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Volumn , Issue , 2003, Pages 259-282

SARs and QSARs of mutagens and carcinogens: Understanding action mechanisms and improving risk assessment

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EID: 85041427248     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9780203010822     Document Type: Chapter
Times cited : (13)

References (71)
  • 1
    • 0001059812 scopus 로고
    • Quantitative structure-activity relationships and the unnamed science
    • Hansch, C., Quantitative structure-activity relationships and the unnamed science, Acc. Chem. Res., 26, 147, 1993.
    • (1993) Acc. Chem. Res. , vol.26 , pp. 147
    • Hansch, C.1
  • 2
    • 33746106422 scopus 로고
    • Multifactor interaction network of carcinogenesis: A “tour guide”
    • Arcos, J.C., Argus, M.F., Woo, Y.T., Eds., Birkhauser, Boston
    • Arcos, J.C. and Argus, M.F., Multifactor interaction network of carcinogenesis: a “tour guide”, in Chemical Induction of Cancer: Modulation and Combination Effects, Arcos, J.C., Argus, M.F., Woo, Y.T., Eds., Birkhauser, Boston, 1995, p. 1.
    • (1995) Chemical Induction of Cancer: Modulation and Combination Effects , pp. 1
    • Arcos, J.C.1    Argus, M.F.2
  • 3
    • 84974803514 scopus 로고    scopus 로고
    • Mechanisms of action of chemical carcinogens, and their role in structure- activity relationship (SAR) analysis and risk assessment
    • Benigni, R., Ed., CRC Press, Boca Raton, FL
    • Woo, Y.-T., Mechanisms of action of chemical carcinogens, and their role in structure- activity relationship (SAR) analysis and risk assessment, in Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens, Benigni, R., Ed., CRC Press, Boca Raton, FL, 2003.
    • (2003) Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens
    • Woo, Y.-T.1
  • 4
    • 0003078007 scopus 로고
    • Ultimate chemical carcinogens as reactive mutagenic electrophiles
    • Hiatt, H.H., Watson, J.D., and Winsten, J.A., Eds., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
    • Miller, J.A. and Miller, E.C., Ultimate chemical carcinogens as reactive mutagenic electrophiles, in Origins of Human Cancer, Hiatt, H.H., Watson, J.D., and Winsten, J.A., Eds., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1977, p. 605.
    • (1977) Origins of Human Cancer , pp. 605
    • Miller, J.A.1    Miller, E.C.2
  • 5
    • 0022400101 scopus 로고
    • Fundamental structural alerts to potential carcinogenicity or non-carcinogenicity
    • Ashby, J., Fundamental structural alerts to potential carcinogenicity or non-carcinogenicity, Environ. Mutagen., 7, 919, 1995.
    • (1995) Environ. Mutagen. , vol.7 , pp. 919
    • Ashby, J.1
  • 6
    • 0029153221 scopus 로고
    • Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals
    • Woo, Y.-T., et al., Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals, Toxicol. Lett., 79, 219, 1995.
    • (1995) Toxicol. Lett. , vol.79 , pp. 219
    • Woo, Y.-T.1
  • 7
    • 0036179149 scopus 로고    scopus 로고
    • Use of mechanism-based structure-activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products
    • Woo, Y.-T., et al., Use of mechanism-based structure-activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products, Environ. Health Perspect., 110, 75, 2002.
    • (2002) Environ. Health Perspect. , vol.110 , pp. 75
    • Woo, Y.-T.1
  • 8
    • 0031698019 scopus 로고    scopus 로고
    • Quantitative structure-based modeling applied to characterization and prediction of chemical toxicity
    • Benigni, R. and Richard, A.M., Quantitative structure-based modeling applied to characterization and prediction of chemical toxicity, Methods, 14, 264, 1998.
    • (1998) Methods , vol.14 , pp. 264
    • Benigni, R.1    Richard, A.M.2
  • 9
    • 0031904573 scopus 로고    scopus 로고
    • QSAR models for discriminating between mutagenic and nonmutagenic aromatic and heteroaromatic amines
    • Benigni, R. et al., QSAR models for discriminating between mutagenic and nonmutagenic aromatic and heteroaromatic amines, Environ. Mol. Mutagen., 32, 75, 1998.
    • (1998) Environ. Mol. Mutagen. , vol.32 , pp. 75
    • Benigni, R.1
  • 10
    • 0031419526 scopus 로고    scopus 로고
    • Avoided and avoidable risks of cancer
    • Tomatis, L. et al., Avoided and avoidable risks of cancer, Carcinogenesis, 18, 97, 1997.
    • (1997) Carcinogenesis , vol.18 , pp. 97
    • Tomatis, L.1
  • 11
    • 0025736936 scopus 로고
    • Scientific concepts, value, and significance of chemical carcinogenesis studies
    • Huff, J.E., Haseman, J.K., and Rall, D.P., Scientific concepts, value, and significance of chemical carcinogenesis studies, Annu. Rev. Pharmacol. Toxicol., 31, 621, 1991.
    • (1991) Annu. Rev. Pharmacol. Toxicol. , vol.31 , pp. 621
    • Huff, J.E.1    Haseman, J.K.2    Rall, D.P.3
  • 12
    • 0026342471 scopus 로고
    • The carcinogenic potency database: Analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program
    • Gold, L.S. et al., The carcinogenic potency database: analyses of 4000 chronic animal cancer experiments published in the general literature and by the U.S. National Cancer Institute/National Toxicology Program, Environ. Health Perspect., 96, 11, 1991.
    • (1991) Environ. Health Perspect. , vol.96 , pp. 11
    • Gold, L.S.1
  • 13
    • 0027175399 scopus 로고
    • Chemicals and cancer in humans: First evidence in experimental animals
    • Huff, J., Chemicals and cancer in humans: first evidence in experimental animals, Environ. Health Perspect., 100, 201, 1993.
    • (1993) Environ. Health Perspect. , vol.100 , pp. 201
    • Huff, J.1
  • 14
    • 0002702420 scopus 로고    scopus 로고
    • Value, validity, and historical development of carcinogenesis studies for predicting and confirming carcinogenic risks to humans
    • Kitchin, K.T., Ed., Marcel Dekker, New York
    • Huff, J., Value, validity, and historical development of carcinogenesis studies for predicting and confirming carcinogenic risks to humans, in Carcinogenicity: Testing, Predicting, and Interpreting Chemical Effects., Kitchin, K.T., Ed., Marcel Dekker, New York, 1999, p. 21.
    • (1999) Carcinogenicity: Testing, Predicting, and Interpreting Chemical Effects. , pp. 21
    • Huff, J.1
  • 15
    • 0033403543 scopus 로고    scopus 로고
    • Long-term chemical carcinogenesis bioassays predict human cancer hazards: Issues, controversies, and uncertainties
    • Huff, J., Long-term chemical carcinogenesis bioassays predict human cancer hazards: issues, controversies, and uncertainties, Ann. N.Y. Acad. Sci., 895, 56, 1999.
    • (1999) Ann. N.Y. Acad. Sci. , vol.895 , pp. 56
    • Huff, J.1
  • 16
    • 0032912955 scopus 로고    scopus 로고
    • Tumor profiles and carcinogenic potency in rodents and humans: Value for cancer risk assessment
    • Benigni, R. and Giuliani, A., Tumor profiles and carcinogenic potency in rodents and humans: value for cancer risk assessment, Environ. Carcino. Ecotoxicol. Rev., C17, 45, 1999.
    • (1999) Environ. Carcino. Ecotoxicol. Rev. , vol.C17 , pp. 45
    • Benigni, R.1    Giuliani, A.2
  • 17
    • 0024244903 scopus 로고
    • Correlation between carcinogenic potency of chemicals in animals and humans
    • Allen, B.C., Crump, K.S., and Shipp, A.M., Correlation between carcinogenic potency of chemicals in animals and humans, Risk Anal., 8, 531, 1988.
    • (1988) Risk Anal. , vol.8 , pp. 531
    • Allen, B.C.1    Crump, K.S.2    Shipp, A.M.3
  • 18
    • 0025936262 scopus 로고
    • Quantitative prediction of human cancer risk from rodent carcinogenic potencies: A closer look at the epidemiological evidence for some chemicals not definitively carcinogenic in humans
    • Goodman, G. and Wilson, R., Quantitative prediction of human cancer risk from rodent carcinogenic potencies: a closer look at the epidemiological evidence for some chemicals not definitively carcinogenic in humans, Regulat. Pharmacol. Toxicol., 14, 118, 1991.
    • (1991) Regulat. Pharmacol. Toxicol. , vol.14 , pp. 118
    • Goodman, G.1    Wilson, R.2
  • 19
    • 0021809192 scopus 로고
    • Profiles of induced tumors in animals
    • Bucci, T.J., Profiles of induced tumors in animals, Toxicol. Pathol., 13, 105, 1985.
    • (1985) Toxicol. Pathol. , vol.13 , pp. 105
    • Bucci, T.J.1
  • 20
    • 0032511834 scopus 로고    scopus 로고
    • Profiles of chemically-induced tumors in rodents: Quantitative relationships
    • Benigni, R. and Pino, A., Profiles of chemically-induced tumors in rodents: quantitative relationships. Mutat. Res., 421, 93, 1998.
    • (1998) Mutat. Res. , vol.421 , pp. 93
    • Benigni, R.1    Pino, A.2
  • 21
    • 0034807089 scopus 로고    scopus 로고
    • Prediction of rodent carcinogenicity of aromatic amines: A quantitative structure-activity relationships model
    • Franke, R. et al., Prediction of rodent carcinogenicity of aromatic amines: a quantitative structure-activity relationships model, Carcinogenesis, 22, 1561, 2001.
    • (2001) Carcinogenesis , vol.22 , pp. 1561
    • Franke, R.1
  • 22
    • 0034970078 scopus 로고    scopus 로고
    • Carcinogenesis bioassays: Study duration and biological relevance
    • Haseman, J.K. et al., Carcinogenesis bioassays: study duration and biological relevance, Food Chem. Toxicol., 39, 739, 2001.
    • (2001) Food Chem. Toxicol. , vol.39 , pp. 739
    • Haseman, J.K.1
  • 23
    • 0029912210 scopus 로고    scopus 로고
    • Quantitative structure-activity relationship (QSAR) studies of mutagens and carcinogens
    • Benigni, R. and Giuliani, A., Quantitative structure-activity relationship (QSAR) studies of mutagens and carcinogens, Med. Res. Rev., 16, 267, 1996.
    • (1996) Med. Res. Rev. , vol.16 , pp. 267
    • Benigni, R.1    Giuliani, A.2
  • 24
    • 0028839283 scopus 로고
    • QSAR in toxicology. 3. Prediction of chronic toxicities
    • Cronin, M.T.D. and Dearden, J.C., QSAR in toxicology. 3. Prediction of chronic toxicities, Quant. Struct.-Act. Relat., 14, 329, 1995.
    • (1995) Quant. Struct.-Act. Relat. , vol.14 , pp. 329
    • Cronin, M.T.D.1    Dearden, J.C.2
  • 25
    • 0028144409 scopus 로고
    • The importance of the hydrophobic interaction in the mutagenicity of organic compounds
    • Debnath, A.K. et al., The importance of the hydrophobic interaction in the mutagenicity of organic compounds, Mutat. Res., 305, 63, 1994.
    • (1994) Mutat. Res. , vol.305 , pp. 63
    • Debnath, A.K.1
  • 26
    • 0026321207 scopus 로고
    • Structure-activity relationships of chemical mutagens and carcinogens
    • Hansch, C., Structure-activity relationships of chemical mutagens and carcinogens, Sci. Tot. Environ., 109/110, 17, 1991.
    • (1991) Sci. Tot. Environ. , vol.109 , Issue.110 , pp. 17
    • Hansch, C.1
  • 28
    • 0035263818 scopus 로고    scopus 로고
    • Chem-bioinformatics and QSAR: A review of QSAR lacking positive hydrophobic terms
    • Hansch, C. et al., Chem-bioinformatics and QSAR: a review of QSAR lacking positive hydrophobic terms, Chem. Rev., 101, 619, 2001.
    • (2001) Chem. Rev. , vol.101 , pp. 619
    • Hansch, C.1
  • 29
    • 0036516054 scopus 로고    scopus 로고
    • Chem-bioinformatics: Comparative QSAR at the interface between chemistry and biology
    • Hansch, C. et al., Chem-bioinformatics: comparative QSAR at the interface between chemistry and biology, Chem. Rev., 102, 783, 2002.
    • (2002) Chem. Rev. , vol.102 , pp. 783
    • Hansch, C.1
  • 30
    • 0036095371 scopus 로고    scopus 로고
    • Carcinogenicity of the aromatic amines: From structure- activity relationships to mechanisms of action and risk assessment
    • Benigni, R. and Passerini, L., Carcinogenicity of the aromatic amines: from structure- activity relationships to mechanisms of action and risk assessment, Mutat. Res. Rev., 511, 191, 2002.
    • (2002) Mutat. Res. Rev. , vol.511 , pp. 191
    • Benigni, R.1    Passerini, L.2
  • 31
    • 0028721103 scopus 로고
    • Implications of council regulation 793/93 on the evaluation and control of existing substances
    • McCutcheon, P., Implications of council regulation 793/93 on the evaluation and control of existing substances, Ann. Ist. Super. Sanità, 30, 367, 1994.
    • (1994) Ann. Ist. Super. Sanità , vol.30 , pp. 367
    • McCutcheon, P.1
  • 32
    • 0029586108 scopus 로고
    • QSAR in toxicology. 4. Prediction of non-lethal mammalian toxicological end points, and expert systems for toxicity prediction
    • Cronin, M.T.D. and Dearden, J.C., QSAR in toxicology. 4. Prediction of non-lethal mammalian toxicological end points, and expert systems for toxicity prediction, Quant. Struct.-Act. Relat., 14, 518, 1995.
    • (1995) Quant. Struct.-Act. Relat. , vol.14 , pp. 518
    • Cronin, M.T.D.1    Dearden, J.C.2
  • 33
    • 0001383515 scopus 로고    scopus 로고
    • The development and validation of expert systems for predicting toxicity
    • Dearden, J.C. et al., The development and validation of expert systems for predicting toxicity, Alternative to Laboratory Animals (ATLA), 25, 223, 1997.
    • (1997) Alternative to Laboratory Animals (ATLA) , vol.25 , pp. 223
    • Dearden, J.C.1
  • 34
    • 0036491315 scopus 로고    scopus 로고
    • AI and SAR approaches for predicting chemical carcinogenicity: Survey and status report
    • Richard, A.M. and Benigni, R., AI and SAR approaches for predicting chemical carcinogenicity: survey and status report, SAR QSAR Environ. Res., 13, 1, 2002.
    • (2002) SAR QSAR Environ. Res. , vol.13 , pp. 1
    • Richard, A.M.1    Benigni, R.2
  • 35
    • 0025266201 scopus 로고
    • Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program
    • Tennant, R.W. et al., Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program, Mutagenesis, 5, 3, 1990.
    • (1990) Mutagenesis , vol.5 , pp. 3
    • Tennant, R.W.1
  • 36
    • 0029850743 scopus 로고    scopus 로고
    • The NIEHS predictive-toxicology evaluation project: Chemcarcinogenicity biossay
    • Bristol, D.W., Wachsman, J.T., and Greenwell, A., The NIEHS predictive-toxicology evaluation project: chemcarcinogenicity biossay, Environ. Health Perspect., 104, 1001, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1001
    • Bristol, D.W.1    Wachsman, J.T.2    Greenwell, A.3
  • 37
    • 0025940664 scopus 로고
    • On the rodent bioassays currently being conducted on 44 chemicals: A RASH analysis to predict test results from the National Toxicology Program
    • Jones, J.D. and Easterly, C.E., On the rodent bioassays currently being conducted on 44 chemicals: a RASH analysis to predict test results from the National Toxicology Program, Mutagenesis, 6, 507, 1991.
    • (1991) Mutagenesis , vol.6 , pp. 507
    • Jones, J.D.1    Easterly, C.E.2
  • 38
    • 0025049544 scopus 로고
    • Prediction of the carcinogenicity in rodents of chemicals currently being tested by the U.S. National Toxicology Program: Structure- activity correlations
    • Rosenkranz, H.S. and Klopman, G., Prediction of the carcinogenicity in rodents of chemicals currently being tested by the U.S. National Toxicology Program: structure- activity correlations, Mutagenesis, 5, 425, 1990.
    • (1990) Mutagenesis , vol.5 , pp. 425
    • Rosenkranz, H.S.1    Klopman, G.2
  • 39
    • 0025006006 scopus 로고
    • Prediction of probability of carcinogenicity for a set of ongoing NTP bioassays
    • Enslein, K., Blake, B.W., and Borgstedt, H.H., Prediction of probability of carcinogenicity for a set of ongoing NTP bioassays, Mutagenesis, 5, 305, 1990.
    • (1990) Mutagenesis , vol.5 , pp. 305
    • Enslein, K.1    Blake, B.W.2    Borgstedt, H.H.3
  • 40
    • 0025083966 scopus 로고
    • A prospective toxicity evalution (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program
    • Lewis, D.F.V., Ionnides, C., and Parke, D.V., A prospective toxicity evalution (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program, Mutagenesis, 5, 433, 1990.
    • (1990) Mutagenesis , vol.5 , pp. 433
    • Lewis, D.F.V.1    Ionnides, C.2    Parke, D.V.3
  • 41
    • 0025863682 scopus 로고
    • Computer prediction of possible toxic action from chemical structure: The DEREK system
    • Sanderson, D.M. and Earnshaw, C.G., Computer prediction of possible toxic action from chemical structure: the DEREK system, Hum. Exp. Toxicol., 10, 261, 1991.
    • (1991) Hum. Exp. Toxicol. , vol.10 , pp. 261
    • Sanderson, D.M.1    Earnshaw, C.G.2
  • 42
    • 0026612818 scopus 로고
    • Prospective Ke screening of potential carcinogens being tested in rodent bioassay by the U.S. National Toxicology Program
    • Bakale, G. and McCreary, R.D., Prospective Ke screening of potential carcinogens being tested in rodent bioassay by the U.S. National Toxicology Program, Mutagenesis, 7, 91, 1992.
    • (1992) Mutagenesis , vol.7 , pp. 91
    • Bakale, G.1    McCreary, R.D.2
  • 43
    • 0342409716 scopus 로고
    • QSAR prediction of rodent carcinogenicity for a set of chemicals currently bioassayed by the U.S. National Toxicology Program
    • Benigni, R., QSAR prediction of rodent carcinogenicity for a set of chemicals currently bioassayed by the U.S. National Toxicology Program, Mutagenesis, 19, 83, 1991.
    • (1991) Mutagenesis , vol.19 , pp. 83
    • Benigni, R.1
  • 44
    • 0026612315 scopus 로고
    • Electrophilicity as measured by Ke: Molecular determinants, relationship with other physical chemical and quantum mechanical parameters, and ability to predict rodent carcinogenicity
    • Benigni, R. et al., Electrophilicity as measured by Ke: molecular determinants, relationship with other physical chemical and quantum mechanical parameters, and ability to predict rodent carcinogenicity, Carcinogenesis, 13, 547, 1992.
    • (1992) Carcinogenesis , vol.13 , pp. 547
    • Benigni, R.1
  • 46
    • 0030755884 scopus 로고    scopus 로고
    • The first U.S. National Toxicology Program exercise on the prediction of rodent carcinogenicity: Definitive results
    • Benigni, R., The first U.S. National Toxicology Program exercise on the prediction of rodent carcinogenicity: definitive results, Mutat. Res., 387, 35, 1997.
    • (1997) Mutat. Res. , vol.387 , pp. 35
    • Benigni, R.1
  • 47
    • 20144370898 scopus 로고    scopus 로고
    • Robust classification for imprecise environment
    • Provost, F. and Fawcett, T., Robust classification for imprecise environment, Machine Learn. J., 42, 5, 2001.
    • (2001) Machine Learn. J. , vol.42 , pp. 5
    • Provost, F.1    Fawcett, T.2
  • 48
    • 0003061963 scopus 로고    scopus 로고
    • Structure-activity relationships in mutagenesis and carcinogenesis
    • Balls, M., van Zeller, A.M., and Halder, M.E., Eds., Elsevier Science, Amsterdam
    • Benigni, R., Structure-activity relationships in mutagenesis and carcinogenesis, in Progress in the Reduction, Refinement and Replacement of Animal Experimentation, Balls, M., van Zeller, A.M., and Halder, M.E., Eds., Elsevier Science, Amsterdam, 2000, p. 469.
    • (2000) Progress in the Reduction, Refinement and Replacement of Animal Experimentation , pp. 469
    • Benigni, R.1
  • 49
    • 0031464198 scopus 로고    scopus 로고
    • Mechanism-based structure-activity relationship (SAR) analysis of carcinogenic potential of 30 NTP test chemicals
    • Woo, Y.T. et al., Mechanism-based structure-activity relationship (SAR) analysis of carcinogenic potential of 30 NTP test chemicals, Environ. Carcino. Ecotoxicol. Rev., C15, 139, 1997.
    • (1997) Environ. Carcino. Ecotoxicol. Rev. , vol.C15 , pp. 139
    • Woo, Y.T.1
  • 50
    • 0029842286 scopus 로고    scopus 로고
    • Multiconponent criteria for predicting carcinogenicity: Dataset of 30 NTP chemicals
    • Huff, J., Weisburger, E., and Fung, V.A., Multiconponent criteria for predicting carcinogenicity: dataset of 30 NTP chemicals, Environ. Health Perspect., 104, 1105, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1105
    • Huff, J.1    Weisburger, E.2    Fung, V.A.3
  • 51
    • 0029800749 scopus 로고    scopus 로고
    • Prediction of the carcinogenicity of further 30 chemicals biossayed by the U.S. National Toxicology Program
    • Benigni, R., Andreoli, C., and Zito, R., Prediction of the carcinogenicity of further 30 chemicals biossayed by the U.S. National Toxicology Program, Environ. Health Perspect., 104, 1041, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1041
    • Benigni, R.1    Andreoli, C.2    Zito, R.3
  • 52
    • 0029849049 scopus 로고    scopus 로고
    • Predictions for the outcome of rodent carcinogenicity biossays: Identification of trans-species carcinogens and noncarcinogens
    • Tennant, R.W. and Spalding, J., Predictions for the outcome of rodent carcinogenicity biossays: identification of trans-species carcinogens and noncarcinogens, Environ. Health Perspect., 104, 1095, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1095
    • Tennant, R.W.1    Spalding, J.2
  • 53
    • 0029804837 scopus 로고    scopus 로고
    • Prediction of rodent carcinogenicity for 30 chemicals
    • Ashby, J., Prediction of rodent carcinogenicity for 30 chemicals, Environ. Health Perspect., 104, 1101, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1101
    • Ashby, J.1
  • 54
    • 0029850744 scopus 로고    scopus 로고
    • Prediction of the rodent carcinogenicity of organic compounds from their chemical structures using the FALS method
    • Moriguchi, I., Hirano, H., and Hirono, S., Prediction of the rodent carcinogenicity of organic compounds from their chemical structures using the FALS method, Environ. Health Perspect., 104, 1051, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1051
    • Moriguchi, I.1    Hirano, H.2    Hirono, S.3
  • 55
    • 0030002065 scopus 로고    scopus 로고
    • Speculations on the rodent carcinogenicity of 30 chemicals currently under evaluation in rat and mouse bioassays organised by the U.S. National Toxicology Program
    • Bootman, J., Speculations on the rodent carcinogenicity of 30 chemicals currently under evaluation in rat and mouse bioassays organised by the U.S. National Toxicology Program, Environ. Mol. Mutagen., 27, 237, 1996.
    • (1996) Environ. Mol. Mutagen. , vol.27 , pp. 237
    • Bootman, J.1
  • 56
    • 0029823285 scopus 로고    scopus 로고
    • A RASH analysis of National Toxicity Program data: Predictions for 30 compounds to be tested in rodent carcinogenesis experiments
    • Jones, T.D. and Easterly, C.E., A RASH analysis of National Toxicity Program data: predictions for 30 compounds to be tested in rodent carcinogenesis experiments, Environ. Health Perspect., 104, 1017, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1017
    • Jones, T.D.1    Easterly, C.E.2
  • 57
    • 0029841726 scopus 로고    scopus 로고
    • Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent biossays
    • Kerckaert, G.A. et al., Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent biossays, Environ. Health Perspect., 104, 1075, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1075
    • Kerckaert, G.A.1
  • 58
    • 0029850561 scopus 로고    scopus 로고
    • Carcinogenicity predictions for a group of 30 chemicals undergoing rodent cancer biossays based on rules derived from subchronic organic toxicities
    • Lee, Y., Buchanan, B.G., and Rosenkranz, H.S., Carcinogenicity predictions for a group of 30 chemicals undergoing rodent cancer biossays based on rules derived from subchronic organic toxicities, Environ. Health Perspect., 104, 1059, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1059
    • Lee, Y.1    Buchanan, B.G.2    Rosenkranz, H.S.3
  • 59
    • 0029803504 scopus 로고    scopus 로고
    • Prediction of the carcinogenicity of a second group of organic chemicals undergoing carcinogenicity testing
    • Zhang, Y.P. et al., Prediction of the carcinogenicity of a second group of organic chemicals undergoing carcinogenicity testing, Environ. Health Perspect., 104, 1045, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1045
    • Zhang, Y.P.1
  • 60
    • 0029824974 scopus 로고    scopus 로고
    • Prediction of rodent carcinogenicity biossays from molecular structure using inductive logic programming
    • King, R.D. and Srinivasan, A., Prediction of rodent carcinogenicity biossays from molecular structure using inductive logic programming, Environ. Health Perspect., 104, 1031, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1031
    • King, R.D.1    Srinivasan, A.2
  • 61
    • 0029822722 scopus 로고    scopus 로고
    • Prediction of rodent carcinogenicity using the DEREK system for 30 chemicals currently being tested by the National Toxicology Program
    • Marchant, C.A., Prediction of rodent carcinogenicity using the DEREK system for 30 chemicals currently being tested by the National Toxicology Program, Environ. Health Perspect., 104, 1065, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1065
    • Marchant, C.A.1
  • 62
    • 0029850983 scopus 로고    scopus 로고
    • A Mechanism-mediated model for carcinogenicity: Model content and prediction of the outcome of rodent carcinogenicity biossays currently being conducted on 25 organic chemicals
    • Purdy, R., A Mechanism-mediated model for carcinogenicity: model content and prediction of the outcome of rodent carcinogenicity biossays currently being conducted on 25 organic chemicals, Environ. Health Perspect., 104, 1085, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1085
    • Purdy, R.1
  • 63
    • 0029831688 scopus 로고    scopus 로고
    • COMPACT and molecular structure in toxicity assessment: A prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP
    • Lewis, D.F.V., Ioannides, C., and Parke, D.V., COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP, Environ. Health Perspect., 104, 1011, 1996.
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1011
    • Lewis, D.F.V.1    Ioannides, C.2    Parke, D.V.3
  • 64
    • 0026584756 scopus 로고
    • The structure-activity relationships of skin carcinogenicity of aromatic hydrocarbons and heterocycles
    • Zhang, L. et al., The structure-activity relationships of skin carcinogenicity of aromatic hydrocarbons and heterocycles, Chem. Biol. Interact., 81, 149, 1992.
    • (1992) Chem. Biol. Interact. , vol.81 , pp. 149
    • Zhang, L.1
  • 65
    • 0034301460 scopus 로고    scopus 로고
    • Quantitative structure-activity relationships of mutagenic and carcinogenic aromatic amines
    • Benigni, R. et al. Quantitative structure-activity relationships of mutagenic and carcinogenic aromatic amines, Chem. Rev., 100, 3697, 2000.
    • (2000) Chem. Rev. , vol.100 , pp. 3697
    • Benigni, R.1
  • 66
    • 0030569257 scopus 로고    scopus 로고
    • QSARs of mutagens and carcinogens: Two case studies illustrating problems in the construction of models for noncongeneric chemicals
    • Benigni, R. and Richard, A.M., QSARs of mutagens and carcinogens: two case studies illustrating problems in the construction of models for noncongeneric chemicals, Mutat. Res., 371, 29, 1996.
    • (1996) Mutat. Res. , vol.371 , pp. 29
    • Benigni, R.1    Richard, A.M.2
  • 67
    • 0029153806 scopus 로고
    • The carcinogenesis biossay in perspective: Application in identifying human cancer hazards
    • Fung, V.A., Barrett, J.C., and Huff, J., The carcinogenesis biossay in perspective: application in identifying human cancer hazards, Environ. Health Perspect., 103, 680, 1995.
    • (1995) Environ. Health Perspect. , vol.103 , pp. 680
    • Fung, V.A.1    Barrett, J.C.2    Huff, J.3
  • 68
    • 0033403085 scopus 로고    scopus 로고
    • Mega-experiments to identify and assess diffuse carcinogenic risks
    • Soffritti, M. et al., Mega-experiments to identify and assess diffuse carcinogenic risks, Ann. N.Y. Acad. Sci., 895, 34, 1999.
    • (1999) Ann. N.Y. Acad. Sci. , vol.895 , pp. 34
    • Soffritti, M.1
  • 70
    • 0032458218 scopus 로고    scopus 로고
    • A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSARES software
    • Matthews, E.J. and Contrera, J.F., A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSARES software, Regulat. Pharmacol. Toxicol., 28, 242, 1998.
    • (1998) Regulat. Pharmacol. Toxicol. , vol.28 , pp. 242
    • Matthews, E.J.1    Contrera, J.F.2
  • 71
    • 0031128199 scopus 로고    scopus 로고
    • Carcinogenicity testing and the evaluation of regulatory requirements for pharmaceuticals
    • Contrera, J.F., Jacobs, A.C., and DeGeorge, J.J., Carcinogenicity testing and the evaluation of regulatory requirements for pharmaceuticals, Regulat. Pharmacol. Toxicol., 25, 130, 1997.
    • (1997) Regulat. Pharmacol. Toxicol. , vol.25 , pp. 130
    • Contrera, J.F.1    Jacobs, A.C.2    DeGeorge, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.