Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Nature Genetics

Volumn 50, Issue 1, 2018, Pages 42-50

  Demenais, Florence ^a,b   Margaritte Jeannin, Patricia ^a,b   Barnes, Kathleen C ^c   Cookson, William O C ^d   Altmüller, Janine ^e   Ang, Wei ^f   Barr, R Graham ^g   Beaty, Terri H ^h   Becker, Allan B ⁱ   Beilby, John ^j   Bisgaard, Hans ^k   Bjornsdottir, Unnur Steina ^l   Bleecker, Eugene ^m   Bønnelykke, Klaus ^k   Boomsma, Dorret I ⁿ   Bouzigon, Emmanuelle ^a,b   Brightling, Christopher E ^o   Brossard, Myriam ^a,b   Brusselle, Guy G ^p,q   Burchard, Esteban ^r   Burkart, Kristin M ^s   Bush, Andrew ^d,t   Chan Yeung, Moira ^u   Chung, Kian Fan ^d,t   Couto Alves, Alexessander ^v   Curtin, John A ^w   Custovic, Adnan ^v   Daley, Denise ^u   De Jongste, Johan C ^q   Del Rio Navarro, Blanca E ^x   Donohue, Kathleen M ^g   Duijts, Liesbeth ^q   Eng, Celeste ^y   Eriksson, Johan G ^z   Farrall, Martin ^aa,ab   Fedorova, Yuliya ^ac   Feenstra, Bjarke ^ad   Ferreira, Manuel A ^ae   Freidin, Maxim B ^af   Gajdos, Zofia ^ag,ah   Gauderman, Jim ^ai   Gehring, Ulrike ^aj   Geller, Frank ^ad   Genuneit, Jon ^ak   Gharib, Sina A ^al   Gilliland, Frank ^ai   Granell, Raquel ^am,an   Graves, Penelope E ^ao   Gudbjartsson, Daniel F ^ap,aq   Haahtela, Tari ^z   Heckbert, Susan R ^al   Heederik, Dick ^aj   Heinrich, Joachim ^ar,as   Heliövaara, Markku ^at   Henderson, John ^am,an   Himes, Blanca E ^au   Hirose, Hiroshi ^av   Hirschhorn, Joel N ^ag,ah,aw   Hofman, Albert ^q,ax   Holt, Patrick ^ay   Hottenga, Jouke ⁿ   Hudson, Thomas J ^az,ba   Hui, Jennie ^j,bb,bc   Imboden, Medea ^bd,be   Ivanov, Vladimir ^bf   Jaddoe, Vincent W V ^q   James, Alan ^bg,bh   Janson, Christer ^bi   Jarvelin, Marjo Riitta ^v,bj,bk,bl   Jarvis, Deborah ^d,v   Jones, Graham ^bm   Jonsdottir, Ingileif ^ap,aq   Jousilahti, Pekka ^at   Kabesch, Michael ^bn   Kähönen, Mika ^bo   Kantor, David B ^ag,aw   Karunas, Alexandra S ^ac,bp   Khusnutdinova, Elza ^ac,bp   Koppelman, Gerard H ^bq,br   Kozyrskyj, Anita L ^bs   Kreiner, Eskil ^k   Kubo, Michiaki ^bt   Kumar, Rajesh ^bu,bv   Kumar, Ashish ^bd,be,bw   Kuokkanen, Mikko ^z,at   Lahousse, Lies ^q,bx   Laitinen, Tarja ^by   Laprise, Catherine ^bz,ca   Lathrop, Mark ^cb   Lau, Susanne ^cc   Lee, Young Ae ^cc,cd   Lehtimäki, Terho ^bo   Letort, Sébastien ^a,b   Levin, Albert M ^ce   Li, Guo ^al   Liang, Liming ^ax   Loehr, Laura R ^cf   London, Stephanie J ^cg   Loth, Daan W ^q   Manichaikul, Ani ^ch   Marenholz, Ingo ^cc,cd   Martinez, Fernando J ^ao   Matheson, Melanie C ^ci   Mathias, Rasika A ^cj   Matsumoto, Kenji ^ck   Mbarek, Hamdi ⁿ   McArdle, Wendy L ^an   Melbye, Mads ^k,ad,cl   Melén, Erik ^bw,cm,cn   Meyers, Deborah ^m   Michel, Sven ^bn   Mohamdi, Hamida ^a,b   Musk, Arthur W ^bc,bg   Myers, Rachel A ^co   Nieuwenhuis, Maartje A E ^br,cp   Noguchi, Emiko ^cq   O'Connor, George T ^cr,cs   Ogorodova, Ludmila M ^ct   Palmer, Cameron D ^ag,ah   Palotie, Aarno ^z,ah,cu   Park, Julie E ^u   Pennell, Craig E ^f   Pershagen, Göran ^bw,cm   Polonikov, Alexey ^bf   Postma, Dirkje S ^br,cp   Probst Hensch, Nicole ^bd,be   Puzyrev, Valery P ^af   Raby, Benjamin A ^aw   Raitakari, Olli T ^by   Ramasamy, Adaikalavan ^v,cv   Rich, Stephen S ^ch   Robertson, Colin F ^cw   Romieu, Isabelle ^cx,cy   Salam, Muhammad T ^ai,cz   Salomaa, Veikko ^at   Schlünssen, Vivi ^da   Scott, Robert ^db   Selivanova, Polina A ^ct   Sigsgaard, Torben ^da   Simpson, Angela ^w,dc   Siroux, Valérie ^a,dd   Smith, Lewis J ^bv   Solodilova, Maria ^bf   Standl, Marie ^as   Stefansson, Kari ^ap,aq   Strachan, David P ^de   Stricker, Bruno H ^q,df   Takahashi, Atsushi ^bt   Thompson, Philip J ^bc   Thorleifsson, Gudmar ^ap   Thorsteinsdottir, Unnur ^ap,aq   Tiesler, Carla M T ^ar,as   Torgerson, Dara G ^y   Tsunoda, Tatsuhiko ^bt,dg   Uitterlinden, André G ^q   Van Der Valk, Ralf J P ^q   Vaysse, Amaury ^a,b   Vedantam, Sailaja ^ag,ah   Von Berg, Andrea ^dh   Von Mutius, Erika ^ar,di   Vonk, Judith M ^br,cp   Waage, Johannes ^k   Wareham, Nick J ^db   Weiss, Scott T ^aw   White, Wendy B ^dj   Wickman, Magnus ^bi,bw   Widén, Elisabeth ^z   Willemsen, Gonneke ⁿ   Williams, L Keoki ^ce   Wouters, Inge M ^aj   Yang, James J ^dk   Zhao, Jing Hua ^db   Moffatt, Miriam F ^d   Ober, Carole ^dl   Nicolae, Dan L ^dl   more..

^a INSERM   (France)

^b UNIVERSITÉ PARIS DIDEROT   (France)

^c UNIVERSITY OF COLORADO   (United States)

^d NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^e UNIVERSITY OF COLOGNE   (Germany)

^f UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^g Och Spine at New York Presbyterian Hospitals   (United States)

^h JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

ⁱ UNIVERSITY OF MANITOBA   (Canada)

^j PATHWEST LABORATORY MEDICINE   (Australia)

^k UNIVERSITY OF COPENHAGEN   (Denmark)

^l LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^m WAKE FOREST SCHOOL OF MEDICINE   (United States)

ⁿ UNIVERSITY OF AMSTERDAM   (Netherlands)

^o UNIVERSITY OF LEICESTER   (United Kingdom)

^p GHENT UNIVERSITY HOSPITAL   (Belgium)

^q ERASMUS MEDICAL CENTER   (Netherlands)

^r UNIVERSITY OF CALIFORNIA   (United States)

^s Imperial College London ^*  (United States)

^t ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^u UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^v IMPERIAL COLLEGE LONDON   (United Kingdom)

^w UNIVERSITY OF MANCHESTER   (United Kingdom)

^x HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^y UNIVERSITY OF CALIFORNIA   (United States)

^z UNIVERSITY OF HELSINKI   (Finland)

^aa UNIVERSITY OF OXFORD   (United Kingdom)

^ab UNIVERSITY OF OXFORD   (United Kingdom)

^ac INSTITUTE OF BIOCHEMISTRY AND GENETICS   (Russian Federation)

^ad STATENS SERUM INSTITUT   (Denmark)

^ae QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^af RESEARCH INSTITUTE OF MEDICAL GENETICS   (Russian Federation)

^ag BOSTON CHILDREN S HOSPITAL   (United States)

^ah BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^ai UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^aj UTRECHT UNIVERSITY   (Netherlands)

^ak UNIVERSITY OF ULM   (Germany)

^al UNIVERSITY OF WASHINGTON   (United States)

^am UNIVERSITY OF BRISTOL   (United Kingdom)

^an UNIVERSITY OF BRISTOL   (United Kingdom)

^ao UNIVERSITY OF ARIZONA   (United States)

^ap DECODE GENETICS   (Iceland)

^aq UNIVERSITY OF ICELAND   (Iceland)

^ar LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^as INSTITUTE OF EPIDEMIOLOGY   (Germany)

^at NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^au UNIVERSITY OF PENNSYLVANIA   (United States)

^av KEIO UNIVERSITY   (Japan)

^aw HARVARD MEDICAL SCHOOL   (United States)

^ax HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^ay UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^az ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^ba ABBVIE INC   (United States)

^bb Busselton Pop Med Res Foundation   (Australia)

^bc UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^bd SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^be UNIVERSITY OF BASEL   (Switzerland)

^bf KURSK STATE MEDICAL UNIVERSITY   (Russian Federation)

^bg SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^bh UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^bi UPPSALA UNIVERSITY   (Sweden)

^bj UNIVERSITY OF OULU   (Finland)

^bk UNIVERSITY OF OULU   (Finland)

^bl OULU UNIVERSITY HOSPITAL   (Finland)

^bm UNIVERSITY OF WESTERN SYDNEY   (Australia)

^bn UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^bo TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^bp Birsk Branch of Federal State Budgetary Educational Establishment of Higher Education Bashkir State University   (Russian Federation)

^bq UNIVERSITY OF GRONINGEN   (Netherlands)

^br Groningen Research Institute for Asthma and COPD   (Netherlands)

^bs UNIVERSITY OF ALBERTA   (Canada)

^bt RIKEN Center for Integrative Medical Sciences   (Japan)

^bu CHILDREN'S MEMORIAL HOSPITAL   (United States)

^bv NORTHWESTERN UNIVERSITY   (United States)

^bw KAROLINSKA INSTITUTE   (Sweden)

^bx GHENT UNIVERSITY   (Belgium)

^by TURKU UNIVERSITY HOSPITAL   (Finland)

^bz UNIVERSITÉ DU QUÉBEC À CHICOUTIMI   (Canada)

^ca Centre Integre Universitaire de Sante et de Services Sociaux du Saguenay Lac Saint Jean   (Canada)

^cb MCGILL UNIVERSITY   (Canada)

^cc CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^cd MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^ce HENRY FORD HEALTH SYSTEM   (United States)

^cf UNIVERSITY OF NORTH CAROLINA   (United States)

^cg NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^ch UNIVERSITY OF VIRGINIA   (United States)

^ci UNIVERSITY OF MELBOURNE   (Australia)

^cj JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ck NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^cl STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^cm STOCKHOLM COUNTY COUNCIL   (Sweden)

^cn SACHS CHILDREN S HOSPITAL   (Sweden)

^co DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^cp UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^cq UNIVERSITY OF TSUKUBA   (Japan)

^cr BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^cs FRAMINGHAM HEART STUDY   (United States)

^ct SIBERIAN STATE MEDICAL UNIVERSITY   (Russian Federation)

^cu MASSACHUSETTS GENERAL HOSPITAL   (United States)

^cv KING'S COLLEGE LONDON   (United Kingdom)

^cw MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^cx EMORY UNIVERSITY   (United States)

^cy INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^cz National Health Service ^*  (United States)

^da AARHUS UNIVERSITY   (Denmark)

^db UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^dc MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^dd UNIV GRENOBLE ALPES   (France)

^de ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^df Netherlands Health Care Inspectorate   (Netherlands)

^dg TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^dh MARIEN HOSPITAL WESEL   (Germany)

^di German Center for Lung Research   (Germany)

^dj Undergraduate Training and Education Center (UTEC)   (United States)

^dk UNIVERSITY OF MICHIGAN   (United States)

^dl UNIVERSITY OF CHICAGO   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CDK12 PROTEIN; DEOXYRIBONUCLEASE I; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GSDMA PROTEIN; GSDMB PROTEIN; HLA C ANTIGEN; INTERLEUKIN 13; INTERLEUKIN 4; LST1 PROTEIN; LTA PROTEIN; ORMDL3 PROTEIN; PGAP3 PROTEIN; PROTEIN; PROTEIN KINASE B; STAT6 PROTEIN; TRANSCRIPTION FACTOR BACH2; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG;

ALLELE; ANCESTRY GROUP; ARTICLE; ASTHMA; AUTOIMMUNE DISEASE; CLINICAL ASSESSMENT; COMORBIDITY; DISEASE ASSOCIATION; ENHANCER REGION; ENVIRONMENTAL EXPOSURE; ETHNIC GROUP; GENE LOCUS; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC RISK; GENETIC VARIABILITY; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HEREDITY; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATORY DISEASE; META ANALYSIS; PLEIOTROPY; POLLEN ALLERGY; POPULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; RISK FACTOR; ETHNOLOGY; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; HISTONE CODE; IMMUNOLOGY; LEUKOCYTE; METABOLISM; PHENOTYPE; PROMOTER REGION; RISK;

ALLELES; ASTHMA; ENHANCER ELEMENTS, GENETIC; EPIGENESIS, GENETIC; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HISTONE CODE; HUMANS; LEUKOCYTES; PHENOTYPE; PROMOTER REGIONS, GENETIC; RHINITIS, ALLERGIC, SEASONAL; RISK;

EID: 85039152884     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-017-0014-7     Document Type: Article

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