메뉴 건너뛰기




Volumn 1277, Issue 1, 2013, Pages 105-114

New β-lactam-β-lactamase inhibitor combinations in clinical development

Author keywords

Beta lactam beta lactamase inhibitor combinations; Beta lactamase; Clinical development

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; AVIBACTAM; AVIBACTAM PLUS CEFTAROLINE; AVIBACTAM PLUS CEFTAZIDIME; AZTREONAM; BETA LACTAMASE AMPC; BETA LACTAMASE INHIBITOR; BETA LACTAMASE TEM 1; CARBAPENEM; CARBAPENEMASE; CEFTAROLINE; CEFTAZIDIME; CEFTOLOZANE; CEFTOZOLANE PLUS TAZOBACTAM; CEPHALOSPORIN; CILASTATIN PLUS IMIPENEM; CILASTATIN PLUS IMIPENEM PLUS MK 7655; METRONIDAZOLE; MK 7655; PIPERACILLIN PLUS TAZOBACTAM; RPX 7009; TAZOBACTAM; UNCLASSIFIED DRUG;

EID: 84872844727     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12010     Document Type: Article
Times cited : (119)

References (44)
  • 1
    • 84455169919 scopus 로고    scopus 로고
    • In vivo comparison of CXA-101 (FR264205) with and without tazobactam versus piperacillin-tazobactam using human simulated exposures against phenotypically diverse gram-negative organisms
    • Bulik, C.C., P.R. Tessier, R.A. Keel, et al. 2012. In vivo comparison of CXA-101 (FR264205) with and without tazobactam versus piperacillin-tazobactam using human simulated exposures against phenotypically diverse gram-negative organisms. Antimicrob. Agents Chemother. 56: 544-549.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 544-549
    • Bulik, C.C.1    Tessier, P.R.2    Keel, R.A.3
  • 2
    • 80053247739 scopus 로고    scopus 로고
    • Epidemiological expansion, structural studies, and clinical challenges of new β-lactamases from gram-negative bacteria
    • Bush, K. & J.F. Fisher 2011. Epidemiological expansion, structural studies, and clinical challenges of new β-lactamases from gram-negative bacteria. Annu. Rev. Microbiol. 65: 455-478.
    • (2011) Annu. Rev. Microbiol. , vol.65 , pp. 455-478
    • Bush, K.1    Fisher, J.F.2
  • 3
    • 74249108028 scopus 로고    scopus 로고
    • Three decades of beta-lactamase inhibitors
    • Drawz, S.M. & R.A. Bonomo 2010. Three decades of beta-lactamase inhibitors. Clin. Microbiol. Rev. 23: 160-201.
    • (2010) Clin. Microbiol. Rev. , vol.23 , pp. 160-201
    • Drawz, S.M.1    Bonomo, R.A.2
  • 4
    • 0027515959 scopus 로고
    • Kinetic interactions of tazobactam with beta-lactamases from all major structural classes
    • Bush, K., C. Macalintal, B.A. Rasmussen, et al. 1993. Kinetic interactions of tazobactam with beta-lactamases from all major structural classes. Antimicrob. Agents Chemother. 37: 851-588.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 851-588
    • Bush, K.1    Macalintal, C.2    Rasmussen, B.A.3
  • 5
    • 81155162497 scopus 로고    scopus 로고
    • Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors
    • Coleman, K. 2011. Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors. Curr. Opin. Microbiol. 14: 550-555.
    • (2011) Curr. Opin. Microbiol. , vol.14 , pp. 550-555
    • Coleman, K.1
  • 6
    • 0035852794 scopus 로고    scopus 로고
    • Inhibition of the SHV-1 B-lactamase by sulfones: crytallographic observation of two reaction intermediates
    • Kuzin, A., M. Nukaga, Y. Nukaga, et al. 2001. Inhibition of the SHV-1 B-lactamase by sulfones: crytallographic observation of two reaction intermediates. Biochemical 40: 1861-1868.
    • (2001) Biochemical , vol.40 , pp. 1861-1868
    • Kuzin, A.1    Nukaga, M.2    Nukaga, Y.3
  • 7
    • 84862573378 scopus 로고    scopus 로고
    • In vitro activity of MK-7655, a novel β-lactamase inhibitor, in combination with imipenem against carbapenem-resistant Gram-negative bacteria
    • Hirsch, E.B., K.R. Ledesma, K.T. Chang, et al. 2012. In vitro activity of MK-7655, a novel β-lactamase inhibitor, in combination with imipenem against carbapenem-resistant Gram-negative bacteria. Antimicrob. Agents Chemother. 56: 3753-3757.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 3753-3757
    • Hirsch, E.B.1    Ledesma, K.R.2    Chang, K.T.3
  • 8
    • 84872845446 scopus 로고    scopus 로고
    • Activity of RPX2003/RPX7009, a carbapenem combined with a novel B-lactamase inhibitor tested against clinical isolates product defined enzymes. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract F-855.
    • Castanheira, M., O. Lomovskaya, P.R. Rhomberg & R.N. Jones 2012. Activity of RPX2003/RPX7009, a carbapenem combined with a novel B-lactamase inhibitor tested against clinical isolates product defined enzymes. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract F-855.
    • (2012)
    • Castanheira, M.1    Lomovskaya, O.2    Rhomberg, P.R.3    Jones, R.N.4
  • 9
    • 84872844008 scopus 로고    scopus 로고
    • Antimicrobial activity of ceftazidime/NXL-104 tested against Gram negative organisms including multidrug-resistant subsets, causing infections in USA and European mecial centers. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E-811.
    • Sader, H.S., M. Castanheira, D.J. Farrell & R.N. Jones 2010. Antimicrobial activity of ceftazidime/NXL-104 tested against Gram negative organisms including multidrug-resistant subsets, causing infections in USA and European mecial centers. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E-811.
    • (2010)
    • Sader, H.S.1    Castanheira, M.2    Farrell, D.J.3    Jones, R.N.4
  • 10
    • 78649683457 scopus 로고    scopus 로고
    • Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor
    • Stachyra, T., M.C. Péchereau, J.M. Bruneau, et al. 2010. Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor. Antimicrob. Agents Chemother. 54: 5132-5138.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 5132-5138
    • Stachyra, T.1    Péchereau, M.C.2    Bruneau, J.M.3
  • 11
    • 84872871896 scopus 로고    scopus 로고
    • In vitro activity of the class A and class C B-lactamase inhibitor MK-7655. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting Abstract F1-2139.
    • Young, K.L., S.L. Raghoobar, N.N. Hairston, et al. 2010. In vitro activity of the class A and class C B-lactamase inhibitor MK-7655. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting Abstract F1-2139.
    • (2010)
    • Young, K.L.1    Raghoobar, S.L.2    Hairston, N.N.3
  • 12
    • 84863905057 scopus 로고    scopus 로고
    • Avibactam is a covalent, reversible, non-B-lactam B-lactamase inhibitor
    • Ehmann, D.E., H. Jahic, P.L. Ross, et al. 2012. Avibactam is a covalent, reversible, non-B-lactam B-lactamase inhibitor. Proc. Natl. Acad. Sci. USA 109: 11663-11668.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 11663-11668
    • Ehmann, D.E.1    Jahic, H.2    Ross, P.L.3
  • 13
    • 84872846828 scopus 로고    scopus 로고
    • Response to Imipenem plus MK-7655, a novel β-lactamase inhibitor, in a surveillance study population of P. aeruginosa from SMART 2009. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract C2-724.
    • Young, K., M. Hackel, C. Lascols, et al. 2012. Response to Imipenem plus MK-7655, a novel β-lactamase inhibitor, in a surveillance study population of P. aeruginosa from SMART 2009. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract C2-724.
    • (2012)
    • Young, K.1    Hackel, M.2    Lascols, C.3
  • 14
    • 0028073633 scopus 로고
    • Inhibition of the renal excretion of tazobactam by piperacillin
    • Komuro, M., T. Maeda, H. Kakuo, et al. 1994. Inhibition of the renal excretion of tazobactam by piperacillin. J. Antimicrob. Chemother. 34: 555-564.
    • (1994) J. Antimicrob. Chemother. , vol.34 , pp. 555-564
    • Komuro, M.1    Maeda, T.2    Kakuo, H.3
  • 15
    • 0029835539 scopus 로고    scopus 로고
    • Ceftazidime-resistant Klebsiellapneumoniae isolates recovered at the Cleveland Department of Veterans Affairs Medical Center
    • Rice, L.B., E.C. Eckstein, J. DeVente & D.M. Shlaes 1996. Ceftazidime-resistant Klebsiellapneumoniae isolates recovered at the Cleveland Department of Veterans Affairs Medical Center. Clin. Infect. Dis. 23: 118-124.
    • (1996) Clin. Infect. Dis. , vol.23 , pp. 118-124
    • Rice, L.B.1    Eckstein, E.C.2    DeVente, J.3    Shlaes, D.M.4
  • 16
    • 0031009295 scopus 로고    scopus 로고
    • Complex mutant of TEM-1 beta-lactamase with mutations encountered in both IRT-4 and extended-spectrum TEM-15, produced by an Escherichia coli clinical isolate
    • Sirot, D., C. Recule, E.B. Chaibi, et al. 1997. Complex mutant of TEM-1 beta-lactamase with mutations encountered in both IRT-4 and extended-spectrum TEM-15, produced by an Escherichia coli clinical isolate. Antimicrob. Agents Chemother. 41: 1322-1325.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1322-1325
    • Sirot, D.1    Recule, C.2    Chaibi, E.B.3
  • 17
    • 0033180477 scopus 로고    scopus 로고
    • Class A beta-lactamases-enzyme-inhibitor interactions and resistance
    • Yang, Y., B.A. Rasmussen & D.M. Shlaes 1999. Class A beta-lactamases-enzyme-inhibitor interactions and resistance. Pharmacol. Ther 83: 141-151.
    • (1999) Pharmacol. Ther , vol.83 , pp. 141-151
    • Yang, Y.1    Rasmussen, B.A.2    Shlaes, D.M.3
  • 18
    • 0031105398 scopus 로고    scopus 로고
    • Tazobactam is a potent inactivator of selected inhibitor-resistant class A beta-lactamases
    • Bonomo, R.A., S.A. Rudin & D.M. Shlaes 1997. Tazobactam is a potent inactivator of selected inhibitor-resistant class A beta-lactamases. FEMS Microbiol. Lett. 148: 59-62.
    • (1997) FEMS Microbiol. Lett. , vol.148 , pp. 59-62
    • Bonomo, R.A.1    Rudin, S.A.2    Shlaes, D.M.3
  • 19
    • 84872856670 scopus 로고    scopus 로고
    • Activity of CXA-101 against a large collection of P. aeruginosa blood stream isolates overexpressing AmpC and the major efflux pumps. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E-816.
    • Cabot, G., M.D. Macià, M. Gozalo, et al. 2010. Activity of CXA-101 against a large collection of P. aeruginosa blood stream isolates overexpressing AmpC and the major efflux pumps. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E-816.
    • (2010)
    • Cabot, G.1    Macià, M.D.2    Gozalo, M.3
  • 20
    • 84872860900 scopus 로고    scopus 로고
    • Impact of NXL-104 on ceftaroline MICs for bacteria producing extended spectrum, AmpC or KPC B-lactamases. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E-804.
    • Badal, R., S. Bouchillon, M. Hackel, et al. 2010. Impact of NXL-104 on ceftaroline MICs for bacteria producing extended spectrum, AmpC or KPC B-lactamases. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E-804.
    • (2010)
    • Badal, R.1    Bouchillon, S.2    Hackel, M.3
  • 21
    • 84872862427 scopus 로고    scopus 로고
    • Potent activity of ceftazidime/NXL-104 against Enterobactereaceae isolates carrying multiple B-lactamase enzymes. ECCMID Annual Meeting, Abstract 1265.
    • Castanheira, M., P.R. Rhomberg, R.N. Jones & D.J. Farrell 2010. Potent activity of ceftazidime/NXL-104 against Enterobactereaceae isolates carrying multiple B-lactamase enzymes. ECCMID Annual Meeting, Abstract 1265.
    • (2010)
    • Castanheira, M.1    Rhomberg, P.R.2    Jones, R.N.3    Farrell, D.J.4
  • 22
    • 34547422759 scopus 로고    scopus 로고
    • Carbapenemases: the versatile lactamases
    • Queenan, A. M. & K. Bush 2007. Carbapenemases: the versatile lactamases. Clin. Microbiol. Rev. 20: 440-458.
    • (2007) Clin. Microbiol. Rev. , vol.20 , pp. 440-458
    • Queenan, A.M.1    Bush, K.2
  • 23
    • 79955005040 scopus 로고    scopus 로고
    • In vitro activity of CXA-101 plus tazobactam (CXA-201) against CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae
    • Titelman, E., I.M. Karlsson, Y. Ge & C.G. Giske 2011. In vitro activity of CXA-101 plus tazobactam (CXA-201) against CTX-M-14- and CTX-M-15-producing Escherichia coli and Klebsiella pneumoniae. Diagn. Microbiol. Infect. Dis 70: 137-141.
    • (2011) Diagn. Microbiol. Infect. Dis , vol.70 , pp. 137-141
    • Titelman, E.1    Karlsson, I.M.2    Ge, Y.3    Giske, C.G.4
  • 24
    • 79955536362 scopus 로고    scopus 로고
    • Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes
    • Sader, H.S., P.R. Rhomberg, D.J. Farrell & R.N. Jones 2011. Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes. Antimicrob. Agents Chemother. 55: 2390-2394.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 2390-2394
    • Sader, H.S.1    Rhomberg, P.R.2    Farrell, D.J.3    Jones, R.N.4
  • 25
    • 84872843643 scopus 로고    scopus 로고
    • Activity of the novel antimicrobial ceftolozane/tazobactam tested against contemporary clinical strains from USA hospitals (2011). 52ndInterscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting Abstract E-199.
    • Sader, H.S., R.K. Flamm, J.M. Streit & R.N. Jones 2012. Activity of the novel antimicrobial ceftolozane/tazobactam tested against contemporary clinical strains from USA hospitals (2011). 52ndInterscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting Abstract E-199.
    • (2012)
    • Sader, H.S.1    Flamm, R.K.2    Streit, J.M.3    Jones, R.N.4
  • 26
    • 84865424472 scopus 로고    scopus 로고
    • Activity of ceftaroline-avibactam tested against Gram-negative organism populations, including strains expressing one or more β-lactamases and methicillin-resistant Staphylococcus aureus carrying various SCCmec types
    • Castanheira, M., H.S. Sader, D.J. Farrell, R.E. Mendes, R.N. Jones 2012. Activity of ceftaroline-avibactam tested against Gram-negative organism populations, including strains expressing one or more β-lactamases and methicillin-resistant Staphylococcus aureus carrying various SCCmec types. Antimicrob. Agents Chemother. 56: 4779-4785.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 4779-4785
    • Castanheira, M.1    Sader, H.S.2    Farrell, D.J.3    Mendes, R.E.4    Jones, R.N.5
  • 27
    • 79956326529 scopus 로고    scopus 로고
    • In vitro activity of ceftazidime combined with NXL104 versus Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals (CANWARD 2009 study)
    • Walkty, A., M. DeCorby, P.R. Lagac, et al. 2011. In vitro activity of ceftazidime combined with NXL104 versus Pseudomonas aeruginosa isolates obtained from patients in Canadian hospitals (CANWARD 2009 study). Antimicrob. Agents Chemother. 55: 2992-2994.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 2992-2994
    • Walkty, A.1    DeCorby, M.2    Lagac, P.R.3
  • 28
    • 84872836687 scopus 로고    scopus 로고
    • A semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model for MK-7655, a novel β-lactamase inhibitor (BLI) for use in combination with imipenem/cilastatin. 52nd Interscience Conference on Antimicrobial Agents and ChemotherapyAnnual Meeting, Abstract A-1763.
    • Rizk, M.L., G.F. Ahmed, K. Young, et al. 2012. A semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model for MK-7655, a novel β-lactamase inhibitor (BLI) for use in combination with imipenem/cilastatin. 52nd Interscience Conference on Antimicrobial Agents and ChemotherapyAnnual Meeting, Abstract A-1763.
    • (2012)
    • Rizk, M.L.1    Ahmed, G.F.2    Young, K.3
  • 29
    • 84872833416 scopus 로고    scopus 로고
    • Avibactam reverts the MIC90 of a recent set of European clinical isolates of Gram negative bacteria back to the epidemiological cutoff value. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E-187.
    • Flamm, R.K., W. Nichols, H. Sader & R.N. Jones 2012. Avibactam reverts the MIC90 of a recent set of European clinical isolates of Gram negative bacteria back to the epidemiological cutoff value. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E-187.
    • (2012)
    • Flamm, R.K.1    Nichols, W.2    Sader, H.3    Jones, R.N.4
  • 30
    • 84872865484 scopus 로고    scopus 로고
    • Activity of ceftaroline-avibactam against contemporary clinical isolates from USA medical centers. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E186.
    • Sader, H.S., R.K. Flamm, J.M. Streit & R.N. Jones 2012. Activity of ceftaroline-avibactam against contemporary clinical isolates from USA medical centers. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E186.
    • (2012)
    • Sader, H.S.1    Flamm, R.K.2    Streit, J.M.3    Jones, R.N.4
  • 31
    • 84872852992 scopus 로고    scopus 로고
    • Activity of MK-7655 with imipenem vs.β-lactamase producers. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E-192.
    • Livermore, D.M., M. Warner & S. Mushtaq 2012. Activity of MK-7655 with imipenem vs.β-lactamase producers. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract E-192.
    • (2012)
    • Livermore, D.M.1    Warner, M.2    Mushtaq, S.3
  • 32
    • 84861121770 scopus 로고    scopus 로고
    • Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104)
    • Livermore, D.M., S. Mushtaq, K. Barker, et al. 2012. Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104). J. Antimicrob. Chemother. 67: 1354-1358.
    • (2012) J. Antimicrob. Chemother. , vol.67 , pp. 1354-1358
    • Livermore, D.M.1    Mushtaq, S.2    Barker, K.3
  • 33
    • 84872847887 scopus 로고    scopus 로고
    • Importance of NXL-104 pharmacokinetics in the pharmacodynamics of ceftazidime-NXL-104 combinations. 48th Interscience Conference on Antimicrobial Agents and Chemotherapy Abstract A-023.
    • Borgonovi, M., H. Merdjan, A.M. Girard, et al. 2008. Importance of NXL-104 pharmacokinetics in the pharmacodynamics of ceftazidime-NXL-104 combinations. 48th Interscience Conference on Antimicrobial Agents and Chemotherapy Abstract A-023.
    • (2008)
    • Borgonovi, M.1    Merdjan, H.2    Girard, A.M.3
  • 34
    • 84872869260 scopus 로고    scopus 로고
    • A threshold concentration of avibactam during the pharmacokinetic decline ph52nd ase, below which B-lactamase inhibition in Enterobacteriaceae becomes ineffective. Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract A-1760.
    • Nichols, W., P. Levasseur & S. Das 2012. A threshold concentration of avibactam during the pharmacokinetic decline ph52nd ase, below which B-lactamase inhibition in Enterobacteriaceae becomes ineffective. Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract A-1760.
    • (2012)
    • Nichols, W.1    Levasseur, P.2    Das, S.3
  • 35
    • 84872837737 scopus 로고    scopus 로고
    • In vivo efficacy of simulated human exposures of cetazidime-avibactam against Pseudomonas aeruginosa in a hollow fiber model. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract A-632.
    • Schuck, V., M. Tanudra, M.E. Beaudoin, et al. 2012. In vivo efficacy of simulated human exposures of cetazidime-avibactam against Pseudomonas aeruginosa in a hollow fiber model. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract A-632.
    • (2012)
    • Schuck, V.1    Tanudra, M.2    Beaudoin, M.E.3
  • 36
    • 84455161611 scopus 로고    scopus 로고
    • Pharmacodynamics of β-lactamase inhibition by NXL104 in combination with ceftaroline: examining organisms with multiple types of β-lactamases
    • Louie, A., M. Castanheira, W. Liu, et al. 2012. Pharmacodynamics of β-lactamase inhibition by NXL104 in combination with ceftaroline: examining organisms with multiple types of β-lactamases. Antimicrob. Agents Chemother. 56: 258-270.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 258-270
    • Louie, A.1    Castanheira, M.2    Liu, W.3
  • 37
    • 34547841550 scopus 로고    scopus 로고
    • In vitro activity of ceftaroline (PPI-0903M, T-91825) against bacteria with defined resistance mechanisms and phenotypes
    • Mushtaq, S., M. Warner, Y. Ge, et al. 2007. In vitro activity of ceftaroline (PPI-0903M, T-91825) against bacteria with defined resistance mechanisms and phenotypes. J. Antimicrob. Chemother. 60: 300-311
    • (2007) J. Antimicrob. Chemother. , vol.60 , pp. 300-311
    • Mushtaq, S.1    Warner, M.2    Ge, Y.3
  • 38
    • 84872856229 scopus 로고    scopus 로고
    • th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract F1-2142.
    • th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract F1-2142.
    • (2010)
    • Mavridou, E.1    Melchers, R.2    Mil, A.V.3
  • 39
    • 84872833047 scopus 로고    scopus 로고
    • A double-blind randomized phase 2 study to compare the safety and efficacy of intravenous CXA-101 and intravenous ceftazidime in complicated urinary tract infection. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract L1-361A.
    • Umeh, O., D. Cebrik & I.R. Friedland 2010. A double-blind randomized phase 2 study to compare the safety and efficacy of intravenous CXA-101 and intravenous ceftazidime in complicated urinary tract infection. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract L1-361A.
    • (2010)
    • Umeh, O.1    Cebrik, D.2    Friedland, I.R.3
  • 40
    • 84872875135 scopus 로고    scopus 로고
    • Efficacy and safety of ceftazidimeavibactam (ceftazidime/NXL-104) plus metronidazole versus meropenem in the treatment of complicated intraabdominal infections in hospitalized adults. ECCMID Annual Meeting Abstract 1532.
    • Lucasti, C., I. Popescu, M. Ramesh, et al. 2010. Efficacy and safety of ceftazidimeavibactam (ceftazidime/NXL-104) plus metronidazole versus meropenem in the treatment of complicated intraabdominal infections in hospitalized adults. ECCMID Annual Meeting Abstract 1532.
    • (2010)
    • Lucasti, C.1    Popescu, I.2    Ramesh, M.3
  • 41
    • 84872840212 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of ceftazidimeavibactam (ceftazidime/NXL-104) versus imipenemcilastatin in the treatment of complicated urinary tract infections in hospitalized adults. ECCMID Annual Meeting, Abstract 1533.
    • Vasquez, J.A., L.D.G. Patzan, J. Lipka & C. Sable 2010. Efficacy, safety and tolerability of ceftazidimeavibactam (ceftazidime/NXL-104) versus imipenemcilastatin in the treatment of complicated urinary tract infections in hospitalized adults. ECCMID Annual Meeting, Abstract 1533.
    • (2010)
    • Vasquez, J.A.1    Patzan, L.D.G.2    Lipka, J.3    Sable, C.4
  • 42
    • 84872850268 scopus 로고    scopus 로고
    • Discovery of RPX7009, a borad spectrum B-lactamase inhibnitor with utility vs. class A serine carbapenemases. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract F-848.
    • Hecker, S.J., K.R. Reddy, M. Totrov, et al. 2012. Discovery of RPX7009, a borad spectrum B-lactamase inhibnitor with utility vs. class A serine carbapenemases. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract F-848.
    • (2012)
    • Hecker, S.J.1    Reddy, K.R.2    Totrov, M.3
  • 43
    • 84872873735 scopus 로고    scopus 로고
    • Microbiological characterization of the B-lactamase inhibitor RPX7009. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract F-850.
    • Lomovskaya, O., P. King, D. Sun, et al. 2012. Microbiological characterization of the B-lactamase inhibitor RPX7009. 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy Annual Meeting, Abstract F-850.
    • (2012)
    • Lomovskaya, O.1    King, P.2    Sun, D.3
  • 44
    • 78650636489 scopus 로고    scopus 로고
    • Activities of NXL-104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae
    • Livermore, D.M., S. Mushtaq, M. Warner, et al. 2011. Activities of NXL-104 combinations with ceftazidime and aztreonam against carbapenemase-producing Enterobacteriaceae. Antimicrob. Agents and Chemother. 55: 390-394.
    • (2011) Antimicrob. Agents and Chemother. , vol.55 , pp. 390-394
    • Livermore, D.M.1    Mushtaq, S.2    Warner, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.