Prediction of rodent carcinogenicity using the DEREK system for 30 chemicals currently being tested by the National Toxicology Program

Environmental Health Perspectives

Volumn 104, Issue SUPPL. 5, 1996, Pages 1065-1073

  Marchant, Carol A ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Carcinogenicity; Computer prediction; DEREK; Genotoxicity; Mutagenicity; National Toxicology Program; Toxicity

Indexed keywords

CARCINOGEN;

CARCINOGENICITY; CONFERENCE PAPER; EXPERT SYSTEM; GENOTOXICITY; NONHUMAN; PRIORITY JOURNAL; RODENT; TOXICITY TESTING;

RODENTIA; SALMONELLA;

EID: 0029822722     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.96104s51065     Document Type: Conference Paper

References (49)

1. Wachsman JT, Bristol DW, Spalding J, Shelby M, Tennant RW. Predicting chemical carcinogenesis in rodents. Environ Health Perspect 101:444-445 (1993).
2. Sanderson DM, Earnshaw CG. Computer prediction of possible toxic action from chemical structure; the DEREK system. Hum Exp Toxicol 10:261-273 (1991).
3. Ridings JE, Barratt MD, Cary R, Earnshaw CG, Eggington CE, Ellis MK, Judson PN, Langowski JJ, Marchant CA, Payne MP, Watson WP, Yih TD. Computer prediction of possible toxic action from chemical structure: an update on the DEREK system. Toxicology 106:267-279 (1996).
4. Ashby J, Tennant RW. Prediction of rodent carcinogenicity for 44 chemicals: results. Mutagenesis 9:7-15 (1994).
5. US FDA. Carcinogen structure guide. In: General principles for evaluating the safety of compounds used in food-producing animals. Washington:US Food and Drug Administration, 1986; Appendix I:7-17.
6. McConnell EE. NTP carcinogens - interpretational problems. Mutat Res 248:233-237 (1991).
7. Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella, mutagenicity test results for 250 chemicals. Environ Mutagen 5(Suppl 1):3-142 (1983).
8. Mortelmans K, Haworth S, Lawlor T, Speck W, Tainer B, Zeiger E. Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ Mutagen 8(Suppl 7):1-119 (1986).
9. Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen 9(Suppl 9): 1-109 (1987).
10. Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ Mol Mutagen 11(Suppl 12):1-158 (1988).
11. Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ Mol Mutagen 19(Suppl 21):2-141 (1992).
12. Ashby J, Paton D. The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 55 different human carcinogen exposures. Mutat Res 286:3-74 (1993).
13. Fiala ES, Sodum RS, Hussain NS, Rivenson A, Dolan L. Secondary nitroalkanes: induction of DNA repair in rat hepatocytes, activation by aryl sulfotransferase and hepatocarcinogenicity of 2-nitrobutane and 3-nitropentane in male F344 rats. Toxicology 99:89-97 (1995).
14. Kari FW, Bucher J, Eustis SL, Haseman JK, Huff JE. Toxicity and carcinogenicity of hydroquinone in F344/N rats and B6C3F1 mice. Food Chem Toxicol 30:737-747 (1992).
15. Ito N, Fukushima S, Hagiwara A, Shibata M, Ogiso T. Carcinogenicity of butylated hydroxyanisole in F344 rats. J Natl Cancer Inst 70:343-352 (1983).
16. Maltoni C, Conti B, Cotti G, Belpoggi F. Experimental studies on benzene carcinogenicity at the Bologna Institute of Oncology: current results and ongoing research. Am J Ind Med 7:415-446 (1985).
17. Reuzel PGJ, Bosland MC, Van der Meulen HC, Feron VJ. A 2-year inhalation carcinogenicity study of chloroprene in rats. Rpt No R6077. Zeist, The Netherlands:Centraal Instituut Voor Voedingsonderzoek, 1980.
18. IARC. Chloroprene. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Suppl 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42. Lyon:International Agency for Research on Cancer, 1987;160.
19. Hartwig A. Current aspects in metal genotoxicity. BioMetals 8:3-11 (1995).
20. 2μ-globulin nephropathy. Toxicol In Vitro 8:885-887 (1994).
21. Allavena A, Martelli A, Robbiano L, Brambilla G. Evaluation in a battery of in vivo assays of four in vitro genotoxins proved to be noncarcinogens in rodents. Teratog Carcinog Mutagen 12:31-41 (1992).
22. NTP. Toxicology and Carcinogenesis Studies of 2-Chloroethanol (Ethylene Chlorohydrin) (CAS No. 107-07-3) in F344/N Rats and Swiss CD-1 Mice. (Dermal Studies). NTP Technical Rpt No 275. Research Triangle Park, NC:National Toxicology Program, 1985.
23. Nomeir AA, Silveita DM, McComish MF, Chadwick M. Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Drug Metab Dispos 20:198-204 (1992).
24. NTP. Toxicology and Carcinogenesis Studies of Furfural (CAS No. 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP Technical Rpt No 382. Research Triangle Park, NC:National Toxicology Program, 1990.
25. NTP. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344/N Rats and B6C3F1 Mice. (Gavage Studies). NTP Technical Rpt No 402. Research Triangle Park, NC:National Toxicology Program, 1993.
26. McElhatton PR, Sullivan FM, Toseland PA. Teratogenic activity and metabolism of primidone in the mouse. Epilepsia 18:1-11 (1977).
27. Shaw IC, Jones HB. Mechanisms of non-genotoxic carcinogenesis. Trends Pharmacol Sci 15:89-93 (1994).
28. Jönsson A-K, Steen G. n-Butoxyacetic acid, a urinary metabolite from inhaled n-butoxyethanol (butylcellosolve). Acta Pharmacol Toxicol 42:354-356 (1978).
29. ECETOC. Hepatic Peroxisome Proliferation. ECETOC Monograph No 17. Brussels:European Centre for Ecotoxicology and Toxicology of Chemicals, 1992.
30. Rosner MH, Carter DE. Metabolism and excretion of gallium arsenide and arsenic oxides by hamsters following intratracheal instillation. Fundam Appl Toxicol 9:730-737 (1987).
31. Ashby J, Tennant RW, Zeiger E, Stasiewicz S. Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U.S. National Toxicology Program. Mutat Res 223:73-103 (1989).
32. IARC. Arsenic and arsenic compounds. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Suppl 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42. Lyon:International Agency for Research on Cancer, 1987;100-106.
33. Cornet M, Castelain P, Vercruysse A, Laib R, Kirsch-Volders M, Rogiers V. Mutagenicity of 2-methylpropene (isobutene) and its epoxide in a modified Salmonella assay for volatile compounds. Mutat Res 271:213-221 (1992).
34. NTP. Toxicology and Carcinogenesis Studies of Propylene (CAS no. 115-07-1) in F-344/N Rats and B6C3F1 Mice (Inhalation Studies). NTP Technical Rpt No 272. Research Triangle Park, NC:National Toxicology Program, 1985.
35. Howes AJ, Chan VSW, Caldwell J. Structure-specificity of the genotoxicity of some naturally occurring alkenyfbenzenes determined by the unscheduled DNA synthesis assay in rat hepatocytes. Food Chem Toxicol 28:537-542 (1990).
36. Miller EC, Swanson AB, Phillips DH, Fletcher TL, Liem A, Miller JA. Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. Cancer Res 43:1124-1134 (1983).
37. NTP. Carcinogenesis Studies of Eugenol (CAS No. 97-53-0) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP Technical Rpt No 223. Research Triangle Park, NC:National Toxicology Program, 1983.
38. Shimoji N, Imaida K, Hasegawa R, Matsuoka C, Takahashi Uneyama C, Takahashi M, Hayashi Y. Enhancing effect of oxymetholone, an anabolic steroid, on development of liver cell foci in rats initiated with N-diethylnitrosamine. Cancer Lett 49:165-168 (1990).
39. IARC. Androgenic (anabolic) steroids. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Suppl 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42. Lyon:International Agency for Research on Cancer, 1987;96-99.
40. Mori H, Yoshimi N, Iwata H, Mori Y, Hara A, Tanaka T, Kawai K. Carcinogenicity of naturally-occurring 1-hydroxyanthraquinone in rats - induction of large-bowel, liver and stomach neoplasms. Carcinogenesis 11:799-802 (1990).
41. Bosch R, Friederich U, Lutz WK, Brocker E, Bachmann M, Schlatter C. Investigations on DNA binding in rat liver and in Salmonella and on mutagenicity in the Ames test by emodin, a natural anthraquinone. Mutat Res 188:161-168 (1987).
42. Wölfle D, Schmutte C, Westendorf J, Marquardt H. Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes. Cancer Res 50:6540-6544 (1990).
43. Eder E, Deininger C, Neudecker T, Deininger D. Mutagenicity of β-alkyl substituted acrolein congeners in the Salmonella typhimurium strain TA100 and genotoxicity testing in the SOS chromotest. Environ Mol Mutagen 19:338-345 (1992).
44. Geldof AA, Engel C, Rao BR. Estrogenic action of commonly used fragrant agent citral induces prostatic hyperplasia. Urol Res 20:139-144 (1992).
45. Mukherjee A, Giri AK, Talukder G, Sharma A. Sister chromatid exchanges and micronuclei formations induced by sorbic acid and sorbic acid-nitrite in vivo in mice. Toxicol Lett 42:47-53 (1988).
46. Mirvish SS, Bulay O, Runge RG, Patil K. Study of the carcinogenicity of large doses of dimethylnitramine, N-nitroso-L-proline, and sodium nitrite administered in drinking water to rats. J Natl Cancer Inst 64:1435-1442 (1980).
47. Lijinsky W, Kovatch R, Riggs CW. Altered incidences of hepatic and hemopoietic neoplasms in F344 rats fed sodium nitrite. Carcinogenesis 4:1189-1191 (1983).
48. Hebert CD, Yuan J, Dieter MP. Comparison of the toxicity of cinnamaldehyde when administered by microencapsulation in feed or by corn oil gavage. Food Chem Toxicol 32:1107-1115 (1994).
49. Léonard A, Gerber GB. Mutagenicity, Carcinogenicity and teratogenicity of vanadium compounds. Mutat Res 317:81-88 (1994).