, J.W.4
Domenech-Sanchez, A.5
Alberti, S.6
-
55
-
-
84928412328
-
In vitro susceptibility of characterized β-lactamase-producing Gram-negative bacteria isolated in Japan to ceftazidime-, ceftaroline-, and aztreonam-avibactam combinations
-
Yoshizumi, A., Ishii, Y., Aoki, K., Testa, R., Nichols, W.W., Tateda, K., In vitro susceptibility of characterized β-lactamase-producing Gram-negative bacteria isolated in Japan to ceftazidime-, ceftaroline-, and aztreonam-avibactam combinations. J Infect Chemother 21 (2015), 148–151.
-
(2015)
J Infect Chemother
, vol.21
, pp. 148-151
-
-
Yoshizumi, A.1
Ishii, Y.2
Aoki, K.3
Testa, R.4
Nichols, W.W.5
Tateda, K.6
-
56
-
-
84931266123
-
In vitro activity of aztreonam-avibactam against a global collection of Gram-negative pathogens from 2012 and 2013
-
Biedenbach, D.J., Kazmierczak, K., Bouchillon, S.K., Sahm, D.F., Bradford, P.A., In vitro activity of aztreonam-avibactam against a global collection of Gram-negative pathogens from 2012 and 2013. Antimicrob Agents Chemother 59 (2015), 4239–4248.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 4239-4248
-
-
Biedenbach, D.J.1
Kazmierczak, K.2
Bouchillon, S.K.3
Sahm, D.F.4
Bradford, P.A.5
-
57
-
-
84979519309
-
Global dissemination of blaKPC into bacterial species beyond Klebsiella pneumoniae and in vitro susceptibility to ceftazidime-avibactam and aztreonam-avibactam
-
Kazmierczak, K.M., Biedenbach, D.J., Hackel, M., Rabine, S., de Jonge, B.L., Bouchillon, S.K., et al. Global dissemination of blaKPC into bacterial species beyond Klebsiella pneumoniae and in vitro susceptibility to ceftazidime-avibactam and aztreonam-avibactam. Antimicrob Agents Chemother 60 (2016), 4490–4500.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, pp. 4490-4500
-
-
Kazmierczak, K.M.1
Biedenbach, D.J.2
Hackel, M.3
Rabine, S.4
de Jonge, B.L.5
Bouchillon, S.K.6
-
58
-
-
85030658647
-
-
Determine the PK and safety and tolerability of ATM-AVI for the treatment of ciais in hospitalized adults (REJUVENATE). 2016. Available at: accessed February
-
ClinicalTrials.gov. Determine the PK and safety and tolerability of ATM-AVI for the treatment of ciais in hospitalized adults (REJUVENATE). 2016. Available at: https://clinicaltrials.gov/ct2/show/NCT02655419; accessed February 2017.
-
(2017)
-
-
-
59
-
-
85016960515
-
Can ceftazidime-avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae?
-
Marshall, S., Hujer, A.M., Rojas, L.J., Papp-Wallace, K.M., Humphries, R.M., Spellberg, B., et al. Can ceftazidime-avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae?. Antimicrob Agents Chemother 61 (2017), 2243–2316.
-
(2017)
Antimicrob Agents Chemother
, vol.61
, pp. 2243-2316
-
-
Marshall, S.1
Hujer, A.M.2
Rojas, L.J.3
Papp-Wallace, K.M.4
Humphries, R.M.5
Spellberg, B.6
-
60
-
-
85028284880
-
Ceftazidime-Avibactam and Aztreonam an interesting strategy to Overcome Β-lactam Resistance Conferred by Metallo-β-lactamases in Enterobacteriaceae and Pseudomonas aeruginosa
-
Davido, B., Fellous, L., Lawrence, C., Maxime, V., Rottman, M., Dinh, A., Ceftazidime-Avibactam and Aztreonam an interesting strategy to Overcome Β-lactam Resistance Conferred by Metallo-β-lactamases in Enterobacteriaceae and Pseudomonas aeruginosa. Antimicrob Agents Chemother, 61(9), 2017 Aug 24.
-
(2017)
Antimicrob Agents Chemother
, vol.61
, Issue.9
-
-
Davido, B.1
Fellous, L.2
Lawrence, C.3
Maxime, V.4
Rottman, M.5
Dinh, A.6
-
61
-
-
84983593578
-
successful treatment of bloodstream infection due to metallo-β-lactamase-producing Stenotrophomonas maltophilia in a renal transplant patient
-
Mojica, M.F., Ouellette, C.P., Leber, A., Becknell, M.B., Ardura, M.I., Perez, F., et al. successful treatment of bloodstream infection due to metallo-β-lactamase-producing Stenotrophomonas maltophilia in a renal transplant patient. Antimicrob Agents Chemother 60 (2016), 5130–5140.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, pp. 5130-5140
-
-
Mojica, M.F.1
Ouellette, C.P.2
Leber, A.3
Becknell, M.B.4
Ardura, M.I.5
Perez, F.6
-
62
-
-
84893029558
-
Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli
-
Zhanel, G.G., Chung, P., Adam, H., Zelenitsky, S., Denisuik, A., Schweizer, F., et al. Ceftolozane/tazobactam: a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli. Drugs 74 (2014), 31–51.
-
(2014)
Drugs
, vol.74
, pp. 31-51
-
-
Zhanel, G.G.1
Chung, P.2
Adam, H.3
Zelenitsky, S.4
Denisuik, A.5
Schweizer, F.6
-
63
-
-
33847621194
-
In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa
-
Takeda, S., Nakai, T., Wakai, Y., Ikeda, F., Hatano, K., In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa. Antimicrob Agents Chemother 51 (2007), 826–830.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 826-830
-
-
Takeda, S.1
Nakai, T.2
Wakai, Y.3
Ikeda, F.4
Hatano, K.5
-
64
-
-
84901280909
-
Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC
-
Cabot, G., Bruchmann, S., Mulet, X., Zamorano, L., Moya, B., Juan, C., et al. Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC. Antimicrob Agents Chemother 58 (2014), 3091–3099.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 3091-3099
-
-
Cabot, G.1
Bruchmann, S.2
Mulet, X.3
Zamorano, L.4
Moya, B.5
Juan, C.6
-
65
-
-
75749148334
-
Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains
-
Juan, C., Zamorano, L., Perez, J.L., Ge, Y., Oliver, A., Spanish Group for the Study of P, et al. Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. Antimicrob Agents Chemother 54:2 (2010), 846–851.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, Issue.2
, pp. 846-851
-
-
Juan, C.1
Zamorano, L.2
Perez, J.L.3
Ge, Y.4
Oliver, A.5
Spanish Group for the Study of P6
-
66
-
-
79955536362
-
Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes
-
Sader, H.S., Rhomberg, P.R., Farrell, D.J., Jones, R.N., Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes. Antimicrob Agents Chemother 55 (2011), 2390–2394.
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 2390-2394
-
-
Sader, H.S.1
Rhomberg, P.R.2
Farrell, D.J.3
Jones, R.N.4
-
67
-
-
84921029928
-
Antimicrobial activity of ceftolozane/tazobactam tested against Pseudomonas aeruginosa and Enterobacteriaceae with various resistance patterns isolated in European hospitals (2011–12)
-
Sader, H.S., Farrell, D.J., Castanheira, M., Flamm, R.K., Jones, R.N., Antimicrobial activity of ceftolozane/tazobactam tested against Pseudomonas aeruginosa and Enterobacteriaceae with various resistance patterns isolated in European hospitals (2011–12). J Antimicrob Chemother 69 (2014), 2713–2722.
-
(2014)
J Antimicrob Chemother
, vol.69
, pp. 2713-2722
-
-
Sader, H.S.1
Farrell, D.J.2
Castanheira, M.3
Flamm, R.K.4
Jones, R.N.5
-
68
-
-
85019081486
-
Ceftolozane/tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing urinary tract and intraabdominal infections in Europe: report from an antimicrobial surveillance programme (2012–15)
-
Pfaller, M.A., Bassetti, M., Duncan, L.R., Castanheira, M., Ceftolozane/tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing urinary tract and intraabdominal infections in Europe: report from an antimicrobial surveillance programme (2012–15). J Antimicrob Chemother 72 (2017), 1386–1395.
-
(2017)
J Antimicrob Chemother
, vol.72
, pp. 1386-1395
-
-
Pfaller, M.A.1
Bassetti, M.2
Duncan, L.R.3
Castanheira, M.4
-
69
-
-
84908344741
-
In vitro activity of ceftolozane-tazobactam as determined by broth dilution and agar diffusion assays against recent U.S. Escherichia coli isolates from 2010 to 2011 carrying CTX-M-type extended-spectrum β-lactamases
-
Estabrook, M., Bussell, B., Clugston, S.L., Bush, K., In vitro activity of ceftolozane-tazobactam as determined by broth dilution and agar diffusion assays against recent U.S. Escherichia coli isolates from 2010 to 2011 carrying CTX-M-type extended-spectrum β-lactamases. J Clin Microbiol 52 (2014), 4049–4052.
-
(2014)
J Clin Microbiol
, vol.52
, pp. 4049-4052
-
-
Estabrook, M.1
Bussell, B.2
Clugston, S.L.3
Bush, K.4
-
70
-
-
84929206762
-
Ceftolozane/tazobactam plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: results from a randomized, double-blind, phase 3 trial (ASPECT-cIAI)
-
Solomkin, J., Hershberger, E., Miller, B., Popejoy, M., Friedland, I., Steenbergen, J., et al. Ceftolozane/tazobactam plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: results from a randomized, double-blind, phase 3 trial (ASPECT-cIAI). Clin Infect Dis 60 (2015), 1462–1471.
-
(2015)
Clin Infect Dis
, vol.60
, pp. 1462-1471
-
-
Solomkin, J.1
Hershberger, E.2
Miller, B.3
Popejoy, M.4
Friedland, I.5
Steenbergen, J.6
-
71
-
-
84929606496
-
Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI)
-
Wagenlehner, F.M., Umeh, O., Steenbergen, J., Yuan, G., Darouiche, R.O., Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI). Lancet 385:9981 (2015), 1949–1956.
-
(2015)
Lancet
, vol.385
, Issue.9981
, pp. 1949-1956
-
-
Wagenlehner, F.M.1
Umeh, O.2
Steenbergen, J.3
Yuan, G.4
Darouiche, R.O.5
-
72
-
-
84979072369
-
Efficacy of ceftolozane/tazobactam versus levofloxacin in the treatment of complicated urinary tract infections (cUTIs) caused by levofloxacin-resistant pathogens: results from the ASPECT-cUTI trial
-
Huntington, J.A., Sakoulas, G., Umeh, O., Cloutier, D.J., Steenbergen, J.N., Bliss, C., et al. Efficacy of ceftolozane/tazobactam versus levofloxacin in the treatment of complicated urinary tract infections (cUTIs) caused by levofloxacin-resistant pathogens: results from the ASPECT-cUTI trial. J Antimicrob Chemother 71 (2016), 2014–2021.
-
(2016)
J Antimicrob Chemother
, vol.71
, pp. 2014-2021
-
-
Huntington, J.A.1
Sakoulas, G.2
Umeh, O.3
Cloutier, D.J.4
Steenbergen, J.N.5
Bliss, C.6
-
73
-
-
85014538017
-
Efficacy of ceftolozane/tazobactam against urinary tract and intra-abdominal infections caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae: a pooled analysis of Phase 3 clinical trials
-
Popejoy, M.W., Paterson, D.L., Cloutier, D., Huntington, J.A., Miller, B., Bliss, C.A., et al. Efficacy of ceftolozane/tazobactam against urinary tract and intra-abdominal infections caused by ESBL-producing Escherichia coli and Klebsiella pneumoniae: a pooled analysis of Phase 3 clinical trials. J Antimicrob Chemother 72 (2017), 268–272.
-
(2017)
J Antimicrob Chemother
, vol.72
, pp. 268-272
-
-
Popejoy, M.W.1
Paterson, D.L.2
Cloutier, D.3
Huntington, J.A.4
Miller, B.5
Bliss, C.A.6
-
74
-
-
85030696449
-
-
Safety and efficacy study of ceftolozane/tazobactam to treat ventilated nosocomial pneumonia (ASPECT-NP). Available at: accessed February
-
ClinicalTrials.gov. Safety and efficacy study of ceftolozane/tazobactam to treat ventilated nosocomial pneumonia (ASPECT-NP). Available at: www.clinicaltrials.gov/ ct2/show/NCT0207075; accessed February 2017.
-
(2017)
-
-
-
75
-
-
85021792400
-
Multicenter evaluation of ceftolozane/tazobactam for serious infections caused by carbapenem-resistant Pseudomonas aeruginosa
-
cix014
-
Munita, J.M., Aitken, S.L., Miller, W.R., Perez, F., Rosa, R., et al. Multicenter evaluation of ceftolozane/tazobactam for serious infections caused by carbapenem-resistant Pseudomonas aeruginosa. Clin Infect Dis, 2017, 10.1093/cid/cix014 cix014.
-
(2017)
Clin Infect Dis
-
-
Munita, J.M.1
Aitken, S.L.2
Miller, W.R.3
Perez, F.4
Rosa, R.5
-
76
-
-
77952614275
-
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli
-
Page, M.G., Dantier, C., Desarbre, E., In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli. Antimicrob Agents Chemother 54 (2010), 2291–2302.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 2291-2302
-
-
Page, M.G.1
Dantier, C.2
Desarbre, E.3
-
77
-
-
84877127230
-
Combined effects of the siderophore monosulfactam BAL30072 and carbapenems on multidrug-resistant Gram-negative bacilli
-
Hofer, B., Dantier, C., Gebhardt, K., Desarbre, E., Schmitt-Hoffmann, A., Page, M.G., Combined effects of the siderophore monosulfactam BAL30072 and carbapenems on multidrug-resistant Gram-negative bacilli. J Antimicrob Chemother 68 (2013), 1120–1129.
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 1120-1129
-
-
Hofer, B.1
Dantier, C.2
Gebhardt, K.3
Desarbre, E.4
Schmitt-Hoffmann, A.5
Page, M.G.6
-
78
-
-
84879488177
-
Activity of BAL30072 alone or combined with β-lactamase inhibitors or with meropenem against carbapenem-resistant Enterobacteriaceae and non-fermenters
-
Mushtaq, S., Woodford, N., Hope, R., Adkin, R., Livermore, D.M., Activity of BAL30072 alone or combined with β-lactamase inhibitors or with meropenem against carbapenem-resistant Enterobacteriaceae and non-fermenters. J Antimicrob Chemother 68 (2013), 1601–1608.
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 1601-1608
-
-
Mushtaq, S.1
Woodford, N.2
Hope, R.3
Adkin, R.4
Livermore, D.M.5
-
79
-
-
85030657960
-
-
accessed February
-
http://www.basilea.com/Portfolio/Portfolio/, accessed February 2017.
-
(2017)
-
-
-
80
-
-
67651247638
-
Siderophores as drug delivery agents: application of the “Trojan Horse” strategy
-
Mollmann, U., Heinisch, L., Bauernfeind, A., Kohler, T., Ankel-Fuchs, D., Siderophores as drug delivery agents: application of the “Trojan Horse” strategy. Biometals 22 (2009), 615–624.
-
(2009)
Biometals
, vol.22
, pp. 615-624
-
-
Mollmann, U.1
Heinisch, L.2
Bauernfeind, A.3
Kohler, T.4
Ankel-Fuchs, D.5
-
81
-
-
84960837126
-
In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria
-
Ito, A., Kohira, N., Bouchillon, S.K., West, J., Rittenhouse, S., Sader, H.S., et al. In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria. J Antimicrob Chemother 71 (2016), 670–677.
-
(2016)
J Antimicrob Chemother
, vol.71
, pp. 670-677
-
-
Ito, A.1
Kohira, N.2
Bouchillon, S.K.3
West, J.4
Rittenhouse, S.5
Sader, H.S.6
-
82
-
-
84957895337
-
In vitro antimicrobial activity of a siderophore cephalosporin, S-649266, against Enterobacteriaceae clinical isolates, including carbapenem-resistant strains
-
Kohira, N., West, J., Ito, A., Ito-Horiyama, T., Nakamura, R., Sato, T., et al. In vitro antimicrobial activity of a siderophore cephalosporin, S-649266, against Enterobacteriaceae clinical isolates, including carbapenem-resistant strains. Antimicrob Agents Chemother 60 (2016), 729–734.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, pp. 729-734
-
-
Kohira, N.1
West, J.2
Ito, A.3
Ito-Horiyama, T.4
Nakamura, R.5
Sato, T.6
-
83
-
-
84977110010
-
Stability of novel siderophore cephalosporin S-649266 against clinically relevant carbapenemases
-
Ito-Horiyama, T., Ishii, Y., Ito, A., Sato, T., Nakamura, R., Fukuhara, N., et al. Stability of novel siderophore cephalosporin S-649266 against clinically relevant carbapenemases. Antimicrob Agents Chemother 60 (2016), 4384–4386.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, pp. 4384-4386
-
-
Ito-Horiyama, T.1
Ishii, Y.2
Ito, A.3
Sato, T.4
Nakamura, R.5
Fukuhara, N.6
-
84
-
-
85030667775
-
-
Cefiderocol compared with imipenem/cilastatin in the treatment of adults with complicated urinary tract infections with or without pyelonephritis or acute uncomplicated pyelonephritis: results from a multicentre, double-blind, randomized study. Presented at 27th European Congress of Clinical Microbiology and Infectious Diseases, Vienna April
-
Portsmouth S, Vennhuyzen D, Echols R, Machida M, Ferrreira JCA, et al. Cefiderocol compared with imipenem/cilastatin in the treatment of adults with complicated urinary tract infections with or without pyelonephritis or acute uncomplicated pyelonephritis: results from a multicentre, double-blind, randomized study. Presented at 27th European Congress of Clinical Microbiology and Infectious Diseases, Vienna April 2017.
-
(2017)
-
-
Portsmouth, S.1
Vennhuyzen, D.2
Echols, R.3
Machida, M.4
Ferrreira, J.C.A.5
-
85
-
-
85030686524
-
-
Study of S-649266 or best available therapy for the treatment of severe infections caused by carbapenem-resistant Gram-negative pathogens (CREDIBLE – CR). Available at: accessed February
-
ClinicalTrials.gov. Study of S-649266 or best available therapy for the treatment of severe infections caused by carbapenem-resistant Gram-negative pathogens (CREDIBLE – CR). Available at: https://clinicaltrials.gov/ct2/show/NCT02714595?term=649266&rank=2; accessed February 2017.
-
(2017)
-
-
-
86
-
-
77957764600
-
Synthesis and spectrum of the neoglycoside ACHN-490
-
Aggen, J.B., Armstrong, E.S., Goldblum, A.A., Dozzo, P., Linsell, M.S., Gliedt, M.J., et al. Synthesis and spectrum of the neoglycoside ACHN-490. Antimicrob Agents Chemother 54 (2010), 4636–4642.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 4636-4642
-
-
Aggen, J.B.1
Armstrong, E.S.2
Goldblum, A.A.3
Dozzo, P.4
Linsell, M.S.5
Gliedt, M.J.6
-
87
-
-
78650378928
-
Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates
-
Livermore, D.M., Mushtaq, S., Warner, M., Zhang, J.C., Maharjan, S., Doumith, M., et al. Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates. J Antimicrob Chemother 66 (2011), 48–53.
-
(2011)
J Antimicrob Chemother
, vol.66
, pp. 48-53
-
-
Livermore, D.M.1
Mushtaq, S.2
Warner, M.3
Zhang, J.C.4
Maharjan, S.5
Doumith, M.6
-
88
-
-
84866248918
-
Activity of plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece
-
Galani, I., Souli, M., Daikos, G.L., Chrysouli, Z., Poulakou, G., Psichogiou, M., et al. Activity of plazomicin (ACHN-490) against MDR clinical isolates of Klebsiella pneumoniae, Escherichia coli, and Enterobacter spp. from Athens, Greece. J Chemother 24 (2012), 191–194.
-
(2012)
J Chemother
, vol.24
, pp. 191-194
-
-
Galani, I.1
Souli, M.2
Daikos, G.L.3
Chrysouli, Z.4
Poulakou, G.5
Psichogiou, M.6
-
89
-
-
84905393404
-
Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents
-
Almaghrabi, R., Clancy, C.J., Doi, Y., Hao, B., Chen, L., Shields, R.K., et al. Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents. Antimicrob Agents Chemother 58 (2014), 4443–4451.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 4443-4451
-
-
Almaghrabi, R.1
Clancy, C.J.2
Doi, Y.3
Hao, B.4
Chen, L.5
Shields, R.K.6
-
90
-
-
84898640237
-
In vitro activity of plazomicin against 5,015 gram-negative and gram-positive clinical isolates obtained from patients in Canadian hospitals as part of the CANWARD study, 2011–2012
-
Walkty, A., Adam, H., Baxter, M., Denisuik, A., Lagace-Wiens, P., Karlowsky, J.A., et al. In vitro activity of plazomicin against 5,015 gram-negative and gram-positive clinical isolates obtained from patients in Canadian hospitals as part of the CANWARD study, 2011–2012. Antimicrob Agents Chemother 58 (2014), 2554–2563.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 2554-2563
-
-
Walkty, A.1
Adam, H.2
Baxter, M.3
Denisuik, A.4
Lagace-Wiens, P.5
Karlowsky, J.A.6
-
91
-
-
84942239862
-
Can plazomicin alone or in combination be a therapeutic option against carbapenem-resistant Acinetobacter baumannii?
-
Garcia-Salguero, C., Rodriguez-Avial, I., Picazo, J.J., Culebras, E., Can plazomicin alone or in combination be a therapeutic option against carbapenem-resistant Acinetobacter baumannii?. Antimicrob Agents Chemother 59 (2015), 5959–5966.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 5959-5966
-
-
Garcia-Salguero, C.1
Rodriguez-Avial, I.2
Picazo, J.J.3
Culebras, E.4
-
92
-
-
85030691960
-
-
http://www.achaogen.com/media-all/2012/5/15/achaogen-announces-all-objectives-met-in-phase-2-plazomicin-complicated-urinary-tract-infections-study-and-start-of-first-in-human-study-with-achn-975.
-
-
-
-
93
-
-
85030658897
-
-
Krause et al. Plazomicin versus meropenem for the treatment of complicated urinary tract infection (cUTI) and acute pyelonephritis (AP): results of the EPIC study. Presented at 27th European Congress of Clinical Microbiology and Infectious Diseases, Vienna April
-
Cloutier D, Miller L, Komirenko A, Cebrik D, Krause et al. Plazomicin versus meropenem for the treatment of complicated urinary tract infection (cUTI) and acute pyelonephritis (AP): results of the EPIC study. Presented at 27th European Congress of Clinical Microbiology and Infectious Diseases, Vienna April 2017.
-
(2017)
-
-
Cloutier, D.1
Miller, L.2
Komirenko, A.3
Cebrik, D.4
-
94
-
-
85030696486
-
-
Plazomicin associated with improved survival and safety compared with colistin in serious carbapenem-resistant Enterobacteriaceae (CRE) infections: results of the CARE Study. Presented at ASM Microbe, New Orleans June
-
Connolly LE, Jubb AM, O'Keeffe B, Serio AW, Smith A, Gall J, et al. Plazomicin associated with improved survival and safety compared with colistin in serious carbapenem-resistant Enterobacteriaceae (CRE) infections: results of the CARE Study. Presented at ASM Microbe, New Orleans June 2017.
-
(2017)
-
-
Connolly, L.E.1
Jubb, A.M.2
O'Keeffe, B.3
Serio, A.W.4
Smith, A.5
Gall, J.6
-
95
-
-
84957703595
-
Review of eravacycline, a novel fluorocycline antibacterial agent
-
Zhanel, G.G., Cheung, D., Adam, H., Zelenitsky, S., Golden, A., Schweizer, F., et al. Review of eravacycline, a novel fluorocycline antibacterial agent. Drugs 76 (2016), 567–588.
-
(2016)
Drugs
, vol.76
, pp. 567-588
-
-
Zhanel, G.G.1
Cheung, D.2
Adam, H.3
Zelenitsky, S.4
Golden, A.5
Schweizer, F.6
-
96
-
-
84911871699
-
Eravacycline for the treatment of intra-abdominal infections
-
Bassetti, M., Righi, E., Eravacycline for the treatment of intra-abdominal infections. Expert Opin Investig Drugs 23 (2014), 1575–1584.
-
(2014)
Expert Opin Investig Drugs
, vol.23
, pp. 1575-1584
-
-
Bassetti, M.1
Righi, E.2
-
97
-
-
84885921693
-
Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens
-
Sutcliffe, J.A., O'Brien, W., Fyfe, C., Grossman, T.H., Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens. Antimicrob Agents Chemother 57 (2013), 5548–5558.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 5548-5558
-
-
Sutcliffe, J.A.1
O'Brien, W.2
Fyfe, C.3
Grossman, T.H.4
-
98
-
-
84860123958
-
Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic
-
Grossman, T.H., Starosta, A.L., Fyfe, C., O'Brien, W., Rothstein, D.M., Mikolajka, A., et al. Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic. Antimicrob Agents Chemother 56 (2012), 2559–2564.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 2559-2564
-
-
Grossman, T.H.1
Starosta, A.L.2
Fyfe, C.3
O'Brien, W.4
Rothstein, D.M.5
Mikolajka, A.6
-
99
-
-
84923255578
-
Activity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from New York City
-
Abdallah, M., Olafisoye, O., Cortes, C., Urban, C., Landman, D., Quale, J., Activity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from New York City. Antimicrob Agents Chemother 59 (2015), 1802–1805.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, pp. 1802-1805
-
-
Abdallah, M.1
Olafisoye, O.2
Cortes, C.3
Urban, C.4
Landman, D.5
Quale, J.6
-
100
-
-
84984815298
-
In vitro susceptibility of β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE) to eravacycline
-
Zhang, Y., Lin, X., Bush, K., In vitro susceptibility of β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE) to eravacycline. J Antibiot (Tokyo) 69 (2016), 600–604.
-
(2016)
J Antibiot (Tokyo)
, vol.69
, pp. 600-604
-
-
Zhang, Y.1
Lin, X.2
Bush, K.3
-
101
-
-
84973616512
-
In vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii
-
Livermore, D.M., Mushtaq, S., Warner, M., Woodford, N., In vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii. Antimicrob Agents Chemother 60 (2016), 3840–3844.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, pp. 3840-3844
-
-
Livermore, D.M.1
Mushtaq, S.2
Warner, M.3
Woodford, N.4
-
102
-
-
85017643118
-
Assessing the efficacy and safety of eravacycline vs ertapenem in complicated intra-abdominal infections in the investigating gram-negative infections treated with eravacycline (IGNITE 1) trial: a randomized clinical trial
-
Solomkin, J., Evans, D., Slepavicius, A., Lee, P., Marsh, A., Tsai, L., et al. Assessing the efficacy and safety of eravacycline vs ertapenem in complicated intra-abdominal infections in the investigating gram-negative infections treated with eravacycline (IGNITE 1) trial: a randomized clinical trial. JAMA Surg 152 (2016), 224–232.
-
(2016)
JAMA Surg
, vol.152
, pp. 224-232
-
-
Solomkin, J.1
Evans, D.2
Slepavicius, A.3
Lee, P.4
Marsh, A.5
Tsai, L.6
-
103
-
-
85030705985
-
-
Tetraphase announces top-line results from IGNITE2 phase 3 clinical trial of eravacycline in cuti. Available at: accessed February
-
Tetraphase announces top-line results from IGNITE2 phase 3 clinical trial of eravacycline in cuti. Available at: http://ir.tphase.com/releasedetail.cfm?releaseid=930613; accessed February 2017.
-
(2017)
-
-
-
104
-
-
84861505966
-
Excess deaths associated with tigecycline after approval based on noninferiority trials
-
Prasad, P., Sun, J., Danner, R.L., Natanson, C., Excess deaths associated with tigecycline after approval based on noninferiority trials. Clin Infect Dis 54 (2012), 1699–1709.
-
(2012)
Clin Infect Dis
, vol.54
, pp. 1699-1709
-
-
Prasad, P.1
Sun, J.2
Danner, R.L.3
Natanson, C.4
-
105
-
-
84941208313
-
Efficacy and safety of tigecycline for the treatment of severe infectious diseases: an updated meta-analysis of RCTs
-
Shen, F., Han, Q., Xie, D., Fang, M., Zeng, H., Deng, Y., Efficacy and safety of tigecycline for the treatment of severe infectious diseases: an updated meta-analysis of RCTs. Int J Infect Dis 39 (2015), 25–33.
-
(2015)
Int J Infect Dis
, vol.39
, pp. 25-33
-
-
Shen, F.1
Han, Q.2
Xie, D.3
Fang, M.4
Zeng, H.5
Deng, Y.6
-
106
-
-
84978763327
-
The antibiotic pipeline for multi-drug resistant gram negative bacteria: what can we expect?
-
Falagas, M.E., Mavroudis, A.D., Vardakas, K.Z., The antibiotic pipeline for multi-drug resistant gram negative bacteria: what can we expect?. Expert Rev Anti Infect Ther 14 (2016), 747–763.
-
(2016)
Expert Rev Anti Infect Ther
, vol.14
, pp. 747-763
-
-
Falagas, M.E.1
Mavroudis, A.D.2
Vardakas, K.Z.3
|