When enough data are not enough to enact policy: The failure to ban chlorpyrifos

PLoS Biology

Volumn 15, Issue 12, 2017, Pages

  Trasande, Leonardo ^a,b,c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPYRIFOS; ORGANOPHOSPHATE; PESTICIDE;

AGRICULTURE; ARTICLE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; ENVIRONMENTAL POLICY; GOVERNMENT; HEALTH HAZARD; HUMAN; NEUROTOXICITY; GOVERNMENT REGULATION; LEGISLATION AND JURISPRUDENCE; POLICY; POLLUTANT; TOXICITY; UNITED STATES;

AGRICULTURE; CHLORPYRIFOS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; GOVERNMENT REGULATION; HUMANS; ORGANOPHOSPHATES; PESTICIDES; POLICY; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 85039924093     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.2003671     Document Type: Article

References (39)

1. Kass D, McKelvey W, Carlton E, Hernandez M, Chew G, Nagle S, et al. Effectiveness of an integrated pest management intervention in controlling cockroaches, mice, and allergens in New York City public housing. Environ Health Perspect. 2009;117(8):1219–25. Epub 2009/08/13. doi: 10.1289/ehp.0800149 19672400.
2. Grandjean P, Landrigan P.J, Neurobehavioural impact of developmental toxicity. Lancet Neurol. 2014;13:330–8. doi: 10.1016/S1474-4422(13)70278-3 24556010
3. Marsillach J, Costa LG, Furlong CE, Paraoxonase-1 and Early-Life Environmental Exposures. Ann Glob Health. 2016;82(1):100–10. Epub 2016/06/22. doi: 10.1016/j.aogh.2016.01.009 27325068.
4. Bouchard M, Chevrier J, Harley K, Kogut K, Vedar M, Calderon N, et al. Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environ Health Perspect. 2011;119:1189. doi: 10.1289/ehp.1003185 21507776
5. Engel S, Wetmur J, Chen J, Zhu C, Barr D, Canfield R, et al. Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood. Environ Health Perspect. 2011;119:1182. doi: 10.1289/ehp.1003183 21507778
6. Rauh VA, Perera FP, Horton MK, Whyatt RM, Bansal R, Hao X, et al. Brain anomalies in children exposed prenatally to a common organophosphate pesticide. Proc Natl Acad Sci U S A. 2012;109(20):7871–6. Epub 2012/05/02. doi: 10.1073/pnas.1203396109 22547821.
7. De Angelis S, Tassinari R, Maranghi F, Eusepi A, Di Virgilio A, Chiarotti F, et al. Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in CD-1 mice. Toxicological sciences: an official journal of the Society of Toxicology. 2009;108(2):311–9. Epub 2009/02/05. doi: 10.1093/toxsci/kfp017 19190125.
8. Jeong SH, Kim BY, Kang HG, Ku HO, Cho JH, Effect of chlorpyrifos-methyl on steroid and thyroid hormones in rat F0- and F1-generations. Toxicology. 2006;220(2–3):189–202. Epub 2006/02/14. doi: 10.1016/j.tox.2006.01.005 16472551.
9. Levin ED, Addy N, Baruah A, Elias A, Christopher NC, Seidler FJ, et al. Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations. Neurotoxicology and teratology. 2002;24(6):733–41. Epub 2002/12/04. 12460655.
10. Berbel P, Auso E, Garcia-Velasco JV, Molina ML, Camacho M, Role of thyroid hormones in the maturation and organisation of rat barrel cortex. Neuroscience. 2001;107(3):383–94. Epub 2001/11/24. 11718994.
11. Bernal J, Thyroid hormone receptors in brain development and function. Nat Clin Pract Endocrinol Metab. 2007;3(3):249–59. Epub 2007/02/23. doi: 10.1038/ncpendmet0424 17315033.
12. Demeneix B, Losing our minds: chemical pollution and the mental health of future generations. Oxford series in behavioral neuroendocrinology, Oxford University Press, 2014.
13. Wise A, Parham F, Axelrad DA, Guyton KZ, Portier C, Zeise L, et al. Upstream adverse effects in risk assessment: A model of polychlorinated biphenyls, thyroid hormone disruption and neurological outcomes in humans. Environmental Research. 2012;117(0):90–9. http://dx.doi.org/10.1016/j.envres.2012.05.013.
14. Brown AS, Surcel H-M, Hinkka-Yli-Salomäki S, Cheslack-Postava K, Bao Y, Sourander A, Maternal thyroid autoantibody and elevated risk of autism in a national birth cohort. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2015;57(0):86–92. http://dx.doi.org/10.1016/j.pnpbp.2014.10.010.
15. Yau V, Lutsky M, Yoshida C, Lasley B, Kharrazi M, Windham G, et al. Prenatal and Neonatal Thyroid Stimulating Hormone Levels and Autism Spectrum Disorders. Journal of Autism and Developmental Disorders. 2014:1–12. doi: 10.1007/s10803-014-2227-2 25178989
16. Berbel P, Navarro D, Román GC, An evo-devo approach to thyroid hormones in cerebral and cerebellar cortical development: Etiological implications for autism. Frontiers in Endocrinology. 2014;5. doi: 10.3389/fendo.2014.00146 25250016
17. Andersen SL, Laurberg P, Wu CS, Olsen J, Attention deficit hyperactivity disorder and autism spectrum disorder in children born to mothers with thyroid dysfunction: a Danish nationwide cohort study. BJOG: An International Journal of Obstetrics & Gynaecology. 2014;121(11):1365–74. doi: 10.1111/1471-0528.12681 24605987
18. Korevaar TI, Muetzel R, Medici M, Chaker L, Jaddoe VW, de Rijke YB, et al. Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study. Lancet Diabetes Endocrinol. 2016;4(1):35–43. Epub 2015/10/27. doi: 10.1016/S2213-8587(15)00327-7 26497402.
19. Whyatt RM, Rauh V, Barr DB, Camann DE, Andrews HF, Garfinkel R, et al. Prenatal Insecticide Exposures and Birth Weight and Length among an Urban Minority Cohort. Environmental Health Perspectives. 2004;112(10):1125–32. doi: 10.1289/ehp.6641 15238288
20. Allen RW, Barn PK, Lanphear BP, Randomized controlled trials in environmental health research: unethical or underutilized?PLoS Med. 2015;12(1):e1001775. Epub 2015/01/07. doi: 10.1371/journal.pmed.1001775 25562846.
21. Rauh VA, Garcia WE, Whyatt RM, Horton MK, Barr DB, Louis ED, Prenatal exposure to the organophosphate pesticide chlorpyrifos and childhood tremor. Neurotoxicology. 2015;51:80–6. Epub 2015/09/20. doi: 10.1016/j.neuro.2015.09.004 26385760.
22. Bellanger M, Demeneix B, Grandjean P, Zoeller RT, Trasande L, Neurobehavioral Deficits, Diseases and Associated Costs of Exposure to Endocrine Disrupting Chemicals in the European Union. J Clin Endocrinol Metab. 2015:jc20144323. Epub 2015/03/06. doi: 10.1210/jc.2014-4323 25742515.
23. US EPA. EPA Administrator Pruitt Denies Petition to Ban Widely Used Pesticide [Speeches, Testimony and Transcripts]. 2017 [updated 2017-05-30]. https://www.epa.gov/newsreleases/epa-administrator-pruitt-denies-petition-ban-widely-used-pesticide-0.
24. US Government Printing Office. 80 FR 69079—CHLORPYRIFOS; TOLERANCE REVOCATIONS 2017. https://www.gpo.gov/fdsys/search/pagedetails.action?granuleId=2015-28083&packageId=FR-2015-11-06&acCode=FR.
25. US EPA. Revised Human Health Risk Assessment on Chlorpyrifos [Overviews and Factsheets]. 2018 [updated 2018-04-26; cited 2017 June 29]. https://www.epa.gov/ingredients-used-pesticide-products/revised-human-health-risk-assessment-chlorpyrifos.
26. New York Times. E.P.A. Chief, Rejecting Agency’s Science, Chooses Not to Ban Insecticide 2017 [updated 20170329]. https://www.nytimes.com/2017/03/29/us/politics/epa-insecticide-chlorpyrifos.html.
27. US Government Printing Office. Chlorpyrifos; Order Denying PANNA and NRDC’s Petition To Revoke Tolerances 2017. https://www.gpo.gov/fdsys/pkg/FR-2017-04-05/html/2017-06777.htm.
28. Seufert V, Ramankutty N, Foley JA, Comparing the yields of organic and conventional agriculture. Nature. 2012;485:229–32. doi: 10.1038/nature11069 22535250
29. United Nations Human Rights Office of the High Commissioner. OHCHR | Special Rapporteur on the right to food 2017 [cited 2017 June 29]. http://www.ohchr.org/EN/Issues/Food/Pages/FoodIndex.aspx.
30. Bellanger M, Demeneix B, Grandjean P, Zoeller RT, Trasande L, Neurobehavioral deficits, diseases, and associated costs of exposure to endocrine-disrupting chemicals in the European union. The Journal of clinical endocrinology and metabolism. 2015;100(4):1256–66. Epub 2015/03/06. doi: 10.1210/jc.2014-4323 25742515.
31. Attina TM, Hauser R, Sathyanarayana S, Hunt PA, Bourguignon JP, Myers JP, et al. Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis. Lancet Diabetes Endocrinol. 2016;4(12):996–1003. Epub 2016/10/22. doi: 10.1016/S2213-8587(16)30275-3 27765541.
32. Salkever DS, Assessing the IQ-earnings link in environmental lead impacts on children: have hazard effects been overstated?Environ Res. 2014;131:219–30. Epub 2014/05/13. doi: 10.1016/j.envres.2014.03.018 24814698.
33. Hill A, The Environment and Disease: Association or Causation?Proc R Soc Med. 1965;58(5):295–300.
34. Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, et al. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015:er20151010. Epub 2015/11/07. doi: 10.1210/er.2015-1010 26544531.
35. Bergman Å HJ, Jobling S, Kidd KA, Zoeller RT (eds),. Global Assessment of State-of-the-science for Endocrine Disruptors. http://www.who.int/ipcs/publications/new_issues/endocrine_disruptors/en/ (Accessed 6 October 2014). 2012.
36. Bergman A, Becher G, Blumberg B, Bjerregaard P, Bornman R, Brandt I, et al. Manufacturing doubt about endocrine disrupter science—A rebuttal of industry-sponsored critical comments on the UNEP/WHO report "State of the Science of Endocrine Disrupting Chemicals 2012". Regulatory toxicology and pharmacology: RTP. 2015. Epub 2015/08/05. doi: 10.1016/j.yrtph.2015.07.026 26239693.
37. Dietrich DR, EU safety regulations: Don’t mar legislation with pseudoscience. Nature. 2016;535(7612):355-. http://www.nature.com/nature/journal/v535/n7612/abs/535355c.html#supplementary-information. doi: 10.1038/535355c 27443732
38. Bond GG, Dietrich DR, Human cost burden of exposure to endocrine disrupting chemicals. A critical review. Arch Toxicol. 2017. Epub 2017/05/22. doi: 10.1007/s00204-017-1985-y 28528477.
39. Dietrich DR, Hengstler JG, Conflict of interest statements: current dilemma and a possible way forward. Arch Toxicol. 2016;90(9):2293–5. doi: 10.1007/s00204-016-1783-y 27351767.