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Volumn 72, Issue 12, 2017, Pages 1703-1709

Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults

Author keywords

Aging; Gene expression; Polyphenols; Prediabetes

Indexed keywords

GLUCOSE; RESVERATROL; STILBENE DERIVATIVE;

EID: 85038129867     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glx041     Document Type: Article
Times cited : (80)

References (49)
  • 1
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5:493-506. doi:10.1038/nrd2060
    • (2006) Nat Rev Drug Discov. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 2
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425:191-196. doi:10.1038/nature01960
    • (2003) Nature. , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3
  • 4
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337-342. doi:10.1038/nature05354
    • (2006) Nature. , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 5
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006;127:1109-1122. doi:10.1016/j. cell.2006.11.013
    • (2006) Cell. , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 6
    • 84865181393 scopus 로고    scopus 로고
    • Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
    • Bhatt JK, Thomas S, Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res. 2012;32:537-541. doi:10.1016/j.nutres.2012.06.003
    • (2012) Nutr Res. , vol.32 , pp. 537-541
    • Bhatt, J.K.1    Thomas, S.2    Nanjan, M.J.3
  • 7
    • 77956585215 scopus 로고    scopus 로고
    • An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol
    • Ghanim H, Sia CL, Abuaysheh S, et al. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab. 2010;95:E1-E8. doi:10.1210/jc.2010-0482
    • (2010) J Clin Endocrinol Metab. , vol.95 , pp. E1-E8
    • Ghanim, H.1    Sia, C.L.2    Abuaysheh, S.3
  • 8
    • 84875431034 scopus 로고    scopus 로고
    • High-dose resveratrol supplementation in obese men: An investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition
    • Poulsen MM, Vestergaard PF, Clasen BF, et al. High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Diabetes. 2013;62:1186-1195. doi:10.2337/ db12-0975
    • (2013) Diabetes. , vol.62 , pp. 1186-1195
    • Poulsen, M.M.1    Vestergaard, P.F.2    Clasen, B.F.3
  • 9
    • 80455143206 scopus 로고    scopus 로고
    • Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    • Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011;14:612-622. doi:10.1016/j.cmet.2011.10.002
    • (2011) Cell Metab. , vol.14 , pp. 612-622
    • Timmers, S.1    Konings, E.2    Bilet, L.3
  • 10
    • 84871445402 scopus 로고    scopus 로고
    • Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
    • Yoshino J, Conte C, Fontana L, et al. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab. 2012;16:658-664. doi:10.1016/j.cmet.2012.09.015
    • (2012) Cell Metab. , vol.16 , pp. 658-664
    • Yoshino, J.1    Conte, C.2    Fontana, L.3
  • 11
    • 84860131782 scopus 로고    scopus 로고
    • Pilot study of resveratrol in older adults with impaired glucose tolerance
    • Crandall JP, Oram V, Trandafirescu G, et al. Pilot study of resveratrol in older adults with impaired glucose tolerance. J Gerontol A Biol Sci Med Sci. 2012;67:1307-1312. doi:10.1093/gerona/glr235
    • (2012) J Gerontol A Biol Sci Med Sci. , vol.67 , pp. 1307-1312
    • Crandall, J.P.1    Oram, V.2    Trandafirescu, G.3
  • 12
    • 33947321153 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats
    • Chi TC, Chen WP, Chi TL, et al. Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats. Life Sci. 2007;80:1713-1720. doi:10.1016/j.lfs.2007.02.002
    • (2007) Life Sci. , vol.80 , pp. 1713-1720
    • Chi, T.C.1    Chen, W.P.2    Chi, T.L.3
  • 13
    • 0034650163 scopus 로고    scopus 로고
    • Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies
    • Hanson RL, Pratley RE, Bogardus C, et al. Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol. 2000;151:190-198. doi:10.1093/oxfordjournals.aje. a010187
    • (2000) Am J Epidemiol. , vol.151 , pp. 190-198
    • Hanson, R.L.1    Pratley, R.E.2    Bogardus, C.3
  • 14
    • 0032821965 scopus 로고    scopus 로고
    • Insulin sensitivity indices obtained from oral glucose tolerance testing: Comparison with the euglycemic insulin clamp
    • Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22:1462-1470. doi:10.2337/diacare.22.9.1462
    • (1999) Diabetes Care. , vol.22 , pp. 1462-1470
    • Matsuda, M.1    DeFronzo, R.A.2
  • 15
    • 33646488685 scopus 로고    scopus 로고
    • Evaluation of insulin sensitivity and glucose effectiveness during a standardized breakfast test: Comparison with the minimal model analysis of an intravenous glucose tolerance test
    • Aloulou I, Brun JF, Mercier J. Evaluation of insulin sensitivity and glucose effectiveness during a standardized breakfast test: comparison with the minimal model analysis of an intravenous glucose tolerance test. Metabolism. 2006;55:676-690. doi:10.1016/j.metabol.2006.01.002
    • (2006) Metabolism. , vol.55 , pp. 676-690
    • Aloulou, I.1    Brun, J.F.2    Mercier, J.3
  • 16
    • 0026504160 scopus 로고
    • Estimation of insulin secretion rates from C-peptide levels Comparison of individual and standard kinetic parameters for C-peptide clearance
    • Van Cauter E, Mestrez F, Sturis J, Polonsky KS. Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes. 1992;41:368-377. doi:10.2337/diab.41.3.368
    • (1992) Diabetes. , vol.41 , pp. 368-377
    • Van Cauter, E.1    Mestrez, F.2    Sturis, J.3    Polonsky, K.S.4
  • 17
    • 61849106040 scopus 로고    scopus 로고
    • Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels
    • Utzschneider KM, Prigeon RL, Faulenbach MV, et al. Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care. 2009;32:335-341. doi:10.2337/ dc08-1478
    • (2009) Diabetes Care. , vol.32 , pp. 335-341
    • Utzschneider, K.M.1    Prigeon, R.L.2    Faulenbach, M.V.3
  • 18
    • 84885132460 scopus 로고    scopus 로고
    • Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet
    • Fiori JL, Shin YK, Kim W, et al. Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet. Diabetes. 2013;62:3500-3513. doi:10.2337/db13-0266
    • (2013) Diabetes. , vol.62 , pp. 3500-3513
    • Fiori, J.L.1    Shin, Y.K.2    Kim, W.3
  • 19
    • 9644265239 scopus 로고    scopus 로고
    • Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia
    • Bonetti PO, Pumper GM, Higano ST, Holmes DR Jr, Kuvin JT, Lerman A. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol. 2004;44:2137-2141. doi:10.1016/j.jacc.2004.08.062
    • (2004) J Am Coll Cardiol. , vol.44 , pp. 2137-2141
    • Bonetti, P.O.1    Pumper, G.M.2    Higano, S.T.3    Holmes, D.R.4    Kuvin, J.T.5    Lerman, A.6
  • 20
    • 79551607371 scopus 로고    scopus 로고
    • Effect of exenatide on inflammatory and oxidative stress markers in patients with type 2 diabetes mellitus
    • Wu JD, Xu XH, Zhu J, et al. Effect of exenatide on inflammatory and oxidative stress markers in patients with type 2 diabetes mellitus. Diabetes Technol Ther. 2011;13:143-148. doi:10.1089/dia.2010.0048
    • (2011) Diabetes Technol Ther. , vol.13 , pp. 143-148
    • Wu, J.D.1    Xu, X.H.2    Zhu, J.3
  • 21
    • 75249087100 scopus 로고    scopus 로고
    • EdgeR: A Bioconductor package for differential expression analysis of digital gene expression data
    • Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139-140. doi:10.1093/bioinformatics/btp616
    • (2010) Bioinformatics. , vol.26 , pp. 139-140
    • Robinson, M.D.1    McCarthy, D.J.2    Smyth, G.K.3
  • 22
    • 84961289551 scopus 로고    scopus 로고
    • Orchestrating high-throughput genomic analysis with Bioconductor
    • Huber W, Carey VJ, Gentleman R, et al. Orchestrating high-throughput genomic analysis with Bioconductor. Nat Methods. 2015;12:115-121. doi:10.1038/nmeth.3252
    • (2015) Nat Methods. , vol.12 , pp. 115-121
    • Huber, W.1    Carey, V.J.2    Gentleman, R.3
  • 23
    • 85041191414 scopus 로고    scopus 로고
    • Data Were Analyzed Through the Use of QIAGEN's Ingenuity Pathway Analysis. Redwood City, CA: IPA, QIAGEN. Accessed March 3
    • Data Were Analyzed Through the Use of QIAGEN's Ingenuity Pathway Analysis. Redwood City, CA: IPA, QIAGEN. http://www.qiagen.com/ingenuity. Accessed March 3, 2017.
    • (2017)
  • 24
    • 78651265049 scopus 로고    scopus 로고
    • Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor
    • Alic N, Hoddinott MP, Vinti G, Partridge L. Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. Aging Cell. 2011;10:137-147. doi:10.1111/j.1474-9726.2010.00653.x
    • (2011) Aging Cell. , vol.10 , pp. 137-147
    • Alic, N.1    Hoddinott, M.P.2    Vinti, G.3    Partridge, L.4
  • 25
    • 66149165914 scopus 로고    scopus 로고
    • Gene expression profiles associated with aging and mortality in humans
    • Kerber RA, O'Brien E, Cawthon RM. Gene expression profiles associated with aging and mortality in humans. Aging Cell. 2009;8:239-250. doi:10.1111/j.1474-9726.2009.00467.x
    • (2009) Aging Cell. , vol.8 , pp. 239-250
    • Kerber, R.A.1    O'Brien, E.2    Cawthon, R.M.3
  • 26
    • 84943536506 scopus 로고    scopus 로고
    • A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging
    • Su J, Ekman C, Oskolkov N, et al. A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging. Skelet Muscle. 2015;5:35. doi:10.1186/s13395-015-0059-1
    • (2015) Skelet Muscle. , vol.5 , pp. 35
    • Su, J.1    Ekman, C.2    Oskolkov, N.3
  • 27
    • 84896855902 scopus 로고    scopus 로고
    • Resveratrol: Therapeutic potential for improving cardiometabolic health
    • Pollack RM, Crandall JP. Resveratrol: therapeutic potential for improving cardiometabolic health. Am J Hypertens. 2013;26:1260-1268. doi:10.1093/ajh/hpt165
    • (2013) Am J Hypertens. , vol.26 , pp. 1260-1268
    • Pollack, R.M.1    Crandall, J.P.2
  • 28
    • 76649084868 scopus 로고    scopus 로고
    • Resveratrol/SRT501
    • Elliot PJ, Walpote SM, Morelli L, et al. Resveratrol/SRT501. Drugs Fut. 2009;34:291-295. doi:10.1358/dof.2009.034.04.1360696
    • (2009) Drugs Fut. , vol.34 , pp. 291-295
    • Elliot, P.J.1    Walpote, S.M.2    Morelli, L.3
  • 29
    • 84875409043 scopus 로고    scopus 로고
    • Exploring the promise of resveratrol: Where do we go from here?
    • Crandall JP, Barzilai N. Exploring the promise of resveratrol: where do we go from here? Diabetes. 2013;62:1022-1023. doi:10.2337/db12-1788
    • (2013) Diabetes. , vol.62 , pp. 1022-1023
    • Crandall, J.P.1    Barzilai, N.2
  • 30
    • 0031444083 scopus 로고    scopus 로고
    • Resveratrol has no effect on lipoprotein profile and does not prevent peroxidation of serum lipids in normal rats
    • Turrens JF, Lariccia J, Nair MG. Resveratrol has no effect on lipoprotein profile and does not prevent peroxidation of serum lipids in normal rats. Free Radic Res. 1997;27:557-562. doi:10.3109/10715769709097859
    • (1997) Free Radic Res. , vol.27 , pp. 557-562
    • Turrens, J.F.1    Lariccia, J.2    Nair, M.G.3
  • 31
    • 84860477354 scopus 로고    scopus 로고
    • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
    • Price NL, Gomes AP, Ling AJ, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 2012;15:675-690. doi:10.1016/j.cmet.2012.04.003
    • (2012) Cell Metab. , vol.15 , pp. 675-690
    • Price, N.L.1    Gomes, A.P.2    Ling, A.J.3
  • 32
    • 84893691592 scopus 로고    scopus 로고
    • HOMA and Matsuda indices of insulin sensitivity: Poor correlation with minimal model-based estimates of insulin sensitivity in longitudinal settings
    • Xiang AH, Watanabe RM, Buchanan TA. HOMA and Matsuda indices of insulin sensitivity: poor correlation with minimal model-based estimates of insulin sensitivity in longitudinal settings. Diabetologia. 2014;57:334-338. doi:10.1007/s00125-013-3121-8
    • (2014) Diabetologia. , vol.57 , pp. 334-338
    • Xiang, A.H.1    Watanabe, R.M.2    Buchanan, T.A.3
  • 33
    • 84887615201 scopus 로고    scopus 로고
    • Anti-estrogenic activity of a human resveratrol metabolite
    • Ruotolo R, Calani L, Fietta E, et al. Anti-estrogenic activity of a human resveratrol metabolite. Nutr Metab Cardiovasc Dis. 2013;23:1086-1092. doi:10.1016/j.numecd.2013.01.002
    • (2013) Nutr Metab Cardiovasc Dis. , vol.23 , pp. 1086-1092
    • Ruotolo, R.1    Calani, L.2    Fietta, E.3
  • 34
    • 84896925980 scopus 로고    scopus 로고
    • Resveratrol-sulfates provide an intracellular reservoir for generation of parent resveratrol, which induces autophagy in cancer cells
    • Andreadi C, Britton RG, Patel KR, Brown K. Resveratrol-sulfates provide an intracellular reservoir for generation of parent resveratrol, which induces autophagy in cancer cells. Autophagy. 2014;10:524-525. doi:10.4161/auto.27593
    • (2014) Autophagy. , vol.10 , pp. 524-525
    • Andreadi, C.1    Britton, R.G.2    Patel, K.R.3    Brown, K.4
  • 36
    • 84855483249 scopus 로고    scopus 로고
    • Exenatide exerts a potent antiinflammatory effect
    • Chaudhuri A, Ghanim H, Vora M, et al. Exenatide exerts a potent antiinflammatory effect. J Clin Endocrinol Metab. 2012;97:198-207. doi:10.1210/jc.2011-1508
    • (2012) J Clin Endocrinol Metab. , vol.97 , pp. 198-207
    • Chaudhuri, A.1    Ghanim, H.2    Vora, M.3
  • 37
    • 84861697559 scopus 로고    scopus 로고
    • Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial
    • Tome-Carneiro J, Gonzalvez M, Larrosa M, et al. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Mol Nutr Food Res. 2012;56:810-821. doi:10.1002/mnfr.201100673
    • (2012) Mol Nutr Food Res. , vol.56 , pp. 810-821
    • Tome-Carneiro, J.1    Gonzalvez, M.2    Larrosa, M.3
  • 38
    • 84877002108 scopus 로고    scopus 로고
    • One-year supplementation with a grape extract containing resveratrol modulates inflammatoryrelated microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease
    • Tomé-Carneiro J, Larrosa M, Yáñez-Gascón MJ, et al. One-year supplementation with a grape extract containing resveratrol modulates inflammatoryrelated microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82. doi:10.1016/j.phrs.2013.03.011
    • (2013) Pharmacol Res. , vol.72 , pp. 69-82
    • Tomé-Carneiro, J.1    Larrosa, M.2    Yáñez-Gascón, M.J.3
  • 39
    • 84863515154 scopus 로고    scopus 로고
    • Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects
    • De Groote D, Van Belleghem K, Devière J, Van Brussel W, Mukaneza A, Amininejad L. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects. Ann Nutr Metab. 2012;61:15-24. doi:10.1159/000338634
    • (2012) Ann Nutr Metab. , vol.61 , pp. 15-24
    • De Groote, D.1    Van Belleghem, K.2    Devière, J.3    Van Brussel, W.4    Mukaneza, A.5    Amininejad, L.6
  • 40
    • 84950170835 scopus 로고    scopus 로고
    • Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure
    • Wong RH, Howe PR, Buckley JD, Coates AM, Kunz I, Berry NM. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis. 2011;21:851-856. doi:10.1016/j. numecd.2010.03.003
    • (2011) Nutr Metab Cardiovasc Dis. , vol.21 , pp. 851-856
    • Wong, R.H.1    Howe, P.R.2    Buckley, J.D.3    Coates, A.M.4    Kunz, I.5    Berry, N.M.6
  • 41
    • 84950170739 scopus 로고    scopus 로고
    • Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults
    • Wong RH, Berry NM, Coates AM, et al. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. J Hypertens. 2013;31:1819-1827. doi:10.1097/HJH.0b013e328362b9d6
    • (2013) J Hypertens. , vol.31 , pp. 1819-1827
    • Wong, R.H.1    Berry, N.M.2    Coates, A.M.3
  • 42
    • 0031927113 scopus 로고    scopus 로고
    • Contribution of nitric oxide to reactive hyperemia: Impact of endothelial dysfunction
    • Dakak N, Husain S, Mulcahy D, et al. Contribution of nitric oxide to reactive hyperemia: impact of endothelial dysfunction. Hypertension. 1998;32:9-15. doi:10.1161/01.HYP.32.1.9
    • (1998) Hypertension. , vol.32 , pp. 9-15
    • Dakak, N.1    Husain, S.2    Mulcahy, D.3
  • 43
    • 60949087943 scopus 로고    scopus 로고
    • Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats
    • Rivera L, Morón R, Zarzuelo A, Galisteo M. Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol. 2009;77:1053-1063. doi:10.1016/j.bcp.2008.11.027
    • (2009) Biochem Pharmacol. , vol.77 , pp. 1053-1063
    • Rivera, L.1    Morón, R.2    Zarzuelo, A.3    Galisteo, M.4
  • 44
    • 84904063673 scopus 로고    scopus 로고
    • Resveratrol prevents high fat/ sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates
    • Mattison JA, Wang M, Bernier M, et al. Resveratrol prevents high fat/ sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metab. 2014;20:183-190. doi:10.1016/j. cmet.2014.04.018
    • (2014) Cell Metab. , vol.20 , pp. 183-190
    • Mattison, J.A.1    Wang, M.2    Bernier, M.3
  • 45
    • 85041213853 scopus 로고    scopus 로고
    • National Institute of Aging (NIA). Bethesda, MD: National Library of Medicine. Cited May 11 Accessed March 3, 2017
    • National Institute of Aging (NIA). Resveratrol and Cardiovascular Health in the Elderly. Bethesda, MD: National Library of Medicine. https:// clinicaltrials.gov/ct2/show/NCT01842399. Cited May 11, 2016. Accessed March 3, 2017.
    • (2016) Resveratrol and Cardiovascular Health in the Elderly
  • 46
    • 84907370814 scopus 로고    scopus 로고
    • Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
    • Bridges HR, Jones AJ, Pollak MN, Hirst J. Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochem J. 2014;462:475-487. doi:10.1042/BJ2014062
    • (2014) Biochem J. , vol.462 , pp. 475-487
    • Bridges, H.R.1    Jones, A.J.2    Pollak, M.N.3    Hirst, J.4
  • 47
    • 84863601677 scopus 로고    scopus 로고
    • Metformin reduces endogenous reactive oxygen species and associated DNA damage
    • Algire C, Moiseeva O, Deschênes-Simard X, et al. Metformin reduces endogenous reactive oxygen species and associated DNA damage. Cancer Prev Res (Phila). 2012;5:536-543. doi:10.1158/1940-6207. CAPR-11-0536
    • (2012) Cancer Prev Res (Phila). , vol.5 , pp. 536-543
    • Algire, C.1    Moiseeva, O.2    Deschênes-Simard, X.3
  • 48
    • 0035942222 scopus 로고    scopus 로고
    • Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys
    • Kayo T, Allison DB, Weindruch R, Prolla TA. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci USA. 2001;98:5093-5098. doi:10.1073/pnas.081061898
    • (2001) Proc Natl Acad Sci USA. , vol.98 , pp. 5093-5098
    • Kayo, T.1    Allison, D.B.2    Weindruch, R.3    Prolla, T.A.4
  • 49
    • 78549288940 scopus 로고    scopus 로고
    • Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: Safety, pharmacokinetics, and effect on the insulin-like growth factor axis
    • Brown VA, Patel KR, Viskaduraki M, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 2010;70:9003-9011. doi:10.1158/0008-5472.CAN-10-2364
    • (2010) Cancer Res. , vol.70 , pp. 9003-9011
    • Brown, V.A.1    Patel, K.R.2    Viskaduraki, M.3


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