Carcinogenesis bioassays: Study duration and biological relevance

Food and Chemical Toxicology

Volumn 39, Issue 7, 2001, Pages 739-744

  Haseman, J ^a   Melnick, R ^a   Tomatis, L ^a   Huff, J ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

National Toxicology Program; Relevance to humans; Rodent carcinogenicity bioassay; Study duration; Time to tumor

Indexed keywords

ADULT; ANIMAL MODEL; ARTICLE; CANCER STAGING; CARCINOGENESIS; CARCINOGENICITY; CONTROLLED STUDY; DATA BASE; HUMAN; LABORATORY DIAGNOSIS; NONHUMAN; RELIABILITY; RODENT;

ANIMALS; CARCINOGENS; FEMALE; MALE; MAXIMUM TOLERATED DOSE; MICE; MODELS, ANIMAL; PUBLIC POLICY; RATS; RISK ASSESSMENT; SPECIES SPECIFICITY; TIME FACTORS; UNITED STATES;

ANIMALIA; RODENTIA;

EID: 0034970078     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(01)00010-2     Document Type: Article

References (27)

1. Pollution, pesticides and cancer misconceptions
2. Paracelsus to parascience: The environmental cancer distraction
3. Ageing and the mechanisms of carcinogenesis: Some practical implications
4. Tumor profiles and carcinogenic potency in rodents and humans: Value for cancer risk assessment
5. Doses in rodent cancer studies: Sorting fact from fiction
6. Rodent carcinogenicity tests need be no longer than 18 months: An analysis based on 210 chemicals in the IARC Monographs
7. The carcinogenesis bioassay in perspective: Application in identifying human cancer hazards
8. Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two year carcinogenicity studies: A National Toxicology Program update
9. Applicability to humans of rodent-specific sites of chemical carcinogenicity: Tumors of the forestomach and of the Harderian, preputial, and zymbal glands induced by benzene
10. Chemicals and cancer in humans: First evidence in experimental animals
11. Chemicals causally associated with cancers in humans and in laboratory animals: A perfect concordance
12. Value, validity, and historical development of carcinogenesis studies for predicting and confirming carcinogenic risks to humans
13. Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents
14. Availability of epidemiologic data for chemicals known to cause cancer in animals: An update
15. The effect of discounting certain tumor types/sites on evaluations of carcinogenicity in laboratory animals
16. Species differences in carcinogenesis
17. The scientific and methodological bases of experimental studies for detecting and quantifying carcinogenic risks
18. Are lifespan rodent carcinogenicity studies defensible for pharmaceutical agents?
19. Report of Discussion Group 4: Inception and duration of tests
20. The predictive value of rodent carcinogenicity tests in the evaluation of human risks
21. Etiologic evidence and primary prevention of cancer
22. Human carcinogens so far identified
23. Alleged "misconceptions" distort perceptions of environmental cancer risks
24. Response of experimental animals to human carcinogens: An analysis based upon the IARC Monographs programme