-
1
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O’Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010; 363: 711-723.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O’Day, S.J.2
McDermott, D.F.3
-
2
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366: 2443-2454.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
3
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma
-
Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013; 369: 134-144.
-
(2013)
N Engl J Med
, vol.369
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
-
4
-
-
84898973055
-
Survival, durable tumor remission, and longterm safety in patients with advanced melanoma receiving nivolumab
-
Topalian SL, Sznol M, McDermott DF, et al. Survival, durable tumor remission, and longterm safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014; 32: 1020-1030.
-
(2014)
J Clin Oncol
, vol.32
, pp. 1020-1030
-
-
Topalian, S.L.1
Sznol, M.2
McDermott, D.F.3
-
5
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 2015; 373: 1627-1639.
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
6
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
-
Herbst RS, Baas P, Kim DW, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 2016; 387: 1540-1550.
-
(2016)
Lancet
, vol.387
, pp. 1540-1550
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.W.3
-
7
-
-
84962038946
-
Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): A multicentre, open-label, phase 2 randomised controlled trial
-
Fehrenbacher L, Spira A, Ballinger M, et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial. Lancet 2016; 387: 1837-1846.
-
(2016)
Lancet
, vol.387
, pp. 1837-1846
-
-
Fehrenbacher, L.1
Spira, A.2
Ballinger, M.3
-
8
-
-
85007564166
-
Atezolizumab as first-line treatment in cisplatinineligible patients with locally advanced and metastatic urothelial carcinoma: A single-arm, multicentre, phase 2 trial
-
Balar AV, Galsky MD, Rosenberg JE, et al. Atezolizumab as first-line treatment in cisplatinineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial. Lancet 2017; 389: 67-76.
-
(2017)
Lancet
, vol.389
, pp. 67-76
-
-
Balar, A.V.1
Galsky, M.D.2
Rosenberg, J.E.3
-
9
-
-
84969988424
-
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): An open-label, multicentre, phase 1b trial
-
Seiwert TY, Burtness B, Mehra R, et al. Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial. Lancet Oncol 2016; 17: 956-965.
-
(2016)
Lancet Oncol
, vol.17
, pp. 956-965
-
-
Seiwert, T.Y.1
Burtness, B.2
Mehra, R.3
-
10
-
-
84994812847
-
Nivolumab for recurrent squamous-cell carcinoma of the head and neck
-
Ferris RL, Blumenschein G Jr, Fayette J, et al. Nivolumab for recurrent squamous-cell carcinoma of the head and neck. N Engl J Med 2016; 375: 1856-1867.
-
(2016)
N Engl J Med
, vol.375
, pp. 1856-1867
-
-
Ferris, R.L.1
Blumenschein, G.2
Fayette, J.3
-
11
-
-
84989918072
-
Safety and efficacy of durvalumab (MEDI4736), an anti-programmed cell death ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder cancer
-
Massard C, Gordon MS, Sharma S, et al. Safety and efficacy of durvalumab (MEDI4736), an anti-programmed cell death ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder cancer. J Clin Oncol 2016; 34: 3119-3125.
-
(2016)
J Clin Oncol
, vol.34
, pp. 3119-3125
-
-
Massard, C.1
Gordon, M.S.2
Sharma, S.3
-
12
-
-
84992340907
-
Avelumab in patients with chemotherapyrefractory metastatic Merkel cell carcinoma: A multicentre, single-group, open-label, phase 2 trial
-
Kaufman HL, Russell J, Hamid O, et al. Avelumab in patients with chemotherapyrefractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial. Lancet Oncol 2016; 17: 1374-1385.
-
(2016)
Lancet Oncol
, vol.17
, pp. 1374-1385
-
-
Kaufman, H.L.1
Russell, J.2
Hamid, O.3
-
13
-
-
84994802263
-
Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer
-
Reck M, Rodriguez-Abreu D, Robinson AG, et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med 2016; 375: 1823-1833.
-
(2016)
N Engl J Med
, vol.375
, pp. 1823-1833
-
-
Reck, M.1
Rodriguez-Abreu, D.2
Robinson, A.G.3
-
14
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 2015; 372: 320-330.
-
(2015)
N Engl J Med
, vol.372
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
-
15
-
-
84931083080
-
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial
-
Weber JS, D’Angelo SP, Minor D, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 2015; 16: 375-384.
-
(2015)
Lancet Oncol
, vol.16
, pp. 375-384
-
-
Weber, J.S.1
D’Angelo, S.P.2
Minor, D.3
-
16
-
-
84929481480
-
Pembrolizumab for the treatment of non-smallcell lung cancer
-
Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-smallcell lung cancer. N Engl J Med 2015; 372: 2018-2028.
-
(2015)
N Engl J Med
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
-
17
-
-
84946607195
-
Nivolumab versus everolimus in advanced renalcell carcinoma
-
Motzer RJ, Escudier B, McDermott DF, et al. Nivolumab versus everolimus in advanced renalcell carcinoma. N Engl J Med 2015; 373: 1803-1813.
-
(2015)
N Engl J Med
, vol.373
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
-
18
-
-
85029163151
-
PD-L1 expression in advanced NSCLC: Insights into risk stratification and treatment selection from a systematic literature review
-
Brody R, Zhang Y, Ballas M, et al. PD-L1 expression in advanced NSCLC: insights into risk stratification and treatment selection from a systematic literature review. Lung Cancer 2017; 112: 200-215.
-
(2017)
Lung Cancer
, vol.112
, pp. 200-215
-
-
Brody, R.1
Zhang, Y.2
Ballas, M.3
-
19
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015; 348: 124-128.
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
-
20
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le DT, Uram JN, Wang H, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 2015; 372: 2509-2520.
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
21
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 2014; 371: 2189-2199.
-
(2014)
N Engl J Med
, vol.371
, pp. 2189-2199
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
-
22
-
-
84943516465
-
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
-
Van Allen EM, Miao D, Schilling B, et al. Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science 2015; 350: 207-211.
-
(2015)
Science
, vol.350
, pp. 207-211
-
-
van Allen, E.M.1
Miao, D.2
Schilling, B.3
-
23
-
-
85046072368
-
Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
-
Hugo W, Zaretsky JM, Sun L, et al. Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma. Cell 2017; 168: 542.
-
(2017)
Cell
, vol.168
, pp. 542
-
-
Hugo, W.1
Zaretsky, J.M.2
Sun, L.3
-
24
-
-
0035953308
-
IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
-
Shankaran V, Ikeda H, Bruce AT, et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001; 410: 1107-1111.
-
(2001)
Nature
, vol.410
, pp. 1107-1111
-
-
Shankaran, V.1
Ikeda, H.2
Bruce, A.T.3
-
25
-
-
84983216790
-
Mutations associated with acquired resistance to PD-1 blockade in melanoma
-
Zaretsky JM, Garcia-Diaz A, Shin DS, et al. Mutations associated with acquired resistance to PD-1 blockade in melanoma. N Engl J Med 2016; 375: 819-829.
-
(2016)
N Engl J Med
, vol.375
, pp. 819-829
-
-
Zaretsky, J.M.1
Garcia-Diaz, A.2
Shin, D.S.3
-
26
-
-
84962540914
-
Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome
-
Tripathi SC, Peters HL, Taguchi A, et al. Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome. Proc Natl Acad Sci USA 2016; 113: E1555-E1564.
-
(2016)
Proc Natl Acad Sci USA
, vol.113
, pp. E1555-E1564
-
-
Tripathi, S.C.1
Peters, H.L.2
Taguchi, A.3
-
27
-
-
84940381273
-
Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses
-
Chiappinelli KB, Strissel PL, Desrichard A, et al. Inhibiting DNA methylation causes an interferon response in cancer via dsRNA including endogenous retroviruses. Cell 2015; 162: 974-986.
-
(2015)
Cell
, vol.162
, pp. 974-986
-
-
Chiappinelli, K.B.1
Strissel, P.L.2
Desrichard, A.3
-
28
-
-
84940403834
-
DNAdemethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts
-
Roulois D, Loo Yau H, Singhania R, et al. DNAdemethylating agents target colorectal cancer cells by inducing viral mimicry by endogenous transcripts. Cell 2015; 162: 961-973.
-
(2015)
Cell
, vol.162
, pp. 961-973
-
-
Roulois, D.1
Loo Yau, H.2
Singhania, R.3
-
29
-
-
84959019222
-
Epigenetic modulators and the new immunotherapies
-
Dear AE. Epigenetic modulators and the new immunotherapies. N Engl J Med 2016; 374: 684-686.
-
(2016)
N Engl J Med
, vol.374
, pp. 684-686
-
-
Dear, A.E.1
-
30
-
-
84986903108
-
Vitamin C increases viral mimicry induced by 5-aza-2’-deoxycytidine
-
Liu M, Ohtani H, Zhou W, et al. Vitamin C increases viral mimicry induced by 5-aza-2’-deoxycytidine. Proc Natl Acad Sci USA 2016; 113: 10238-10244.
-
(2016)
Proc Natl Acad Sci USA
, vol.113
, pp. 10238-10244
-
-
Liu, M.1
Ohtani, H.2
Zhou, W.3
-
31
-
-
85017265055
-
Co-activation of STAT3 and YES-associated protein 1 (YAP1) pathway in EGFR-mutant NSCLC
-
Chaib I, Karachaliou N, Pilotto S, et al. Co-activation of STAT3 and YES-associated protein 1 (YAP1) pathway in EGFR-mutant NSCLC. J Natl Cancer Inst 2017; 109: 1-12.
-
(2017)
J Natl Cancer Inst
, vol.109
, pp. 1-12
-
-
Chaib, I.1
Karachaliou, N.2
Pilotto, S.3
-
32
-
-
84901641673
-
Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial
-
Kwon ED, Drake CG, Scher HI, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol 2014; 15: 700-712.
-
(2014)
Lancet Oncol
, vol.15
, pp. 700-712
-
-
Kwon, E.D.1
Drake, C.G.2
Scher, H.I.3
-
33
-
-
85009783306
-
Randomized, double-blind, phase III trial of ipilimumab versus placebo in asymptomatic or minimally symptomatic patients with metastatic chemotherapy-naive castration-resistant prostate cancer
-
Beer TM, Kwon ED, Drake CG, et al. Randomized, double-blind, phase III trial of ipilimumab versus placebo in asymptomatic or minimally symptomatic patients with metastatic chemotherapy-naive castration-resistant prostate cancer. J Clin Oncol 2017; 35: 40-47.
-
(2017)
J Clin Oncol
, vol.35
, pp. 40-47
-
-
Beer, T.M.1
Kwon, E.D.2
Drake, C.G.3
-
34
-
-
84954053129
-
Targeting YAPdependent MDSC infiltration impairs tumor progression
-
Wang G, Lu X, Dey P, et al. Targeting YAPdependent MDSC infiltration impairs tumor progression. Cancer Discov 2016; 6: 80-95.
-
(2016)
Cancer Discov
, vol.6
, pp. 80-95
-
-
Wang, G.1
Lu, X.2
Dey, P.3
-
35
-
-
34249868449
-
Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
-
Yang J, Liao X, Agarwal MK, et al. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev 2007; 21: 1396-1408.
-
(2007)
Genes Dev
, vol.21
, pp. 1396-1408
-
-
Yang, J.1
Liao, X.2
Agarwal, M.K.3
-
36
-
-
84871127292
-
Tumorinfiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
-
Schlecker E, Stojanovic A, Eisen C, et al. Tumorinfiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth. J Immunol 2012; 189: 5602-5611.
-
(2012)
J Immunol
, vol.189
, pp. 5602-5611
-
-
Schlecker, E.1
Stojanovic, A.2
Eisen, C.3
-
37
-
-
84870230232
-
Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection
-
Paley MA, Kroy DC, Odorizzi PM, et al. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science 2012; 338: 1220-1225.
-
(2012)
Science
, vol.338
, pp. 1220-1225
-
-
Paley, M.A.1
Kroy, D.C.2
Odorizzi, P.M.3
-
38
-
-
84872201790
-
IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer
-
Guo J, Kim D, Gao J, et al. IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer. Oncogene 2013; 32: 151-159.
-
(2013)
Oncogene
, vol.32
, pp. 151-159
-
-
Guo, J.1
Kim, D.2
Gao, J.3
-
39
-
-
84992484423
-
IκB kinase ε is an NFATc1 kinase that inhibits T cell immune response
-
Zhang J, Feng H, Zhao J, et al. IκB kinase ε is an NFATc1 kinase that inhibits T cell immune response. Cell Rep 2016; 16: 405-418.
-
(2016)
Cell Rep
, vol.16
, pp. 405-418
-
-
Zhang, J.1
Feng, H.2
Zhao, J.3
-
40
-
-
84904046340
-
Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D
-
Baumgart S, Chen NM, Siveke JT, et al. Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D. Cancer Discov 2014; 4: 688-701.
-
(2014)
Cancer Discov
, vol.4
, pp. 688-701
-
-
Baumgart, S.1
Chen, N.M.2
Siveke, J.T.3
-
41
-
-
79952264325
-
Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations
-
Rosell R, Molina MA, Costa C, et al. Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin Cancer Res 2011; 17: 1160-1168.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1160-1168
-
-
Rosell, R.1
Molina, M.A.2
Costa, C.3
-
42
-
-
67049158197
-
Impaired interferon signaling is a common immune defect in human cancer
-
Critchley-Thorne RJ, Simons DL, Yan N, et al. Impaired interferon signaling is a common immune defect in human cancer. Proc Natl Acad Sci USA 2009; 106: 9010-9015.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 9010-9015
-
-
Critchley-Thorne, R.J.1
Simons, D.L.2
Yan, N.3
-
43
-
-
85011827059
-
Primary resistance to PD-1 blockade mediated by JAK1/2 mutations
-
Shin DS, Zaretsky JM, Escuin-Ordinas H, et al. Primary resistance to PD-1 blockade mediated by JAK1/2 mutations. Cancer Discov 2017; 7: 188-201.
-
(2017)
Cancer Discov
, vol.7
, pp. 188-201
-
-
Shin, D.S.1
Zaretsky, J.M.2
Escuin-Ordinas, H.3
-
44
-
-
0035337444
-
The role of adoptively transferred CD8 T cells and host cells in the control of the growth of the EG7 thymoma: Factors that determine the relative effectiveness and homing properties of Tc1 and Tc2 effectors
-
Helmich BK and Dutton RW. The role of adoptively transferred CD8 T cells and host cells in the control of the growth of the EG7 thymoma: factors that determine the relative effectiveness and homing properties of Tc1 and Tc2 effectors. J Immunol 2001; 166: 6500-6508.
-
(2001)
J Immunol
, vol.166
, pp. 6500-6508
-
-
Helmich, B.K.1
Dutton, R.W.2
-
45
-
-
85019945399
-
Interferon-γ drives treg fragility to promote anti-tumor immunity
-
Overacre-Delgoffe AE, Chikina M, Dadey RE, et al. Interferon-γ drives treg fragility to promote anti-tumor immunity. Cell 2017; 169: 1130.e11-1141.e11.
-
(2017)
Cell
, vol.169
, pp. 11
-
-
Overacre-Delgoffe, A.E.1
Chikina, M.2
Dadey, R.E.3
-
46
-
-
62449309334
-
Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues
-
Chen H, Liakou CI, Kamat A, et al. Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues. Proc Natl Acad Sci USA 2009; 106: 2729-2734.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2729-2734
-
-
Chen, H.1
Liakou, C.I.2
Kamat, A.3
-
47
-
-
84904055758
-
Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation
-
Bald T, Landsberg J, Lopez-Ramos D, et al. Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Cancer Discov 2014; 4: 674-687.
-
(2014)
Cancer Discov
, vol.4
, pp. 674-687
-
-
Bald, T.1
Landsberg, J.2
Lopez-Ramos, D.3
-
48
-
-
85027409839
-
Interferon-γ is a master checkpoint regulator of cytokineinduced differentiation
-
Zha Z, Bucher F, Nejatfard A, et al. Interferon-γ is a master checkpoint regulator of cytokineinduced differentiation. Proc Natl Acad Sci USA 2017; 114: E6867-E6874.
-
(2017)
Proc Natl Acad Sci USA
, vol.114
, pp. E6867-E6874
-
-
Zha, Z.1
Bucher, F.2
Nejatfard, A.3
-
49
-
-
84883863501
-
Up-regulation of PD-L1, IDO, and T(Regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells
-
200ra116
-
Spranger S, Spaapen RM, Zha Y, et al. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Sci Transl Med 2013; 5: 200ra116.
-
(2013)
Sci Transl Med
, vol.5
-
-
Spranger, S.1
Spaapen, R.M.2
Zha, Y.3
-
50
-
-
84935474357
-
PD-L1 expression as a predictive biomarker in cancer immunotherapy
-
Patel SP and Kurzrock R. PD-L1 expression as a predictive biomarker in cancer immunotherapy. Mol Cancer Ther 2015; 14: 847-856.
-
(2015)
Mol Cancer Ther
, vol.14
, pp. 847-856
-
-
Patel, S.P.1
Kurzrock, R.2
-
51
-
-
84937569436
-
Tumor immune microenvironment characterization and response to anti-PD-1 therapy
-
Santarpia M and Karachaliou N. Tumor immune microenvironment characterization and response to anti-PD-1 therapy. Cancer Biol Med 2015; 12: 74-78.
-
(2015)
Cancer Biol Med
, vol.12
, pp. 74-78
-
-
Santarpia, M.1
Karachaliou, N.2
-
52
-
-
84953885167
-
PD-L1 expression as a potential predictive biomarker
-
Fusi A, Festino L, Botti G, et al. PD-L1 expression as a potential predictive biomarker. Lancet Oncol 2015; 16: 1285-1287.
-
(2015)
Lancet Oncol
, vol.16
, pp. 1285-1287
-
-
Fusi, A.1
Festino, L.2
Botti, G.3
-
53
-
-
85015345322
-
PDL1 immunohistochemistry assays for lung cancer: Results from phase 1 of the blueprint PD-L1 IHC assay comparison project
-
Hirsch FR, McElhinny A, Stanforth D, et al. PDL1 immunohistochemistry assays for lung cancer: results from phase 1 of the blueprint PD-L1 IHC assay comparison project. J Thorac Oncol 2017; 12: 208-222.
-
(2017)
J Thorac Oncol
, vol.12
, pp. 208-222
-
-
Hirsch, F.R.1
McElhinny, A.2
Stanforth, D.3
-
54
-
-
85018212139
-
A quantitative comparison of antibodies to programmed cell death 1 ligand 1
-
Gaule P, Smithy JW, Toki M, et al. A quantitative comparison of antibodies to programmed cell death 1 ligand 1. JAMA Oncol 2016. DOI: 10.1001/jamaoncol.2016.3015.
-
(2016)
JAMA Oncol
-
-
Gaule, P.1
Smithy, J.W.2
Toki, M.3
-
55
-
-
85028949327
-
A prospective, multi-institutional, pathologist-based assessment of 4 immunohistochemistry assays for PD-L1 expression in non-small cell lung cancer
-
Rimm DL, Han G, Taube JM, et al. A prospective, multi-institutional, pathologist-based assessment of 4 immunohistochemistry assays for PD-L1 expression in non-small cell lung cancer. JAMA Oncol 2017; 3: 1051-1058.
-
(2017)
JAMA Oncol
, vol.3
, pp. 1051-1058
-
-
Rimm, D.L.1
Han, G.2
Taube, J.M.3
-
56
-
-
85032796880
-
Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers
-
Goodman AM, Kato S, Bazhenova L, et al. Tumor mutational burden as an independent predictor of response to immunotherapy in diverse cancers. Mol Cancer Ther 2017; 16: 2598-2608.
-
(2017)
Mol Cancer Ther
, vol.16
, pp. 2598-2608
-
-
Goodman, A.M.1
Kato, S.2
Bazhenova, L.3
-
57
-
-
85013836274
-
Targeting neoantigens to augment antitumour immunity
-
Yarchoan M, Johnson BA III, Lutz ER, et al. Targeting neoantigens to augment antitumour immunity. Nat Rev Cancer 2017; 17: 569.
-
(2017)
Nat Rev Cancer
, vol.17
, pp. 569
-
-
Yarchoan, M.1
Johnson, B.2
Lutz, E.R.3
-
58
-
-
85012254479
-
Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope
-
Textor A, Schmidt K, Kloetzel PM, et al. Correction: preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med 2017; 214: 567.
-
(2017)
J Exp Med
, vol.214
, pp. 567
-
-
Textor, A.1
Schmidt, K.2
Kloetzel, P.M.3
-
59
-
-
84944458835
-
Local production of the chemokines CCL5 and CXCL10 attracts CD8+ T lymphocytes into esophageal squamous cell carcinoma
-
Liu J, Li F, Ping Y, et al. Local production of the chemokines CCL5 and CXCL10 attracts CD8+ T lymphocytes into esophageal squamous cell carcinoma. Oncotarget 2015; 6: 24978-24989.
-
(2015)
Oncotarget
, vol.6
, pp. 24978-24989
-
-
Liu, J.1
Li, F.2
Ping, Y.3
-
60
-
-
84920956732
-
PD-1 blockade induces responses by inhibiting adaptive immune resistance
-
Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 2014; 515: 568-571.
-
(2014)
Nature
, vol.515
, pp. 568-571
-
-
Tumeh, P.C.1
Harview, C.L.2
Yearley, J.H.3
-
61
-
-
84859128199
-
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
-
Taube JM, Anders RA, Young GD, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012; 4: 127-137.
-
(2012)
Sci Transl Med
, vol.4
, pp. 127-137
-
-
Taube, J.M.1
Ers, R.A.2
Young, G.D.3
-
62
-
-
84928774156
-
The future of immune checkpoint therapy
-
Sharma P and Allison JP. The future of immune checkpoint therapy. Science 2015; 348: 56-61.
-
(2015)
Science
, vol.348
, pp. 56-61
-
-
Sharma, P.1
Allison, J.P.2
-
63
-
-
84941800472
-
Adaptive immune resistance: how cancer protects from immune attack
-
Ribas A. Adaptive immune resistance: how cancer protects from immune attack. Cancer Discov 2015; 5: 915-919.
-
(2015)
Cancer Discov
, vol.5
, pp. 915-919
-
-
Ribas, A.1
-
64
-
-
84936821508
-
Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature
-
Ribas A, Robert C, Hodi FS, et al. Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature. J Clin Oncol 2015; 33: 3001.
-
(2015)
J Clin Oncol
, vol.33
, pp. 3001
-
-
Ribas, A.1
Robert, C.2
Hodi, F.S.3
-
65
-
-
85026675148
-
IFNgamma-related mRNA profile predicts clinical response to PD-1 blockade
-
Ayers M, Lunceford J, Nebozhyn M, et al. IFNgamma-related mRNA profile predicts clinical response to PD-1 blockade. J Clin Invest 2017; 127: 2930-2940.
-
(2017)
J Clin Invest
, vol.127
, pp. 2930-2940
-
-
Ayers, M.1
Lunceford, J.2
Nebozhyn, M.3
-
66
-
-
85041417013
-
Abstract 1773: A baseline IFNG gene expression signature correlates with clinical outcomes in durvalumab-treated advanced NSCLC cancer patients
-
Higgs BW, Morehouse CA, Streicher K, et al. Abstract 1773: a baseline IFNG gene expression signature correlates with clinical outcomes in durvalumab-treated advanced NSCLC cancer patients. Cancer Res 2017; 77: 1773.
-
(2017)
Cancer Res
, vol.77
, pp. 1773
-
-
Higgs, B.W.1
Morehouse, C.A.2
Streicher, K.3
-
67
-
-
85022062788
-
Immune-related gene expression profiling after PD-1 blockade in non-small cell lung carcinoma, head and neck squamous cell carcinoma, and melanoma
-
Prat A, Navarro A, Pare L, et al. Immune-related gene expression profiling after PD-1 blockade in non-small cell lung carcinoma, head and neck squamous cell carcinoma, and melanoma. Cancer Res 2017; 77: 3540-3550.
-
(2017)
Cancer Res
, vol.77
, pp. 3540-3550
-
-
Prat, A.1
Navarro, A.2
Pare, L.3
-
68
-
-
85028707868
-
Identification of essential genes for cancer immunotherapy
-
Patel SJ, Sanjana NE, Kishton RJ, et al. Identification of essential genes for cancer immunotherapy. Nature 2017; 548: 537-542.
-
(2017)
Nature
, vol.548
, pp. 537-542
-
-
Patel, S.J.1
Sanjana, N.E.2
Kishton, R.J.3
-
69
-
-
85029029250
-
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
-
Burr ML, Sparbier CE, Chan YC, et al. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature 2017; 549: 101-105.
-
(2017)
Nature
, vol.549
, pp. 101-105
-
-
Burr, M.L.1
Sparbier, C.E.2
Chan, Y.C.3
-
70
-
-
85029041186
-
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
-
Mezzadra R, Sun C, Jae LT, et al. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature 2017; 549: 106-110.
-
(2017)
Nature
, vol.549
, pp. 106-110
-
-
Mezzadra, R.1
Sun, C.2
Jae, L.T.3
-
71
-
-
85014439476
-
Identification of ALK, ROS1 and RET fusions by a multiplexed mRNA-based assay in formalinfixed, paraffin-embedded samples from advanced non-small-cell lung cancer patients
-
Reguart N, Teixido C, Gimenez-Capitan A, et al. Identification of ALK, ROS1 and RET fusions by a multiplexed mRNA-based assay in formalinfixed, paraffin-embedded samples from advanced non-small-cell lung cancer patients. Clin Chem 2017; 63: 751-760.
-
(2017)
Clin Chem
, vol.63
, pp. 751-760
-
-
Reguart, N.1
Teixido, C.2
Gimenez-Capitan, A.3
|