Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 15, 2017, Pages 3957-3962

  Briseño, Carlos G ^a   Gargaro, Marco ^a   Durai, Vivek ^a   Davidson, Jesse T ^a   Theisen, Derek J ^a   Anderson, David A ^a   Novack, Deborah V ^a,b   Murphy, Theresa L ^a   Murphy, Kenneth M ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dendritic cells; Hematopoiesis; Hematopoietic niche; Transcription factors

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOTOXIN BETA RECEPTOR; NOTCH2 RECEPTOR; TRANSCRIPTION FACTOR RELB; LTBR PROTEIN, MOUSE; LYMPHOTOXIN BETA; NF-KAPPA B KINASE; PROTEIN SERINE THREONINE KINASE; RELB PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; BONE MARROW; BONE MARROW CELL; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CELL HYPERPLASIA; CELL MATURATION; CHIMERA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GERMLINE MUTATION; HEMATOPOIETIC CELL; HOST CELL; IN VITRO STUDY; LISTERIA MONOCYTOGENES; MESENTERY LYMPH NODE; MOUSE; MYELOPOIESIS; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RADIATION CHIMERA; SPLEEN CELL; SPLENOMEGALY; T LYMPHOCYTE; ANIMAL; C57BL MOUSE; CD4+ T LYMPHOCYTE; CYTOLOGY; GENETICS; HEMATOPOIETIC SYSTEM; METABOLISM; MUTANT MOUSE STRAIN; PHYSIOLOGY; SPLEEN;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; HEMATOPOIETIC SYSTEM; LYMPHOTOXIN BETA RECEPTOR; LYMPHOTOXIN-BETA; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MYELOID CELLS; PROTEIN-SERINE-THREONINE KINASES; SPLEEN; TRANSCRIPTION FACTOR RELB;

EID: 85035018283     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1619863114     Document Type: Article

References (39)

1. Ryseck RP, et al. (1992) RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B. Mol Cell Biol 12:674–684.
2. Carrasco D, Ryseck RP, Bravo R (1993) Expression of relB transcripts during lymphoid organ development: Specific expression in dendritic antigen-presenting cells. Development 118:1221–1231.
3. Weih F, et al. (1995) Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family. Cell 80:331–340.
4. Burkly L, et al. (1995) Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 373:531–536.
5. DeKoning J, et al. (1997) Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice. J Immunol 158:2558–2566.
6. Elewaut D, et al. (2003) NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. J Exp Med 197:1623–1633.
7. Powolny-Budnicka I, et al. (2011) RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells. Immunity 34:364–374.
8. Weih DS, Yilmaz ZB, Weih F (2001) Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines. J Immunol 167:1909–1919.
9. Crotty S (2014) T follicular helper cell differentiation, function, and roles in disease. Immunity 41:529–542.
10. Snapper CM, et al. (1996) B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching. J Exp Med 184:1537–1541.
11. Gerloni M, Lo D, Zanetti M (1998) DNA immunization in relB-deficient mice discloses a role for dendritic cells in IgM→IgG1 switch in vivo. Eur J Immunol 28:516–524.
12. Gerloni M, Lo D, Ballou WR, Zanetti M (1998) Immunological memory after somatic transgene immunization is positively affected by priming with GM-CSF and does not require bone marrow-derived dendritic cells. Eur J Immunol 28:1832–1838.
13. Crowley MT, Lo D (1999) Targeted Gene Knockouts: Insights into Dendritic Cell Biology (Academic, San Diego), pp 579–593.
14. Wu L, et al. (1998) RelB is essential for the development of myeloid-related CD8alpha-dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity 9:839–847.
15. Kobayashi T, et al. (2003) TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19:353–363.
16. Hofmann J, Mair F, Greter M, Schmidt-Supprian M, Becher B (2011) NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses. J Exp Med 208:1917–1929.
17. Murphy TL, et al. (2016) Transcriptional control of dendritic cell development. Annu Rev Immunol 34:93–119.
18. Seki T, et al. (2015) Visualization of RelB expression and activation at the single-cell level during dendritic cell maturation in Relb-Venus knock-in mice. J Biochem 158:485–495.
19. Kabashima K, et al. (2005) Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity 22:439–450.
20. Satpathy AT, et al. (2013) Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol 14:937–948.
21. Yin L, et al. (2001) Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science 291:2162–2165.
22. Lewis KL, et al. (2011) Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity 35:780–791.
23. Naik SH, et al. (2005) Cutting edge: Generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol 174:6592–6597.
24. Ridge JP, Di Rosa F, Matzinger P (1998) A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 393:474–478.
25. Bennett SR, et al. (1998) Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature 393:478–480.
26. Schoenberger SP, Toes RE, van der Voort EI, Offringa R, Melief CJ (1998) T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393:480–483.
27. Ohtsuka H, et al. (2011) Bcl6 is required for the development of mouse CD4+ and CD8α+ dendritic cells. J Immunol 186:255–263.
28. Scott CL, et al. (2016) The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2. J Exp Med 213:897–911.
29. Weih F, et al. (1996) Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent. J Immunol 157:3974–3979.
30. Fasnacht N, et al. (2014) Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. J Exp Med 211:2265–2279.
31. Kumar V, et al. (2015) A dendritic-cell-stromal axis maintains immune responses in lymph nodes. Immunity 42:719–730.
32. De Silva NS, Silva K, Anderson MM, Bhagat G, Klein U (2016) Impairment of mature B cell maintenance upon combined deletion of the alternative NF-κB transcription factors RELB and NF-κB2 in B cells. J Immunol 196:2591–2601.
33. Durai V, Murphy KM (2016) Functions of murine dendritic cells. Immunity 45:719–736.
34. Tumanov AV, et al. (2011) Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge. Cell Host Microbe 10:44–53.
35. Reboldi A, et al. (2016) IgA production requires B cell interaction with subepithelial dendritic cells in Peyer’s patches. Science 352:aaf4822.
36. Laidlaw BJ, Craft JE, Kaech SM (2016) The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. Nat Rev Immunol 16:102–111.
37. Kretzer NM, et al. (2016) RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells. J Exp Med 213:2871–2883.
38. Carbone FR, Bevan MJ (1990) Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo. J Exp Med 171:377–387.
39. Briseño CG, et al. (2016) Distinct transcriptional programs control cross-priming in classical and monocyte-derived dendritic cells. Cell Reports 15:2462–2474.