Inhibition of Acinetobacter -Derived Cephalosporinase: Exploring the Carboxylate Recognition Site Using Novel β-Lactamase Inhibitors

ACS Infectious Diseases

Volumn 4, Issue 3, 2018, Pages 337-348

  Caselli, Emilia ^a   Romagnoli, Chiara ^a   Powers, Rachel A ^b   Taracila, Magdalena A ^d   Bouza, Alexandra A ^b   Swanson, Hollister C ^b   Smolen, Kali A ^b   Fini, Francesco ^a   Wallar, Bradley J ^b   Bonomo, Robert A ^c,d   Prati, Fabio ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b GRAND VALLEY STATE UNIVERSITY   (United States)

^c Louis Stokes Cleveland DVAMC Psychiatry Service   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CARBOXAMIDO[1,2,3]TRIAZOL 1 YL) 1 (2 THIENYLACETYLAMINO)ETHANEBORONATE; 2 (4 CARBOXYMETHYL[1,2,3]TRIAZOL 1 YL)(2 THIENYLACETYLAMINO)ETHANEBORONIC ACID; 2 (4 IDROXYCARBAMOYL[1,2,3]TRIAZOL 1 YL) 1 (2 THIENYLACETYLAMINO)ETHANEBORONIC ACID; 2 [4 (2H TETRAZOL 5 YL)[1,2,3]TRIAZOL 1 YL] 1 (2 THIENYLACETYLAMINO)ETHANEBORONIC ACID; 2 [4 [3 (2H TETRAZOL 5 YL)PHENYL][1,2,3]TRIAZOL 1 YL] 1 (2 THIENYLACETYLAMINO)ETHANEBORONATE; BACTERIAL ENZYME; BETA LACTAMASE INHIBITOR; CARBOXYLIC ACID; CEFTAZIDIME; CEPHALOSPORINASE; EC 04; S 02030; S 08127; SM 23; SULBACTAM; UNCLASSIFIED DRUG; BORONIC ACID DERIVATIVE; PROTEIN BINDING;

ACINETOBACTER; ACINETOBACTER BAUMANNII; ARTICLE; DRUG BINDING SITE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESCHERICHIA COLI; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SURFACE CHARGE; X RAY CRYSTALLOGRAPHY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION; SYNTHESIS;

ACINETOBACTER; BETA-LACTAMASE INHIBITORS; BINDING SITES; BORONIC ACIDS; CEPHALOSPORINASE; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 85043456080     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.7b00153     Document Type: Article

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