메뉴 건너뛰기




Volumn 66, Issue 5, 2018, Pages 778-788

Understanding the promises and hurdles of metagenomic next-generation sequencing as a diagnostic tool for infectious diseases

Author keywords

Bioinformatics; Diagnosis; Metagenomics; Next generation sequencing

Indexed keywords

NUCLEIC ACID;

EID: 85044099727     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cix881     Document Type: Article
Times cited : (541)

References (51)
  • 1
    • 84871036375 scopus 로고    scopus 로고
    • Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010
    • Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380:2095-128.
    • (2012) Lancet , vol.380 , pp. 2095-2128
    • Lozano, R.1    Naghavi, M.2    Foreman, K.3
  • 2
    • 84866460224 scopus 로고    scopus 로고
    • Prospective evaluation of a matrix-assisted laser desorption ionization-time of flight mass spectrometry system in a hospital clinical microbiology laboratory for identification of bacteria and yeasts: A bench-by-bench study for assessing the impact on time to identification and cost-effectiveness
    • Tan KE, Ellis BC, Lee R, Stamper PD, Zhang SX, Carroll KC. Prospective evaluation of a matrix-assisted laser desorption ionization-time of flight mass spectrometry system in a hospital clinical microbiology laboratory for identification of bacteria and yeasts: a bench-by-bench study for assessing the impact on time to identification and cost-effectiveness. J Clin Microbiol 2012; 50:3301-8.
    • (2012) J Clin Microbiol , vol.50 , pp. 3301-3308
    • Tan, K.E.1    Ellis, B.C.2    Lee, R.3    Stamper, P.D.4    Zhang, S.X.5    Carroll, K.C.6
  • 3
    • 33845459637 scopus 로고    scopus 로고
    • Beyond viruses: Clinical profiles and etiologies associated with encephalitis
    • Glaser CA, Honarmand S, Anderson LJ, et al. Beyond viruses: clinical profiles and etiologies associated with encephalitis. Clin Infect Dis 2006; 43:1565-77.
    • (2006) Clin Infect Dis , vol.43 , pp. 1565-1577
    • Glaser, C.A.1    Honarmand, S.2    Anderson, L.J.3
  • 4
    • 85020233774 scopus 로고    scopus 로고
    • Validation of metagenomic next-generation sequencing tests for universal pathogen detection
    • Schlaberg R, Chiu CY, Miller S, Procop GW, Weinstock G; Professional Practice Committee and Committee on Laboratory Practices of the American Society for Microbiology; Microbiology Resource Committee of the College of American Pathologists. Validation of metagenomic next-generation sequencing tests for universal pathogen detection. Arch Pathol Lab Med 2017; 141:776-86.
    • (2017) Arch Pathol Lab Med , vol.141 , pp. 776-786
    • Schlaberg, R.1    Chiu, C.Y.2    Miller, S.3    Procop, G.W.4    Weinstock, G.5
  • 5
    • 80052150179 scopus 로고    scopus 로고
    • Origins of the E. Coli strain causing an outbreak of hemolytic-uremic syndrome in Germany
    • Rasko DA, Webster DR, Sahl JW, et al. Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N Engl J Med 2011; 365:709-17.
    • (2011) N Engl J Med , vol.365 , pp. 709-717
    • Rasko, D.A.1    Webster, D.R.2    Sahl, J.W.3
  • 6
    • 84920650884 scopus 로고    scopus 로고
    • Large-scale genomic sequencing of extraintestinal pathogenic Escherichia coli strains
    • Salipante SJ, Roach DJ, Kitzman JO, et al. Large-scale genomic sequencing of extraintestinal pathogenic Escherichia coli strains. Genome Res 2015; 25:119-28.
    • (2015) Genome Res , vol.25 , pp. 119-128
    • Salipante, S.J.1    Roach, D.J.2    Kitzman, J.O.3
  • 7
    • 84912016357 scopus 로고    scopus 로고
    • Whole genome sequencing indicates Corynebacterium jeikeium comprises 4 separate genomospecies and identifies a dominant genomospecies among clinical isolates
    • Salipante SJ, Sengupta DJ, Cummings LA, et al. Whole genome sequencing indicates Corynebacterium jeikeium comprises 4 separate genomospecies and identifies a dominant genomospecies among clinical isolates. Int J Med Microbiol 2014; 304:1001-10.
    • (2014) Int J Med Microbiol , vol.304 , pp. 1001-1010
    • Salipante, S.J.1    Sengupta, D.J.2    Cummings, L.A.3
  • 8
    • 84899537734 scopus 로고    scopus 로고
    • Coinfection of Fusobacterium nucleatum and Actinomyces israelii in mastoiditis diagnosed by next-generation DNA sequencing
    • Salipante SJ, Hoogestraat DR, Abbott AN, et al. Coinfection of Fusobacterium nucleatum and Actinomyces israelii in mastoiditis diagnosed by next-generation DNA sequencing. J Clin Microbiol 2014; 52:1789-92.
    • (2014) J Clin Microbiol , vol.52 , pp. 1789-1792
    • Salipante, S.J.1    Hoogestraat, D.R.2    Abbott, A.N.3
  • 9
    • 85018328404 scopus 로고    scopus 로고
    • Precision metagenomics: Rapid metagenomic analyses for infectious disease diagnostics and public health surveillance
    • Afshinnekoo E, Chou C, Alexander N, Ahsanuddin S, Schuetz AN, Mason CE. Precision metagenomics: rapid metagenomic analyses for infectious disease diagnostics and public health surveillance. J Biomol Tech 2017; 28:40-5.
    • (2017) J Biomol Tech , vol.28 , pp. 40-45
    • Afshinnekoo, E.1    Chou, C.2    Alexander, N.3    Ahsanuddin, S.4    Schuetz, A.N.5    Mason, C.E.6
  • 10
    • 84952836879 scopus 로고    scopus 로고
    • Making the leap from research laboratory to clinic: Challenges and opportunities for next-generation sequencing in infectious disease diagnostics
    • Goldberg B, Sichtig H, Geyer C, Ledeboer N, Weinstock GM. Making the leap from research laboratory to clinic: challenges and opportunities for next-generation sequencing in infectious disease diagnostics. MBio 2015; 6:e01888-15.
    • (2015) MBio , vol.6 , pp. e01888-e01915
    • Goldberg, B.1    Sichtig, H.2    Geyer, C.3    Ledeboer, N.4    Weinstock, G.M.5
  • 11
    • 84984972166 scopus 로고    scopus 로고
    • Third generation sequencing technologies applied to diagnostic microbiology: Benefits and challenges in applications and data analysis
    • Lavezzo E, Barzon L, Toppo S, Palù G. Third generation sequencing technologies applied to diagnostic microbiology: benefits and challenges in applications and data analysis. Expert Rev Mol Diagn 2016; 16:1011-23.
    • (2016) Expert Rev Mol Diagn , vol.16 , pp. 1011-1023
    • Lavezzo, E.1    Barzon, L.2    Toppo, S.3    Palù, G.4
  • 12
    • 79951475133 scopus 로고    scopus 로고
    • A decade's perspective on DNA sequencing technology
    • Mardis ER. A decade's perspective on DNA sequencing technology. Nature 2011; 470:198-203.
    • (2011) Nature , vol.470 , pp. 198-203
    • Mardis, E.R.1
  • 13
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies-the next generation
    • Metzker ML. Sequencing technologies-the next generation. Nat Rev Genet 2010; 11:31-46.
    • (2010) Nat Rev Genet , vol.11 , pp. 31-46
    • Metzker, M.L.1
  • 14
    • 84954556725 scopus 로고    scopus 로고
    • An evaluation of the accuracy and speed of metagenome analysis tools
    • Lindgreen S, Adair KL, Gardner PP. An evaluation of the accuracy and speed of metagenome analysis tools. Sci Rep 2016; 6:19233.
    • (2016) Sci Rep , vol.6 , pp. 19233
    • Lindgreen, S.1    Adair, K.L.2    Gardner, P.P.3
  • 15
    • 85008312194 scopus 로고    scopus 로고
    • Application of next generation sequencing in clinical microbiology and infection prevention
    • Deurenberg RH, Bathoorn E, Chlebowicz MA, et al. Application of next generation sequencing in clinical microbiology and infection prevention. J Biotechnol 2017; 243:16-24.
    • (2017) J Biotechnol , vol.243 , pp. 16-24
    • Deurenberg, R.H.1    Bathoorn, E.2    Chlebowicz, M.A.3
  • 16
    • 85008613637 scopus 로고    scopus 로고
    • The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: Report from the EUCAST Subcommittee
    • PMID: 27890457
    • Ellington MJ, Ekelund O, Aarestrup FM, et al. The role of whole genome sequencing in antimicrobial susceptibility testing of bacteria: report from the EUCAST Subcommittee. Clin Microbiol Infect 2017; 23:2-22. PMID: 27890457.
    • (2017) Clin Microbiol Infect , vol.23 , pp. 2-22
    • Ellington, M.J.1    Ekelund, O.2    Aarestrup, F.M.3
  • 17
    • 85010620671 scopus 로고    scopus 로고
    • Next-generation sequencing in neuro-pathologic diagnosis of infections of the nervous system
    • Salzberg SL, Breitwieser FP, Kumar A, et al. Next-generation sequencing in neuro-pathologic diagnosis of infections of the nervous system. Neurol Neuroimmunol Neuroinflamm 2016; 3:e251.
    • (2016) Neurol Neuroimmunol Neuroinflamm , vol.3 , pp. e251
    • Salzberg, S.L.1    Breitwieser, F.P.2    Kumar, A.3
  • 18
    • 84962595445 scopus 로고    scopus 로고
    • Depletion of human DNA in spiked clinical specimens for improvement of sensitivity of pathogen detection by next-generation sequencing
    • Hasan MR, Rawat A, Tang P, et al. Depletion of human DNA in spiked clinical specimens for improvement of sensitivity of pathogen detection by next-generation sequencing. J Clin Microbiol 2016; 54:919-27.
    • (2016) J Clin Microbiol , vol.54 , pp. 919-927
    • Hasan, M.R.1    Rawat, A.2    Tang, P.3
  • 19
    • 85052538152 scopus 로고    scopus 로고
    • Metagenomic next-generation seqeuceng detects pulmonary pathogens in hematopoietic cellular transplant patients with acute respiratory illnesses
    • Langelier C, Zinter MS, Kalatar K, et al. Metagenomic next-generation seqeuceng detects pulmonary pathogens in hematopoietic cellular transplant patients with acute respiratory illnesses. bioRxiv 2017. doi:https://doi.org/10.1101/102798.
    • (2017) bioRxiv
    • Langelier, C.1    Zinter, M.S.2    Kalatar, K.3
  • 20
    • 85031894236 scopus 로고    scopus 로고
    • Central nervous system infection diagnosis by next-generation sequencing: A glimpse into the future?
    • Mai NTH, Phu NH, Nhu LNT, et al. Central nervous system infection diagnosis by next-generation sequencing: a glimpse into the future? Open Forum Infect Dis 2017; 4:ofx046.
    • (2017) Open Forum Infect Dis , vol.4 , pp. ofx046
    • Mai, N.T.H.1    Phu, N.H.2    Nhu, L.N.T.3
  • 22
    • 84902602767 scopus 로고    scopus 로고
    • Actionable diagnosis of neuroleptospirosis by next-generation sequencing
    • Wilson MR, Naccache SN, Samayoa E, et al. Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N Engl J Med 2014; 370:2408-17.
    • (2014) N Engl J Med , vol.370 , pp. 2408-2417
    • Wilson, M.R.1    Naccache, S.N.2    Samayoa, E.3
  • 23
    • 85025683403 scopus 로고    scopus 로고
    • A novel cause of chronic viral meningoencephalitis: Cache Valley virus
    • Wilson MR, Suan D, Duggins A, et al. A novel cause of chronic viral meningoencephalitis: Cache Valley virus. Ann Neurol 2017; 82:105-14.
    • (2017) Ann Neurol , vol.82 , pp. 105-114
    • Wilson, M.R.1    Suan, D.2    Duggins, A.3
  • 25
    • 85036543744 scopus 로고    scopus 로고
    • Rapid pathogen identification in bacterial pneumonia using real-time metagenomics
    • Pendleton KM, Erb-Downward JR, Bao Y, et al. Rapid pathogen identification in bacterial pneumonia using real-time metagenomics. Am J Respir Crit Care Med 2017. doi:10.1164/rccm.201703-0537LE.
    • (2017) Am J Respir Crit Care Med
    • Pendleton, K.M.1    Erb-Downward, J.R.2    Bao, Y.3
  • 26
    • 84996526198 scopus 로고    scopus 로고
    • Adjusting microbiome profiles for differences in microbial load by spike-in bacteria
    • Stämmler F, Gläsner J, Hiergeist A, et al. Adjusting microbiome profiles for differences in microbial load by spike-in bacteria. Microbiome 2016; 4:28.
    • (2016) Microbiome , vol.4 , pp. 28
    • Stämmler, F.1    Gläsner, J.2    Hiergeist, A.3
  • 27
    • 84886301115 scopus 로고    scopus 로고
    • The perils of pathogen discovery: Origin of a novel parvovirus-like hybrid genome traced to nucleic acid extraction spin columns
    • Naccache SN, Greninger AL, Lee D, et al. The perils of pathogen discovery: origin of a novel parvovirus-like hybrid genome traced to nucleic acid extraction spin columns. J Virol 2013; 87:11966-77.
    • (2013) J Virol , vol.87 , pp. 11966-11977
    • Naccache, S.N.1    Greninger, A.L.2    Lee, D.3
  • 28
    • 84920644670 scopus 로고    scopus 로고
    • Reagent and laboratory contamination can critically impact sequence-based microbiome analyses
    • Salter SJ, Cox MJ, Turek EM, et al. Reagent and laboratory contamination can critically impact sequence-based microbiome analyses. BMC Biol 2014; 12:87.
    • (2014) BMC Biol , vol.12 , pp. 87
    • Salter, S.J.1    Cox, M.J.2    Turek, E.M.3
  • 29
    • 85021817801 scopus 로고    scopus 로고
    • Pavian: Interactive analysis of metagenomics data for microbiomics and pathogen identification
    • Breitwieser FP, Salzberg SL. Pavian: interactive analysis of metagenomics data for microbiomics and pathogen identification. bioRxiv 2016. doi:https://doi. org/10.1101/084715.
    • (2016) bioRxiv
    • Breitwieser, F.P.1    Salzberg, S.L.2
  • 30
    • 84963783968 scopus 로고    scopus 로고
    • Comparative evaluation of DNA extraction methods from feces of multiple host species for downstream next-generation sequencing
    • Hart ML, Meyer A, Johnson PJ, Ericsson AC. Comparative evaluation of DNA extraction methods from feces of multiple host species for downstream next-generation sequencing. PLoS One 2015; 10:e0143334.
    • (2015) PLoS One , vol.10 , pp. e0143334
    • Hart, M.L.1    Meyer, A.2    Johnson, P.J.3    Ericsson, A.C.4
  • 31
    • 84982129304 scopus 로고    scopus 로고
    • Multicenter evaluation of BioFire FilmArray meningitis/encephalitis panel for detection of bacteria, viruses, and yeast in cerebrospinal fluid specimens
    • Leber AL, Everhart K, Balada-Llasat JM, et al. Multicenter evaluation of BioFire FilmArray meningitis/encephalitis panel for detection of bacteria, viruses, and yeast in cerebrospinal fluid specimens. J Clin Microbiol 2016; 54:2251-61.
    • (2016) J Clin Microbiol , vol.54 , pp. 2251-2261
    • Leber, A.L.1    Everhart, K.2    Balada-Llasat, J.M.3
  • 32
    • 85021819540 scopus 로고    scopus 로고
    • Presence of human hepegi-virus-1 in a cohort of people who inject drugs
    • Kandathil AJ, Breitwieser FP, Sachithanandham J, et al. Presence of human hepegi-virus-1 in a cohort of people who inject drugs. Ann Intern Med 2017; 167:1-7.
    • (2017) Ann Intern Med , vol.167 , pp. 1-7
    • Kandathil, A.J.1    Breitwieser, F.P.2    Sachithanandham, J.3
  • 33
    • 84901005679 scopus 로고    scopus 로고
    • Routes for breaching and protecting genetic privacy
    • Erlich Y, Narayanan A. Routes for breaching and protecting genetic privacy. Nat Rev Genet 2014; 15:409-21.
    • (2014) Nat Rev Genet , vol.15 , pp. 409-421
    • Erlich, Y.1    Narayanan, A.2
  • 34
    • 84929339945 scopus 로고    scopus 로고
    • Microbiome privacy risk
    • Callaway E. Microbiome privacy risk. Nature 2015; 521:136.
    • (2015) Nature , vol.521 , pp. 136
    • Callaway, E.1
  • 35
    • 84929461429 scopus 로고    scopus 로고
    • Diagnosis of neuroinvasive astrovirus infection in an immunocompromised adult with encephalitis by unbiased next-generation sequencing
    • Naccache SN, Peggs KS, Mattes FM, et al. Diagnosis of neuroinvasive astrovirus infection in an immunocompromised adult with encephalitis by unbiased next-generation sequencing. Clin Infect Dis 2015; 60:919-23.
    • (2015) Clin Infect Dis , vol.60 , pp. 919-923
    • Naccache, S.N.1    Peggs, K.S.2    Mattes, F.M.3
  • 36
    • 84904255806 scopus 로고    scopus 로고
    • A cloud-compatible bioinformatics pipeline for ultrarapid pathogen identification from next-generation sequencing of clinical samples
    • Naccache SN, Federman S, Veeraraghavan N, et al. A cloud-compatible bioinformatics pipeline for ultrarapid pathogen identification from next-generation sequencing of clinical samples. Genome Res 2014; 24:1180-92.
    • (2014) Genome Res , vol.24 , pp. 1180-1192
    • Naccache, S.N.1    Federman, S.2    Veeraraghavan, N.3
  • 37
    • 84899090573 scopus 로고    scopus 로고
    • Kraken: Ultrafast metagenomic sequence classification using exact alignments
    • Wood DE, Salzberg SL. Kraken: ultrafast metagenomic sequence classification using exact alignments. Genome Biol 2014; 15:R46.
    • (2014) Genome Biol , vol.15 , pp. R46
    • Wood, D.E.1    Salzberg, S.L.2
  • 38
    • 84976443441 scopus 로고    scopus 로고
    • Role of clinicogenomics in infectious disease diagnostics and public health microbiology
    • Westblade LF, van Belkum A, Grundhoff A, et al. Role of clinicogenomics in infectious disease diagnostics and public health microbiology. J Clin Microbiol 2016; 54:1686-93.
    • (2016) J Clin Microbiol , vol.54 , pp. 1686-1693
    • Westblade, L.F.1    Van Belkum, A.2    Grundhoff, A.3
  • 39
    • 84925104897 scopus 로고    scopus 로고
    • Geospatial resolution of human and bacterial diversity with city-scale metagenomics
    • Afshinnekoo E, Meydan C, Chowdhury S, et al. Geospatial resolution of human and bacterial diversity with city-scale metagenomics. Cell Syst 2015; 1:97-97.e3.
    • (2015) Cell Syst , vol.1 , pp. 97-97e3
    • Afshinnekoo, E.1    Meydan, C.2    Chowdhury, S.3
  • 40
    • 85046163958 scopus 로고    scopus 로고
    • Accessed 17 July 2017
    • US Food and Drug Administration. Database for Reference Grade Microbial Sequences (FDA-ARGOS). Available at: https://www.fda.gov/MedicalDevices/ScienceandResearch/DatabaseforReferenceGradeMicrobialSequences/default. htm. Accessed 17 July 2017.
    • Database for Reference Grade Microbial Sequences (FDA-ARGOS)
  • 41
    • 84942518081 scopus 로고    scopus 로고
    • Rapid metagenomic identification of viral pathogens in clinical samples by real-time nanopore sequencing analysis
    • Greninger AL, Naccache SN, Federman S, et al. Rapid metagenomic identification of viral pathogens in clinical samples by real-time nanopore sequencing analysis. Genome Med 2015; 7:99.
    • (2015) Genome Med , vol.7 , pp. 99
    • Greninger, A.L.1    Naccache, S.N.2    Federman, S.3
  • 42
    • 85018326977 scopus 로고    scopus 로고
    • Comprehensive diagnosis of bacterial infection associated with acute cholecystitis using metagenomic approach
    • Kujiraoka M, Kuroda M, Asai K, et al. Comprehensive diagnosis of bacterial infection associated with acute cholecystitis using metagenomic approach. Front Microbiol 2017; 8:685.
    • (2017) Front Microbiol , vol.8 , pp. 685
    • Kujiraoka, M.1    Kuroda, M.2    Asai, K.3
  • 43
    • 84936768371 scopus 로고    scopus 로고
    • A variegated squirrel bornavirus associated with fatal human encephalitis
    • Hoffmann B, Tappe D, Höper D, et al. A variegated squirrel bornavirus associated with fatal human encephalitis. N Engl J Med 2015; 373:154-62.
    • (2015) N Engl J Med , vol.373 , pp. 154-162
    • Hoffmann, B.1    Tappe, D.2    Höper, D.3
  • 44
    • 84952984120 scopus 로고    scopus 로고
    • Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: The continuing case for reference genome sequencing
    • Greninger AL, Messacar K, Dunnebacke T, et al. Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing. Genome Med 2015; 7:113.
    • (2015) Genome Med , vol.7 , pp. 113
    • Greninger, A.L.1    Messacar, K.2    Dunnebacke, T.3
  • 45
    • 85041590459 scopus 로고    scopus 로고
    • Hepatitis E virus-associated meningoencephalitis in a lung transplant recipient diagnosed by clinical metagenomic sequencing
    • Murkey JA, Chew KW, Carlson M, et al. Hepatitis E virus-associated meningoencephalitis in a lung transplant recipient diagnosed by clinical metagenomic sequencing. Open Fourm Infect Dis 2017; 4:ofx121.
    • (2017) Open Fourm Infect Dis , vol.4 , pp. ofx121
    • Murkey, J.A.1    Chew, K.W.2    Carlson, M.3
  • 46
    • 85046149967 scopus 로고    scopus 로고
    • Diagnosis of fatal human case of mosquito-borne St. Louis encephalitis virus infection diagnosed by metagenomic sequencing, California, 2016
    • Chiu CY, Coffey LL,Murkey J, et al. Diagnosis of fatal human case of mosquito-borne St. Louis encephalitis virus infection diagnosed by metagenomic sequencing, California, 2016. Emerg Infect Dis 2017; 23:1964-68.
    • (2017) Emerg Infect Dis , vol.23 , pp. 1964-1968
    • Chiu, C.Y.1    Coffey, L.L.2    Murkey, J.3
  • 47
    • 84983591865 scopus 로고    scopus 로고
    • Illuminating uveitis: Metagenomic deep sequencing identifies common and rare pathogens
    • Doan T, Wilson MR, Crawford ED, et al. Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens. Genome Med 2016; 8:90.
    • (2016) Genome Med , vol.8 , pp. 90
    • Doan, T.1    Wilson, M.R.2    Crawford, E.D.3
  • 48
    • 84983606013 scopus 로고    scopus 로고
    • Coinfections of Zika and Chikungunya viruses in Bahia, Brazil, identified by metagenomic next-generation sequencing
    • Sardi SI, Somasekar S, Naccache SN, et al. Coinfections of Zika and Chikungunya viruses in Bahia, Brazil, identified by metagenomic next-generation sequencing. J Clin Microbiol 2016; 54:2348-53.
    • (2016) J Clin Microbiol , vol.54 , pp. 2348-2353
    • Sardi, S.I.1    Somasekar, S.2    Naccache, S.N.3
  • 49
    • 84947489692 scopus 로고    scopus 로고
    • Metagenomic analysis for detecting pathogens in culture-negative infective endocarditis
    • Fukui Y, Aoki K, Okuma S, Sato T, Ishii Y, Tateda K. Metagenomic analysis for detecting pathogens in culture-negative infective endocarditis. J Infect Chemother 2015; 21:882-4.
    • (2015) J Infect Chemother , vol.21 , pp. 882-884
    • Fukui, Y.1    Aoki, K.2    Okuma, S.3    Sato, T.4    Ishii, Y.5    Tateda, K.6
  • 50
    • 84866951390 scopus 로고    scopus 로고
    • A novel rhabdovirus associated with acute hemorrhagic fever in central Africa
    • Grard G, Fair JN, Lee D, et al. A novel rhabdovirus associated with acute hemorrhagic fever in central Africa. PLoS Pathog 2012; 8:e1002924.
    • (2012) PLoS Pathog , vol.8 , pp. e1002924
    • Grard, G.1    Fair, J.N.2    Lee, D.3
  • 51
    • 84956668654 scopus 로고    scopus 로고
    • Metagenomic approach for identification of the pathogens associated with diarrhea in stool specimens
    • Zhou Y, Wylie KM, El Feghaly RE, et al. Metagenomic approach for identification of the pathogens associated with diarrhea in stool specimens. J Clin Microbiol 2016; 54:368-75.
    • (2016) J Clin Microbiol , vol.54 , pp. 368-375
    • Zhou, Y.1    Wylie, K.M.2    El Feghaly, R.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.