Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3596-3601

  Wang, Si Hong ^a   Wang, Shou Feng ^a   Xuan, Wei ^a   Zeng, Zong Hao ^b   Jin, Jing Yi ^a   Ma, Jie ^c   Tian, Guan Rong ^a  

^a YANBIAN UNIVERSITY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

^c QIQIHAR UNIVERSITY   (China)

Author keywords

Carboxypeptidase A; Inhibition; Nitro; Transition state analog inhibitor; X ray crystallography; Zinc binding group

Indexed keywords

2 BENZYL 3 NITROPROPANOIC ACID; ARGININE; CARBOXYPEPTIDASE A; CARBOXYPEPTIDASE A INHIBITOR; ENZYME INHIBITOR; GLUTAMIC ACID; GLYCERYL TRINITRATE; UNCLASSIFIED DRUG; ZINC BINDING PROTEIN; ZINC ION;

ANIMAL TISSUE; ARTICLE; DRUG DESIGN; ENZYME INACTIVATION; HUMAN; HYDROGEN BOND; HYDROLYSIS; NONHUMAN; X RAY CRYSTALLOGRAPHY;

CARBOXYPEPTIDASES A; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 41849088116     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.010     Document Type: Article

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