메뉴 건너뛰기




Volumn 71, Issue 15, 2018, Pages 1696-1706

Myocardial Interstitial Fibrosis in Heart Failure: Biological and Translational Perspectives

Author keywords

diagnosis; fibrosis; heart failure; mechanisms; myocardium; therapeutics

Indexed keywords

COLLAGEN; INTERSTITIAL COLLAGENASE; LISINOPRIL; LOSARTAN; MINERALOCORTICOID ANTAGONIST; PROCOLLAGEN TYPE 1 CARBOXYPROPEPTIDE; PROCOLLAGEN TYPE 3 AMINOPROPEPTIDE; SACUBITRIL PLUS VALSARTAN; SPIRONOLACTONE; TORASEMIDE; UNCLASSIFIED DRUG; VALSARTAN; BIOLOGICAL MARKER;

EID: 85044595745     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2018.02.021     Document Type: Review
Times cited : (484)

References (63)
  • 2
    • 0028230940 scopus 로고
    • Structural remodeling in hypertensive heart disease and the role of hormones
    • Weber, K.T., Sun, Y., Guarda, E., Structural remodeling in hypertensive heart disease and the role of hormones. Hypertension 23;6 Pt 2 (1994), 869–877.
    • (1994) Hypertension , vol.23;6 Pt 2 , pp. 869-877
    • Weber, K.T.1    Sun, Y.2    Guarda, E.3
  • 3
    • 0028154103 scopus 로고
    • Structural basis of end-stage failure in ischemic cardiomyopathy in humans
    • Beltrami, C.A., Finato, N., Rocco, M., et al. Structural basis of end-stage failure in ischemic cardiomyopathy in humans. Circulation 89 (1994), 151–163.
    • (1994) Circulation , vol.89 , pp. 151-163
    • Beltrami, C.A.1    Finato, N.2    Rocco, M.3
  • 4
    • 0021351344 scopus 로고
    • Computer-assisted quantitation of myocardial fibrosis in histologic sections
    • Hoyt, R.H., Ericksen, E., Collins, S.M., Skorton, D.J., Computer-assisted quantitation of myocardial fibrosis in histologic sections. Arch Pathol Lab Med 108 (1984), 280–283.
    • (1984) Arch Pathol Lab Med , vol.108 , pp. 280-283
    • Hoyt, R.H.1    Ericksen, E.2    Collins, S.M.3    Skorton, D.J.4
  • 5
    • 85042599386 scopus 로고    scopus 로고
    • Reappraising myocardial fibrosis in severe aortic stenosis: an invasive and non-invasive study in 133 patients
    • Treibel, T.A., López, B., González, A., et al. Reappraising myocardial fibrosis in severe aortic stenosis: an invasive and non-invasive study in 133 patients. Eur Heart J 39 (2018), 699–709.
    • (2018) Eur Heart J , vol.39 , pp. 699-709
    • Treibel, T.A.1    López, B.2    González, A.3
  • 6
    • 84894466867 scopus 로고    scopus 로고
    • Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure
    • López, B., González, A., Querejeta, R., Larman, M., Rábago, G., Díez, J., Association of cardiotrophin-1 with myocardial fibrosis in hypertensive patients with heart failure. Hypertension 63 (2014), 483–489.
    • (2014) Hypertension , vol.63 , pp. 483-489
    • López, B.1    González, A.2    Querejeta, R.3    Larman, M.4    Rábago, G.5    Díez, J.6
  • 7
    • 85020397006 scopus 로고    scopus 로고
    • Role of myocardial collagen in severe aortic stenosis with preserved ejection fraction and symptoms of heart failure
    • Echegaray, K., Andreu, I., Lazkano, A., et al. Role of myocardial collagen in severe aortic stenosis with preserved ejection fraction and symptoms of heart failure. Rev Esp Cardiol (English ed) 70 (2017), 832–840.
    • (2017) Rev Esp Cardiol (English ed) , vol.70 , pp. 832-840
    • Echegaray, K.1    Andreu, I.2    Lazkano, A.3
  • 8
    • 0026079936 scopus 로고
    • Alteration of collagen phenotypes in ischemic cardiomyopathy
    • Mukherjee, D., Sen, S., Alteration of collagen phenotypes in ischemic cardiomyopathy. J Clin Invest 88 (1991), 1141–1146.
    • (1991) J Clin Invest , vol.88 , pp. 1141-1146
    • Mukherjee, D.1    Sen, S.2
  • 9
    • 67650726873 scopus 로고    scopus 로고
    • Collagen structure and stability
    • Shoulders, M.D., Raines, R.T., Collagen structure and stability. Annu Rev Biochem 78 (2009), 929–958.
    • (2009) Annu Rev Biochem , vol.78 , pp. 929-958
    • Shoulders, M.D.1    Raines, R.T.2
  • 10
    • 79951611029 scopus 로고    scopus 로고
    • Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction
    • Kasner, M., Westermann, D., López, B., et al. Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction. J Am Coll Cardiol 57 (2011), 977–985.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 977-985
    • Kasner, M.1    Westermann, D.2    López, B.3
  • 11
    • 84865497468 scopus 로고    scopus 로고
    • Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase
    • López, B., Querejeta, R., González, A., et al. Collagen cross-linking but not collagen amount associates with elevated filling pressures in hypertensive patients with stage C heart failure: potential role of lysyl oxidase. Hypertension 60 (2012), 677–683.
    • (2012) Hypertension , vol.60 , pp. 677-683
    • López, B.1    Querejeta, R.2    González, A.3
  • 12
    • 84929376932 scopus 로고    scopus 로고
    • Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin
    • Zile, M.R., Baicu, C.F., Ikonomidis, J., et al. Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin. Circulation 131 (2015), 1247–1259.
    • (2015) Circulation , vol.131 , pp. 1247-1259
    • Zile, M.R.1    Baicu, C.F.2    Ikonomidis, J.3
  • 14
  • 15
    • 84957586420 scopus 로고    scopus 로고
    • Non-coding RNAs as modulators of the cardiac fibroblast phenotype
    • Piccoli, M.T., Bär, C., Thum, T., Non-coding RNAs as modulators of the cardiac fibroblast phenotype. J Mol Cell Cardiol 92 (2016), 75–81.
    • (2016) J Mol Cell Cardiol , vol.92 , pp. 75-81
    • Piccoli, M.T.1    Bär, C.2    Thum, T.3
  • 16
    • 84958532091 scopus 로고    scopus 로고
    • Myofibroblast secretome and its auto-paracrine signaling
    • Bomb, R., Heckle, M.R., Sun, Y., et al. Myofibroblast secretome and its auto-paracrine signaling. Expert Rev Cardiovasc Ther 14 (2016), 591–598.
    • (2016) Expert Rev Cardiovasc Ther , vol.14 , pp. 591-598
    • Bomb, R.1    Heckle, M.R.2    Sun, Y.3
  • 17
    • 0029020059 scopus 로고
    • Collagen turnover and its regulation in the normal and hypertrophying heart
    • Bishop, J.E., Laurent, G.J., Collagen turnover and its regulation in the normal and hypertrophying heart. Eur Heart J 16 Suppl C (1995), 38–44.
    • (1995) Eur Heart J , vol.16 Suppl C , pp. 38-44
    • Bishop, J.E.1    Laurent, G.J.2
  • 18
    • 84961202173 scopus 로고    scopus 로고
    • Lysyl oxidase isoforms and potential therapeutic opportunities for fibrosis and cancer
    • Trackman, P.C., Lysyl oxidase isoforms and potential therapeutic opportunities for fibrosis and cancer. Expert Opin Ther Targets 20 (2016), 935–945.
    • (2016) Expert Opin Ther Targets , vol.20 , pp. 935-945
    • Trackman, P.C.1
  • 19
    • 18844395926 scopus 로고    scopus 로고
    • The type of collagen cross-link determines the reversibility of experimental skin fibrosis
    • van der Slot-Verhoven, A.J., van Dura, E.A., Attema, J., et al. The type of collagen cross-link determines the reversibility of experimental skin fibrosis. Biochim Biophys Acta 1740 (2005), 60–67.
    • (2005) Biochim Biophys Acta , vol.1740 , pp. 60-67
    • van der Slot-Verhoven, A.J.1    van Dura, E.A.2    Attema, J.3
  • 20
    • 80054948842 scopus 로고    scopus 로고
    • Prognostic impact of myocardial interstitial fibrosis in non-ischemic heart failure. Comparison between preserved and reduced ejection fraction heart failure
    • Aoki, T., Fukumoto, Y., Sugimura, K., et al. Prognostic impact of myocardial interstitial fibrosis in non-ischemic heart failure. Comparison between preserved and reduced ejection fraction heart failure. Circ J 75 (2011), 2605–2613.
    • (2011) Circ J , vol.75 , pp. 2605-2613
    • Aoki, T.1    Fukumoto, Y.2    Sugimura, K.3
  • 21
    • 0027449199 scopus 로고
    • Influence of collagen network on left ventricular systolic and diastolic function in aortic valve disease
    • Villari, B., Campbell, S.E., Hess, O.M., et al. Influence of collagen network on left ventricular systolic and diastolic function in aortic valve disease. J Am Coll Cardiol 22 (1993), 1477–1484.
    • (1993) J Am Coll Cardiol , vol.22 , pp. 1477-1484
    • Villari, B.1    Campbell, S.E.2    Hess, O.M.3
  • 23
    • 0025149391 scopus 로고
    • Ventricular arrhythmias in hypertensive left ventricular hypertrophy. Relationship to coronary artery disease, left ventricular dysfunction, and myocardial fibrosis
    • McLenachan, J.M., Dargie, H.J., Ventricular arrhythmias in hypertensive left ventricular hypertrophy. Relationship to coronary artery disease, left ventricular dysfunction, and myocardial fibrosis. Am J Hypertens 3 (1990), 735–740.
    • (1990) Am J Hypertens , vol.3 , pp. 735-740
    • McLenachan, J.M.1    Dargie, H.J.2
  • 24
    • 0029046956 scopus 로고
    • Progression of heart failure: a role for interstitial fibrosis
    • Sabbah, H.N., Sharov, V.G., Lesch, M., Goldstein, S., Progression of heart failure: a role for interstitial fibrosis. Mol Cell Biochem 147 (1995), 29–34.
    • (1995) Mol Cell Biochem , vol.147 , pp. 29-34
    • Sabbah, H.N.1    Sharov, V.G.2    Lesch, M.3    Goldstein, S.4
  • 25
    • 84868613300 scopus 로고    scopus 로고
    • Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure
    • Dai, Z., Aoki, T., Fukumoto, Y., Shimokawa, H., Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure. J Cardiol 60 (2012), 416–421.
    • (2012) J Cardiol , vol.60 , pp. 416-421
    • Dai, Z.1    Aoki, T.2    Fukumoto, Y.3    Shimokawa, H.4
  • 26
    • 77955622287 scopus 로고    scopus 로고
    • Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease
    • Azevedo, C.F., Nigri, M., Higuchi, M.L., et al. Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease. J Am Coll Cardiol 56 (2010), 278–287.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 278-287
    • Azevedo, C.F.1    Nigri, M.2    Higuchi, M.L.3
  • 27
    • 0027446977 scopus 로고
    • Which subgroup of patients with dilated cardiomyopathy would benefit from long-term beta-blocker therapy? A histologic viewpoint
    • Yamada, T., Fukunami, M., Ohmori, M., et al. Which subgroup of patients with dilated cardiomyopathy would benefit from long-term beta-blocker therapy? A histologic viewpoint. J Am Coll Cardiol 21 (1993), 628–633.
    • (1993) J Am Coll Cardiol , vol.21 , pp. 628-633
    • Yamada, T.1    Fukunami, M.2    Ohmori, M.3
  • 28
    • 84957797234 scopus 로고    scopus 로고
    • Myocardial collagen cross-linking is associated with heart failure hospitalization in patients with hypertensive heart failure
    • López, B., Ravassa, S., González, A., et al. Myocardial collagen cross-linking is associated with heart failure hospitalization in patients with hypertensive heart failure. J Am Coll Cardiol 67 (2016), 251–260.
    • (2016) J Am Coll Cardiol , vol.67 , pp. 251-260
    • López, B.1    Ravassa, S.2    González, A.3
  • 29
    • 85021814890 scopus 로고    scopus 로고
    • Phenotyping of myocardial fibrosis in hypertensive patients with heart failure. Influence on clinical outcome
    • Ravassa, S., López, B., Querejeta, R., et al. Phenotyping of myocardial fibrosis in hypertensive patients with heart failure. Influence on clinical outcome. J Hypertens 35 (2017), 853–861.
    • (2017) J Hypertens , vol.35 , pp. 853-861
    • Ravassa, S.1    López, B.2    Querejeta, R.3
  • 30
    • 84930912130 scopus 로고    scopus 로고
    • Circulating biomarkers of myocardial fibrosis: the need for a reappraisal
    • López, B., González, A., Ravassa, S., et al. Circulating biomarkers of myocardial fibrosis: the need for a reappraisal. J Am Coll Cardiol 65 (2015), 2449–2456.
    • (2015) J Am Coll Cardiol , vol.65 , pp. 2449-2456
    • López, B.1    González, A.2    Ravassa, S.3
  • 31
    • 0029006974 scopus 로고
    • Collagens: molecular biology, diseases, and potentials for therapy
    • Prockop, D.J., Kivirikko, K.I., Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem 64 (1995), 403–434.
    • (1995) Annu Rev Biochem , vol.64 , pp. 403-434
    • Prockop, D.J.1    Kivirikko, K.I.2
  • 32
    • 4444229005 scopus 로고    scopus 로고
    • Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis
    • Querejeta, R., López, B., González, A., et al. Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis. Circulation 110 (2004), 1263–1268.
    • (2004) Circulation , vol.110 , pp. 1263-1268
    • Querejeta, R.1    López, B.2    González, A.3
  • 33
    • 17144455013 scopus 로고    scopus 로고
    • Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure
    • López, B., Querejeta, R., González, A., Sánchez, E., Larman, M., Díez, J., Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure. J Am Coll Cardiol 43 (2004), 2028–2035.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 2028-2035
    • López, B.1    Querejeta, R.2    González, A.3    Sánchez, E.4    Larman, M.5    Díez, J.6
  • 34
    • 27744459326 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study
    • Izawa, H., Murohara, T., Nagata, K., et al. Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study. Circulation 112 (2005), 2940–2945.
    • (2005) Circulation , vol.112 , pp. 2940-2945
    • Izawa, H.1    Murohara, T.2    Nagata, K.3
  • 35
    • 84907235563 scopus 로고    scopus 로고
    • Biomarkers of collagen type I metabolism are related to B-type natriuretic peptide, left ventricular size, and diastolic function in heart failure
    • Löfsjögård, J., Kahan, T., Díez, J., et al. Biomarkers of collagen type I metabolism are related to B-type natriuretic peptide, left ventricular size, and diastolic function in heart failure. J Cardiovasc Med (Hagerstown) 15 (2014), 463–469.
    • (2014) J Cardiovasc Med (Hagerstown) , vol.15 , pp. 463-469
    • Löfsjögård, J.1    Kahan, T.2    Díez, J.3
  • 36
    • 81855171057 scopus 로고    scopus 로고
    • Relation of peripheral collagen markers to death and hospitalization in patients with heart failure and preserved ejection fraction: results of the I-PRESERVE collagen substudy
    • Krum, H., Elsik, M., Schneider, H.G., et al. Relation of peripheral collagen markers to death and hospitalization in patients with heart failure and preserved ejection fraction: results of the I-PRESERVE collagen substudy. Circ Heart Fail 4 (2011), 561–568.
    • (2011) Circ Heart Fail , vol.4 , pp. 561-568
    • Krum, H.1    Elsik, M.2    Schneider, H.G.3
  • 37
    • 85018286678 scopus 로고    scopus 로고
    • Usefulness of collagen carboxy-terminal propeptide and telopeptide to predict disturbances of long-term mortality in patients ≥60 years with heart failure and reduced ejection fraction
    • Löfsjögård, J., Kahan, T., Díez, J., et al. Usefulness of collagen carboxy-terminal propeptide and telopeptide to predict disturbances of long-term mortality in patients ≥60 years with heart failure and reduced ejection fraction. Am J Cardiol 119 (2017), 2042–2048.
    • (2017) Am J Cardiol , vol.119 , pp. 2042-2048
    • Löfsjögård, J.1    Kahan, T.2    Díez, J.3
  • 38
    • 84867548106 scopus 로고    scopus 로고
    • Serum markers of deranged myocardial collagen turnover: their relation to malignant ventricular arrhythmias in cardioverter-defibrillator recipients with heart failure
    • Flevari, P., Theodorakis, G., Leftheriotis, D., et al. Serum markers of deranged myocardial collagen turnover: their relation to malignant ventricular arrhythmias in cardioverter-defibrillator recipients with heart failure. Am Heart J 164 (2012), 530–537.
    • (2012) Am Heart J , vol.164 , pp. 530-537
    • Flevari, P.1    Theodorakis, G.2    Leftheriotis, D.3
  • 39
    • 0028920377 scopus 로고
    • Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis
    • Klappacher, G., Franzen, P., Haab, D., et al. Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis. Am J Cardiol 75 (1995), 913–918.
    • (1995) Am J Cardiol , vol.75 , pp. 913-918
    • Klappacher, G.1    Franzen, P.2    Haab, D.3
  • 40
    • 0034727695 scopus 로고    scopus 로고
    • Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators
    • Zannad, F., Alla, F., Dousset, B., Perez, A., Pitt, B., Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators. Circulation 102 (2000), 2700–2706.
    • (2000) Circulation , vol.102 , pp. 2700-2706
    • Zannad, F.1    Alla, F.2    Dousset, B.3    Perez, A.4    Pitt, B.5
  • 41
    • 84874719002 scopus 로고    scopus 로고
    • Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy
    • Gulati, A., Jabbour, A., Ismail, T.F., et al. Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy. JAMA 309 (2013), 896–908.
    • (2013) JAMA , vol.309 , pp. 896-908
    • Gulati, A.1    Jabbour, A.2    Ismail, T.F.3
  • 42
    • 85021854474 scopus 로고    scopus 로고
    • Employing extracellular volume cardiovascular magnetic resonance measures of myocardial fibrosis to foster novel therapeutics
    • Schelbert, E.B., Sabbah, H.N., Butler, J., Gheorghiade, M., Employing extracellular volume cardiovascular magnetic resonance measures of myocardial fibrosis to foster novel therapeutics. Circ Cardiovasc Imaging, 10, 2017, e005619.
    • (2017) Circ Cardiovasc Imaging , vol.10
    • Schelbert, E.B.1    Sabbah, H.N.2    Butler, J.3    Gheorghiade, M.4
  • 43
    • 85010669626 scopus 로고    scopus 로고
    • Myocardial fibrosis and cardiac decompensation in aortic stenosis
    • Chin, C.W., Everett, R.J., Kwiecinski, J., et al. Myocardial fibrosis and cardiac decompensation in aortic stenosis. J Am Coll Cardiol Img 10 (2017), 1320–1333.
    • (2017) J Am Coll Cardiol Img , vol.10 , pp. 1320-1333
    • Chin, C.W.1    Everett, R.J.2    Kwiecinski, J.3
  • 44
    • 84991406890 scopus 로고    scopus 로고
    • Myocardial fibrosis quantified by extracellular volume is associated with subsequent hospitalization for heart failure, death, or both across the spectrum of ejection fraction and heart failure stage
    • Schelbert, E.B., Piehler, K.M., Zareba, K.M., et al. Myocardial fibrosis quantified by extracellular volume is associated with subsequent hospitalization for heart failure, death, or both across the spectrum of ejection fraction and heart failure stage. J Am Heart Assoc, 4, 2015, e002613.
    • (2015) J Am Heart Assoc , vol.4
    • Schelbert, E.B.1    Piehler, K.M.2    Zareba, K.M.3
  • 45
    • 85039851026 scopus 로고    scopus 로고
    • Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis
    • Diao, K., Yang, Z., Xu, H., et al. Histologic validation of myocardial fibrosis measured by T1 mapping: a systematic review and meta-analysis. J Cardiovasc Magn Reson, 18, 2016, 92.
    • (2016) J Cardiovasc Magn Reson , vol.18 , pp. 92
    • Diao, K.1    Yang, Z.2    Xu, H.3
  • 46
    • 84879987413 scopus 로고    scopus 로고
    • Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume
    • Miller, C.A., Naish, J., Bishop, P., et al. Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume. Circ Cardiovasc Imaging 6 (2013), 373–383.
    • (2013) Circ Cardiovasc Imaging , vol.6 , pp. 373-383
    • Miller, C.A.1    Naish, J.2    Bishop, P.3
  • 47
    • 84872905484 scopus 로고    scopus 로고
    • Comparison of T1 mapping techniques for ECV quantification. Histological validation and reproducibility of ShMOLLI versus multibreath-hold T1 quantification equilibrium contrast CMR
    • Fontana, M., White, S.K., Banypersad, S.M., et al. Comparison of T1 mapping techniques for ECV quantification. Histological validation and reproducibility of ShMOLLI versus multibreath-hold T1 quantification equilibrium contrast CMR. J Cardiovasc Magn Reson, 14, 2012, 88.
    • (2012) J Cardiovasc Magn Reson , vol.14 , pp. 88
    • Fontana, M.1    White, S.K.2    Banypersad, S.M.3
  • 48
    • 79958028694 scopus 로고    scopus 로고
    • Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus
    • Schelbert, E.B., Testa, S.M., Meier, C.G., et al. Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus. J Cardiovasc Magn Reson, 13, 2011, 16.
    • (2011) J Cardiovasc Magn Reson , vol.13 , pp. 16
    • Schelbert, E.B.1    Testa, S.M.2    Meier, C.G.3
  • 49
    • 84898890012 scopus 로고    scopus 로고
    • Optimization and comparison of myocardial T1 techniques at 3T in patients with aortic stenosis
    • Chin, C.W., Semple, S., Malley, T., et al. Optimization and comparison of myocardial T1 techniques at 3T in patients with aortic stenosis. Eur Heart J Cardiovasc Imaging 15 (2014), 556–565.
    • (2014) Eur Heart J Cardiovasc Imaging , vol.15 , pp. 556-565
    • Chin, C.W.1    Semple, S.2    Malley, T.3
  • 50
    • 84940566690 scopus 로고    scopus 로고
    • Myocardial T1 and extracellular volume fraction measurement in asymptomatic patients with aortic stenosis: reproducibility and comparison with age-matched controls
    • Singh, A., Horsfield, M.A., Bekele, S., Khan, J., Greiser, A., McCann, G.P., Myocardial T1 and extracellular volume fraction measurement in asymptomatic patients with aortic stenosis: reproducibility and comparison with age-matched controls. Eur Heart J Cardiovasc Imaging 16 (2015), 763–770.
    • (2015) Eur Heart J Cardiovasc Imaging , vol.16 , pp. 763-770
    • Singh, A.1    Horsfield, M.A.2    Bekele, S.3    Khan, J.4    Greiser, A.5    McCann, G.P.6
  • 51
    • 85032642734 scopus 로고    scopus 로고
    • Temporal relation between myocardial fibrosis and heart failure with preserved ejection fraction: association with baseline disease severity and subsequent outcome JAMA
    • Schelbert, E.B., Fridman, Y., Wong, T.C., et al. Temporal relation between myocardial fibrosis and heart failure with preserved ejection fraction: association with baseline disease severity and subsequent outcome JAMA. Cardiol 2 (2017), 1–12.
    • (2017) Cardiol , vol.2 , pp. 1-12
    • Schelbert, E.B.1    Fridman, Y.2    Wong, T.C.3
  • 52
    • 85014177594 scopus 로고    scopus 로고
    • Automatic quantification of the myocardial extracellular volume by cardiac computed tomography: synthetic ECV by CCT
    • Treibel, T.A., Fontana, M., Steeden, J.A., et al. Automatic quantification of the myocardial extracellular volume by cardiac computed tomography: synthetic ECV by CCT. J Cardiovasc Comput Tomogr 11 (2017), 221–226.
    • (2017) J Cardiovasc Comput Tomogr , vol.11 , pp. 221-226
    • Treibel, T.A.1    Fontana, M.2    Steeden, J.A.3
  • 53
    • 84952902243 scopus 로고    scopus 로고
    • T1-mapping and outcome in nonischemic cardiomyopathy: All-cause mortality and heart failure
    • Puntmann, V.O., Carr-White, G., Jabbour, A., et al. T1-mapping and outcome in nonischemic cardiomyopathy: All-cause mortality and heart failure. J Am Coll Cardiol Img 9 (2016), 40–50.
    • (2016) J Am Coll Cardiol Img , vol.9 , pp. 40-50
    • Puntmann, V.O.1    Carr-White, G.2    Jabbour, A.3
  • 54
    • 0034687149 scopus 로고    scopus 로고
    • Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease
    • Brilla, C.G., Funck, R.C., Rupp, H., Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease. Circulation 102 (2000), 1388–1393.
    • (2000) Circulation , vol.102 , pp. 1388-1393
    • Brilla, C.G.1    Funck, R.C.2    Rupp, H.3
  • 55
    • 0037188574 scopus 로고    scopus 로고
    • Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients
    • Díez, J., Querejeta, R., López, B., et al. Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients. Circulation 105 (2002), 2512–2517.
    • (2002) Circulation , vol.105 , pp. 2512-2517
    • Díez, J.1    Querejeta, R.2    López, B.3
  • 56
    • 59849107057 scopus 로고    scopus 로고
    • Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure
    • López, B., Querejeta, R., González, A., Beaumont, J., Larman, M., Díez, J., Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure. Hypertension 53 (2009), 236–242.
    • (2009) Hypertension , vol.53 , pp. 236-242
    • López, B.1    Querejeta, R.2    González, A.3    Beaumont, J.4    Larman, M.5    Díez, J.6
  • 57
    • 84955612078 scopus 로고    scopus 로고
    • Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease
    • Gourdie, R.G., Dimmeler, S., Kohl, P., Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease. Nat Rev Drug Discov 15 (2016), 620–638.
    • (2016) Nat Rev Drug Discov , vol.15 , pp. 620-638
    • Gourdie, R.G.1    Dimmeler, S.2    Kohl, P.3
  • 59
    • 85011561353 scopus 로고    scopus 로고
    • Myocardial fibrosis: biomedical research from bench to bedside
    • Gyöngyösi, M., Winkler, J., Ramos, I., et al. Myocardial fibrosis: biomedical research from bench to bedside. Eur J Heart Fail 19 (2017), 177–191.
    • (2017) Eur J Heart Fail , vol.19 , pp. 177-191
    • Gyöngyösi, M.1    Winkler, J.2    Ramos, I.3
  • 60
    • 84982806121 scopus 로고    scopus 로고
    • Effect of omega-3 acid ethyl esters on left ventricular remodeling after acute myocardial infarction: the OMEGA-REMODEL randomized clinical trial
    • Heydari, B., Abdullah, S., Pottala, J.V., et al. Effect of omega-3 acid ethyl esters on left ventricular remodeling after acute myocardial infarction: the OMEGA-REMODEL randomized clinical trial. Circulation 134 (2016), 378–391.
    • (2016) Circulation , vol.134 , pp. 378-391
    • Heydari, B.1    Abdullah, S.2    Pottala, J.V.3
  • 61
    • 85044535810 scopus 로고    scopus 로고
    • Reverse myocardial remodeling in aortic stenosis: Cellular hypertrophy and extracellular volume but not focal fibrosis regress following aortic valve replacement
    • Treibel, T.A., Kozor, R., Schofield, R., et al. Reverse myocardial remodeling in aortic stenosis: Cellular hypertrophy and extracellular volume but not focal fibrosis regress following aortic valve replacement. J Am Coll Cardiol 71 (2018), 860–871.
    • (2018) J Am Coll Cardiol , vol.71 , pp. 860-871
    • Treibel, T.A.1    Kozor, R.2    Schofield, R.3
  • 62
    • 21244431940 scopus 로고    scopus 로고
    • Effect of MR blockade on collagen formation and cardiovascular disease with a specific emphasis on heart failure
    • Zannad, F., Radauceanu, A., Effect of MR blockade on collagen formation and cardiovascular disease with a specific emphasis on heart failure. Heart Fail Rev 10 (2005), 71–78.
    • (2005) Heart Fail Rev , vol.10 , pp. 71-78
    • Zannad, F.1    Radauceanu, A.2
  • 63
    • 84955263484 scopus 로고    scopus 로고
    • Plasma biomarkers reflecting profibrotic processes in heart failure with a preserved ejection fraction: data from the Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction study
    • Zile, M.R., Jhund, P.S., Baicu, C.F., et al., for the Prospective Comparison of ARNI with ARB on management of heart failure with preserved ejection fraction (PARAMOUNT) Investigators. Plasma biomarkers reflecting profibrotic processes in heart failure with a preserved ejection fraction: data from the Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction study. Circ Heart Fail, 9, 2016, e002551.
    • (2016) Circ Heart Fail , vol.9
    • Zile, M.R.1    Jhund, P.S.2    Baicu, C.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.