메뉴 건너뛰기




Volumn 22, Issue 4, 2018, Pages 501-513.e7

Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo

Author keywords

adjuvant therapy; breast cancer; immune profiling; immunotherapy; melanoma; mesothelioma; metastases; pluripotent stem cells; prophylactic vaccination; shared epitopes

Indexed keywords

CANCER VACCINE; CD11B ANTIGEN; EPITOPE; GAMMA INTERFERON; IMMUNOGLOBULIN G;

EID: 85042036923     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2018.01.016     Document Type: Article
Times cited : (115)

References (54)
  • 1
    • 77958471357 scopus 로고    scopus 로고
    • Differential expression analysis for sequence count data
    • Anders, S., Huber, W., Differential expression analysis for sequence count data. Genome Biol., 11, 2010, R106.
    • (2010) Genome Biol. , vol.11 , pp. R106
    • Anders, S.1    Huber, W.2
  • 2
  • 3
    • 84928987900 scopus 로고    scopus 로고
    • HTSeq—a Python framework to work with high-throughput sequencing data
    • Anders, S., Pyl, P.T., Huber, W., HTSeq—a Python framework to work with high-throughput sequencing data. Bioinformatics 31 (2015), 166–169.
    • (2015) Bioinformatics , vol.31 , pp. 166-169
    • Anders, S.1    Pyl, P.T.2    Huber, W.3
  • 4
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath, I., Thomson, M.W., Carey, V.J., Ge, R., Bell, G.W., Regev, A., Weinberg, R.A., An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet. 40 (2008), 499–507.
    • (2008) Nat. Genet. , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6    Weinberg, R.A.7
  • 8
    • 84897655065 scopus 로고    scopus 로고
    • High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells
    • Chang, G., Gao, S., Hou, X., Xu, Z., Liu, Y., Kang, L., Tao, Y., Liu, W., Huang, B., Kou, X., et al. High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells. Cell Res. 24 (2014), 293–306.
    • (2014) Cell Res. , vol.24 , pp. 293-306
    • Chang, G.1    Gao, S.2    Hou, X.3    Xu, Z.4    Liu, Y.5    Kang, L.6    Tao, Y.7    Liu, W.8    Huang, B.9    Kou, X.10
  • 9
    • 78751485662 scopus 로고    scopus 로고
    • A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways
    • Chen, J.Y., Tang, Y.A., Huang, S.M., Juan, H.F., Wu, L.W., Sun, Y.C., Wang, S.C., Wu, K.W., Balraj, G., Chang, T.T., et al. A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways. Cancer Res. 71 (2011), 473–483.
    • (2011) Cancer Res. , vol.71 , pp. 473-483
    • Chen, J.Y.1    Tang, Y.A.2    Huang, S.M.3    Juan, H.F.4    Wu, L.W.5    Sun, Y.C.6    Wang, S.C.7    Wu, K.W.8    Balraj, G.9    Chang, T.T.10
  • 11
    • 85044898933 scopus 로고    scopus 로고
    • Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods
    • Churko, J., Lee, J., Ameen, M., Gu, M., Venkaasubramanian, M., Diecke, S., Sallam, K., Im, H., Wang, G., Gold, J.D., et al. Transcriptomic and epigenomic differences in human induced pluripotent stem cells generated from six reprogramming methods. Nat. Biomed. Eng. 1 (2017), 826–837.
    • (2017) Nat. Biomed. Eng. , vol.1 , pp. 826-837
    • Churko, J.1    Lee, J.2    Ameen, M.3    Gu, M.4    Venkaasubramanian, M.5    Diecke, S.6    Sallam, K.7    Im, H.8    Wang, G.9    Gold, J.D.10
  • 12
    • 79955550445 scopus 로고    scopus 로고
    • A user's guide to the encyclopedia of DNA elements (ENCODE)
    • Consortium, E.P., ENCODE Project Consortium. A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol., 9, 2011, e1001046.
    • (2011) PLoS Biol. , vol.9 , pp. e1001046
    • Consortium, E.P.1
  • 16
    • 0036735660 scopus 로고    scopus 로고
    • Life and death in effector T cells
    • Dooms, H., Abbas, A.K., Life and death in effector T cells. Nat. Immunol. 3 (2002), 797–798.
    • (2002) Nat. Immunol. , vol.3 , pp. 797-798
    • Dooms, H.1    Abbas, A.K.2
  • 18
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • Gajewski, T.F., Schreiber, H., Fu, Y.X., Innate and adaptive immune cells in the tumor microenvironment. Nat. Immunol. 14 (2013), 1014–1022.
    • (2013) Nat. Immunol. , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 19
    • 84948986254 scopus 로고    scopus 로고
    • Anti-tumor effects after adoptive transfer of IL-12 transposon-modified murine splenocytes in the OT-I-melanoma mouse Model
    • Galvan, D.L., O'Neil, R.T., Foster, A.E., Huye, L., Bear, A., Rooney, C.M., Wilson, M.H., Anti-tumor effects after adoptive transfer of IL-12 transposon-modified murine splenocytes in the OT-I-melanoma mouse Model. PLoS ONE, 10, 2015, e0140744.
    • (2015) PLoS ONE , vol.10 , pp. e0140744
    • Galvan, D.L.1    O'Neil, R.T.2    Foster, A.E.3    Huye, L.4    Bear, A.5    Rooney, C.M.6    Wilson, M.H.7
  • 20
    • 79960425147 scopus 로고    scopus 로고
    • Dissecting the oncogenic and tumorigenic potential of differentiated human induced pluripotent stem cells and human embryonic stem cells
    • Ghosh, Z., Huang, M., Hu, S., Wilson, K.D., Dey, D., Wu, J.C., Dissecting the oncogenic and tumorigenic potential of differentiated human induced pluripotent stem cells and human embryonic stem cells. Cancer Res. 71 (2011), 5030–5039.
    • (2011) Cancer Res. , vol.71 , pp. 5030-5039
    • Ghosh, Z.1    Huang, M.2    Hu, S.3    Wilson, K.D.4    Dey, D.5    Wu, J.C.6
  • 22
    • 78650988917 scopus 로고    scopus 로고
    • A CpG-loaded tumor cell vaccine induces antitumor CD4+ T cells that are effective in adoptive therapy for large and established tumors
    • Goldstein, M.J., Varghese, B., Brody, J.D., Rajapaksa, R., Kohrt, H., Czerwinski, D.K., Levy, S., Levy, R., A CpG-loaded tumor cell vaccine induces antitumor CD4+ T cells that are effective in adoptive therapy for large and established tumors. Blood 117 (2011), 118–127.
    • (2011) Blood , vol.117 , pp. 118-127
    • Goldstein, M.J.1    Varghese, B.2    Brody, J.D.3    Rajapaksa, R.4    Kohrt, H.5    Czerwinski, D.K.6    Levy, S.7    Levy, R.8
  • 25
    • 77951936316 scopus 로고    scopus 로고
    • IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells
    • He, D., Li, H., Yusuf, N., Elmets, C.A., Li, J., Mountz, J.D., Xu, H., IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells. J. Immunol. 184 (2010), 2281–2288.
    • (2010) J. Immunol. , vol.184 , pp. 2281-2288
    • He, D.1    Li, H.2    Yusuf, N.3    Elmets, C.A.4    Li, J.5    Mountz, J.D.6    Xu, H.7
  • 26
    • 85044897040 scopus 로고    scopus 로고
    • Vaccination With Irradiated Induced Pluripotent Stem Cells Genetically Engineered To Produce GM-CSF Confers Potent T Cells-Mediated Antitumor Immunity
    • Accessed February 01, 2018. Retrieved from
    • Inoue, H., Watanabe, A., Sakamoto, C., Narusawa, M., Hiramoto, T., Miyamoto, S., Inoue, M., Takayama, K., Hasegawa, M., Nakanishi, Y., Vaccination With Irradiated Induced Pluripotent Stem Cells Genetically Engineered To Produce GM-CSF Confers Potent T Cells-Mediated Antitumor Immunity. Blood, 122(21), 2013, 4492 Accessed February 01, 2018. Retrieved from http://www.bloodjournal.org/content/122/21/4492.
    • (2013) Blood , vol.122 , Issue.21 , pp. 4492
    • Inoue, H.1    Watanabe, A.2    Sakamoto, C.3    Narusawa, M.4    Hiramoto, T.5    Miyamoto, S.6    Inoue, M.7    Takayama, K.8    Hasegawa, M.9    Nakanishi, Y.10
  • 27
    • 84926519013 scopus 로고    scopus 로고
    • HISAT: a fast spliced aligner with low memory requirements
    • Kim, D., Langmead, B., Salzberg, S.L., HISAT: a fast spliced aligner with low memory requirements. Nat. Methods 12 (2015), 357–360.
    • (2015) Nat. Methods , vol.12 , pp. 357-360
    • Kim, D.1    Langmead, B.2    Salzberg, S.L.3
  • 28
    • 84923561307 scopus 로고    scopus 로고
    • Orthotopic injection of breast cancer cells into the mammary fat pad of mice to study tumor growth
    • Kocatürk, B., Versteeg, H.H., Orthotopic injection of breast cancer cells into the mammary fat pad of mice to study tumor growth. J. Vis. Exp., 96, 2015, 51967.
    • (2015) J. Vis. Exp. , vol.96 , pp. 51967
    • Kocatürk, B.1    Versteeg, H.H.2
  • 29
    • 78649887674 scopus 로고    scopus 로고
    • Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging
    • Kooreman, N.G., Wu, J.C., Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging. J. R. Soc. Interface 7:Suppl 6 (2010), S753–S763.
    • (2010) J. R. Soc. Interface , vol.7 , pp. S753-S763
    • Kooreman, N.G.1    Wu, J.C.2
  • 31
    • 84882239370 scopus 로고    scopus 로고
    • Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies
    • Lee, A.S., Tang, C., Rao, M.S., Weissman, I.L., Wu, J.C., Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies. Nat. Med. 19 (2013), 998–1004.
    • (2013) Nat. Med. , vol.19 , pp. 998-1004
    • Lee, A.S.1    Tang, C.2    Rao, M.S.3    Weissman, I.L.4    Wu, J.C.5
  • 32
    • 84923019006 scopus 로고    scopus 로고
    • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
    • Lee, D.W., Kochenderfer, J.N., Stetler-Stevenson, M., Cui, Y.K., Delbrook, C., Feldman, S.A., Fry, T.J., Orentas, R., Sabatino, M., Shah, N.N., et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet 385 (2015), 517–528.
    • (2015) Lancet , vol.385 , pp. 517-528
    • Lee, D.W.1    Kochenderfer, J.N.2    Stetler-Stevenson, M.3    Cui, Y.K.4    Delbrook, C.5    Feldman, S.A.6    Fry, T.J.7    Orentas, R.8    Sabatino, M.9    Shah, N.N.10
  • 33
    • 73349121617 scopus 로고    scopus 로고
    • Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical responses against colon cancer
    • Li, Y., Zeng, H., Xu, R.H., Liu, B., Li, Z., Vaccination with human pluripotent stem cells generates a broad spectrum of immunological and clinical responses against colon cancer. Stem Cells 27 (2009), 3103–3111.
    • (2009) Stem Cells , vol.27 , pp. 3103-3111
    • Li, Y.1    Zeng, H.2    Xu, R.H.3    Liu, B.4    Li, Z.5
  • 37
    • 84899631361 scopus 로고    scopus 로고
    • Antibody-modified T cells: CARs take the front seat for hematologic malignancies
    • Maus, M.V., Grupp, S.A., Porter, D.L., June, C.H., Antibody-modified T cells: CARs take the front seat for hematologic malignancies. Blood 123 (2014), 2625–2635.
    • (2014) Blood , vol.123 , pp. 2625-2635
    • Maus, M.V.1    Grupp, S.A.2    Porter, D.L.3    June, C.H.4
  • 38
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: differences between mouse and human immunology
    • Mestas, J., Hughes, C.C., Of mice and not men: differences between mouse and human immunology. J. Immunol. 172 (2004), 2731–2738.
    • (2004) J. Immunol. , vol.172 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.2
  • 40
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan, R.A., Yang, J.C., Kitano, M., Dudley, M.E., Laurencot, C.M., Rosenberg, S.A., Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol. Ther. 18 (2010), 843–851.
    • (2010) Mol. Ther. , vol.18 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3    Dudley, M.E.4    Laurencot, C.M.5    Rosenberg, S.A.6
  • 41
    • 33846194189 scopus 로고    scopus 로고
    • MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model
    • Mukherjee, P., Pathangey, L.B., Bradley, J.B., Tinder, T.L., Basu, G.D., Akporiaye, E.T., Gendler, S.J., MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model. Vaccine 25 (2007), 1607–1618.
    • (2007) Vaccine , vol.25 , pp. 1607-1618
    • Mukherjee, P.1    Pathangey, L.B.2    Bradley, J.B.3    Tinder, T.L.4    Basu, G.D.5    Akporiaye, E.T.6    Gendler, S.J.7
  • 42
    • 77955677885 scopus 로고    scopus 로고
    • Adoptive transfer of splenocytes to study cell-mediated immune responses in hepatitis C infection using HCV transgenic mice
    • Naas, T., Ghorbani, M., Soare, C., Scherling, N., Muller, R., Ghorbani, P., Diaz-Mitoma, F., Adoptive transfer of splenocytes to study cell-mediated immune responses in hepatitis C infection using HCV transgenic mice. Comp. Hepatol., 9, 2010, 7.
    • (2010) Comp. Hepatol. , vol.9 , pp. 7
    • Naas, T.1    Ghorbani, M.2    Soare, C.3    Scherling, N.4    Muller, R.5    Ghorbani, P.6    Diaz-Mitoma, F.7
  • 43
    • 84942852568 scopus 로고    scopus 로고
    • Teratoma formation: a tool for monitoring pluripotency in stem cell research
    • 4A.8.1–4A.8.17
    • Nelakanti, R.V., Kooreman, N.G., Wu, J.C., Teratoma formation: a tool for monitoring pluripotency in stem cell research. Curr. Protoc. Stem Cell Biol., 32, 2015 4A.8.1–4A.8.17.
    • (2015) Curr. Protoc. Stem Cell Biol. , vol.32
    • Nelakanti, R.V.1    Kooreman, N.G.2    Wu, J.C.3
  • 45
    • 33745988889 scopus 로고    scopus 로고
    • Cancer vaccines: preclinical studies and novel strategies
    • Palena, C., Abrams, S.I., Schlom, J., Hodge, J.W., Cancer vaccines: preclinical studies and novel strategies. Adv. Cancer Res. 95 (2006), 115–145.
    • (2006) Adv. Cancer Res. , vol.95 , pp. 115-145
    • Palena, C.1    Abrams, S.I.2    Schlom, J.3    Hodge, J.W.4
  • 47
    • 0021934011 scopus 로고
    • Adoptive transfer of immunity against solid fibrosarcoma in mice with splenocytes and peritoneal exudate cells obtained after in vitro sensitization and in vivo immunization with cis-dichlorodiamine platinum(II) treated fibrosarcoma cells
    • Sodhi, A., Tandon, P., Sarna, S., Adoptive transfer of immunity against solid fibrosarcoma in mice with splenocytes and peritoneal exudate cells obtained after in vitro sensitization and in vivo immunization with cis-dichlorodiamine platinum(II) treated fibrosarcoma cells. Arch. Geschwulstforsch. 55 (1985), 47–61.
    • (1985) Arch. Geschwulstforsch. , vol.55 , pp. 47-61
    • Sodhi, A.1    Tandon, P.2    Sarna, S.3
  • 49
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., Yamanaka, S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006), 663–676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 50
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., Yamanaka, S., Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131 (2007), 861–872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 51
    • 85019999371 scopus 로고    scopus 로고
    • In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors
    • Torcellan, T., Hampton, H.R., Bailey, J., Tomura, M., Brink, R., Chtanova, T., In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors. Proc. Natl. Acad. Sci. USA 114 (2017), 5677–5682.
    • (2017) Proc. Natl. Acad. Sci. USA , vol.114 , pp. 5677-5682
    • Torcellan, T.1    Hampton, H.R.2    Bailey, J.3    Tomura, M.4    Brink, R.5    Chtanova, T.6
  • 52
    • 84864487637 scopus 로고    scopus 로고
    • Vaccination with embryonic stem cells protects against lung cancer: is a broad-spectrum prophylactic vaccine against cancer possible?
    • Yaddanapudi, K., Mitchell, R.A., Putty, K., Willer, S., Sharma, R.K., Yan, J., Bodduluri, H., Eaton, J.W., Vaccination with embryonic stem cells protects against lung cancer: is a broad-spectrum prophylactic vaccine against cancer possible?. PLoS ONE, 7, 2012, e42289.
    • (2012) PLoS ONE , vol.7 , pp. e42289
    • Yaddanapudi, K.1    Mitchell, R.A.2    Putty, K.3    Willer, S.4    Sharma, R.K.5    Yan, J.6    Bodduluri, H.7    Eaton, J.W.8
  • 53
    • 79957807595 scopus 로고    scopus 로고
    • Immunogenicity of induced pluripotent stem cells
    • Zhao, T., Zhang, Z.N., Rong, Z., Xu, Y., Immunogenicity of induced pluripotent stem cells. Nature 474 (2011), 212–215.
    • (2011) Nature , vol.474 , pp. 212-215
    • Zhao, T.1    Zhang, Z.N.2    Rong, Z.3    Xu, Y.4
  • 54
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou, W., Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5 (2005), 263–274.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 263-274
    • Zou, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.