메뉴 건너뛰기




Volumn 28, Issue 8, 2014, Pages 1449-1460

Numerical simulations of in vitro nanoparticle toxicity - the case of poly(amido amine) dendrimers

Author keywords

Cytotoxicity; Nanotoxicology; Numerical simulation; Polyamidoamine dendrimer; Quantitative structure activity relationships; Reactive oxygen species

Indexed keywords


EID: 84908674020     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.07.014     Document Type: Article
Times cited : (42)

References (63)
  • 3
    • 31544466218 scopus 로고    scopus 로고
    • Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD
    • Balasundaram G., Sato M., Webster T.J. Using hydroxyapatite nanoparticles and decreased crystallinity to promote osteoblast adhesion similar to functionalizing with RGD. Biomaterials 2006, 27:2798-2805.
    • (2006) Biomaterials , vol.27 , pp. 2798-2805
    • Balasundaram, G.1    Sato, M.2    Webster, T.J.3
  • 4
    • 71649087746 scopus 로고    scopus 로고
    • Predicting physical properties of emerging compounds with limited physical and chemical data: QSAR model uncertainty and applicability to military munitions
    • Bennett E.R., Clausen J., Linkov E., Linkov I. Predicting physical properties of emerging compounds with limited physical and chemical data: QSAR model uncertainty and applicability to military munitions. Chemosphere 2009, 77:1412-1418.
    • (2009) Chemosphere , vol.77 , pp. 1412-1418
    • Bennett, E.R.1    Clausen, J.2    Linkov, E.3    Linkov, I.4
  • 5
    • 66149110011 scopus 로고    scopus 로고
    • Nanoparticles and cancer therapy: a concise review with emphasis on dendrimers
    • Bharali D.J., Khalil M., Gurbuz M., Simone T.M., Mousa S.A. Nanoparticles and cancer therapy: a concise review with emphasis on dendrimers. Int. J. Nanomed. 2009, 4:1-7.
    • (2009) Int. J. Nanomed. , vol.4 , pp. 1-7
    • Bharali, D.J.1    Khalil, M.2    Gurbuz, M.3    Simone, T.M.4    Mousa, S.A.5
  • 6
    • 0021058380 scopus 로고
    • Operational models of pharmacological agonism
    • Black J.W., Leff P. Operational models of pharmacological agonism. Proc. R. Soc. B: Biol. Sci. 1983, 220:141-162.
    • (1983) Proc. R. Soc. B: Biol. Sci. , vol.220 , pp. 141-162
    • Black, J.W.1    Leff, P.2
  • 7
    • 79952697349 scopus 로고    scopus 로고
    • Predictive models for nanotoxicology: current challenges and future opportunities
    • Clark K.A., White R.H., Silbergeld E.K. Predictive models for nanotoxicology: current challenges and future opportunities. Regul. Toxicol. Pharm. 2011, 59:361-512.
    • (2011) Regul. Toxicol. Pharm. , vol.59 , pp. 361-512
    • Clark, K.A.1    White, R.H.2    Silbergeld, E.K.3
  • 8
    • 0002501008 scopus 로고    scopus 로고
    • Dendrimers III: design, dimension, function: dendrimer-encapsulated metals and semiconductors: synthesis, characterisation and applications
    • Crooks R.M., Lemon B.I., Yeung L.K., Zhao M. Dendrimers III: design, dimension, function: dendrimer-encapsulated metals and semiconductors: synthesis, characterisation and applications. Topics Curr. Chem. 2001, 212:81-135.
    • (2001) Topics Curr. Chem. , vol.212 , pp. 81-135
    • Crooks, R.M.1    Lemon, B.I.2    Yeung, L.K.3    Zhao, M.4
  • 9
    • 61349139614 scopus 로고    scopus 로고
    • Drug delivery and nanoparticles: applications and hazards
    • De Jong W.H., Borm P.J.A. Drug delivery and nanoparticles: applications and hazards. Int. J. Nanomed. 2008, 3:133-149.
    • (2008) Int. J. Nanomed. , vol.3 , pp. 133-149
    • De Jong, W.H.1    Borm, P.J.A.2
  • 10
    • 84867864674 scopus 로고    scopus 로고
    • Delivery success rate of engineered nanoparticles in the presence of the protein corona: a systems-level screening
    • Dell'Orco D., Lundqvist M., Cedervall T., Linse S. Delivery success rate of engineered nanoparticles in the presence of the protein corona: a systems-level screening. Nanomed. Nanotechnol. Biol. Med. 2012, 8:1271-1281.
    • (2012) Nanomed. Nanotechnol. Biol. Med. , vol.8 , pp. 1271-1281
    • Dell'Orco, D.1    Lundqvist, M.2    Cedervall, T.3    Linse, S.4
  • 11
    • 0024432603 scopus 로고
    • Regulation of cellular glutathione
    • Deneke S.M., Fanburg B.L. Regulation of cellular glutathione. Am. J. Physiol. 1989, 257:L163-L173.
    • (1989) Am. J. Physiol. , vol.257 , pp. L163-L173
    • Deneke, S.M.1    Fanburg, B.L.2
  • 13
    • 84908681362 scopus 로고    scopus 로고
    • Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes
    • European Union, 2010. Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes.
    • (2010)
  • 15
    • 0036707316 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug delivery and targeting
    • Hans M.L., Lowman A.M. Biodegradable nanoparticles for drug delivery and targeting. Curr. Opin. Solid State Mater. 2002, 6:319-327.
    • (2002) Curr. Opin. Solid State Mater. , vol.6 , pp. 319-327
    • Hans, M.L.1    Lowman, A.M.2
  • 17
    • 0342831768 scopus 로고
    • Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine
    • Issels R.D., Nagele A., Eckert K.-G., Wilmanns W. Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine. Biochem. Pharmacol. 1985, 37:1029-1033.
    • (1985) Biochem. Pharmacol. , vol.37 , pp. 1029-1033
    • Issels, R.D.1    Nagele, A.2    Eckert, K.-G.3    Wilmanns, W.4
  • 18
    • 35649018592 scopus 로고    scopus 로고
    • Applications of nanobiotechnology in clinical diagnostics
    • Jain K.K. Applications of nanobiotechnology in clinical diagnostics. Clin. Chem. 2007, 53:2002-2009.
    • (2007) Clin. Chem. , vol.53 , pp. 2002-2009
    • Jain, K.K.1
  • 20
    • 33751192451 scopus 로고    scopus 로고
    • Toxicity of metal oxide nanoparticles in mammalian cells
    • Jeng H.A., Swanson J. Toxicity of metal oxide nanoparticles in mammalian cells. J. Environ. Sci. Health A 2006, 41:2699-2711.
    • (2006) J. Environ. Sci. Health A , vol.41 , pp. 2699-2711
    • Jeng, H.A.1    Swanson, J.2
  • 21
    • 77956037949 scopus 로고    scopus 로고
    • Uptake and Inflammatory Effects of Nanoparticles in a Human Vascular Endothelial Cell Line
    • HEI Research Report 136, Health Effects Institute, Boston, MA
    • Kennedy, I.M., Wilson, D., Barakat, A.I., 2009. Uptake and Inflammatory Effects of Nanoparticles in a Human Vascular Endothelial Cell Line. HEI Research Report 136, Health Effects Institute, Boston, MA.
    • (2009)
    • Kennedy, I.M.1    Wilson, D.2    Barakat, A.I.3
  • 23
    • 33745513833 scopus 로고    scopus 로고
    • Role of nanotechnology in targeted drug delivery and imaging: a concise review
    • Koo O.M., Rubinstein I., Onyuksel H. Role of nanotechnology in targeted drug delivery and imaging: a concise review. Nanomed. Nanotechnol. Biol. Med. 2005, 1:193-212.
    • (2005) Nanomed. Nanotechnol. Biol. Med. , vol.1 , pp. 193-212
    • Koo, O.M.1    Rubinstein, I.2    Onyuksel, H.3
  • 25
    • 69449091125 scopus 로고    scopus 로고
    • Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction
    • Lee J.H., Cha K.E., Kim M.S., Hong H.W., Chung D.J., Ryu G., Myung H. Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction. Toxicol. Lett. 2009, 190:202-207.
    • (2009) Toxicol. Lett. , vol.190 , pp. 202-207
    • Lee, J.H.1    Cha, K.E.2    Kim, M.S.3    Hong, H.W.4    Chung, D.J.5    Ryu, G.6    Myung, H.7
  • 27
    • 68649093091 scopus 로고    scopus 로고
    • A predictive toxicological paradigm for the safety assessment of nanomaterials
    • Meng T., Xia T., George S., Nel A.E. A predictive toxicological paradigm for the safety assessment of nanomaterials. ACS Nano 2009, 3:1620-1627.
    • (2009) ACS Nano , vol.3 , pp. 1620-1627
    • Meng, T.1    Xia, T.2    George, S.3    Nel, A.E.4
  • 28
    • 78651362518 scopus 로고    scopus 로고
    • Estimation of bioavailability of salmon calcitonin from the hypocalcemic effect in rats (I): pharmacokinetic-pharmacodynamic modeling based on the endogenous Ca regulatory system
    • Miyazaki M., Nakade S., Iwanaga K., Morimoto K., Kakemi M. Estimation of bioavailability of salmon calcitonin from the hypocalcemic effect in rats (I): pharmacokinetic-pharmacodynamic modeling based on the endogenous Ca regulatory system. Drug Metabol. Pharmacokin. 2003, 18:350-357.
    • (2003) Drug Metabol. Pharmacokin. , vol.18 , pp. 350-357
    • Miyazaki, M.1    Nakade, S.2    Iwanaga, K.3    Morimoto, K.4    Kakemi, M.5
  • 29
    • 84873734071 scopus 로고    scopus 로고
    • Polyamidoamine dendrimer nanoparticle cytotoxicity oxidative stress, caspase activation and inflammatory response: experimental observation and numerical simulation
    • Mukherjee S.P., Byrne H.J. Polyamidoamine dendrimer nanoparticle cytotoxicity oxidative stress, caspase activation and inflammatory response: experimental observation and numerical simulation. Nanomed. Nanotechnol. Biol. Med. 2013, 9:202-211.
    • (2013) Nanomed. Nanotechnol. Biol. Med. , vol.9 , pp. 202-211
    • Mukherjee, S.P.1    Byrne, H.J.2
  • 30
    • 72049103654 scopus 로고    scopus 로고
    • In vitro mammalian cytotoxicological study of PAMAM dendrimers - towards quantitative structure activity relationships
    • Mukherjee S.P., Davoren M., Byrne H.J. In vitro mammalian cytotoxicological study of PAMAM dendrimers - towards quantitative structure activity relationships. Toxicol. In Vitro 2010, 24:169-177.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 169-177
    • Mukherjee, S.P.1    Davoren, M.2    Byrne, H.J.3
  • 31
    • 77955982005 scopus 로고    scopus 로고
    • Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells
    • Mukherjee S.P., Lyng F.M., Garcia A., Davoren M., Byrne H.J. Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells. Toxicol. Appl. Pharm. 2010, 248:259-268.
    • (2010) Toxicol. Appl. Pharm. , vol.248 , pp. 259-268
    • Mukherjee, S.P.1    Lyng, F.M.2    Garcia, A.3    Davoren, M.4    Byrne, H.J.5
  • 32
    • 84874532727 scopus 로고    scopus 로고
    • Generation of intracellular reactive oxygen species and genotoxicity effect to exposure of nanosized polyamidoamine (PAMAM) dendrimers in PLHC-1 cells in vitro
    • Naha P.C., Byrne H.J. Generation of intracellular reactive oxygen species and genotoxicity effect to exposure of nanosized polyamidoamine (PAMAM) dendrimers in PLHC-1 cells in vitro. Aquat. Toxicol. 2013, 132-133:61-72.
    • (2013) Aquat. Toxicol. , pp. 61-72
    • Naha, P.C.1    Byrne, H.J.2
  • 33
    • 69549126766 scopus 로고    scopus 로고
    • An ecotoxicological study of poly(amidoamine) dendrimers-toward quantitative structure activity relationships
    • Naha P.C., Davoren M., Casey A., Byrne H.J. An ecotoxicological study of poly(amidoamine) dendrimers-toward quantitative structure activity relationships. Environ. Sci. Technol. 2009, 43:6864-6869.
    • (2009) Environ. Sci. Technol. , vol.43 , pp. 6864-6869
    • Naha, P.C.1    Davoren, M.2    Casey, A.3    Byrne, H.J.4
  • 34
    • 77953691199 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells
    • Naha P.C., Davoren M., Lyng F.M., Byrne H.J. Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells. Toxicol. Appl. Pharm. 2010, 246:91-99.
    • (2010) Toxicol. Appl. Pharm. , vol.246 , pp. 91-99
    • Naha, P.C.1    Davoren, M.2    Lyng, F.M.3    Byrne, H.J.4
  • 35
    • 78049442013 scopus 로고    scopus 로고
    • Delivery of anti-inflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer
    • Nair H.B., Sung B., Yadav V.R., Kannappan R., Chaturvedi M.M., Aggarwal B.B. Delivery of anti-inflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochem. Pharmacol. 2010, 80(2010):1833-1843.
    • (2010) Biochem. Pharmacol. , vol.80 , Issue.2010 , pp. 1833-1843
    • Nair, H.B.1    Sung, B.2    Yadav, V.R.3    Kannappan, R.4    Chaturvedi, M.M.5    Aggarwal, B.B.6
  • 36
    • 0037192453 scopus 로고    scopus 로고
    • Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines
    • Nakagawa Y., Akao Y., Morikawa H., Hirata I., Katsu K., Naoe T., Ohishi N., Yagi K. Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. Life Sci. 2002, 70:2253-2269.
    • (2002) Life Sci. , vol.70 , pp. 2253-2269
    • Nakagawa, Y.1    Akao, Y.2    Morikawa, H.3    Hirata, I.4    Katsu, K.5    Naoe, T.6    Ohishi, N.7    Yagi, K.8
  • 37
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel A., Xia T., Mädler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311:622-627.
    • (2006) Science , vol.311 , pp. 622-627
    • Nel, A.1    Xia, T.2    Mädler, L.3    Li, N.4
  • 38
    • 34249702381 scopus 로고    scopus 로고
    • Discrete deposition of hydroxyapatite nanoparticles on a titanium implant with predisposing substrate microtopography accelerated osseointegration
    • Nishimura I., Huang Y., Butz F., Ogawa T., Lin A., Wang C.J. Discrete deposition of hydroxyapatite nanoparticles on a titanium implant with predisposing substrate microtopography accelerated osseointegration. Nanotechnology 2007, 18:1-9.
    • (2007) Nanotechnology , vol.18 , pp. 1-9
    • Nishimura, I.1    Huang, Y.2    Butz, F.3    Ogawa, T.4    Lin, A.5    Wang, C.J.6
  • 39
    • 0031852098 scopus 로고    scopus 로고
    • A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity
    • Nociari M.M., Shalev A., Benias P., Russo C. A novel one-step, highly sensitive fluorometric assay to evaluate cell-mediated cytotoxicity. J. Immunol. Meth. 1998, 213:157-167.
    • (1998) J. Immunol. Meth. , vol.213 , pp. 157-167
    • Nociari, M.M.1    Shalev, A.2    Benias, P.3    Russo, C.4
  • 40
    • 84908681361 scopus 로고    scopus 로고
    • Guidance Document on the Validation of (Quantitative) Structure Activity Relationships [(Q)SAR] Models, OECD, ENV/JM/MONO(2007) 2.
    • Organisation for Economic Co-Operation and Development (OECD), 2007. Guidance Document on the Validation of (Quantitative) Structure Activity Relationships [(Q)SAR] Models, OECD, ENV/JM/MONO(2007) 2.
    • (2007)
  • 41
    • 84908681360 scopus 로고    scopus 로고
    • Guidance Document On Developing and Assessing Adverse Outcome Pathways, OECD, ENV/JM/MONO(2013) 6
    • Organisation for Economic Co-Operation and Development (OECD), 2013. Guidance Document On Developing and Assessing Adverse Outcome Pathways, OECD, ENV/JM/MONO(2013) 6.
    • (2013)
  • 43
    • 84908681359 scopus 로고    scopus 로고
    • Project on Emerging Nanotechnologies (PEN), 2013. < http://www.nanotechproject.org/>.
    • (2013)
  • 44
    • 73349083717 scopus 로고    scopus 로고
    • Toward the development of "Nano-QSARs": advances and challenges
    • Puzyn T., Leszczynska D., Leszczynski J. Toward the development of "Nano-QSARs": advances and challenges. Small 2009, 22:2494-2509.
    • (2009) Small , vol.22 , pp. 2494-2509
    • Puzyn, T.1    Leszczynska, D.2    Leszczynski, J.3
  • 45
    • 50249171227 scopus 로고    scopus 로고
    • Neutral red uptake assay for the estimation of cell viability/cytotoxicity
    • Repetto G., del Peso A., Zurita J.L. Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat. Protocols 2008, 3:1125-1131.
    • (2008) Nat. Protocols , vol.3 , pp. 1125-1131
    • Repetto, G.1    del Peso, A.2    Zurita, J.L.3
  • 46
    • 35448957273 scopus 로고    scopus 로고
    • Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model
    • Rothen-Rutishauser B., Mühlfeld C., Blank F., Musso C., Gehr P. Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. Part Fibre Toxicol. 2007, 4. http://dx.doi.org/10.1186/1743-8977-4-9.
    • (2007) Part Fibre Toxicol. , vol.4
    • Rothen-Rutishauser, B.1    Mühlfeld, C.2    Blank, F.3    Musso, C.4    Gehr, P.5
  • 48
    • 78651359261 scopus 로고    scopus 로고
    • PK/PD modelling of comb-shaped PEGylated salmon calcitonin conjugates of differing molecular weights
    • Ryan S.M., Frías J.M., Wang X., Sayers C.T., Haddleton D.M., Brayden D.J. PK/PD modelling of comb-shaped PEGylated salmon calcitonin conjugates of differing molecular weights. J. Control. Release 2011, 149:126-132.
    • (2011) J. Control. Release , vol.149 , pp. 126-132
    • Ryan, S.M.1    Frías, J.M.2    Wang, X.3    Sayers, C.T.4    Haddleton, D.M.5    Brayden, D.J.6
  • 49
    • 82255163011 scopus 로고    scopus 로고
    • Experimental and theoretical comparison of intracellular import of polymeric nanoparticles and small molecules: toward models of uptake kinetics
    • Salvati A., Aberg C., dos Santos T., Varela J., Pinto P., Lynch I., Dawson K.A. Experimental and theoretical comparison of intracellular import of polymeric nanoparticles and small molecules: toward models of uptake kinetics. Nanomed. Nanotechnol. Biol. Med. 2011, 7:818-826.
    • (2011) Nanomed. Nanotechnol. Biol. Med. , vol.7 , pp. 818-826
    • Salvati, A.1    Aberg, C.2    dos Santos, T.3    Varela, J.4    Pinto, P.5    Lynch, I.6    Dawson, K.A.7
  • 50
    • 0034283409 scopus 로고    scopus 로고
    • Persistent depletion of I kappa B alpha and interleukin-8 expression in human pulmonary epithelial cells exposed to quartz particles
    • Schins R.P., McAlinden A., MacNee W., Jimenez L.A., Ross J.A., Guy K., Faux S.P., Donaldson K. Persistent depletion of I kappa B alpha and interleukin-8 expression in human pulmonary epithelial cells exposed to quartz particles. Toxicol. Appl. Pharm. 2000, 167:107-117.
    • (2000) Toxicol. Appl. Pharm. , vol.167 , pp. 107-117
    • Schins, R.P.1    McAlinden, A.2    MacNee, W.3    Jimenez, L.A.4    Ross, J.A.5    Guy, K.6    Faux, S.P.7    Donaldson, K.8
  • 51
    • 0034993697 scopus 로고    scopus 로고
    • OxLDL induces macrophage γ-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesis
    • Shen L., Sevanian A. OxLDL induces macrophage γ-GCS-HS protein expression: a role for oxLDL-associated lipid hydroperoxide in GSH synthesis. J. Lipid Res. 2001, 42:813-823.
    • (2001) J. Lipid Res. , vol.42 , pp. 813-823
    • Shen, L.1    Sevanian, A.2
  • 53
    • 24644459501 scopus 로고    scopus 로고
    • Arsenic, mode of action at biologically plausible low doses: what are the implications for low dose cancer risk?
    • Snow E.T., Sykora P., Durham T.R., Klein C.B. Arsenic, mode of action at biologically plausible low doses: what are the implications for low dose cancer risk?. Toxicol. Appl. Pharm. 2005, 207:S557-S564.
    • (2005) Toxicol. Appl. Pharm. , vol.207 , pp. S557-S564
    • Snow, E.T.1    Sykora, P.2    Durham, T.R.3    Klein, C.B.4
  • 54
    • 0037103007 scopus 로고    scopus 로고
    • Discovery of dendrimers and dendritic polymers: a brief historical perspective
    • Tomalia D.A., Fréchet J.M.J. Discovery of dendrimers and dendritic polymers: a brief historical perspective. J. Polym. Sci. Pol. Chem. 2002, 40:2719-2728.
    • (2002) J. Polym. Sci. Pol. Chem. , vol.40 , pp. 2719-2728
    • Tomalia, D.A.1    Fréchet, J.M.J.2
  • 55
    • 0021960720 scopus 로고
    • Enhancement of intracellular glutathione protects endothelial cells against oxidant damage
    • Tsan M.F., Danis E.H., Del Vecchio P.J., Rosano C.L. Enhancement of intracellular glutathione protects endothelial cells against oxidant damage. Biochem. Biophys. Res. Co. 1985, 127:270-276.
    • (1985) Biochem. Biophys. Res. Co. , vol.127 , pp. 270-276
    • Tsan, M.F.1    Danis, E.H.2    Del Vecchio, P.J.3    Rosano, C.L.4
  • 56
    • 0024546827 scopus 로고
    • Modulation of endothelial GSH concentrations: effect of exogenous GSH and GSH monoethyl ester
    • Tsan M.F., White J.E., Rosano C.L. Modulation of endothelial GSH concentrations: effect of exogenous GSH and GSH monoethyl ester. J. Appl. Physiol. 1989, 66:1029-1034.
    • (1989) J. Appl. Physiol. , vol.66 , pp. 1029-1034
    • Tsan, M.F.1    White, J.E.2    Rosano, C.L.3
  • 57
    • 84908681358 scopus 로고    scopus 로고
    • United States 106th Congress - Public Law 106-545, December 19
    • United States 106th Congress - Public Law 106-545, December 19, 2000.
    • (2000)
  • 58
    • 15044355252 scopus 로고    scopus 로고
    • Measurement of particle-bound reactive oxygen species in rubidoux aerosols
    • Venkatachari P., Hopke P.K., Grover B.D., Eatough D.J. Measurement of particle-bound reactive oxygen species in rubidoux aerosols. J. Atmos. Chem. 2005, 50:49-58.
    • (2005) J. Atmos. Chem. , vol.50 , pp. 49-58
    • Venkatachari, P.1    Hopke, P.K.2    Grover, B.D.3    Eatough, D.J.4
  • 59
    • 0033567455 scopus 로고    scopus 로고
    • Nuclear factor-kB-dependent induction of interleukin-8 gene expression by tumor necrosis factor-α: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation
    • Vlahopoulos S., Boldogh I., Casola A., Brasier A.R. Nuclear factor-kB-dependent induction of interleukin-8 gene expression by tumor necrosis factor-α: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation. Blood 1999, 94:1878-1889.
    • (1999) Blood , vol.94 , pp. 1878-1889
    • Vlahopoulos, S.1    Boldogh, I.2    Casola, A.3    Brasier, A.R.4
  • 60
    • 7044235459 scopus 로고    scopus 로고
    • Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells
    • Watson P., Jones A.T., Stephens D.J. Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Adv. Drug Deliver. Rev. 2005, 57:43-61.
    • (2005) Adv. Drug Deliver. Rev. , vol.57 , pp. 43-61
    • Watson, P.1    Jones, A.T.2    Stephens, D.J.3
  • 61
    • 33748310797 scopus 로고    scopus 로고
    • Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm
    • Xia T., Kovochich M., Brant J., Hotze M., Sempf J., Oberley T., Sioutas C., Yeh J.I., Wiesner M.R., Nel A.E. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett. 2006, 6:1794-1807.
    • (2006) Nano Lett. , vol.6 , pp. 1794-1807
    • Xia, T.1    Kovochich, M.2    Brant, J.3    Hotze, M.4    Sempf, J.5    Oberley, T.6    Sioutas, C.7    Yeh, J.I.8    Wiesner, M.R.9    Nel, A.E.10
  • 62
    • 33744914093 scopus 로고    scopus 로고
    • PAMAM dendrimers for efficient siRNA delivery and potent gene silencing
    • Zhou J., Wu J., Hafdi N., Behr J.P., Erbacher P., Peng L. PAMAM dendrimers for efficient siRNA delivery and potent gene silencing. Chem. Commun. 2006, 22:2362-2364.
    • (2006) Chem. Commun. , vol.22 , pp. 2362-2364
    • Zhou, J.1    Wu, J.2    Hafdi, N.3    Behr, J.P.4    Erbacher, P.5    Peng, L.6
  • 63
    • 51249086247 scopus 로고    scopus 로고
    • SBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool
    • Zi Z., Zheng Y., Rundell A.E., Klipp E. SBML-SAT: a systems biology markup language (SBML) based sensitivity analysis tool. BMC Bioinformatics 2008, 9:342.
    • (2008) BMC Bioinformatics , vol.9 , pp. 342
    • Zi, Z.1    Zheng, Y.2    Rundell, A.E.3    Klipp, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.