Bipolar disorder with binge eating behavior: A genome-wide association study implicates PRR5-ARHGAP8

Translational Psychiatry

Volumn 8, Issue 1, 2018, Pages

  McElroy, Susan L ^a,b   Winham, Stacey J ^c   Cuellar Barboza, Alfredo B ^d   Colby, Colin L ^c   Ho, Ada Man Choi ^e   Sicotte, Hugues ^c   Larrabee, Beth R ^c   Crow, Scott ^f   Frye, Mark A ^c   Biernacka, Joanna M ^c  

^a LINDNER CENTER OF HOPE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c MAYO CLINIC   (United States)

^d UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

^e MAYO GRADUATE SCHOOL   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN RHOGAP; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ARHGAP8 PROTEIN, HUMAN; CARRIER PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PRR5 PROTEIN, HUMAN;

ARTICLE; BINGE EATING DISORDER; BIOBANK; BIPOLAR DISORDER; COMORBIDITY; GENE; GENOME-WIDE ASSOCIATION STUDY; HUMAN; META ANALYSIS; PRR5 ARHGAP8 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; ADOLESCENT; ADULT; AGED; BULIMIA; CASE CONTROL STUDY; FEMALE; GENETICS; MALE; META ANALYSIS (TOPIC); MIDDLE AGED; PATHOPHYSIOLOGY; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL SPECIMEN BANKS; BIPOLAR DISORDER; BULIMIA; CARRIER PROTEINS; CASE-CONTROL STUDIES; COMORBIDITY; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GTPASE-ACTIVATING PROTEINS; HUMANS; MALE; META-ANALYSIS AS TOPIC; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 85041623693     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/s41398-017-0085-3     Document Type: Article

References (61)

1. Hudson, J. I., Hiripi, E., Pope, H. G. Jr. & Kessler, R. C. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol. Psychiatry 61, 348-358 (2007).
2. Woldeyohannes, H. O. et al. Binge eating in adults with mood disorders: Results from the International Mood Disorders Collaborative Project. Obes. Res. Clin. Pract. 10, 531-543 (2015).
3. Castrogiovanni, S., Soreca, I., Troiani, D. & Mauri, M. Binge eating, weight gain and psychosocial adjustment in patients with bipolar disorder. Psychiatry Res. 169, 88-90 (2009).
4. McElroy, S. L. et al. Clinical features of bipolar spectrum with binge eating behaviour. J. Affect. Disord. 201, 95-98 (2016).
5. Bulik, C. M., Sullivan, P. F. & Kendler, K. S. Genetic and environmental contributions to obesity and binge eating. Int. J. Eat. Disord. 33, 293-298 (2003).
6. Lichtenstein, P. et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373, 234-239 (2009).
7. McGuffin, P. et al. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch. Gen. Psychiatry 60, 497-502 (2003).
8. Root, T. L. et al. Shared and unique genetic and environmental influences on binge eating and night eating: a Swedish twin study. Eat. Behav. 11, 92-98 (2010).
9. Sullivan, P. F., Bulik, C. M. & Kendler, K. S. Genetic epidemiology of binging and vomiting. Br. J. Psychiatry 173, 75-79 (1998).
10. Bould, H. et al. Parental mental illness and eating disorders in offspring. Int. J. Eat. Disord. 48, 383-391 (2015).
11. Winham, S. J. et al. Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB. J. Affect. Disord. 165, 151-158 (2014).
12. Mailman, M. D. et al. The NCBI dbGaP database of genotypes and phenotypes. Nat. Genet. 39, 1181-1186 (2007).
13. Frye, M. A. et al. Development of a bipolar disorder biobank: differential phenotyping for subsequent biomarker analyses. Int. J. Bipolar Disord. 3, 30 (2015).
14. Olson, J. E. et al. The Mayo Clinic Biobank: a building block for individualized medicine. Mayo. Clin. Proc. 88, 952-962 (2013).
15. First M. B., Spitzer R. L., Gibbon M., Williams J. B. W. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition with Psychotic Screen (SCID-I/P W/PSY SCREEN). Biometric Research. (New York State Psychiatric Institute: New York, 2002).
16. Stice, E., Fisher, M. & Martinez, E. Eating disorder diagnostic scale: additional evidence of reliability and validity. Psychol. Assess. 16, 60-71 (2004).
17. Stice, E., Telch, C. F. & Rizvi, S. L. Development and validation of the eating disorder diagnostic scale: a brief self-report measure of anorexia, bulimia, and binge-eating disorder. Psychol. Assess. 12, 123-131 (2000).
18. Krabbenborg, M. A. et al. The eating disorder diagnostic scale: psychometric features within a clinical population and a cut-off point to differentiate clinical patients from healthy controls. Eur. Eat. Disord. Rev. 20, 315-320 (2012).
19. Smith, E. N. et al. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol. Psychiatry 14, 755-763 (2009).
20. Pritchard, J. K., Stephens, M. & Donnelly, P. Inference of population structure using multilocus genotype data. Genetics 155, 945-959 (2000).
21. Delaneau, O., Marchini, J. & Zagury, J. F. A linear complexity phasing method for thousands of genomes. Nat. Methods 9, 179-181 (2012).
22. Howie, B., Fuchsberger, C., Stephens, M., Marchini, J. & Abecasis, G. R. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat. Genet. 44, 955-959 (2012).
23. Koren, R. et al. Preliminary evidence for the role of HTR2A variants in binge eating in young women. Psychiatr. Genet. 24, 28-33 (2014).
24. Micali, N., Field, A. E., Treasure, J. L. & Evans, D. M. Areobesity risk genes associated with binge eating in adolescence? Obesity 23, 1729-1736 (2015).
25. Wade, T. D. et al. Genetic variants associated with disordered eating. Int. J. Eat. Disord. 46, 594-608 (2013).
26. Kheradpour, P. & Kellis, M. Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments. Nucleic Acids Res. 42, 2976-2987 (2014).
27. Boyle, A. P. et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 22, 1790-1797 (2012).
28. Trabzuni, D. et al. Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies. J. Neurochem. 119, 275-282 (2011).
29. Durand, N. C. et al. Juicebox provides a visualization system for Hi-C contact maps with unlimited zoom. Cell. Syst. 3, 99-101 (2016).
30. Rao, S. S. et al. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell 159, 1665-1680 (2014).
31. GTEx Consortium. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science 348, 648-660 (2015).
32. de Leeuw, C. A., Mooij, J. M., Heskes, T. & Posthuma, D. MAGMA: generalized gene-set analysis of GWAS data. PLoS. Comput. Biol. 11, e1004219 (2015).
33. Wahane, S. D. et al. PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2. J. Neurochem. 130, 255-267 (2014).
34. Kocalis, H. E. et al. Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis. Mol. Metab. 3, 394-407 (2014).
35. Tcherkezian, J. & Lamarche-Vane, N. Current knowledge of the large RhoGAP family of proteins. Biol. Cell. 99, 67-86 (2007).
36. Akiva, P. et al. Transcription-mediated gene fusion in the human genome. Genome Res. 16, 30-36 (2006).
37. O'Leary, N. A. et al. Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation. Nucleic Acids Res. 44, D733-D745 (2016).
38. Bracho-Valdés, I. et al. mTORC1- and mTORC2-interacting proteins keep their multifunctional partners focused. Iubmb. Life. 63, 896-914 (2011).
39. Siddoway, B. A. et al. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J. Neurosci. 33, 11206-11211 (2013).
40. Yang, H. et al. Protein Phosphatase-1 Inhibitor-2 Is a novel memory suppressor. J. Neurosci. 35, 15082-15087 (2015).
41. Tanimukai, H., Grundke-Iqbal, I. & Iqbal, K. Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. Am. J. Pathol. 166, 1761-1771 (2005).
42. Arif, M. et al. Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau. J. Biol. Chem. 289, 27677-27691 (2014).
43. Ceulemans, H. & Bollen, M. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol. Rev. 84, 1-39 (2004).
44. Leach, C., Shenolikar, S. & Brautigan, D. L. Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis. J. Biol. Chem. 278, 26015-26020 (2003).
45. Wang, W., Stukenberg, P. T. & Brautigan, D. L. Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells. Mol. Biol. Cell. 19, 4852-4862 (2008).
46. Wang, X. et al. Endogenous regulators of protein phosphatase-1 during mouse oocyte development and meiosis. Reproduction 128, 493-502 (2004).
47. Terry-Lorenzo, R. T. et al. Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. J. Biol. Chem. 277, 46535-46543 (2002).
48. Grote-Wessels, S. et al. Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload. Cardiovasc. Res. 79, 464-471 (2008).
49. Kirchhefer, U. et al. Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2. Cardiovasc. Res. 68, 98-108 (2005).
50. Yamada, M. et al. Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy. Faseb. J. 20, 1197-1199 (2006).
51. Belforte, J. E. et al. Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes. Nat. Neurosci. 13, 76-83 (2010).
52. Bottiglieri, T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr. Rev. 54, 382-390 (1996).
53. Zhang, Y. et al. Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia. PLoS. One 11, e0146797 (2016).
54. Kim, W. Y. & Snider, W. D. Functions of GSK-3 Signaling in Development of the Nervous System. Front. Mol. Neurosci. 4, 44 (2011).
55. Klein, P. S. & Melton, D. A. Amolecular mechanismfor the effect of lithium on development. Proc. Natl. Acad. Sci. USA 93, 8455-8459 (1996).
56. Helfer, G. & Tups, A. Hypothalamic Wnt Signalling and its Role in Energy Balance Regulation. J. Neuroendocrinol. 28, 12368 (2016).
57. Cuellar-Barboza, A. B. et al. Accumulating evidence for a role of TCF7L2 variants in bipolar disorder with elevated body mass index. Bipolar Disord. 18, 124-135 (2016).
58. Winham, S. J. et al. Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. Mol Psychiatry. 19, 1010-1016 (2014).
59. Boraska, V. et al. A genome-wide association study of anorexia nervosa. Mol. Psychiatry 19, 1085-1094 (2014).
60. Liu, X. Bipolar Genome S, Kelsoe JR, Greenwood TA. A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region. J. Affect. Disord. 189, 141-149 (2016).
61. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat. Genet. 43, 977-983 (2011).