Biosynthesis of polyhydroxyalkanoates containing 2-hydroxy-4-methylvalerate and 2-hydroxy-3-phenylpropionate units from a related or unrelated carbon source

Journal of Bioscience and Bioengineering

Volumn 125, Issue 3, 2018, Pages 295-300

  Mizuno, Shoji ^a   Enda, Yukio ^b   Saika, Azusa ^c   Hiroe, Ayaka ^d   Tsuge, Takeharu ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b Akita Prefectural R&D Center Industrial Technology Center   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

Author keywords

2 Hydroxyalkanoate; Clostridium difficile; Lactate polymerizing enzyme; Leucine; Phenylalanine; Polyhydroxyalkanoate

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CARBON; CLOSTRIDIUM; ENZYMES; ESCHERICHIA COLI;

2-HYDROXYALKANOATE; CLOSTRIDIUM DIFFICILE; LEUCINE; PHENYLALANINE; POLY-HYDROXYALKANOATE;

AMINO ACIDS;

2 HYDROXY 3 PHENYLPROPIONATE; 2 HYDROXY 4 METHYLVALERATE; 2 HYDROXY 4 METHYLVALERATE COENZYME A TRANSFERASE; 2 HYDROXY 4 METHYLVALERATE DEHYDROGENASE; BACTERIAL ENZYME; LACTATE POLYMERIZING ENZYME; POLYHYDROXYALKANOIC ACID; UNCLASSIFIED DRUG; 2-METHYLVALERIC ACID; 3 HYDROXYBUTYRIC ACID; 3-PHENYLPROPIONIC ACID; CARBON; COENZYME A TRANSFERASE; ISOENZYME; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE 5; LACTIC ACID; PHENYLPROPIONIC ACID DERIVATIVE; POLYESTER; VALERIC ACID;

ARTICLE; BIOSYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CARBON SOURCE; CONTROLLED STUDY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM;

3-HYDROXYBUTYRIC ACID; CARBON; CLOSTRIDIUM DIFFICILE; COENZYME A-TRANSFERASES; ESCHERICHIA COLI; ISOENZYMES; L-LACTATE DEHYDROGENASE; LACTIC ACID; PENTANOIC ACIDS; PHENYLPROPIONATES; POLYESTERS; POLYHYDROXYALKANOATES;

EID: 85035068130     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2017.10.010     Document Type: Article

References (25)

1. Sudesh, K., Abe, H., Doi, Y., Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters. Prog. Polym. Sci. 25 (2000), 1503–1555.
2. Steinbüchel, A., Lütke-Eversloh, T., Metabolic engineering and pathway construction for biotechnological production of relevant polyhydroxyalkanoates in microorganisms. Biochem. Eng. J. 16 (2003), 81–96.
3. Tsuge, T., Metabolic improvements and use of inexpensive carbon sources in microbial production of polyhydroxyalkanoates. J. Biosci. Bioeng. 94 (2002), 579–584.
4. Kimura, H., Mouri, K., Takeishi, M., Endo, T., Production and characterization of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) from L-valine by Ralstonia eutropha. Bull. Chem. Soc. Jpn. 76 (2003), 1775–1781.
5. Doi, Y., Kitamura, S., Abe, H., Microbial synthesis and characterization of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). Macromolecules 28 (1995), 4822–4828.
6. Tanadchangsaeng, N., Kitagawa, A., Yamamoto, T., Abe, H., Tsuge, T., Identification, biosynthesis, and characterization of polyhydroxyalkanoate copolymer consisting of 3-hydroxybutyrate and 3-hydroxy-4-methylvalerate. Biomacromolecules 10 (2009), 2866–2874.
7. Tanadchangsaeng, N., Tsuge, T., Abe, H., Comonomer compositional distribution, physical properties, and enzymatic degradability of bacterial poly(3-hydroxybutyrate-co-3-hydroxy-4-methylvalerate) copolyester. Biomacromolecules 11 (2010), 1615–1622.
8. Mizuno, S., Katsumata, S., Hiroe, A., Tsuge, T., Biosynthesis and thermal characterization of polyhydroxyalkanoates bearing phenyl and phenylalkyl side groups. Polym. Degrad. Stab. 109 (2014), 379–384.
9. Mizuno, S., Hiroe, A., Fukui, T., Abe, H., Tsuge, T., Fractionation and thermal characteristics of biosynthesized polyhydoxyalkanoates bearing aromatic groups as side chains. Polym. J. 49 (2017), 557–565.
10. Taguchi, S., Yamada, M., Matsumoto, K., Tajima, K., Satoh, Y., Munekata, M., Ohno, K., Kohda, K., Shimamura, T., Kambe, H., Obata, S., A microbial factory for lactate-based polyesters using a lactate-polymerizing enzyme. Proc. Natl. Acad. Sci. USA 105 (2008), 17323–17327.
11. Matsumoto, K., Taguchi, S., Enzymatic and whole-cell synthesis of lactate-containing polyesters: toward the complete biological production of polylactate. Appl. Microbiol. Biotechnol. 85 (2010), 921–932.
12. Matsumoto, K., Ishiyama, A., Sakai, K., Shiba, T., Taguchi, S., Biosynthesis of glycolate-based polyesters containing medium-chain-length 3-hydroxyalkanoates in recombinant Escherichia coli expressing engineered polyhydroxyalkanoate synthase. J. Biotechnol. 156 (2011), 214–217.
13. Matsumoto, K., Shiba, T., Hiraide, Y., Taguchi, S., Incorporation of glycolate units promotes hydrolytic degradation in flexible poly(glycolate-co-3-hydroxybutyrate) synthesized by engineered Escherichia coli. ACS Biomater. Sci. Eng. 3 (2017), 3058–3063.
14. Ishii, D., Takisawa, K., Matsumoto, K., Ooi, T., Hikima, T., Takata, M., Taguchi, S., Iwata, T., Effect of monomeric composition on the thermal, mechanical and crystalline properties of poly[(R)-lactate-co-(R)-3-hydroxybutyrate]. Polymer 122 (2017), 169–173.
15. Choi, S.Y., Park, S.J., Kim, W.J., Yang, J.E., Lee, H., Shin, J., Lee, S.Y., One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli. Nat. Biotechnol. 34 (2016), 435–440.
16. Kim, J., Darley, D., Selmer, T., Buckel, W., Characterization of (R)-2-hydroxyisocaproate dehydrogenase and a family III coenzyme A transferase involved in reduction of L-leucine to isocaproate by Clostridium difficile. Appl. Environ. Microbiol. 72 (2006), 6062–6069.
17. Kim, J., Darley, D., Buckel, W., 2-Hydroxyisocaproyl-CoA dehydratase and its activator from Clostridium difficile. FEBS J. 272 (2005), 550–561.
18. Stark, M.J., Multicopy expression vectors carrying the lac represser gene for regulated high-level expression of genes in Escherichia coli. Gene 51 (1987), 255–267.
19. Takahashi, T., Ito, K., Ito, A., Enda, Y., Gochi, M., Mori, H., Kobayashi, J., Tandem-ring mill pulverization benefits for enzymatic saccharification of biomass. Renew. Energy 65 (2014), 146–151.
20. Kato, M., Bao, H.J., Kang, C.K., Fukui, T., Doi, Y., Production of a novel copolyester of 3-hydroxybutyric acid and medium-chain-length 3-hydroxyalkanoic acids by Pseudomonas sp. 61-3 from sugars. Appl. Microbiol. Biotechnol. 45 (1996), 363–370.
21. Saika, A., Watanabe, Y., Sudesh, K., Tsuge, T., Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxy-4-methylvalerate) by recombinant Escherichia coli expressing leucine metabolism-related enzymes derived from Clostridium difficile. J. Biosci. Bioeng. 117 (2014), 670–675.
22. Saika, A., Ushimaru, K., Mizuno, S., Tsuge, T., Genome-based analysis and gene dosage studies provide new insight into 3-hydroxy-4-methylvalerate biosynthesis in Ralstonia eutropha. J. Bacteriol. 197 (2015), 1350–1359.
23. Saika, A., Watanabe, S., Sudesh, K., Abe, H., Tsuge, T., Enhanced incorporation of 3-hydroxy-4-methylvalerate unit into biosynthetic polyhydroxyalkanoate using leucine as a precursor. AMB Express, 1, 2011, 6.
24. Salamanca-Cardona, L., Scheel, R.A., Bergey, N.S., Stipanovic, A.J., Matsumoto, K., Taguchi, S., Nomura, C.T., Consolidated bioprocessing of poly(lactate-co-3-hydroxybutyrate) from xylan as a sole feedstock by genetically-engineered Escherichia coli. J. Biosci. Bioeng. 122 (2016), 406–414.
25. Tabata, Y., Abe, H., Effects of composition and sequential structure on thermal properties for copolymer of 3-hydroxybutyrate and lactate units. Polym. Degrad. Stab. 98 (2013), 1796–1803.