Cytotoxicity of demalonyl thyrsiflorin A, a semisynthetic labdane-derived diterpenoid, to melanoma cells

Toxicology in Vitro

Volumn 47, Issue , 2018, Pages 274-280

  Cardile, V ^a   Avola, R ^a   Graziano, A C E ^a   Piovano, M ^b   Russo, A ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b DEPARTAMENTO DE FÍSICA   (Chile)

Author keywords

Apoptosis; Demalonyl thyrsiflorin A; Hsp70 protein; Melanoma; Phenolic diterpenes; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; DEMALONYL THYRSIFLORIN A; HEAT SHOCK PROTEIN 70; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CASP3 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; DITERPENE; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCEOLARIA THYRSIFLORA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; LACTATE DEHYDROGENASE BLOOD LEVEL; MEDICINAL PLANT; MELANOMA CELL LINE; MOLECULAR PROBE; MTT ASSAY; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; WESTERN BLOTTING; AGONISTS; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; COMET ASSAY; DNA FRAGMENTATION; DRUG DESIGN; DRUG EFFECT; MELANOMA; METABOLISM; NECROSIS; OSMOLARITY; OXIDATIVE STRESS; PATHOLOGY; TUMOR CELL LINE; TUNEL ASSAY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COMET ASSAY; DITERPENES; DNA FRAGMENTATION; DRUG DESIGN; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IN SITU NICK-END LABELING; MELANOMA; NECROSIS; NEOPLASM PROTEINS; OSMOLAR CONCENTRATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 85038883781     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2017.12.012     Document Type: Article

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