A Dendritic-Cell-Stromal Axis Maintains Immune Responses in Lymph Nodes

Immunity

Volumn 42, Issue 4, 2015, Pages 719-730

  Kumar, Varsha ^a   Dasoveanu, Dragos C ^a   Chyou, Susan ^a   Tzeng, Te Chen ^a,f   Rozo, Cristina ^a   Liang, Yong ^c   Stohl, William ^d   Fu, Yang Xin ^c   Ruddle, Nancy H ^e   Lu, Theresa T ^a,b  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e YALE UNIVERSITY   (United States)

^f UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; INTERLEUKIN 6; INTERLEUKIN 7; LYMPHOTOXIN BETA RECEPTOR; PODOPLANIN; GP38 PROTEIN, MOUSE; LTBR PROTEIN, MOUSE; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ADHESION; CELL SEPARATION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; GERMINAL CENTER; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETICULUM CELL; STROMA CELL; SURVIVAL FACTOR; ANIMAL; C57BL MOUSE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE DEPLETION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; CELL ADHESION; CELL SURVIVAL; DENDRITIC CELLS; GENE EXPRESSION REGULATION; IMMUNOPHENOTYPING; LYMPH NODES; LYMPHOCYTE DEPLETION; LYMPHOTOXIN BETA RECEPTOR; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; STROMAL CELLS;

EID: 84928201383     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2015.03.015     Document Type: Article

References (43)

1. Acton S.E., Farrugia A.J., Astarita J.L., Mourão-Sá D., Jenkins R.P., Nye E., Hooper S., van Blijswijk J., Rogers N.C., Snelgrove K.J., et al. Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature 2014, 514:498-502.
2. Astarita J.L., Acton S.E., Turley S.J. Podoplanin: Emerging functions in development, the immune system, and cancer. Front. Immunol. 2012, 3:283.
3. Astarita J.L., Cremasco V., Fu J., Darnell M.C., Peck J.R., Nieves-Bonilla J.M., Song K., Kondo Y., Woodruff M.C., Gogineni A., et al. The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nat. Immunol. 2015, 16:75-84.
4. Bajénoff M., Egen J.G., Koo L.Y., Laugier J.P., Brau F., Glaichenhaus N., Germain R.N. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 2006, 25:989-1001.
5. Bannard O., Horton R.M., Allen C.D., An J., Nagasawa T., Cyster J.G. Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection. Immunity 2013, 39:912-924.
6. Baumjohann D., Preite S., Reboldi A., Ronchi F., Ansel K.M., Lanzavecchia A., Sallusto F. Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity 2013, 38:596-605.
7. + cells collaboratively express IL-1β to modulate stromal vascular endothelial growth factor and lymph node vascular-stromal growth. J.Immunol. 2014, 192:4153-4163.
8. Boulianne B., Porfilio E.A., Pikor N., Gommerman J.L. Lymphotoxin-sensitive microenvironments in homeostasis and inflammation. Front. Immunol. 2012, 3:243.
9. Braun A., Worbs T., Moschovakis G.L., Halle S., Hoffmann K., Bölter J., Münk A., Förster R. Afferent lymph-derived Tcells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nat. Immunol. 2011, 12:879-887.
10. + cells and then by T and B cells. J.Immunol. 2011, 187:5558-5567.
11. Chyou S., Tian S., Ekland E.H., Lu T.T. Normalization of the lymph node Tcell stromal microenvironment in lpr/lpr mice is associated with SU5416-induced reduction in autoantibodies. PLoS ONE 2012, 7:e32828.
12. Cremasco V., Woodruff M.C., Onder L., Cupovic J., Nieves-Bonilla J.M., Schildberg F.A., Chang J., Cremasco F., Harvey C.J., Wucherpfennig K., et al. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nat. Immunol. 2014, 15:973-981.
13. Cyster J.G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 2005, 23:127-159.
14. + Tcells. Proc. Natl. Acad. Sci. USA 2014, 111:12139-12144.
15. Fornaro M., Plescia J., Chheang S., Tallini G., Zhu Y.-M., King M., Altieri D.C., Languino L.R. Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway. J.Biol. Chem. 2003, 278:50402-50411.
16. Geiger B., Spatz J.P., Bershadsky A.D. Environmental sensing through focal adhesions. Nat. Rev. Mol. Cell Biol. 2009, 10:21-33.
17. Hargreaves D.C., Hyman P.L., Lu T.T., Ngo V.N., Bidgol A., Suzuki G., Zou Y.R., Littman D.R., Cyster J.G. A coordinated change in chemokine responsiveness guides plasma cell movements. J.Exp. Med. 2001, 194:45-56.
18. Hase H., Kanno Y., Kojima M., Hasegawa K., Sakurai D., Kojima H., Tsuchiya N., Tokunaga K., Masawa N., Azuma M., et al. BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood 2004, 103:2257-2265.
19. Jarjour M., Jorquera A., Mondor I., Wienert S., Narang P., Coles M.C., Klauschen F., Bajénoff M. Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells. J.Exp. Med. 2014, 211:1109-1122.
20. + Tcells by exogenous cell-associated antigens. Immunity 2002, 17:211-220.
21. Junt T., Tumanov A.V., Harris N., Heikenwalder M., Zeller N., Kuprash D.V., Aguzzi A., Ludewig B., Nedospasov S.A., Zinkernagel R.M. Expression of lymphotoxin beta governs immunity at two distinct levels. Eur. J. Immunol. 2006, 36:2061-2075.
22. Katakai T., Suto H., Sugai M., Gonda H., Togawa A., Suematsu S., Ebisuno Y., Katagiri K., Kinashi T., Shimizu A. Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. J.Immunol. 2008, 181:6189-6200.
23. Koni P.A., Sacca R., Lawton P., Browning J.L., Ruddle N.H., Flavell R.A. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity 1997, 6:491-500.
24. Lambrecht B.N., Hammad H. Lung dendritic cells in respiratory viral infection and asthma: From protection to immunopathology. Annu. Rev. Immunol. 2012, 30:243-270.
25. Lesley R., Xu Y., Kalled S.L., Hess D.M., Schwab S.R., Shu H.B., Cyster J.G. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 2004, 20:441-453.
26. Link A., Vogt T.K., Favre S., Britschgi M.R., Acha-Orbea H., Hinz B., Cyster J.G., Luther S.A. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive Tcells. Nat. Immunol. 2007, 8:1255-1265.
27. Lu T.T., Browning J.L. Role of the lymphotoxin/LIGHT System in the development and maintenance of reticular networks and vasculature in lymphoid tissues. Front. Immunol. 2014, 5:47.
28. Mackay F., Leung H. The role of the BAFF/APRIL system on Tcell function. Semin. Immunol. 2006, 18:284-289.
29. Malhotra D., Fletcher A.L., Turley S.J. Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity. Immunol. Rev. 2013, 251:160-176.
30. Martín-Villar E., Megías D., Castel S., Yurrita M.M., Vilaró S., Quintanilla M. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. J.Cell Sci. 2006, 119:4541-4553.
31. Merad M., Sathe P., Helft J., Miller J., Mortha A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 2013, 31:563-604.
32. Meredith M.M., Liu K., Darrasse-Jeze G., Kamphorst A.O., Schreiber H.A., Guermonprez P., Idoyaga J., Cheong C., Yao K.H., Niec R.E., Nussenzweig M.C. Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J.Exp. Med. 2012, 209:1153-1165.
33. Mionnet C., Mondor I., Jorquera A., Loosveld M., Maurizio J., Arcangeli M.L., Ruddle N.H., Nowak J., Aurrand-Lions M., Luche H., Bajénoff M. Identification of a new stromal cell type involved in the regulation of inflamed B cell follicles. PLoS Biol. 2013, 11:e1001672.
34. Mitra S.K., Schlaepfer D.D. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 2006, 18:516-523.
35. Mohr E., Serre K., Manz R.A., Cunningham A.F., Khan M., Hardie D.L., Bird R., MacLennan I.C.M. Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature. J.Immunol. 2009, 182:2113-2123.
36. Moussion C., Girard J.P. Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules. Nature 2011, 479:542-546.
37. Satpathy A.T., Kc W., Albring J.C., Edelson B.T., Kretzer N.M., Bhattacharya D., Murphy T.L., Murphy K.M. Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J.Exp. Med. 2012, 209:1135-1152.
38. Schacht V., Ramirez M.I., Hong Y.K., Hirakawa S., Feng D., Harvey N., Williams M., Dvorak A.M., Dvorak H.F., Oliver G., Detmar M. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 2003, 22:3546-3556.
39. Suzuki K., Maruya M., Kawamoto S., Sitnik K., Kitamura H., Agace W.W., Fagarasan S. The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity 2010, 33:71-83.
40. Tzeng T.C., Chyou S., Tian S., Webster B., Carpenter A.C., Guaiquil V.H., Lu T.T. CD11c(hi) dendritic cells regulate the re-establishment of vascular quiescence and stabilization after immune stimulation of lymph nodes. J.Immunol. 2010, 184:4247-4257.
41. Wang X., Cho B., Suzuki K., Xu Y., Green J.A., An J., Cyster J.G. Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers. J.Exp. Med. 2011, 208:2497-2510.
42. Yang C.-Y., Vogt T.K., Favre S., Scarpellino L., Huang H.-Y., Tacchini-Cottier F., Luther S.A. Trapping of naive lymphocytes triggers rapid growth and remodeling of the fibroblast network in reactive murine lymph nodes. Proc. Natl. Acad. Sci. USA 2014, 111:E109-E118.
43. Zhu M., Yang Y., Wang Y., Wang Z., Fu Y.-X. LIGHT regulates inflamed draining lymph node hypertrophy. J.Immunol. 2011, 186:7156-7163.