Ellagic acid attenuates arsenic induced neuro-inflammation and mitochondrial dysfunction associated apoptosis

Toxicology Reports

Volumn 5, Issue , 2018, Pages 411-417

  Firdaus, Fakiha ^a   Zafeer, Mohd Faraz ^a   Anis, Ehraz ^a   Ahmad, Masood ^a   Afzal, Mohammad ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

Arsenic; Ellagic acid; Inflammation; Mitochondrial membrane potential; Neurotoxicity; ROS generation

Indexed keywords

CASPASE 3; ELLAGIC ACID; GAMMA INTERFERON; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARSENIC POISONING; ARTICLE; BIOCHEMICAL ANALYSIS; COMET ASSAY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; DOWN REGULATION; DRUG DOSE COMPARISON; ENZYME ACTIVITY; FLOW CYTOMETRY; HIPPOCAMPAL CA1 REGION; IMMUNOASSAY; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 85044122856     PISSN: 22147500     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxrep.2018.02.017     Document Type: Article

References (52)

1. Das, A.K., Bag, S., Sahu, R., Dua, T.K., Sinha, M.K., Gangopadhya, M., Protective effect of Corchorus olitorius leaves on sodium arsenite-induced toxicity in experimental rats. Food Chem. Toxicol. 48 (2010), 326–335.
2. Rodríguez, V.M., Jiménez-Capdeville, M.E., Giordano, M., The effects of arsenic exposure on the nervous system. Toxicol. Lett. 145 (2003), 1–18.
3. Jin, Y., Xi, S., Li, X., Lu, C., Li, G., Xu, Y., Qu, C., Niu, Y., Sun, G., Arsenic speciation transported through the placenta from mother mice to their newborn pups. Environ. Res. 101 (2006), 349–355.
4. Rodriguez, V.M., Carrizales, L., Jimenez-Capdeville, M.E., Dufour, L., Giordano, M., The effect of sodium arsenite exposure on behavioral parameters in the rat. Brain Res. Bull. 55 (2001), 301–308.
5. Rosado, J.L., Ronquillo, D., Kordas, K., Rojas, O., Alatorre, J., Lopez, P., Arsenic exposure and cognitive performance in Mexican schoolchildren. Environ. Health Perspect. 115 (2007), 1371–1375.
6. Kannan, G.M., Tripathi, N., Dube, S.N., Gupta, M., Flora, S.J., Toxic effects of arsenic (III) on some hematopoietic and central nervous system variables in rats and guinea pigs. J. Toxicol. Clin. Toxicol. 39 (2001), 675–682.
7. Rodriguez, V.M., Dufour, L., Carrizales, L., Diaz-Barriga, F., Jimenez-Capdeville, M.E., Effects of oral exposure to mining waste on in vivo dopamine release from rat striatum. Environ. Health Perspect. 106 (1998), 487–491.
8. Luo, J.H., Qiu, Z.Q., Shu, W.Q., Zhang, Y.Y., Zhang, L., Chen, J.A., Effects of arsenic exposure from drinking water on spatial memory, ultra-structures and NMDAR gene expression of hippocampus in rats. Toxicol. Lett. 184 (2009), 121–125.
9. Wang, Y., Li, S., Piao, F., Hong, Y., Liu, P., Zhao, Y., Arsenic down-regulates the expression of Camk4, an important gene related to cerebellar LTD in mice. Neurotoxicol. Teratol. 31 (2009), 318–322.
10. Tripathi, N., Kannan, G.M., Pant, B.P., Jaiswal, D.K., Malhotra, P.R., Flora, J.S., Arsenic-induced changes in certain neurotransmitter levels and their recoveries following chelation in rat whole brain. Toxicol. Lett. 92 (1997), 201–208.
11. Flora, S.J., Bhatt, K., Mehta, A., Arsenic moiety in gallium arsenide is responsible for neuronal apoptosis and behavioral alterations in rats. Toxicol. Appl. Pharmacol. 240 (2009), 236–244.
12. Flora, S.J., Arsenic-induced oxidative stress and its reversibility. Free Radic. Biol. Med. 51 (2011), 257–281.
13. Sinha, M., Manna, P., Sil, P.C., Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain. J. Biochem. Mol. Toxicol. 22 (2008), 15–26.
14. Barchowsky, A., Dudek, E.J., Treadwell, M.D., Wetterharn, K.E., Arsenic induces oxidant stress and NF-κB activation in cultured aortic endothelial cells. Free Radic. Biol. Med. 21 (1996), 783–790.
15. Gurr, J.R., Yih, L.H., Samikkannu, T., Bau, D.T., Lin, S.Y., Jan, K.Y., Nitric oxide production by arsenite. Mutat. Res. 533 (2003), 173–182.
16. Lynn, S., Gurr, J.R., Lai, H.T., Jan, K.Y., NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells. Circ. Res. 86 (2000), 514–519.
17. Aposhian, H.V., Aposhian, M.M., Arsenic toxicology: five questions. Chem. Res. Toxicol. 19 (2006), 1–15.
18. Shila, S., Kokilavani, V., Subathra, M., Panneerselvam, C., Brain regional response in antioxidant system to a-lipoic acid in arsenic intoxicated rat. Toxicology 210 (2005), 25–36.
19. Shila, S., Ramanathan, K., Tamilselvan, J., Panneerselvam, C., Protein oxidative damage in arsenic induced rat brain: influence of DL-αlipoic acid. Toxicol. Lett. 155 (2005), 27–34.
20. WHO, Exposure to Arsenic: A Major Public Health Concern. 2010, WHO Press, Geneva.
21. Anderson, K.J., Teuber, S.S., Gobeille, A., Cremin, P., Waterhouse, A.L., Steinberg, F.M., Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. J. Nutr. 131 (2001), 2837–2842.
22. Sellappan, S., Akoh, C.C., Krewer, G., Phenolic compounds and antioxidant capacity of Georgia grown blueberries and blackberries. J. Agric. Food Chem. 50 (2002), 2432–2438.
23. Wada, L., Ou, B., Antioxidant activity and phenolic content of Oregon caneberries. J. Agric. Food Chem. 50 (2002), 3495–3500.
24. Iino, T., Tashima, K., Umeda, M., Ogawa, Y., Takeeda, M., Takata, K., Takeuchi, K., Effect of ellagic acid on gastric damage induced in ischemic rat stomachs following ammonia or reperfusion. Life Sci. 70 (2002), 1139–1150.
25. Lei, F., Xing, D.M., Xiang, L., Pharmacokinetic study of ellagic acid in rat after oral administration of pomegranate leaf extract. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 796 (2003), 189–194.
26. Priyadarsini, K.I., Khopde, S.M., Kumar, S.S., Mohan, H., Free radical studies of ellagic acid, a natural phenolic antioxidant. J. Agric. Food Chem. 50 (2002), 2200–2206.
27. Cozzi, R., Ricordy, R., Bartolini, F., Ramadori, L., Perticone, P., De Salvia, R., Taurine and ellagic acid: two differently-acting natural antioxidants. Environ. Mol. Mutagen. 26 (1995), 248–254.
28. Iino, T., Nakahara, K., Miki, W., Kiso, Y., Ogawa, Y., Kato, S., Takeuchi, K., Less damaging effect of whisky in rat stomachs in comparison with pure ethanol: role of ellagic acid the nonalcoholic component. Digestion 64 (2001), 214–221.
29. Laranjinha, J., Vierira, O., Almeida, L., Madeira, V., Inhibition of metmyoglobin/H2O2-dependent low density lipoprotein lipid peroxidation by naturally occurring phenolic acids. Biochem. Pharmacol. 51 (1996), 395–402.
30. Takagi, A., Sai, K., Umemura, T., Hasegawa, R., Kurokawa, Y., Inhibitory effects of vitamin E and ellagic acid on 8-hydroxydeoxyguanosine formation in liver nuclear DNA of rats treated with 2-nitropropane. Cancer Lett. 91 (1995), 139–144.
31. Ayhanci, A., Cengiz, M., Mehtap Kutlu, H., Vejselova, D., Protective effects of ellagic acid in D-galactosamine-induced kidney damage in rats. Cytotechnol 68 (2016), 1763–1770.
32. Bhattacharya, S., Haldar, P.K., Ameliorative effect Trichosanthes dioica root against experimentally induced arsenic toxicity in male albino rats. Environ. Toxicol. Pharmacol. 33 (2012), 394–402.
33. Gu, L., Deng, W.S., Liu, Y., Jiang, C.H., Sun, L.C., Sun, X.F., Xu, Q., Zhou, H., Ellagic acid protects lipopolysachharide/D-galactosamine-induced acute hepatic injury in mice. Int. Immunopharmacol. 22 (2014), 341–345.
34. Singh, N.P., McCoy, M.T., Tice, R.R., Schneider, E.L., A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175 (1988), 184–191.
35. Baluchnejadmojarad, T., Rabiee, N., Zabihnejad, S., Roghani, M., Ellagic acid exerts protective effect in intrastriatal 6-hydroxydopamine rat model of Parkinson's disease: possible involvement of ERβ/Nrf2/HO-1 signaling. Brain Res. 1662 (2017), 23–30.
36. Hwang, J.M., Cho, J.S., Kim, T.H., Lee, Y.I., Ellagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species. Biomed. Pharmacother. 64 (2010), 264–270.
37. Kiasalari, Z., Heydarifard, R., Khalili, M., Afshin-Majd, S., Baluchnejadmojarad, T., Zahedi, E., Sanaierad, A., Roghani, M., Ellagic acid ameliorates learning and memory deficits in a rat model of Alzheimer's disease: an exploration of underlying mechanisms. Psychopharmacology (Berl) 234 (2017), 1841–1852.
38. Deng, W., Garrett, C., Dombert, B., Soura, V., Banks, G., Fisher, E.M., van der Brug, M.P., Hafezparast, M., Neurodegenerative mutation in cytoplasmic dynein alters its organization and dynein-dynactin and dynein-kinesin interactions. J. Biol. Chem. 285 (2010), 39922–39934.
39. Kaufmann, S.H., Hengartner, M.O., Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 11 (2001), 526–534.
40. Mc Donald, E.R., El-Deiry, W.S., Cell cycle control as a basis for cancer drug development. Int. J. Oncol. 16 (2000), 871–886.
41. Desagher, S., Martinou, J.C., Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10 (2000), 369–377.
42. Green, D.R., Kroemer, G., The pathophysiology of mitochondrial cell death. Science 305 (2004), 626–629.
43. Kühlbrandt, W., Structure and function of mitochondrial membrane protein complexes. BMC Biol., 13, 2015, 89.
44. Chalmers, S., McCarron, J.G., The mitochondrial membrane potential and Ca2 + oscillations in smooth muscle. J. Cell Sci. 121 (2008), 75–85.
45. Marchi, S., Giorgi, C., Suski, J.M., Agnoletto, C., Bononi, A., Bonora, M., De Marchi, E., Missiroli, S., Patergnani, S., Poletti, F., Rimessi, A., Duszynski, J., Wieckowski, M.R., Pinton, P., Mitochondria-ros crosstalk in the control of cell death and aging. J. Signal Transduct., 2012, 329635.
46. Marchenko, N.D., Moll, U.M., Mitochondrial death functions of p53. Mol. Cell Oncol., 1, 2014.
47. Amor, S., Puentes, F., Baker, D., Van der Valk, P., Inflammation in neurodegenerative diseases. Immunol 129 (2010), 154–169.
48. Glass, C.K., Saijo, K., Beate, W., Marchetto, M.C., Gage, F.H., Mechanisms underlying inflammation in neurodegeneration. Cell 140 (2010), 918–934.
49. Carniglia, L., Ramírez, D., Durand, D., Saba, J., Turati, J., Caruso, C., Scimonelli, T.N., Lasaga, M., Neuropeptides and microglial activation in inflammation, painand neurodegenerative diseases. Mediators Inflamm., 2017, 5048616.
50. Kraft, A.D., Harry, G.J., Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity. Int. J. Environ. Res. Public Health. 8 (2011), 2980–3018.
51. Los M, M., Mozoluk, M., Ferrari, D., Stepczynska, A., Stroh, C., Renz, A., Herceg, Z., Wang, Z.Q., Schulze-Osthoff, K., Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblastnecrosis and apoptosis in death receptor signaling. Mol. Biol. Cell. 13 (2002), 978–988.
52. Uzar, E., Alp, H., Cevik, M.U., Fırat, U., Evliyaoglu, O., Tufek, A., Altun, Y., Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats. Neurol. Sci. 33 (2012), 567–574.