Predictions for the outcome of rodent carcinogenicity bioassays: Identification of trans-species carcinogens and noncarcinogens

Environmental Health Perspectives

Volumn 104, Issue SUPPL. 5, 1996, Pages 1095-1100

  Tennant, Raymond W ^a   Spalding, Judson ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Carcinogenicity bioassays; Carcinogens; Genotoxicity; Predicting carcinogens; Predictive toxicology

Indexed keywords

CARCINOGEN;

BIOASSAY; CARCINOGENICITY; CONFERENCE PAPER; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RODENT;

RODENTIA; SALMONELLA;

EID: 0029849049     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.96104s51095     Document Type: Conference Paper

References (15)

1. Tennant RW, Spalding J, Stasiewicz S, Ashby J. Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program. Mutagenesis 5:3-14 (1990).
2. Wachsman JT, Bristol DW, Spalding J, Shelby M, Tennant RW. Predicting chemical carcinogenesis in rodents. Environ Health Perspect 101:444-445 (1993).
3. Ashby J, Tennant RW. Prediction of rodent carcinogenicity for 44 chemicals: results. Mutagenesis 9:7-15 (1994).
4. Tennant RW, Stasiewicz S, Spalding J. Comparison of multiple parameters of rodent carcinogenicity and in vitro genetic toxicity. Environ Mutagen 8:205-227 (1986).
5. Ashby J, Tennant RW. Definitive relationships between chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutat Res 257:229-306 (1991).
6. Tennant RW. Stratification of rodent carcinogenicity bioassay results to reflect relative human hazard. Mutat Res 286:111-118 (1993).
7. Festing MFW. Use of multistrain assay could improve the NTP carcinogenesis bioassay. Environ Health Perspect 103:44-52 (1995).
8. Tennant RW, French JE, Spalding JW. Transgenic mouse models identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models. Environ Health Perspect 103(10):942-950 (1995).
9. 2μ-globulin nephropathy. Annu Rev Pharmacol Toxicol 30:349-367 (1990).
10. 2μ-globulin, hyaline droplet nephropathy, and tubule neoplasia in the kidneys of male rats. Environ Health Perspect 99:313-349 (1993).
11. Swenberg JA, Dietrich DR, McClain RM, Cohen SM. Mechanisms of Carcinogenesis in Risk Identification (Vainio H, McGee PN, McGregor DB, McMichael AJ, eds). Lyon:International Agency for Research on Cancer, 1992;477-500.
12. Isseman I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650 (1990).
13. Popp JA, Cattley RC. Peroxisome proliferators as initiators and promoters of rodent hepatocarcinogenesis. In: Monograph on Peroxisome Proliferation (Gibson G, Lake B, eds). London:Taylor and Francis, 1993:653-665.
14. Green S. PPAR: a mediator of peroxisome proliferator action. Mutat Res 333(1-2): 101-109 (1995).
15. Lake BG. Peroxisome proliferation: current mechanisms relating to nongenotoxic carcinogenesis. Toxicol Lett 82-83:673-681 (1995).