A review of the role of estrogen in dermal aging and facial attractiveness in women

Journal of Cosmetic Dermatology

Volumn 17, Issue 3, 2018, Pages 282-288

  Lephart, Edwin D ^a  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

aging; attractiveness; dermal; estrogen receptors; estrogens; human skin

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR;

AGE; CUTANEOUS PARAMETERS; ESTROGEN URINE LEVEL; FACIES; HORMONAL REGULATION; HORMONAL THERAPY; HUMAN; MENOPAUSE; PHYSICAL ATTRACTIVENESS; PRIORITY JOURNAL; REVIEW; SKIN COLOR; BLOOD; ESTHETICS; ESTROGEN THERAPY; FACE; FEMALE; METABOLISM; PHYSIOLOGY; SKIN PIGMENTATION;

ANDROGENS; BEAUTY; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FACE; FEMALE; HUMANS; MENOPAUSE; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; SKIN AGING; SKIN PIGMENTATION;

EID: 85041834627     PISSN: 14732130     EISSN: 14732165     Source Type: Journal    
DOI: 10.1111/jocd.12508     Document Type: Review

References (49)

1. Lephart ED. Skin aging and oxidative stress: equol's anti-aging effects via biochemical and molecular mechanisms. Ageing Res Rev. 2016;2016:36-54.
2. Farage MA, Miller KW, Elsner P, Maibach HI. Degenerative changes in aging skin. In: Farage MA, Miller KW, Maibach HI, eds. Textbook of Aging Skin. Berlin, Heidelberg, Germany: Springer-Verlag; 2017:15-30.
3. Gonzaga ER. Role of UV light in photoaging, skin aging, and skin cancer. Am J Clin Derm. 2009;10(Supl. 1):19-24.
4. Khol E, Steinbauer J, Landthaler M, et al. Skin aging. J Eur Acad Dermatol Venereol. 2011;25:873-884.
5. Natarajan VT, Ganju P, Ramkumar A, et al. Multifaceted pathways protect human skin from UV radiation. Nature Chem. Biol. 2014;10:542-551.
6. Thornton MJ. Estrogens and aging skin. Dermato-Endocrinol. 2013;5:264-270.
7. Farage MA, Miller KW, Elsner P, et al. Structural characteristics of the aging skin: a review. Cutaneous Ocular Tox. 2007;2007:343-357.
8. Ashworth JL, Murphy G, Rock MJ, et al. Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodeling. Biochem J. 1999;340:171-181.
9. Qin Z, Voorhees JJ, Fisher GJ, et al. Age-associated reduction of cellular spreading/mechanical force up-regulates matrix metalloproteinase-1 expression and collagen fibril fragmentation via c-Jun/AP-1 in human dermal fibroblasts. Aging Cell. 2014;13:1028-1037.
10. Quan C, Cho MK, Perry D, et al. Age-associated reduction of cell spreading induces mitochondrial DNA common deletion by oxidative stress in human skin dermal fibroblasts: implication for human skin connective tissue aging. J Biomed Sci. 2015;22:62.
11. Verdier-Sevrain S, Bonte G, Gilchrest B. Biology of estrogen in skin: implications for skin aging. Exper Derm. 2006;15:83-94.
12. Naftolin F. Prevention during the menopause is critical for good health: skin studies support protracted hormone therapy. Fert Steril. 2005;84:293-294.
13. Wend K, Wend P, Krum SA. Tissue-specific effects of loss of estrogen during menopause and aging. Front Endocrinol. 2012;3:1-9.
14. Archer DF. Postmenopausal skin and estrogen. Gynecol Endocrinol. 2012;28:2-6.
15. Hall G, Phillips TJ. Estrogen and skin: the effects of estrogen, menopause, and hormone replacement therapy on the skin. J Am Acad Derm. 2005;53:555-568.
16. Gopaul R, Knaggs H, Lephart ED. Biochemical investigation and gene analysis of equol: a plant and soy-derived isoflavonoid with anti-aging and anti-oxidant properties with potential human skin applications. BioFactors. 2012;38:44-52.
17. Enmark E, Gustafsson J-A. Oestrogen receptors-an overview. J Inter Med. 1999;246:133-138.
18. Setchell KDR, Clerici C, Lephart ED, et al. S-Equol, a potent ligand for estrogen receptor {beta}, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005;81:1072-1079.
19. Bhavnani BR, Stanczyk FZ. Pharmacology of conjugated equine estrogen: efficacy, safety and mechanism of action. J Steroid Biochem Mole Biol. 2014;142:16-29.
20. Murphy LC, Leygue E. The role of estrogen receptor-β in breast cancer. Sem Reprod Med. 2012;30:5-13.
21. Ellem SJ, Risbridger GP. The dual, opposing role of estrogens in the prostate. Ann New York Acad Sci. 2009;1155:174-186.
22. Jackson RL, Greiwe JS, Schwen RJ. Ageing skin: oestrogen receptor β agonists offer an approach to change the outcome. Exper Derm. 2011;20:879-882.
23. Pelletier G, Ren L. Localization of sex steroid receptors in human skin. Histol Histopathol. 2004;19:629-636.
24. Thornton MJ, Taylor AH, Mulligan K, et al. The distribution of estrogen receptor β is distinct to that of estrogen receptor α and the androgen receptor in human skin and the pilosebaceous unit. J Invest Derm Symp Proc. 2003;8:100-103.
25. Zouboulis CC, Chen W-C, Thornton MJ, et al. Sexual hormones in human skin. Horm Metab Res. 2007;39:85-95.
26. Pomari E, Valle LD, Pertile P, et al. Intracrine sex steroid synthesis and signaling in human epidermal keratinocytes and dermal fibroblasts. FASEB J. 2015;29:508-524.
27. Inoue T, Miki Y, Abe K, et al. The role of estrogen-metabolizing enzymes and estrogen receptors in human epidermis. Mole Cell Endocrinol. 2011;344:35-40.
28. Simpson ER, Santen RJ. Celebrating 75 years of oestradiol. J Mole Endocrinol. 2015;55:T1-T20.
29. Lee MJ, Cha JH, Lim KM, et al. Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5α-dihydrotestosterone. Mole Med Rep. 2015;12:1205-1212.
30. Makrantonaki E, Zouboulis CC. Androgens and ageing of the skin. Curr Opin Endocrinol Diab Obes. 2009;16:240-245.
31. Russell DW, Wilson JD. Steroid 5α-reductase: two genes/two enzymes. Annu Rev Biochem. 1994;63:25-61.
32. von Deutsch DA, Abukhalaf IK, Lapu-Bula R. Anabolic doping agents. In: Mozayani A, Raymon L, eds. Handbook of Drug Interactions: A Clinical and Forensic Guide, 2nd ed. New York, NY: Humana Press, Springer Science + Business Media; 2012:656.
33. Al-Azzawi F, Palacios S. Hormonal changes during pregnancy. Maturitas. 2009;63:135-137.
34. Gurney EP, Nachtifgall MJ, Nachtigall LE, et al. The women's health initiative trial and related studies: 10 years later: a clinician's view. J Steroid Biochem Mole Biol. 2014;142:4-11.
35. Nelson HD. Menopause. Lancet. 2008;371:760-770.
36. Khoudary SR, McClure CK, VoPham T, et al. Longitudinal assessment of the menopausal transition: endogenous sex hormones, and perception of physical functioning: the study of women's health across the nation. J Gerontol A Biol Sci Med Sci. 2014;69:1011-1017.
37. Toz E, Ozcan A, Balsak D, et al. Potential adverse effects of prophylactic bilateral salpingo-oophorectomy on skin aging in premenopausal women undergoing hysterectomy for benign conditions. Menopause. 2016;23:138-142.
38. Masuda Y, Hirao T, Mizunuma H. Improvement of skin surface texture by topical estradiol treatment in climacteric women. J Dermatol Treat. 2013;24:312-317.
39. Wildt L, Petermann T. Oestrogen and age estimations of perimenopausal women. Lancet. 1999;354:224.
40. Aizen E, Gilhar A. Smoking effect on skin wrinkling in the aged population. Internat J Derm. 2001;40:431-433.
41. Malnick SDH, Somin M, Attali M. Smoking, aging, and oestrogen. Lancet. 1999;354:995.
42. Law-Smith MJ, Perret DI, Jones BC, et al. Facial appearance is a cue to oestrogen levels in women. Proc Royal Soc B. 2006;273:135-140.
43. Puts DA, Bailey DH, Cardens RA, et al. Women's attractiveness changes with estradiol and progesterone levels across the ovulatory cycle. Horm Behav. 2013;63:13-19.
44. Maestriperi D, Klimczuk ACE, Traficonte DM, et al. A greater decline in female facial attractiveness during middle age reflects women's loss of reproductive value. Frontier Psych. 2014;5:179.
45. Gunn DA, Larsen LA, Lall JS, et al. Mortality is written on the face. J Gerontol A Biol Med Sci. 2016;71:72-77.
46. Fink B, Grammer K, Matts PJ. Visible skin color distribution plays a role in the perception of age, attractiveness, and health in female faces. Evolution Human Behav. 2006;27:433-442.
47. Jones BC, Hahn AC, Fisher CI, et al. Facial coloration tracks changes in women's estradiol. Psychoneuroendocrinol. 2015;56:29-34.
48. Draelos ZD, Puglises PT. Physiology of the Skin, 3rd ed. Carol Stream, IL: Allurebooks; 2011.
49. Stanczyk FZ. Production, clearance, and measurement of steroid hormones. Glob Libr Women's Med. 2009:1-19. https://doi.org/10.3843/glowm.10278.