Asialoglycoprotein receptor 1 mediates productive uptake of N-Acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes

Nucleic Acids Research

Volumn 45, Issue 21, 2017, Pages 12388-12400

  Tanowitz, Michael ^a   Hettrick, Lisa ^a   Revenko, Alexey ^a   Kinberger, Garth A ^a   Prakash, Thazha P ^a   Seth, Punit P ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ASIALOGLYCOPROTEIN RECEPTOR; ASIALOGLYCOPROTEIN RECEPTOR 1; N ACETYLGALACTOSAMINE; PHOSPHOROTHIOIC ACID; UNCLASSIFIED DRUG; ASGR1 PROTEIN, HUMAN; ASGR2 PROTEIN, HUMAN; OLIGONUCLEOTIDE PHOSPHOROTHIOATE;

AMINE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONJUGATE; CONTROLLED STUDY; EMBRYO; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFANT; INTERNALIZATION; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL LINE; CHEMISTRY; HEK293 CELL LINE; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ACETYLGALACTOSAMINE; ANIMALS; ASIALOGLYCOPROTEIN RECEPTOR; BIOLOGICAL TRANSPORT; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; HEK293 CELLS; HEPATOCYTES; HUMANS; MALE; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOROTHIOATE OLIGONUCLEOTIDES;

EID: 85039034524     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkx960     Document Type: Article

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