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Volumn 24, Issue 1, 2018, Pages 19-26

Emerging Therapeutics for the Control of Chronic Graft-versus-Host Disease

Author keywords

Allogeneic hematopoietic cell transplantation; Chronic GVHD; Graft versus host disease; Interleukin 17A; JAK inhibitor

Indexed keywords

ANTIFIBROTIC AGENT; CSF 1; CYTOKINE; INTERLEUKIN 17; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; JANUS KINASE INHIBITOR; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

EID: 85038961905     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2017.10.006     Document Type: Review
Times cited : (18)

References (123)
  • 1
    • 28744444180 scopus 로고    scopus 로고
    • National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. I. Diagnosis and Staging Working Group report
    • Filipovich, A.H., Weisdorf, D., Pavletic, S., et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. I. Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant 11 (2005), 945–956.
    • (2005) Biol Blood Marrow Transplant , vol.11 , pp. 945-956
    • Filipovich, A.H.1    Weisdorf, D.2    Pavletic, S.3
  • 2
    • 84922766049 scopus 로고    scopus 로고
    • National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. I. The 2014 Diagnosis and Staging Working Group report
    • Jagasia, M.H., Greinix, H.T., Arora, M., et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. I. The 2014 Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant 21 (2015), 389–401.
    • (2015) Biol Blood Marrow Transplant , vol.21 , pp. 389-401
    • Jagasia, M.H.1    Greinix, H.T.2    Arora, M.3
  • 3
    • 56549114909 scopus 로고    scopus 로고
    • Treatment change as a predictor of outcome among patients with classic chronic graft-versus-host disease
    • Flowers, M.E., Storer, B., Carpenter, P., et al. Treatment change as a predictor of outcome among patients with classic chronic graft-versus-host disease. Biol Blood Marrow Transplant 14 (2008), 1380–1384.
    • (2008) Biol Blood Marrow Transplant , vol.14 , pp. 1380-1384
    • Flowers, M.E.1    Storer, B.2    Carpenter, P.3
  • 4
    • 79955632748 scopus 로고    scopus 로고
    • Consensus conference on clinical practice in chronic GVHD: second-line treatment of chronic graft-versus-host disease
    • Wolff, D., Schleuning, M., von Harsdorf, S., et al. Consensus conference on clinical practice in chronic GVHD: second-line treatment of chronic graft-versus-host disease. Biol Blood Marrow Transplant 17 (2011), 1–17.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 1-17
    • Wolff, D.1    Schleuning, M.2    von Harsdorf, S.3
  • 5
    • 42649134787 scopus 로고    scopus 로고
    • Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease?
    • Murata, M., Fujimoto, M., Matsushita, T., et al. Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease?. J Dermatol Sci 50 (2008), 240–242.
    • (2008) J Dermatol Sci , vol.50 , pp. 240-242
    • Murata, M.1    Fujimoto, M.2    Matsushita, T.3
  • 6
    • 77956899738 scopus 로고    scopus 로고
    • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model
    • Yoshizaki, A., Yanaba, K., Iwata, Y., et al. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J Immunol 185 (2010), 2502–2515.
    • (2010) J Immunol , vol.185 , pp. 2502-2515
    • Yoshizaki, A.1    Yanaba, K.2    Iwata, Y.3
  • 7
    • 84983402172 scopus 로고    scopus 로고
    • Interleukin-17 inhibitors. A new era in treatment of psoriasis and other skin diseases
    • Wasilewska, A., Winiarska, M., Olszewska, M., Rudnicka, L., Interleukin-17 inhibitors. A new era in treatment of psoriasis and other skin diseases. Postepy Dermatol Alergol 33 (2016), 247–252.
    • (2016) Postepy Dermatol Alergol , vol.33 , pp. 247-252
    • Wasilewska, A.1    Winiarska, M.2    Olszewska, M.3    Rudnicka, L.4
  • 8
    • 84907495480 scopus 로고    scopus 로고
    • CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease
    • Alexander, K.A., Flynn, R., Lineburg, K.E., et al. CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease. J Clin Invest 124 (2014), 4266–4280.
    • (2014) J Clin Invest , vol.124 , pp. 4266-4280
    • Alexander, K.A.1    Flynn, R.2    Lineburg, K.E.3
  • 9
    • 77955873442 scopus 로고    scopus 로고
    • Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma
    • Hill, G.R., Olver, S.D., Kuns, R.D., et al. Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma. Blood 116 (2010), 819–828.
    • (2010) Blood , vol.116 , pp. 819-828
    • Hill, G.R.1    Olver, S.D.2    Kuns, R.D.3
  • 10
    • 85059002611 scopus 로고    scopus 로고
    • An activated Th17-prone T-cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition
    • Forcade, E., Paz, K., Flynn, R., et al. An activated Th17-prone T-cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition. JCI Insight, 2, 2017.
    • (2017) JCI Insight , vol.2
    • Forcade, E.1    Paz, K.2    Flynn, R.3
  • 11
    • 84925228691 scopus 로고    scopus 로고
    • Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial
    • Kennedy, G.A., Varelias, A., Vuckovic, S., et al. Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial. Lancet Oncol 15 (2014), 1451–1459.
    • (2014) Lancet Oncol , vol.15 , pp. 1451-1459
    • Kennedy, G.A.1    Varelias, A.2    Vuckovic, S.3
  • 12
    • 78751469023 scopus 로고    scopus 로고
    • Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation
    • Tawara, I., Koyama, M., Liu, C., et al. Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation. Clin Cancer Res 17 (2011), 77–88.
    • (2011) Clin Cancer Res , vol.17 , pp. 77-88
    • Tawara, I.1    Koyama, M.2    Liu, C.3
  • 13
    • 84942275251 scopus 로고    scopus 로고
    • Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects
    • Gartlan, K.H., Markey, K.A., Varelias, A., et al. Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects. Blood 126 (2015), 1609–1620.
    • (2015) Blood , vol.126 , pp. 1609-1620
    • Gartlan, K.H.1    Markey, K.A.2    Varelias, A.3
  • 14
    • 85038905072 scopus 로고    scopus 로고
    • Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT
    • Gartlan, K.H., Varelias, A., Koyama, M., et al. Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT. Blood Advances 1 (2017), 341–351.
    • (2017) Blood Advances , vol.1 , pp. 341-351
    • Gartlan, K.H.1    Varelias, A.2    Koyama, M.3
  • 15
    • 84961196330 scopus 로고    scopus 로고
    • Small molecule mediated inhibition of RORgamma-dependent gene expression and autoimmune disease pathology in vivo
    • Banerjee, D., Zhao, L., Wu, L., et al. Small molecule mediated inhibition of RORgamma-dependent gene expression and autoimmune disease pathology in vivo. Immunology 147 (2016), 399–413.
    • (2016) Immunology , vol.147 , pp. 399-413
    • Banerjee, D.1    Zhao, L.2    Wu, L.3
  • 16
    • 84958087613 scopus 로고    scopus 로고
    • Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing T(H)17 cells and preserving ILC3
    • Withers, D.R., Hepworth, M.R., Wang, X., et al. Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing T(H)17 cells and preserving ILC3. Nat Med 22 (2016), 319–323.
    • (2016) Nat Med , vol.22 , pp. 319-323
    • Withers, D.R.1    Hepworth, M.R.2    Wang, X.3
  • 17
    • 85135870334 scopus 로고    scopus 로고
    • Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease
    • Li, W., Liu, L., Gomez, A., et al. Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease. JCI Insight, 1, 2016.
    • (2016) JCI Insight , vol.1
    • Li, W.1    Liu, L.2    Gomez, A.3
  • 18
    • 84857618521 scopus 로고    scopus 로고
    • Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling
    • Hume, D.A., MacDonald, K.P., Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. Blood 119 (2012), 1810–1820.
    • (2012) Blood , vol.119 , pp. 1810-1820
    • Hume, D.A.1    MacDonald, K.P.2
  • 19
    • 13744255589 scopus 로고    scopus 로고
    • Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    • Duffield, J.S., Forbes, S.J., Constandinou, C.M., et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 115 (2005), 56–65.
    • (2005) J Clin Invest , vol.115 , pp. 56-65
    • Duffield, J.S.1    Forbes, S.J.2    Constandinou, C.M.3
  • 20
    • 46949087137 scopus 로고    scopus 로고
    • Murine gamma herpesvirus-induced fibrosis is associated with the development of alternatively activated macrophages
    • Gangadharan, B., Hoeve, M.A., Allen, J.E., et al. Murine gamma herpesvirus-induced fibrosis is associated with the development of alternatively activated macrophages. J Leuk Biol 84 (2008), 50–58.
    • (2008) J Leuk Biol , vol.84 , pp. 50-58
    • Gangadharan, B.1    Hoeve, M.A.2    Allen, J.E.3
  • 21
    • 78149462163 scopus 로고    scopus 로고
    • An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation
    • MacDonald, K.P., Palmer, J.S., Cronau, S., et al. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood 116 (2010), 3955–3963.
    • (2010) Blood , vol.116 , pp. 3955-3963
    • MacDonald, K.P.1    Palmer, J.S.2    Cronau, S.3
  • 22
    • 84897018784 scopus 로고    scopus 로고
    • Diverse T-cell responses characterize the different manifestations of cutaneous graft-versus-host disease
    • Bruggen, M.C., Klein, I., Greinix, H., et al. Diverse T-cell responses characterize the different manifestations of cutaneous graft-versus-host disease. Blood 123 (2014), 290–299.
    • (2014) Blood , vol.123 , pp. 290-299
    • Bruggen, M.C.1    Klein, I.2    Greinix, H.3
  • 23
    • 0026308617 scopus 로고
    • Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor-AA, -AB, and -BB isoforms secreted by rat alveolar macrophages
    • Bonner, J.C., Osornio-Vargas, A.R., Badgett, A., Brody, A.R., Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor-AA, -AB, and -BB isoforms secreted by rat alveolar macrophages. Am J Respir Cell Mol Biol 5 (1991), 539–547.
    • (1991) Am J Respir Cell Mol Biol , vol.5 , pp. 539-547
    • Bonner, J.C.1    Osornio-Vargas, A.R.2    Badgett, A.3    Brody, A.R.4
  • 25
    • 84875240891 scopus 로고    scopus 로고
    • Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis
    • Arai, M., Ikawa, Y., Chujo, S., et al. Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis. J Dermatol Sci 69 (2013), 250–258.
    • (2013) J Dermatol Sci , vol.69 , pp. 250-258
    • Arai, M.1    Ikawa, Y.2    Chujo, S.3
  • 26
    • 79955565441 scopus 로고    scopus 로고
    • Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages
    • Barron, L., Wynn, T.A., Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages. Am J Physiol Gastrointest Liver Physiol 300 (2011), G723–G728.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G723-G728
    • Barron, L.1    Wynn, T.A.2
  • 27
    • 24744447794 scopus 로고    scopus 로고
    • TGF-beta in allogeneic stem cell transplantation: friend or foe?
    • Banovic, T., MacDonald, K.P., Morris, E.S., et al. TGF-beta in allogeneic stem cell transplantation: friend or foe?. Blood 106 (2005), 2206–2214.
    • (2005) Blood , vol.106 , pp. 2206-2214
    • Banovic, T.1    MacDonald, K.P.2    Morris, E.S.3
  • 28
    • 65449167961 scopus 로고    scopus 로고
    • IL-17 induces monocyte migration in rheumatoid arthritis
    • Shahrara, S., Pickens, S.R., Dorfleutner, A., Pope, R.M., IL-17 induces monocyte migration in rheumatoid arthritis. J Immunol 182 (2009), 3884–3891.
    • (2009) J Immunol , vol.182 , pp. 3884-3891
    • Shahrara, S.1    Pickens, S.R.2    Dorfleutner, A.3    Pope, R.M.4
  • 29
    • 84898630137 scopus 로고    scopus 로고
    • Interleukin 17 receptor A modulates monocyte subsets and macrophage generation in vivo
    • e85461
    • Ge, S., Hertel, B., Susnik, N., et al. Interleukin 17 receptor A modulates monocyte subsets and macrophage generation in vivo. PLoS One, 9, 2014 e85461.
    • (2014) PLoS One , vol.9
    • Ge, S.1    Hertel, B.2    Susnik, N.3
  • 30
    • 84908120736 scopus 로고    scopus 로고
    • IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis
    • Erbel, C., Akhavanpoor, M., Okuyucu, D., et al. IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis. J Immunol 193 (2014), 4344–4355.
    • (2014) J Immunol , vol.193 , pp. 4344-4355
    • Erbel, C.1    Akhavanpoor, M.2    Okuyucu, D.3
  • 31
    • 85019239756 scopus 로고    scopus 로고
    • Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production
    • Du, J., Paz, K., Flynn, R., et al. Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production. Blood 129 (2017), 2570–2580.
    • (2017) Blood , vol.129 , pp. 2570-2580
    • Du, J.1    Paz, K.2    Flynn, R.3
  • 32
    • 75949102667 scopus 로고    scopus 로고
    • Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
    • Onishi, R.M., Gaffen, S.L., Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology 129 (2010), 311–321.
    • (2010) Immunology , vol.129 , pp. 311-321
    • Onishi, R.M.1    Gaffen, S.L.2
  • 33
    • 61849086101 scopus 로고    scopus 로고
    • Janus kinases in immune cell signaling
    • Ghoreschi, K., Laurence, A., O'Shea, J.J., Janus kinases in immune cell signaling. Immunol Rev 228 (2009), 273–287.
    • (2009) Immunol Rev , vol.228 , pp. 273-287
    • Ghoreschi, K.1    Laurence, A.2    O'Shea, J.J.3
  • 34
    • 84942850964 scopus 로고    scopus 로고
    • Pharmacologic inhibition of JAK1/JAK2 signaling reduces experimental murine acute GVHD while preserving GVT effects
    • Carniti, C., Gimondi, S., Vendramin, A., et al. Pharmacologic inhibition of JAK1/JAK2 signaling reduces experimental murine acute GVHD while preserving GVT effects. Clin Cancer Res 21 (2015), 3740–3749.
    • (2015) Clin Cancer Res , vol.21 , pp. 3740-3749
    • Carniti, C.1    Gimondi, S.2    Vendramin, A.3
  • 35
    • 84868606215 scopus 로고    scopus 로고
    • IFNgammaR signaling mediates alloreactive T-cell trafficking and GVHD
    • Choi, J., Ziga, E.D., Ritchey, J., et al. IFNgammaR signaling mediates alloreactive T-cell trafficking and GVHD. Blood 120 (2012), 4093–4103.
    • (2012) Blood , vol.120 , pp. 4093-4103
    • Choi, J.1    Ziga, E.D.2    Ritchey, J.3
  • 36
    • 84902581112 scopus 로고    scopus 로고
    • Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease
    • Spoerl, S., Mathew, N.R., Bscheider, M., et al. Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease. Blood 123 (2014), 3832–3842.
    • (2014) Blood , vol.123 , pp. 3832-3842
    • Spoerl, S.1    Mathew, N.R.2    Bscheider, M.3
  • 37
    • 84943582032 scopus 로고    scopus 로고
    • Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
    • Zeiser, R., Burchert, A., Lengerke, C., et al. Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey. Leukemia 29 (2015), 2062–2068.
    • (2015) Leukemia , vol.29 , pp. 2062-2068
    • Zeiser, R.1    Burchert, A.2    Lengerke, C.3
  • 38
    • 81055126760 scopus 로고    scopus 로고
    • Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen
    • Betts, B.C., Abdel-Wahab, O., Curran, S.A., et al. Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen. Blood 118 (2011), 5330–5339.
    • (2011) Blood , vol.118 , pp. 5330-5339
    • Betts, B.C.1    Abdel-Wahab, O.2    Curran, S.A.3
  • 39
    • 84887193830 scopus 로고    scopus 로고
    • The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo
    • Heine, A., Held, S.A., Daecke, S.N., et al. The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo. Blood 122 (2013), 1192–1202.
    • (2013) Blood , vol.122 , pp. 1192-1202
    • Heine, A.1    Held, S.A.2    Daecke, S.N.3
  • 40
    • 0029164841 scopus 로고
    • Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)
    • Macchi, P., Villa, A., Giliani, S., et al. Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 377 (1995), 65–68.
    • (1995) Nature , vol.377 , pp. 65-68
    • Macchi, P.1    Villa, A.2    Giliani, S.3
  • 41
    • 84944807941 scopus 로고    scopus 로고
    • Human TYK2 deficiency: mycobacterial and viral infections without hyper-IgE syndrome
    • Kreins, A.Y., Ciancanelli, M.J., Okada, S., et al. Human TYK2 deficiency: mycobacterial and viral infections without hyper-IgE syndrome. J Exp Med 212 (2015), 1641–1662.
    • (2015) J Exp Med , vol.212 , pp. 1641-1662
    • Kreins, A.Y.1    Ciancanelli, M.J.2    Okada, S.3
  • 42
    • 85038936422 scopus 로고    scopus 로고
    • A phase I trial of Janus kinase (JAK) inhibition with INCB039110 in acute graft-versus-host disease (aGVHD) [abstract]
    • Schroeder, M.A., Khoury, H.J., Jagasia, M., et al. A phase I trial of Janus kinase (JAK) inhibition with INCB039110 in acute graft-versus-host disease (aGVHD) [abstract]. Blood, 128, 2016, 390.
    • (2016) Blood , vol.128 , pp. 390
    • Schroeder, M.A.1    Khoury, H.J.2    Jagasia, M.3
  • 43
    • 85038932501 scopus 로고    scopus 로고
    • THU0206 The jak1-selective inhibitor filgotinib reduces multiple markers of inflammation linked to various pathologic cell types and processes in rheumatoid arthritis patients [abstract]
    • Taylor, P., Westhovens, R., et al., Aa AVd. THU0206 The jak1-selective inhibitor filgotinib reduces multiple markers of inflammation linked to various pathologic cell types and processes in rheumatoid arthritis patients [abstract]. Ann Rheum Dis 76:suppl 2 (2017), 281–282.
    • (2017) Ann Rheum Dis , vol.76 , pp. 281-282
    • Taylor, P.1    Westhovens, R.2
  • 44
    • 84994889123 scopus 로고    scopus 로고
    • Targeting JAK2 by gene knockout or pacritinib treatment reduces Gvhd and xenograft rejection by promoting induced treg differentiation [abstract]
    • Betts, B.C., Bastian, D., Nguyen, H., et al. Targeting JAK2 by gene knockout or pacritinib treatment reduces Gvhd and xenograft rejection by promoting induced treg differentiation [abstract]. Blood, 126, 2015, 1874.
    • (2015) Blood , vol.126 , pp. 1874
    • Betts, B.C.1    Bastian, D.2    Nguyen, H.3
  • 45
    • 85038937099 scopus 로고    scopus 로고
    • Pharmacologic co-blockade of IFNγR and IL6R pathways to prevent and treat GvHD [abstract]
    • Choi, J., Cooper, M.L., Vij, K.R., et al. Pharmacologic co-blockade of IFNγR and IL6R pathways to prevent and treat GvHD [abstract]. Blood, 128, 2016, 3353.
    • (2016) Blood , vol.128 , pp. 3353
    • Choi, J.1    Cooper, M.L.2    Vij, K.R.3
  • 46
    • 84930257399 scopus 로고    scopus 로고
    • JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasms
    • Parampalli Yajnanarayana, S., Stubig, T., Cornez, I., et al. JAK1/2 inhibition impairs T cell function in vitro and in patients with myeloproliferative neoplasms. Br J Haematol 169 (2015), 824–833.
    • (2015) Br J Haematol , vol.169 , pp. 824-833
    • Parampalli Yajnanarayana, S.1    Stubig, T.2    Cornez, I.3
  • 47
    • 84939429649 scopus 로고    scopus 로고
    • JAK inhibition impairs NK cell function in myeloproliferative neoplasms
    • Schonberg, K., Rudolph, J., Vonnahme, M., et al. JAK inhibition impairs NK cell function in myeloproliferative neoplasms. Cancer Res 75 (2015), 2187–2199.
    • (2015) Cancer Res , vol.75 , pp. 2187-2199
    • Schonberg, K.1    Rudolph, J.2    Vonnahme, M.3
  • 48
    • 85016132547 scopus 로고    scopus 로고
    • Human dendritic cells mitigate NK-cell dysfunction mediated by nonselective JAK1/2 blockade
    • Curran, S.A., Shyer, J.A., St Angelo, E.T., et al. Human dendritic cells mitigate NK-cell dysfunction mediated by nonselective JAK1/2 blockade. Cancer Immunol Res 5 (2017), 52–60.
    • (2017) Cancer Immunol Res , vol.5 , pp. 52-60
    • Curran, S.A.1    Shyer, J.A.2    St Angelo, E.T.3
  • 49
    • 84892882122 scopus 로고    scopus 로고
    • Ruxolitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?
    • Heine, A., Brossart, P., Wolf, D., Ruxolitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?. Blood 122 (2013), 3843–3844.
    • (2013) Blood , vol.122 , pp. 3843-3844
    • Heine, A.1    Brossart, P.2    Wolf, D.3
  • 50
    • 79955027327 scopus 로고    scopus 로고
    • Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550)
    • Ghoreschi, K., Jesson, M.I., Li, X., et al. Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol 186 (2011), 4234–4243.
    • (2011) J Immunol , vol.186 , pp. 4234-4243
    • Ghoreschi, K.1    Jesson, M.I.2    Li, X.3
  • 51
    • 84992690570 scopus 로고    scopus 로고
    • Impact of tofacitinib treatment on human B-cells in vitro and in vivo
    • Rizzi, M., Lorenzetti, R., Fischer, K., et al. Impact of tofacitinib treatment on human B-cells in vitro and in vivo. J Autoimmun 77 (2017), 55–66.
    • (2017) J Autoimmun , vol.77 , pp. 55-66
    • Rizzi, M.1    Lorenzetti, R.2    Fischer, K.3
  • 52
    • 84902593564 scopus 로고    scopus 로고
    • Tofacitinib versus methotrexate in rheumatoid arthritis
    • Lee, E.B., Fleischmann, R., Hall, S., et al. Tofacitinib versus methotrexate in rheumatoid arthritis. N Engl J Med 370 (2014), 2377–2386.
    • (2014) N Engl J Med , vol.370 , pp. 2377-2386
    • Lee, E.B.1    Fleischmann, R.2    Hall, S.3
  • 53
    • 85007236113 scopus 로고    scopus 로고
    • Filgotinib (GLPG0634/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis and insufficient response to MTX: results from a randomised, dose-finding study (DARWIN 1)
    • Westhovens, R., Taylor, P.C., Alten, R., et al. Filgotinib (GLPG0634/GS-6034), an oral JAK1 selective inhibitor, is effective in combination with methotrexate (MTX) in patients with active rheumatoid arthritis and insufficient response to MTX: results from a randomised, dose-finding study (DARWIN 1). Ann Rheum Dis 76 (2017), 998–1008.
    • (2017) Ann Rheum Dis , vol.76 , pp. 998-1008
    • Westhovens, R.1    Taylor, P.C.2    Alten, R.3
  • 54
    • 0028060150 scopus 로고
    • Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement
    • Saouaf, S.J., Mahajan, S., Rowley, R.B., et al. Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proc Natl Acad Sci USA 91 (1994), 9524–9528.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9524-9528
    • Saouaf, S.J.1    Mahajan, S.2    Rowley, R.B.3
  • 55
    • 85011592509 scopus 로고    scopus 로고
    • Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis
    • Mascarenhas, J.O., Talpaz, M., Gupta, V., et al. Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis. Haematologica 102 (2017), 327–335.
    • (2017) Haematologica , vol.102 , pp. 327-335
    • Mascarenhas, J.O.1    Talpaz, M.2    Gupta, V.3
  • 56
    • 84954227730 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral Janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis
    • Bissonnette, R., Luchi, M., Fidelus-Gort, R., et al. A randomized, double-blind, placebo-controlled, dose-escalation study of the safety and efficacy of INCB039110, an oral Janus kinase 1 inhibitor, in patients with stable, chronic plaque psoriasis. J Dermatolog Treat 27 (2016), 332–338.
    • (2016) J Dermatolog Treat , vol.27 , pp. 332-338
    • Bissonnette, R.1    Luchi, M.2    Fidelus-Gort, R.3
  • 57
    • 85029406764 scopus 로고    scopus 로고
    • A phase 1b/2 study of INCB039110 + nab-paclitaxel (N) and gemcitabine (G) in patients (pts) with advanced solid tumors and pancreatic cancer (PC)
    • Beatty, G.L., Shahda, S., Beck, J.T., et al. A phase 1b/2 study of INCB039110 + nab-paclitaxel (N) and gemcitabine (G) in patients (pts) with advanced solid tumors and pancreatic cancer (PC). J Clin Oncol, 35(4 suppl), 2017, 362.
    • (2017) J Clin Oncol , vol.35 , Issue.4 , pp. 362
    • Beatty, G.L.1    Shahda, S.2    Beck, J.T.3
  • 58
    • 84857837774 scopus 로고    scopus 로고
    • JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    • Harrison, C., Kiladjian, J.J., Al-Ali, H.K., et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med 366 (2012), 787–798.
    • (2012) N Engl J Med , vol.366 , pp. 787-798
    • Harrison, C.1    Kiladjian, J.J.2    Al-Ali, H.K.3
  • 59
    • 85010637353 scopus 로고    scopus 로고
    • Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining treg and antitumor CTL function
    • Betts, B.C., Veerapathran, A., Pidala, J., et al. Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining treg and antitumor CTL function. Sci Transl Med, 9, 2017.
    • (2017) Sci Transl Med , vol.9
    • Betts, B.C.1    Veerapathran, A.2    Pidala, J.3
  • 60
    • 85015784582 scopus 로고    scopus 로고
    • Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial
    • Mesa, R.A., Vannucchi, A.M., Mead, A., et al. Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial. Lancet Haematol 4 (2017), e225–e236.
    • (2017) Lancet Haematol , vol.4 , pp. e225-e236
    • Mesa, R.A.1    Vannucchi, A.M.2    Mead, A.3
  • 61
    • 85020394170 scopus 로고    scopus 로고
    • Janus kinase-2 inhibitor fedratinib in patients with myelofibrosis previously treated with ruxolitinib (JAKARTA-2): a single-arm, open-label, non-randomised, phase 2, multicentre study
    • Harrison, C.N., Schaap, N., Vannucchi, A.M., et al. Janus kinase-2 inhibitor fedratinib in patients with myelofibrosis previously treated with ruxolitinib (JAKARTA-2): a single-arm, open-label, non-randomised, phase 2, multicentre study. Lancet Haematol 4 (2017), e317–e324.
    • (2017) Lancet Haematol , vol.4 , pp. e317-e324
    • Harrison, C.N.1    Schaap, N.2    Vannucchi, A.M.3
  • 62
    • 85019133160 scopus 로고    scopus 로고
    • Tofacitinib as induction and maintenance therapy for ulcerative colitis
    • Sandborn, W.J., Su, C., Sands, B.E., et al. Tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med 376 (2017), 1723–1736.
    • (2017) N Engl J Med , vol.376 , pp. 1723-1736
    • Sandborn, W.J.1    Su, C.2    Sands, B.E.3
  • 64
    • 85068704242 scopus 로고    scopus 로고
    • Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata
    • Kennedy Crispin, M., Ko, J.M., Craiglow, B.G., et al. Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata. JCI Insight, 1, 2016, e89776.
    • (2016) JCI Insight , vol.1 , pp. e89776
    • Kennedy Crispin, M.1    Ko, J.M.2    Craiglow, B.G.3
  • 65
    • 85014097983 scopus 로고    scopus 로고
    • The emerging safety profile of JAK inhibitors in rheumatic disease
    • Winthrop, K.L., The emerging safety profile of JAK inhibitors in rheumatic disease. Nat Rev Rheumatol 13 (2017), 234–243.
    • (2017) Nat Rev Rheumatol , vol.13 , pp. 234-243
    • Winthrop, K.L.1
  • 66
    • 68249160054 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease
    • Chen, X., Das, R., Komorowski, R., et al. Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. Blood 114 (2009), 891–900.
    • (2009) Blood , vol.114 , pp. 891-900
    • Chen, X.1    Das, R.2    Komorowski, R.3
  • 67
    • 85018399468 scopus 로고    scopus 로고
    • Ruxolitinib as salvage therapy in steroid-refractory acute graft-versus-host disease in pediatric hematopoietic stem cell transplant patients
    • Khandelwal, P., Teusink-Cross, A., Davies, S.M., et al. Ruxolitinib as salvage therapy in steroid-refractory acute graft-versus-host disease in pediatric hematopoietic stem cell transplant patients. Biol Blood Marrow Transplant 23 (2017), 1122–1127.
    • (2017) Biol Blood Marrow Transplant , vol.23 , pp. 1122-1127
    • Khandelwal, P.1    Teusink-Cross, A.2    Davies, S.M.3
  • 68
    • 84929222808 scopus 로고    scopus 로고
    • CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response
    • Betts, B.C., Sagatys, E.M., Veerapathran, A., et al. CD4+ T cell STAT3 phosphorylation precedes acute GVHD, and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response. J Leukoc Biol 97 (2015), 807–819.
    • (2015) J Leukoc Biol , vol.97 , pp. 807-819
    • Betts, B.C.1    Sagatys, E.M.2    Veerapathran, A.3
  • 69
    • 84982095828 scopus 로고    scopus 로고
    • Aberrant B-cell homeostasis in chronic GVHD
    • Sarantopoulos, S., Ritz, J., Aberrant B-cell homeostasis in chronic GVHD. Blood 125 (2015), 1703–1707.
    • (2015) Blood , vol.125 , pp. 1703-1707
    • Sarantopoulos, S.1    Ritz, J.2
  • 70
    • 85014926719 scopus 로고    scopus 로고
    • Introduction to a review series on chronic GVHD: from pathogenic B-cell receptor signaling to novel therapeutic targets
    • Zeiser, R., Negrin, R.S., Introduction to a review series on chronic GVHD: from pathogenic B-cell receptor signaling to novel therapeutic targets. Blood 129 (2017), 1–2.
    • (2017) Blood , vol.129 , pp. 1-2
    • Zeiser, R.1    Negrin, R.S.2
  • 72
    • 84902591280 scopus 로고    scopus 로고
    • Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells
    • Rozovski, U., Wu, J.Y., Harris, D.M., et al. Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells. Blood 123 (2014), 3797–3802.
    • (2014) Blood , vol.123 , pp. 3797-3802
    • Rozovski, U.1    Wu, J.Y.2    Harris, D.M.3
  • 73
    • 84975105678 scopus 로고    scopus 로고
    • STAT3 signaling in B cells is critical for germinal center maintenance and contributes to the pathogenesis of murine models of lupus
    • Ding, C., Chen, X., Dascani, P., et al. STAT3 signaling in B cells is critical for germinal center maintenance and contributes to the pathogenesis of murine models of lupus. J Immunol 196 (2016), 4477–4486.
    • (2016) J Immunol , vol.196 , pp. 4477-4486
    • Ding, C.1    Chen, X.2    Dascani, P.3
  • 74
    • 85021761294 scopus 로고    scopus 로고
    • Cytokine mediators of chronic graft-versus-host disease
    • MacDonald, K.P., Blazar, B.R., Hill, G.R., Cytokine mediators of chronic graft-versus-host disease. J Clin Invest 127 (2017), 2452–2463.
    • (2017) J Clin Invest , vol.127 , pp. 2452-2463
    • MacDonald, K.P.1    Blazar, B.R.2    Hill, G.R.3
  • 75
    • 84907190280 scopus 로고    scopus 로고
    • Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling
    • Hedrich, C.M., Rauen, T., Apostolidis, S.A., et al. Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling. Proc Natl Acad Sci USA 111 (2014), 13457–13462.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 13457-13462
    • Hedrich, C.M.1    Rauen, T.2    Apostolidis, S.A.3
  • 76
    • 84856908923 scopus 로고    scopus 로고
    • Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans
    • Srinivasan, M., Flynn, R., Price, A., et al. Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood 119 (2012), 1570–1580.
    • (2012) Blood , vol.119 , pp. 1570-1580
    • Srinivasan, M.1    Flynn, R.2    Price, A.3
  • 78
    • 84991491965 scopus 로고    scopus 로고
    • Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: results from the RA-BUILD study
    • Dougados, M., van der Heijde, D., Chen, Y.C., et al. Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: results from the RA-BUILD study. Ann Rheum Dis 76 (2017), 88–95.
    • (2017) Ann Rheum Dis , vol.76 , pp. 88-95
    • Dougados, M.1    van der Heijde, D.2    Chen, Y.C.3
  • 79
    • 84897068116 scopus 로고    scopus 로고
    • Reversal of CD8 T-cell-mediated mucocutaneous graft-versus-host-like disease by the JAK inhibitor tofacitinib
    • Okiyama, N., Furumoto, Y., Villarroel, V.A., et al. Reversal of CD8 T-cell-mediated mucocutaneous graft-versus-host-like disease by the JAK inhibitor tofacitinib. J Invest Dermatol 134 (2014), 992–1000.
    • (2014) J Invest Dermatol , vol.134 , pp. 992-1000
    • Okiyama, N.1    Furumoto, Y.2    Villarroel, V.A.3
  • 80
    • 84940923718 scopus 로고    scopus 로고
    • Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. IV. The 2014 Response Criteria Working Group report
    • Lee, S.J., Wolff, D., Kitko, C., et al. Measuring therapeutic response in chronic graft-versus-host disease. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. IV. The 2014 Response Criteria Working Group report. Biol Blood Marrow Transplant 21 (2015), 984–999.
    • (2015) Biol Blood Marrow Transplant , vol.21 , pp. 984-999
    • Lee, S.J.1    Wolff, D.2    Kitko, C.3
  • 81
    • 85008165979 scopus 로고    scopus 로고
    • The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease
    • Cooke, K.R., Luznik, L., Sarantopoulos, S., et al. The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease. Biol Blood Marrow Transplant 23 (2017), 211–234.
    • (2017) Biol Blood Marrow Transplant , vol.23 , pp. 211-234
    • Cooke, K.R.1    Luznik, L.2    Sarantopoulos, S.3
  • 82
    • 84948822862 scopus 로고    scopus 로고
    • Inflammasome effects in GvHD
    • Koehn, B.H., Zeiser, R., Blazar, B.R., Inflammasome effects in GvHD. Oncotarget 6 (2015), 38444–38445.
    • (2015) Oncotarget , vol.6 , pp. 38444-38445
    • Koehn, B.H.1    Zeiser, R.2    Blazar, B.R.3
  • 83
    • 78049428295 scopus 로고    scopus 로고
    • Canakinumab: a human anti-IL-1beta monoclonal antibody for the treatment of cryopyrin-associated periodic syndromes
    • Church, L.D., McDermott, M.F., Canakinumab: a human anti-IL-1beta monoclonal antibody for the treatment of cryopyrin-associated periodic syndromes. Expert Rev Clin Immunol 6 (2010), 831–841.
    • (2010) Expert Rev Clin Immunol , vol.6 , pp. 831-841
    • Church, L.D.1    McDermott, M.F.2
  • 84
    • 66449097622 scopus 로고    scopus 로고
    • Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus
    • Yao, Y., Richman, L., Higgs, B.W., et al. Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus. Arthritis Rheum 60 (2009), 1785–1796.
    • (2009) Arthritis Rheum , vol.60 , pp. 1785-1796
    • Yao, Y.1    Richman, L.2    Higgs, B.W.3
  • 85
    • 0035865161 scopus 로고    scopus 로고
    • CD6+ donor marrow T-cell depletion as the sole form of graft-versus-host disease prophylaxis in patients undergoing allogeneic bone marrow transplant from unrelated donors
    • Soiffer, R.J., Weller, E., Alyea, E.P., et al. CD6+ donor marrow T-cell depletion as the sole form of graft-versus-host disease prophylaxis in patients undergoing allogeneic bone marrow transplant from unrelated donors. J Clin Oncol 19 (2001), 1152–1159.
    • (2001) J Clin Oncol , vol.19 , pp. 1152-1159
    • Soiffer, R.J.1    Weller, E.2    Alyea, E.P.3
  • 86
    • 0035760863 scopus 로고    scopus 로고
    • The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation
    • Ho, V.T., Soiffer, R.J., The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation. Blood 98 (2001), 3192–3204.
    • (2001) Blood , vol.98 , pp. 3192-3204
    • Ho, V.T.1    Soiffer, R.J.2
  • 87
    • 84954064873 scopus 로고    scopus 로고
    • Antilymphocyte globulin for prevention of chronic graft-versus-host disease
    • Kroger, N., Solano, C., Wolschke, C., et al. Antilymphocyte globulin for prevention of chronic graft-versus-host disease. N Engl J Med 374 (2016), 43–53.
    • (2016) N Engl J Med , vol.374 , pp. 43-53
    • Kroger, N.1    Solano, C.2    Wolschke, C.3
  • 88
    • 79959456118 scopus 로고    scopus 로고
    • Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius
    • Socie, G., Schmoor, C., Bethge, W.A., et al. Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti-T-cell globulin ATG-Fresenius. Blood 117 (2011), 6375–6382.
    • (2011) Blood , vol.117 , pp. 6375-6382
    • Socie, G.1    Schmoor, C.2    Bethge, W.A.3
  • 89
    • 84961187570 scopus 로고    scopus 로고
    • Haploidentical bone marrow and stem cell transplantation: experience with post-transplantation cyclophosphamide
    • Robinson, T.M., O'Donnell, P.V., Fuchs, E.J., Luznik, L., Haploidentical bone marrow and stem cell transplantation: experience with post-transplantation cyclophosphamide. Semin Hematol 53 (2016), 90–97.
    • (2016) Semin Hematol , vol.53 , pp. 90-97
    • Robinson, T.M.1    O'Donnell, P.V.2    Fuchs, E.J.3    Luznik, L.4
  • 90
    • 33646421393 scopus 로고    scopus 로고
    • Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines
    • Blanco, B., Perez-Simon, J.A., Sanchez-Abarca, L.I., et al. Bortezomib induces selective depletion of alloreactive T lymphocytes and decreases the production of Th1 cytokines. Blood 107 (2006), 3575–3583.
    • (2006) Blood , vol.107 , pp. 3575-3583
    • Blanco, B.1    Perez-Simon, J.A.2    Sanchez-Abarca, L.I.3
  • 91
    • 74049101534 scopus 로고    scopus 로고
    • Bortezomib can suppress activation of rapamycin-resistant memory T cells without affecting regulatory T-cell viability in non-human primates
    • Kim, J.S., Lee, J.I., Shin, J.Y., et al. Bortezomib can suppress activation of rapamycin-resistant memory T cells without affecting regulatory T-cell viability in non-human primates. Transplantation 88 (2009), 1349–1359.
    • (2009) Transplantation , vol.88 , pp. 1349-1359
    • Kim, J.S.1    Lee, J.I.2    Shin, J.Y.3
  • 92
    • 2542599273 scopus 로고    scopus 로고
    • Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib
    • Sun, K., Welniak, L.A., Panoskaltsis-Mortari, A., et al. Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib. Proc Natl Acad Sci USA 101 (2004), 8120–8125.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8120-8125
    • Sun, K.1    Welniak, L.A.2    Panoskaltsis-Mortari, A.3
  • 93
    • 84908067774 scopus 로고    scopus 로고
    • A phase II study of bortezomib plus prednisone for initial therapy of chronic graft-versus-host disease
    • Herrera, A.F., Kim, H.T., Bindra, B., et al. A phase II study of bortezomib plus prednisone for initial therapy of chronic graft-versus-host disease. Biol Blood Marrow Transplant 20 (2014), 1737–1743.
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 1737-1743
    • Herrera, A.F.1    Kim, H.T.2    Bindra, B.3
  • 94
    • 84907013113 scopus 로고    scopus 로고
    • Treatment of chronic graft-versus-host disease with bortezomib
    • Pai, C.C., Chen, M., Mirsoian, A., et al. Treatment of chronic graft-versus-host disease with bortezomib. Blood 124 (2014), 1677–1688.
    • (2014) Blood , vol.124 , pp. 1677-1688
    • Pai, C.C.1    Chen, M.2    Mirsoian, A.3
  • 95
    • 84885796022 scopus 로고    scopus 로고
    • In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial
    • Koura, D.T., Horan, J.T., Langston, A.A., et al. In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial. Biol Blood Marrow Transplant 19 (2013), 1638–1649.
    • (2013) Biol Blood Marrow Transplant , vol.19 , pp. 1638-1649
    • Koura, D.T.1    Horan, J.T.2    Langston, A.A.3
  • 96
    • 84878580539 scopus 로고    scopus 로고
    • FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin
    • Huu, D.L., Matsushita, T., Jin, G., et al. FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin. Arthritis Rheum 65 (2013), 1624–1635.
    • (2013) Arthritis Rheum , vol.65 , pp. 1624-1635
    • Huu, D.L.1    Matsushita, T.2    Jin, G.3
  • 97
    • 78650881166 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate and immune regulation: trafficking and beyond
    • Chi, H., Sphingosine-1-phosphate and immune regulation: trafficking and beyond. Trends Pharmacol Sci 32 (2011), 16–24.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 16-24
    • Chi, H.1
  • 98
    • 84953439191 scopus 로고    scopus 로고
    • Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases
    • D'Ambrosio, D., Freedman, M.S., Prinz, J., Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases. Ther Adv Chronic Dis 7 (2016), 18–33.
    • (2016) Ther Adv Chronic Dis , vol.7 , pp. 18-33
    • D'Ambrosio, D.1    Freedman, M.S.2    Prinz, J.3
  • 99
    • 1542368420 scopus 로고    scopus 로고
    • Development and function of CD25+CD4+ regulatory T cells
    • Fehervari, Z., Sakaguchi, S., Development and function of CD25+CD4+ regulatory T cells. Curr Opin Immunol 16 (2004), 203–208.
    • (2004) Curr Opin Immunol , vol.16 , pp. 203-208
    • Fehervari, Z.1    Sakaguchi, S.2
  • 100
    • 0037243827 scopus 로고    scopus 로고
    • CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    • Maloy, K.J., Salaun, L., Cahill, R., Dougan, G., Saunders, N.J., Powrie, F., CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 197 (2003), 111–119.
    • (2003) J Exp Med , vol.197 , pp. 111-119
    • Maloy, K.J.1    Salaun, L.2    Cahill, R.3    Dougan, G.4    Saunders, N.J.5    Powrie, F.6
  • 101
    • 84977609937 scopus 로고    scopus 로고
    • Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease
    • Koreth, J., Kim, H.T., Jones, K.T., et al. Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease. Blood 128 (2016), 130–137.
    • (2016) Blood , vol.128 , pp. 130-137
    • Koreth, J.1    Kim, H.T.2    Jones, K.T.3
  • 102
    • 84960337895 scopus 로고    scopus 로고
    • Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect
    • Brunstein, C.G., Miller, J.S., McKenna, D.H., et al. Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect. Blood 127 (2016), 1044–1051.
    • (2016) Blood , vol.127 , pp. 1044-1051
    • Brunstein, C.G.1    Miller, J.S.2    McKenna, D.H.3
  • 103
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    • Di Ianni, M., Falzetti, F., Carotti, A., et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 117 (2011), 3921–3928.
    • (2011) Blood , vol.117 , pp. 3921-3928
    • Di Ianni, M.1    Falzetti, F.2    Carotti, A.3
  • 104
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
    • Brunstein, C.G., Miller, J.S., Cao, Q., et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 117 (2011), 1061–1070.
    • (2011) Blood , vol.117 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 105
    • 33645733724 scopus 로고    scopus 로고
    • Extracorporeal photochemotherapy for the treatment of steroid-resistant chronic GVHD
    • Couriel, D.R., Hosing, C., Saliba, R., et al. Extracorporeal photochemotherapy for the treatment of steroid-resistant chronic GVHD. Blood 107 (2006), 3074–3080.
    • (2006) Blood , vol.107 , pp. 3074-3080
    • Couriel, D.R.1    Hosing, C.2    Saliba, R.3
  • 106
    • 34447635261 scopus 로고    scopus 로고
    • Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4+CD25+GITR+Foxp3+CD62L+ functional regulatory T-cells in patients with graft-versus-host disease
    • Biagi, E., Di Biaso, I., Leoni, V., et al. Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4+CD25+GITR+Foxp3+CD62L+ functional regulatory T-cells in patients with graft-versus-host disease. Transplantation 84 (2007), 31–39.
    • (2007) Transplantation , vol.84 , pp. 31-39
    • Biagi, E.1    Di Biaso, I.2    Leoni, V.3
  • 107
    • 84908645645 scopus 로고    scopus 로고
    • Extracorporeal photopheresis (photochemotherapy) in the treatment of acute and chronic graft versus host disease: immunological mechanisms and the results from clinical studies
    • Bruserud, O., Tvedt, T.H., Paulsen, P.Q., et al. Extracorporeal photopheresis (photochemotherapy) in the treatment of acute and chronic graft versus host disease: immunological mechanisms and the results from clinical studies. Cancer Immunol Immunother 63 (2014), 757–777.
    • (2014) Cancer Immunol Immunother , vol.63 , pp. 757-777
    • Bruserud, O.1    Tvedt, T.H.2    Paulsen, P.Q.3
  • 108
    • 67649622603 scopus 로고    scopus 로고
    • Regulatory T cells and extracorporeal photochemotherapy: correlation with clinical response and decreased frequency of proinflammatory T cells
    • Di Biaso, I., Di Maio, L., Bugarin, C., et al. Regulatory T cells and extracorporeal photochemotherapy: correlation with clinical response and decreased frequency of proinflammatory T cells. Transplantation 87 (2009), 1422–1425.
    • (2009) Transplantation , vol.87 , pp. 1422-1425
    • Di Biaso, I.1    Di Maio, L.2    Bugarin, C.3
  • 109
    • 84876012054 scopus 로고    scopus 로고
    • Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease
    • Matsuoka, K., Koreth, J., Kim, H.T., et al. Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease. Sci Transl Med, 5, 2013, 179ra143.
    • (2013) Sci Transl Med , vol.5 , pp. 179ra143
    • Matsuoka, K.1    Koreth, J.2    Kim, H.T.3
  • 110
    • 82555168440 scopus 로고    scopus 로고
    • Interleukin-2 and regulatory T cells in graft-versus-host disease
    • Koreth, J., Matsuoka, K., Kim, H.T., et al. Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med 365 (2011), 2055–2066.
    • (2011) N Engl J Med , vol.365 , pp. 2055-2066
    • Koreth, J.1    Matsuoka, K.2    Kim, H.T.3
  • 111
    • 33745964855 scopus 로고    scopus 로고
    • Rituximab for steroid-refractory chronic graft-versus-host disease
    • Cutler, C., Miklos, D., Kim, H.T., et al. Rituximab for steroid-refractory chronic graft-versus-host disease. Blood 108 (2006), 756–762.
    • (2006) Blood , vol.108 , pp. 756-762
    • Cutler, C.1    Miklos, D.2    Kim, H.T.3
  • 112
    • 1542472753 scopus 로고    scopus 로고
    • Treatment of chronic graft-versus-host disease with anti-CD20 chimeric monoclonal antibody
    • Ratanatharathorn, V., Ayash, L., Reynolds, C., et al. Treatment of chronic graft-versus-host disease with anti-CD20 chimeric monoclonal antibody. Biol Blood Marrow Transplant 9 (2003), 505–511.
    • (2003) Biol Blood Marrow Transplant , vol.9 , pp. 505-511
    • Ratanatharathorn, V.1    Ayash, L.2    Reynolds, C.3
  • 113
    • 0034662901 scopus 로고    scopus 로고
    • Anti-CD20 chimeric monoclonal antibody treatment of refractory immune-mediated thrombocytopenia in a patient with chronic graft-versus-host disease
    • Ratanatharathorn, V., Carson, E., Reynolds, C., et al. Anti-CD20 chimeric monoclonal antibody treatment of refractory immune-mediated thrombocytopenia in a patient with chronic graft-versus-host disease. Ann Intern Med 133 (2000), 275–279.
    • (2000) Ann Intern Med , vol.133 , pp. 275-279
    • Ratanatharathorn, V.1    Carson, E.2    Reynolds, C.3
  • 114
    • 84933559790 scopus 로고    scopus 로고
    • Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease
    • Flynn, R., Allen, J.L., Luznik, L., et al. Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease. Blood 125 (2015), 4085–4094.
    • (2015) Blood , vol.125 , pp. 4085-4094
    • Flynn, R.1    Allen, J.L.2    Luznik, L.3
  • 115
    • 84875224608 scopus 로고    scopus 로고
    • Targeting the SYK-BTK axis for the treatment of immunological and hematological disorders: recent progress and therapeutic perspectives
    • Tan, S.L., Liao, C., Lucas, M.C., Stevenson, C., DeMartino, J.A., Targeting the SYK-BTK axis for the treatment of immunological and hematological disorders: recent progress and therapeutic perspectives. Pharmacol Ther 138 (2013), 294–309.
    • (2013) Pharmacol Ther , vol.138 , pp. 294-309
    • Tan, S.L.1    Liao, C.2    Lucas, M.C.3    Stevenson, C.4    DeMartino, J.A.5
  • 116
    • 84908656083 scopus 로고    scopus 로고
    • Ibrutinib treatment ameliorates murine chronic graft-versus-host disease
    • Dubovsky, J.A., Flynn, R., Du, J., et al. Ibrutinib treatment ameliorates murine chronic graft-versus-host disease. J Clin Invest 124 (2014), 4867–4876.
    • (2014) J Clin Invest , vol.124 , pp. 4867-4876
    • Dubovsky, J.A.1    Flynn, R.2    Du, J.3
  • 117
    • 84945231899 scopus 로고    scopus 로고
    • Inhibition of BTK and ITK with ibrutinib is effective in the prevention of chronic graft-versus-host disease in mice
    • e0137641
    • Schutt, S.D., Fu, J., Nguyen, H., et al. Inhibition of BTK and ITK with ibrutinib is effective in the prevention of chronic graft-versus-host disease in mice. PLoS One, 10, 2015 e0137641.
    • (2015) PLoS One , vol.10
    • Schutt, S.D.1    Fu, J.2    Nguyen, H.3
  • 118
    • 85014923433 scopus 로고    scopus 로고
    • Multicenter, open-label Phase 1b/2 study of Ibrutinib in steroid dependent/refractory chronic graft-versus-host disease (cGVHD) [abstract]
    • Miklos, D., Cutler, C., Arora, M., et al. Multicenter, open-label Phase 1b/2 study of Ibrutinib in steroid dependent/refractory chronic graft-versus-host disease (cGVHD) [abstract]. Bone Marrow Transplant 51:suppl S1 (2016), S176–S177.
    • (2016) Bone Marrow Transplant , vol.51 , pp. S176-S177
    • Miklos, D.1    Cutler, C.2    Arora, M.3
  • 119
    • 85021126822 scopus 로고    scopus 로고
    • Multicenter open-label phase 2 study of ibrutinib in chronic graft versus host disease (cGVHD) after failure of corticosteroids
    • LBA-3
    • Miklos, D., Arora, M., et al. Multicenter open-label phase 2 study of ibrutinib in chronic graft versus host disease (cGVHD) after failure of corticosteroids. Blood, 128, 2016 LBA-3.
    • (2016) Blood , vol.128
    • Miklos, D.1    Arora, M.2
  • 120
    • 84899925204 scopus 로고    scopus 로고
    • Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability
    • Distler, A., Lang, V., Del Vecchio, T., et al. Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability. Ann Rheum Dis 73 (2014), 1264–1268.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1264-1268
    • Distler, A.1    Lang, V.2    Del Vecchio, T.3
  • 121
    • 84859260199 scopus 로고    scopus 로고
    • Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis
    • Horn, A., Palumbo, K., Cordazzo, C., et al. Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis. Arthritis Rheum 64 (2012), 2724–2733.
    • (2012) Arthritis Rheum , vol.64 , pp. 2724-2733
    • Horn, A.1    Palumbo, K.2    Cordazzo, C.3
  • 122
    • 84857232095 scopus 로고    scopus 로고
    • Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis
    • Ruiz-Heiland, G., Horn, A., Zerr, P., et al. Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis. Ann Rheum Dis 71 (2012), 400–407.
    • (2012) Ann Rheum Dis , vol.71 , pp. 400-407
    • Ruiz-Heiland, G.1    Horn, A.2    Zerr, P.3
  • 123
    • 84867254044 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease
    • Zerr, P., Palumbo-Zerr, K., Distler, A., et al. Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease. Blood 120 (2012), 2909–2917.
    • (2012) Blood , vol.120 , pp. 2909-2917
    • Zerr, P.1    Palumbo-Zerr, K.2    Distler, A.3


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