Na + -mimicking ligands stabilize the inactive state of leukotriene B 4 receptor BLT1

Nature Chemical Biology

Volumn 14, Issue 3, 2018, Pages 262-269

  Hori, Tetsuya ^a,b   Okuno, Toshiaki ^c   Hirata, Kunio ^b,d   Yamashita, Keitaro ^b   Kawano, Yoshiaki ^b   Yamamoto, Masaki ^b   Hato, Masakatsu ^a   Nakamura, Motonao ^e,f   Shimizu, Takao ^e,g   Yokomizo, Takehiko ^c   Miyano, Masashi ^b,h   Yokoyama, Shigeyuki ^a  

^a RIKEN   (Japan)

^b RIKEN SPring 8 Center   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f OKAYAMA UNIVERSITY OF SCIENCE   (Japan)

^g NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^h AOYAMA GAKUIN UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDINE; BLT1 PROTEIN; G PROTEIN COUPLED RECEPTOR; LEUKOTRIENE B4 RECEPTOR; SODIUM ION; UNCLASSIFIED DRUG; AMIDINE; ASPARTIC ACID; INOSITOL PHOSPHATE; LEUKOTRIENE B4; LIGAND; LTB4R PROTEIN, HUMAN; PROTEIN BINDING; TRANSFORMING GROWTH FACTOR ALPHA;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL SURFACE; CRYSTAL STRUCTURE; GUINEA PIG; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN STABILITY; STEREOSPECIFICITY; THERMOSTABILITY; ALLOSTERIC SITE; ANIMAL; BINDING SITE; CHEMISTRY; DRUG DESIGN; HEK293 CELL LINE; HUMAN; METABOLISM; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC SITE; AMIDINES; ANIMALS; ASPARTIC ACID; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GUINEA PIGS; HEK293 CELLS; HUMANS; INOSITOL PHOSPHATES; LEUKOTRIENE B4; LIGANDS; PROTEIN BINDING; PROTEIN DOMAINS; RECEPTORS, LEUKOTRIENE B4; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 85041993235     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2547     Document Type: Article

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