메뉴 건너뛰기




Volumn 16, Issue 9, 2010, Pages 1482-1487

Activity of the new cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa isolates from chronically-infected cystic fibrosis patients

Author keywords

Antibiotic resistance; Cephalosporins; Cystic fibrosis; Pseudomonas aeruginosa

Indexed keywords

CEFEPIME; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; CXA 101; FR 254205; FR 264205; IMIPENEM; LEVOFLOXACIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; TOBRAMYCIN; UNCLASSIFIED DRUG;

EID: 77955637131     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2010.03130.x     Document Type: Article
Times cited : (34)

References (35)
  • 2
    • 0142043977 scopus 로고    scopus 로고
    • Pathophysiology and management of pulmonary infections in cystic fibrosis
    • Gibson RL, Burns JL, Rammsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. Am J Respir Crit Care Med 2003, 168:918-951.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 918-951
    • Gibson, R.L.1    Burns, J.L.2    Rammsey, B.W.3
  • 3
    • 0036498656 scopus 로고    scopus 로고
    • Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?
    • Livermore DM. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare? Clin Infect Dis 2002, 34:634-640.
    • (2002) Clin Infect Dis , vol.34 , pp. 634-640
    • Livermore, D.M.1
  • 4
    • 0034685940 scopus 로고    scopus 로고
    • High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection
    • Oliver A, Cantón R, Campo P, Baquero F, Blázquez J. High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science 2000, 288:1251-1253.
    • (2000) Science , vol.288 , pp. 1251-1253
    • Oliver, A.1    Cantón, R.2    Campo, P.3    Baquero, F.4    Blázquez, J.5
  • 5
    • 19544386997 scopus 로고    scopus 로고
    • Ocurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflamation
    • Ciofu O, Riis B, Pressler P, Poulsen HP, Hoiby N. Ocurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflamation. Antimicrob Agents Chemother 2005, 49:2276-2282.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2276-2282
    • Ciofu, O.1    Riis, B.2    Pressler, P.3    Poulsen, H.P.4    Hoiby, N.5
  • 6
    • 34548048797 scopus 로고    scopus 로고
    • Incidence and risk factors for multiple antibiotic-resistant Pseudomonas aeruginosa in cystic fibrosis
    • Merlo CA, Boyle MP, Diener-West M, Marshall BC, Goss CH, Lechtzin N. Incidence and risk factors for multiple antibiotic-resistant Pseudomonas aeruginosa in cystic fibrosis. Chest 2007, 132:562-568.
    • (2007) Chest , vol.132 , pp. 562-568
    • Merlo, C.A.1    Boyle, M.P.2    Diener-West, M.3    Marshall, B.C.4    Goss, C.H.5    Lechtzin, N.6
  • 7
    • 33644508050 scopus 로고    scopus 로고
    • Outcomes of adults with cystic fibrosis infected with antibiotic-resistant Pseudomonas aeruginosa
    • Leichtzin N, John M, Irizarry R, Merlo C, Diette GB, Boyle MP. Outcomes of adults with cystic fibrosis infected with antibiotic-resistant Pseudomonas aeruginosa. Respiration 2006, 73:27-33.
    • (2006) Respiration , vol.73 , pp. 27-33
    • Leichtzin, N.1    John, M.2    Irizarry, R.3    Merlo, C.4    Diette, G.B.5    Boyle, M.P.6
  • 9
    • 0036841078 scopus 로고    scopus 로고
    • Constitutive high expression of chromosomal β-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD
    • Bagge N, Ciofu O, Hentzer M, Campbell JI, Givskov M, Hoiby N. Constitutive high expression of chromosomal β-lactamase in Pseudomonas aeruginosa caused by a new insertion sequence (IS1669) located in ampD. Antimicrob Agents Chemother 2002, 46:3406-3411.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3406-3411
    • Bagge, N.1    Ciofu, O.2    Hentzer, M.3    Campbell, J.I.4    Givskov, M.5    Hoiby, N.6
  • 10
    • 63449128597 scopus 로고    scopus 로고
    • B-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein
    • Moya B, Döstch A, Juan C et al. B-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein. PLoS Pathog 2009, 5:e1000353.
    • (2009) PLoS Pathog , vol.5
    • Moya, B.1    Döstch, A.2    Juan, C.3
  • 11
    • 0033999155 scopus 로고    scopus 로고
    • Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients
    • Jalal S, Ciofu O, Hoiby N, Gotoh N, Wretlind B. Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother 2000, 44:710-712.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 710-712
    • Jalal, S.1    Ciofu, O.2    Hoiby, N.3    Gotoh, N.4    Wretlind, B.5
  • 12
    • 2142697190 scopus 로고    scopus 로고
    • Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis
    • Vogne C, Aires JR, Bailly C, Hocquet D, Plesiat P. Role of the multidrug efflux system MexXY in the emergence of moderate resistance to aminoglycosides among Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Antimicrob Agents Chemother 2004, 48:1676-1680.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1676-1680
    • Vogne, C.1    Aires, J.R.2    Bailly, C.3    Hocquet, D.4    Plesiat, P.5
  • 13
    • 21244451543 scopus 로고    scopus 로고
    • Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing
    • Foweraker JE, Laughton CR, Brown DF, Bilton D. Phenotypic variability of Pseudomonas aeruginosa in sputa from patients with acute infective exacerbation of cystic fibrosis and its impact on the validity of antimicrobial susceptibility testing. J Antimicrob Chemother 2005, 55:921-927.
    • (2005) J Antimicrob Chemother , vol.55 , pp. 921-927
    • Foweraker, J.E.1    Laughton, C.R.2    Brown, D.F.3    Bilton, D.4
  • 14
    • 33744814106 scopus 로고    scopus 로고
    • Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
    • Smith EE, Buckley DG, Wu Z. Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci USA 2006, 103:8487-8492.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8487-8492
    • Smith, E.E.1    Buckley, D.G.2    Wu, Z.3
  • 15
    • 57349088170 scopus 로고    scopus 로고
    • Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation
    • Mena A, Smith EE, Burns JL. Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation. J Bacteriol 2008, 190:7910-7917.
    • (2008) J Bacteriol , vol.190 , pp. 7910-7917
    • Mena, A.1    Smith, E.E.2    Burns, J.L.3
  • 16
    • 0029814366 scopus 로고    scopus 로고
    • Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia
    • Govan JR, Deretic V. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev 1996, 60:539-574.
    • (1996) Microbiol Rev , vol.60 , pp. 539-574
    • Govan, J.R.1    Deretic, V.2
  • 17
    • 0032797445 scopus 로고    scopus 로고
    • Pulmonary outcome in cystic fibrosis is influenced primarily by mucoid Pseudomonas aeruginosa infection and immune status and only modestly by genotype
    • Parad RB, Gerard CJ, Zurakowski D, Nichols DP, Pier GB. Pulmonary outcome in cystic fibrosis is influenced primarily by mucoid Pseudomonas aeruginosa infection and immune status and only modestly by genotype. Infect Immun 1999, 67:4744-4750.
    • (1999) Infect Immun , vol.67 , pp. 4744-4750
    • Parad, R.B.1    Gerard, C.J.2    Zurakowski, D.3    Nichols, D.P.4    Pier, G.B.5
  • 18
    • 0031976051 scopus 로고    scopus 로고
    • Microbial pathogenesis in cystic fibrosis: pulmonary clearance of mucoid Pseudomonas aeruginosa and inflammation in a mouse model of repeated respiratory challenge
    • Yu H, Hanes M, Chrisp CE, Boucher JC, Deretic V. Microbial pathogenesis in cystic fibrosis: pulmonary clearance of mucoid Pseudomonas aeruginosa and inflammation in a mouse model of repeated respiratory challenge. Infect Immun 1998, 66:280-288.
    • (1998) Infect Immun , vol.66 , pp. 280-288
    • Yu, H.1    Hanes, M.2    Chrisp, C.E.3    Boucher, J.C.4    Deretic, V.5
  • 19
    • 0025006851 scopus 로고
    • Pseudomonas aeruginosa alginate in cystic fibrosis sputum and the inflamatory response
    • Pedersen S, Kharazmi SA, Espersen F, Hoiby N. Pseudomonas aeruginosa alginate in cystic fibrosis sputum and the inflamatory response. Infect Immun 1990, 58:3363-3368.
    • (1990) Infect Immun , vol.58 , pp. 3363-3368
    • Pedersen, S.1    Kharazmi, S.A.2    Espersen, F.3    Hoiby, N.4
  • 20
    • 0031956869 scopus 로고    scopus 로고
    • Alginate lyase promotes diffusion of aminoglycosides through the extracellular polysaccharide of mucoid Pseudomonas aeruginosa
    • Hatch RA, Schiller NL. Alginate lyase promotes diffusion of aminoglycosides through the extracellular polysaccharide of mucoid Pseudomonas aeruginosa. Antimicrob Agents Chemother 1998, 42:974-977.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 974-977
    • Hatch, R.A.1    Schiller, N.L.2
  • 21
    • 0024556654 scopus 로고
    • Scavenging by alginate of free radicals released by macrophages
    • Simpson JA, Smith SE, Dean RT. Scavenging by alginate of free radicals released by macrophages. Free Radic Biol Med 1989, 6:347-353.
    • (1989) Free Radic Biol Med , vol.6 , pp. 347-353
    • Simpson, J.A.1    Smith, S.E.2    Dean, R.T.3
  • 24
    • 33847621194 scopus 로고    scopus 로고
    • In vitro and In vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa
    • Takeda S, Nakai T, Wakai Y, Ikeda F, Hatano K. In vitro and In vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa. Antimicrob Agents Chemother 2007, 51:826-830.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 826-830
    • Takeda, S.1    Nakai, T.2    Wakai, Y.3    Ikeda, F.4    Hatano, K.5
  • 25
    • 85031343490 scopus 로고    scopus 로고
    • Clinical and Laboratory Standards Institute (CLSI), no. 3, 18th informational supplement. M100-S18, Wayne, PA, Clinical and Laboratory Standards Institute
    • Performance standards for antimicrobial susceptibility testing 2008, Clinical and Laboratory Standards Institute (CLSI), vol. 28, no. 3, 18th informational supplement. M100-S18, Wayne, PA, Clinical and Laboratory Standards Institute
    • (2008) Performance standards for antimicrobial susceptibility testing , vol.28
  • 26
    • 85031341180 scopus 로고    scopus 로고
    • CXA-101 (CXA) population PK analysis and Monte Carlo (MC) simulation for PK/PD target attainment and dose regimen selection
    • 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Abstract F1-2003. San Francisco, USA, 12-15 September 2009
    • Ge Y, Liao S. CXA-101 (CXA) population PK analysis and Monte Carlo (MC) simulation for PK/PD target attainment and dose regimen selection. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Abstract F1-2003. San Francisco, USA, 12-15 September 2009
    • Ge, Y.1    Liao, S.2
  • 27
    • 23444434606 scopus 로고    scopus 로고
    • Early eradication therapy against Pseudomonas aeruginosa in cystic fibrosis patients
    • Taccetti G, Campana S, Festini F, Mascherini M, Döring G. Early eradication therapy against Pseudomonas aeruginosa in cystic fibrosis patients. Eur Respir J 2005, 26:458-461.
    • (2005) Eur Respir J , vol.26 , pp. 458-461
    • Taccetti, G.1    Campana, S.2    Festini, F.3    Mascherini, M.4    Döring, G.5
  • 28
    • 23844474727 scopus 로고    scopus 로고
    • Antimicrobial therapy for pulmonary pathogenic colonisation and infection by Pseudomonas aeruginosa in cystic fibrosis patients
    • Cantón R, Cobos N, de Gracia J. Antimicrobial therapy for pulmonary pathogenic colonisation and infection by Pseudomonas aeruginosa in cystic fibrosis patients. Clin Microbiol Infect 2005, 11:690-703.
    • (2005) Clin Microbiol Infect , vol.11 , pp. 690-703
    • Cantón, R.1    Cobos, N.2    de Gracia, J.3
  • 29
    • 0034983569 scopus 로고    scopus 로고
    • Antimicrobial susceptibility of Pseudomonas aeruginosa: results of a UK survey and evaluation of the British Society for Antimicrobial Chemotherapy disc susceptibility test
    • the Pseudomonas study group
    • Henwood CJ, Livermore DM, James D, Warner M. Antimicrobial susceptibility of Pseudomonas aeruginosa: results of a UK survey and evaluation of the British Society for Antimicrobial Chemotherapy disc susceptibility test. J Antimicrob Chemother 2001, 47:789-799. the Pseudomonas study group
    • (2001) J Antimicrob Chemother , vol.47 , pp. 789-799
    • Henwood, C.J.1    Livermore, D.M.2    James, D.3    Warner, M.4
  • 30
    • 19544371927 scopus 로고    scopus 로고
    • In vitro activity of doripenem (S-4661) against multidrug-resistant gram-negative bacilli isolated from patients with cystic fibrosis
    • Chen Y, Garber E, Zhao Q. In vitro activity of doripenem (S-4661) against multidrug-resistant gram-negative bacilli isolated from patients with cystic fibrosis. Antimicrob Agents Chemother 2005, 49:2510-2511.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2510-2511
    • Chen, Y.1    Garber, E.2    Zhao, Q.3
  • 31
    • 3342905057 scopus 로고    scopus 로고
    • Doripenem versus Pseudomonas aeruginosa in vitro: activity against characterized isolates, mutants, and transconjugants and resistance selection potential
    • Mushtaq S, Ge Y, Livermore DM. Doripenem versus Pseudomonas aeruginosa in vitro: activity against characterized isolates, mutants, and transconjugants and resistance selection potential. Antimicrob Agents Chemother 2005, 48:3086-3092.
    • (2005) Antimicrob Agents Chemother , vol.48 , pp. 3086-3092
    • Mushtaq, S.1    Ge, Y.2    Livermore, D.M.3
  • 32
    • 77149179342 scopus 로고    scopus 로고
    • Activity of a new cephalosporin, CXA-101 (FR264205) against β-lactom-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of Intensive Care Unit patients: Antimicrob Agents Chemother
    • doi:10.1128/AAC.01104-09
    • Moya B, Zamorano L, Juan C, Pérez JL, Ge Y, Oliver A. Activity of a new cephalosporin, CXA-101 (FR264205) against β-lactom-resistant Pseudomonas aeruginosa mutants selected in vitro and after antipseudomonal treatment of Intensive Care Unit patients: Antimicrob Agents Chemother. 2010, 10.1128/AAC.01104-09, doi
    • (2010)
    • Moya, B.1    Zamorano, L.2    Juan, C.3    Pérez, J.L.4    Ge, Y.5    Oliver, A.6
  • 33
    • 75749148334 scopus 로고    scopus 로고
    • Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains
    • on behalf of the Spanish Group for the Study of Pseudomonas and REIPI
    • Juan C, Zamorano L, Pérez JL, Ge Y, Oliver A. Activity of a new antipseudomonal cephalosporin, CXA-101 (FR264205), against carbapenem-resistant and multidrug-resistant Pseudomonas aeruginosa clinical strains. Antimicrob Agents Chemother 2009, 54:846-851. on behalf of the Spanish Group for the Study of Pseudomonas and REIPI
    • (2009) Antimicrob Agents Chemother , vol.54 , pp. 846-851
    • Juan, C.1    Zamorano, L.2    Pérez, J.L.3    Ge, Y.4    Oliver, A.5
  • 34
    • 69949120875 scopus 로고    scopus 로고
    • Activity of cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa and Burkholderhia cepacia group strains and isolates
    • Livermore DM, Mushtaq S, Ge Y, Wagner M. Activity of cephalosporin CXA-101 (FR264205) against Pseudomonas aeruginosa and Burkholderhia cepacia group strains and isolates. Int J Antimicrob Agents 2009, 34:402-406.
    • (2009) Int J Antimicrob Agents , vol.34 , pp. 402-406
    • Livermore, D.M.1    Mushtaq, S.2    Ge, Y.3    Wagner, M.4
  • 35
    • 85031335824 scopus 로고    scopus 로고
    • Activity profile of CXA-101 and CXA-101/tazobactam against target Gram-positive and Gram-negative pathogens
    • Abstract F1-1986. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, Ca, 2009
    • Brown NP, Pillar CM, Sham DF, Ge Y. Activity profile of CXA-101 and CXA-101/tazobactam against target Gram-positive and Gram-negative pathogens. Abstract F1-1986. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, Ca, 2009
    • Brown, N.P.1    Pillar, C.M.2    Sham, D.F.3    Ge, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.