Tranexamic acid administration during on-pump cardiac surgery: A survey of current practices among Canadian Anesthetists Working in Academic Centers

Anesthesia and Analgesia

Volumn 125, Issue 6, 2017, Pages 1863-1870

  Spence, Jessica ^a,b   Long, Steven ^c   Tidy, Antonella ^a   Raymer, Karen ^a   Devereaux, P J ^a,b   Lamy, Andre ^a,b   Whitlock, Richard ^a,b   Syed, Summer ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBRINOLYTIC AGENT; TRANEXAMIC ACID;

ANESTHESIST; CANADA; CORONARY ARTERY BYPASS GRAFT; EPIDEMIOLOGY; FEMALE; HUMAN; MALE; OBSERVATIONAL STUDY; PROCEDURES; QUESTIONNAIRE; UNIVERSITY HOSPITAL;

ACADEMIC MEDICAL CENTERS; ANESTHETISTS; ANTIFIBRINOLYTIC AGENTS; CANADA; CORONARY ARTERY BYPASS; FEMALE; HUMANS; MALE; OBSERVATIONAL STUDIES AS TOPIC; SURVEYS AND QUESTIONNAIRES; TRANEXAMIC ACID;

EID: 85038129633     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0000000000002422     Document Type: Article

References (41)

1. Lamy A, Devereaux PJ, Prabhakaran D, et al; CORONARY Investigators. Effects of off-pump and on-pump coronaryartery bypass grafting at 1 year. N Engl J Med. 2013;368: 1179-1188.
2. Taggart DP, Altman DG, Gray AM, et al; ART Investigators. Effects of on-pump and off-pump surgery in the Arterial Revascularization Trial. Eur J Cardiothorac Surg. 2015;47:1059-1065.
3. Mehta RH, Sheng S, O'Brien SM, et al; Society of Thoracic Surgeons National Cardiac Surgery Database Investigators. Reoperation for bleeding in patients undergoing coronary artery bypass surgery: Incidence, risk factors, time trends, and outcomes. Circ Cardiovasc Qual Outcomes. 2009;2:583-590.
4. Woodman RC, Harker LA. Bleeding complications associated with cardiopulmonary bypass. Blood. 1990;76:1680-1697.
5. Corral M, Ferko N, Hollmann S, Broder MS, Chang E. Health and economic outcomes associated with uncontrolled surgical bleeding: A retrospective analysis of the Premier Perspectives Database. Clinicoecon Outcomes Res. 2015;7:409-421.
6. Koch CG, Li L, Sessler DI, et al. Duration of red-cell storage and complications after cardiac surgery. N Engl J Med. 2008;358:1229-1239.
7. Engoren MC, Habib RH, Zacharias A, Schwann TA, Riordan CJ, Durham SJ. Effect of blood transfusion on long-term survival after cardiac operation. Ann Thorac Surg. 2002;74:1180-1186.
8. Ferraris VA, Brown JR, et al; Society of Thoracic Surgeons Blood Conservation Guideline Task Force. 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg. 2011;91:944-982.
9. Levi M, Cromheecke ME, de Jonge E, et al. Pharmacological strategies to decrease excessive blood loss in cardiac surgery: A meta-analysis of clinically relevant endpoints. Lancet. 1999;354:1940-1947.
10. Mangano DT, Rieves RD, Weiss KD. Judging the safety of aprotinin. N Engl J Med. 2006;355:2261-2262.
11. Dunn CJ, Goa KL. Tranexamic acid: A review of its use in surgery and other indications. Drugs. 1999;57:1005-1032.
12. Martin K, Knorr J, Breuer T, et al. Seizures after open heart surgery: Comparison of ϵ-aminocaproic acid and tranexamic acid. J Cardiothorac Vasc Anesth. 2011;25:20-25.
13. Goldstone AB, Bronster DJ, Anyanwu AC, et al. Predictors and outcomes of seizures after cardiac surgery: A multivariable analysis of 2, 578 patients. Ann Thorac Surg. 2011;91:514-518.
14. Manji RA, Grocott HP, Leake J, et al. Seizures following cardiac surgery: The impact of tranexamic acid and other risk factors. Can J Anaesth. 2012;59:6-13.
15. Sharma V, Katznelson R, Jerath A, et al. The association between tranexamic acid and convulsive seizures after cardiac surgery: A multivariate analysis in 11 529 patients. Anaesthesia. 2014;69:124-130.
16. Keyl C, Uhl R, Beyersdorf F, et al. High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. Eur J Cardiothorac Surg. 2011;39:e114-e121.
17. Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M. High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg. 2010;110:350-353.
18. Taneja R, Fernandes P, Marwaha G, Cheng D, Bainbridge D. Perioperative coagulation management and blood conservation in cardiac surgery: A Canadian Survey. J Cardiothorac Vasc Anesth. 2008;22:662-669.
19. McMullan V, Alston RP. The effect of the suspension of the license for aprotinin on the care of patients undergoing cardiac surgery: A survey of cardiac anesthesiologists' and surgeons' opinions in the United Kingdom. J Cardiothorac Vasc Anesth. 2010;24:418-421.
20. Ng W, Jerath A, Wasowicz M. Tranexamic acid: A clinical review. Anaesthesiol Intensive Ther. 2015;47:339-350.
21. Dowd NP, Karski JM, Cheng DC, et al. Pharmacokinetics of tranexamic acid during cardiopulmonary bypass. Anesthesiology. 2002;97:390-399.
22. Karski JM, Dowd NP, Joiner R, et al. The effect of three different doses of tranexamic acid on blood loss after cardiac surgery with mild systemic hypothermia (32 degrees C). J Cardiothorac Vasc Anesth. 1998;12:642-646.
23. Sigaut S, Tremey B, Ouattara A, et al. Comparison of two doses of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass. Anesthesiology. 2014;120:590-600.
24. Armellin G, Vinciguerra A, Bonato R, Pittarello D, Giron GP. Tranexamic acid in primary CABG surgery: High vs low dose. Minerva Anestesiol. 2004;70:97-107.
25. Du Y, Xu J, Wang G, et al. Comparison of two tranexamic acid dose regimens in patients undergoing cardiac valve surgery. J Cardiothorac Vasc Anesth. 2014;28:1233-1237.
26. Faraoni D, Cacheux C, Van Aelbrouck C, Ickx BE, Barvais L, Levy JH. Effect of two doses of tranexamic acid on fibrinolysis evaluated by thromboelastography during cardiac surgery: A randomised, controlled study. Eur J Anaesthesiol. 2014;31:491-498.
27. Grassin-Delyle S, Tremey B, Abe E, et al. Population pharmacokinetics of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass. Br J Anaesth. 2013;111:916-924.
28. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. Lancet. 2007;370:1453-1457.
29. Fergusson DA, Hébert PC, Mazer CD, et al; BART Investigators. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med. 2008;358:2319-2331.
30. Horrow JC, Van Riper DF, Strong MD, Grunewald KE, Parmet JL. The dose-response relationship of tranexamic acid. Anesthesiology. 1995;82:383-392.
31. Myles PS, Smith J, Knight J, et al; ATACAS Trial Group. Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) Trial: Rationale and design. Am Heart J. 2008;155:224-230.
32. Dillman DA, Smyth JD, Christian LM, Dillman DA. Internet, Mail, and Mixed-Mode Surveys: The Tailored Design Method. 3rd ed. Hoboken, NJ: John Wiley & Sons; 2009.
33. Myles PS, Smith JA, Forbes A, et al. Tranexamic acid in patients undergoing coronary-artery surgery. N Engl J Med. 2016;376:136-148.
34. Casati V, Della Valle P, Benussi S, et al. Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: Comparison between onpump and off-pump techniques. J Thorac Cardiovasc Surg. 2004;128:83-91.
35. Van Aelbrouck C, Englberger L, Faraoni D. Review of the fibrinolytic system: Comparison of different antifibrinolytics used during cardiopulmonary bypass. Recent Pat Cardiovasc Drug Discov. 2012;7:175-179.
36. Henry DA, Carless PA, Moxey AJ, et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev. 2011:CD001886.
37. Ker K, Edwards P, Perel P, Shakur H, Roberts I. Effect of tranexamic acid on surgical bleeding: Systematic review and cumulative meta-analysis. BMJ. 2012;344:e3054.
38. Henry D, Carless P, Fergusson D, Laupacis A. The safety of aprotinin and lysine-derived antifibrinolytic drugs in cardiac surgery: A meta-analysis. CMAJ. 2009;180:183-193.
39. Nuttall GA, Gutierrez MC, Dewey JD, et al. A preliminary study of a new tranexamic acid dosing schedule for cardiac surgery. J Cardiothorac Vasc Anesth. 2008;22:230-235.
40. Sharma V, Fan J, Jerath A, et al. Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass. Anaesthesia. 2012;67:1242-1250.
41. Gofton TE, Chu MW, Norton L, et al. A prospective observational study of seizures after cardiac surgery using continuous EEG monitoring. Neurocrit Care. 2014;21:220-227.