메뉴 건너뛰기




Volumn 27, Issue 1, 2018, Pages 29-33

The science and necessity of using animal models in the study of necrotizing enterocolitis

Author keywords

Animal models; Formula; Hypoxia; Necrotizing enterocolitis; Piglet; Rodent

Indexed keywords

ARTICLE; BODY SIZE; COST; DISEASE MODEL; GENETIC VARIABILITY; MOUSE MODEL; NECROTIZING ENTEROCOLITIS; NONHUMAN; PATHOGENESIS; PIGLET; PREMATURITY; PRIMATE MODEL; PRIORITY JOURNAL; PROPHYLAXIS; QUAIL; RABBIT MODEL; RAT MODEL; ANIMAL; MOUSE; PATHOPHYSIOLOGY; PIG; RAT;

EID: 85034846893     PISSN: 10558586     EISSN: 15329453     Source Type: Journal    
DOI: 10.1053/j.sempedsurg.2017.11.006     Document Type: Article
Times cited : (45)

References (46)
  • 1
    • 33750068574 scopus 로고    scopus 로고
    • Necrotising enterocolitis hospitalisations among neonates in the United States
    • Holman, R.C., Stoll, B.J., Curns, A.T., et al. Necrotising enterocolitis hospitalisations among neonates in the United States. Paediatr Perinat Epidemiol 20:6 (2006), 498–506.
    • (2006) Paediatr Perinat Epidemiol , vol.20 , Issue.6 , pp. 498-506
    • Holman, R.C.1    Stoll, B.J.2    Curns, A.T.3
  • 2
    • 84901238153 scopus 로고    scopus 로고
    • Mortality and management of surgical necrotizing enterocolitis in very low birth weight neonates: a prospective cohort study
    • Hull, M.A., Fisher, J.G., Gutierrez, I.M., et al. Mortality and management of surgical necrotizing enterocolitis in very low birth weight neonates: a prospective cohort study. J Am Coll Surg 218:6 (2014), 1148–1155.
    • (2014) J Am Coll Surg , vol.218 , Issue.6 , pp. 1148-1155
    • Hull, M.A.1    Fisher, J.G.2    Gutierrez, I.M.3
  • 3
    • 84874100120 scopus 로고    scopus 로고
    • Intestinal proteome changes during infant necrotizing enterocolitis
    • Jiang, P.P., Smith, B., Qvist, N., et al. Intestinal proteome changes during infant necrotizing enterocolitis. Pediatr Res 73:3 (2013), 268–276.
    • (2013) Pediatr Res , vol.73 , Issue.3 , pp. 268-276
    • Jiang, P.P.1    Smith, B.2    Qvist, N.3
  • 4
    • 84936868571 scopus 로고    scopus 로고
    • Low abdominal NIRS values and elevated plasma intestinal fatty acid-binding protein in a premature piglet model of necrotizing enterocolitis
    • Zamora, I.J., Stoll, B., Ethun, C.G., et al. Low abdominal NIRS values and elevated plasma intestinal fatty acid-binding protein in a premature piglet model of necrotizing enterocolitis. Plos One, 10(6), 2015, e0125437.
    • (2015) Plos One , vol.10 , Issue.6 , pp. e0125437
    • Zamora, I.J.1    Stoll, B.2    Ethun, C.G.3
  • 5
    • 33646356953 scopus 로고    scopus 로고
    • Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs
    • Sangild, P.T., Siggers, R.H., Schmidt, M., et al. Diet- and colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in preterm pigs. Gastroenterology 130:6 (2006), 1776–1792.
    • (2006) Gastroenterology , vol.130 , Issue.6 , pp. 1776-1792
    • Sangild, P.T.1    Siggers, R.H.2    Schmidt, M.3
  • 6
    • 84942862602 scopus 로고    scopus 로고
    • Protective effects of bifidobacteria on intestines in newborn rats with necrotizing enterocolitis and its regulation on TLR2 and TLR4
    • Zhou, W., Lv, H., Li, M.X., et al. Protective effects of bifidobacteria on intestines in newborn rats with necrotizing enterocolitis and its regulation on TLR2 and TLR4. Genet Mol Res 14:3 (2015), 11505–11514.
    • (2015) Genet Mol Res , vol.14 , Issue.3 , pp. 11505-11514
    • Zhou, W.1    Lv, H.2    Li, M.X.3
  • 7
    • 85008419360 scopus 로고    scopus 로고
    • Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats
    • Wu, W., Wang, Y., Zou, J., et al. Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats. BMC Pediatr, 17(1), 2017, 1.
    • (2017) BMC Pediatr , vol.17 , Issue.1 , pp. 1
    • Wu, W.1    Wang, Y.2    Zou, J.3
  • 8
    • 84939479232 scopus 로고    scopus 로고
    • Breast milk protects against the development of necrotizing enterocolitis through inhibition of toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor
    • Good, M., Sodhi, C.P., Egan, C.E., et al. Breast milk protects against the development of necrotizing enterocolitis through inhibition of toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor. Mucosal Immunol 8:5 (2015), 1166–1179.
    • (2015) Mucosal Immunol , vol.8 , Issue.5 , pp. 1166-1179
    • Good, M.1    Sodhi, C.P.2    Egan, C.E.3
  • 9
    • 85020457389 scopus 로고    scopus 로고
    • Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling
    • White, J.R., Gong, H., Pope, B., et al. Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling. Dis Model Mech 10:6 (2017), 727–736.
    • (2017) Dis Model Mech , vol.10 , Issue.6 , pp. 727-736
    • White, J.R.1    Gong, H.2    Pope, B.3
  • 10
    • 0016294579 scopus 로고
    • An experimental study of acute neonatal enterocolitis—the importance of breast milk
    • Barlow, B., Santulli, T.V., Heird, W.C., et al. An experimental study of acute neonatal enterocolitis—the importance of breast milk. J Pediatr Surg 9:5 (1974), 587–595.
    • (1974) J Pediatr Surg , vol.9 , Issue.5 , pp. 587-595
    • Barlow, B.1    Santulli, T.V.2    Heird, W.C.3
  • 11
    • 33747807305 scopus 로고    scopus 로고
    • The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis
    • Jilling, T., Simon, D., Lu, J., et al. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol 177:5 (2006), 3273–3282.
    • (2006) J Immunol , vol.177 , Issue.5 , pp. 3273-3282
    • Jilling, T.1    Simon, D.2    Lu, J.3
  • 12
    • 25444464853 scopus 로고    scopus 로고
    • Evidence for clostridial implication in necrotizing enterocolitis through bacterial fermentation in a gnotobiotic quail model
    • Waligora-Dupriet, A.J., Dugay, A., Auzeil, N., et al. Evidence for clostridial implication in necrotizing enterocolitis through bacterial fermentation in a gnotobiotic quail model. Pediatr Res 58:4 (2005), 629–635.
    • (2005) Pediatr Res , vol.58 , Issue.4 , pp. 629-635
    • Waligora-Dupriet, A.J.1    Dugay, A.2    Auzeil, N.3
  • 13
    • 84872385480 scopus 로고    scopus 로고
    • Smad7 inhibits autocrine expression of TGF-beta2 in intestinal epithelial cells in baboon necrotizing enterocolitis
    • Namachivayam, K., Blanco, C.L., MohanKumar, K., et al. Smad7 inhibits autocrine expression of TGF-beta2 in intestinal epithelial cells in baboon necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 304:2 (2013), G167–G180.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.304 , Issue.2 , pp. G167-G180
    • Namachivayam, K.1    Blanco, C.L.2    MohanKumar, K.3
  • 14
    • 0016733619 scopus 로고
    • Importance of multiple episodes of hypoxia or cold stress on the development of enterocolitis in an animal model
    • Barlow, B., Santulli, T.V., Importance of multiple episodes of hypoxia or cold stress on the development of enterocolitis in an animal model. Surgery 77:5 (1975), 687–690.
    • (1975) Surgery , vol.77 , Issue.5 , pp. 687-690
    • Barlow, B.1    Santulli, T.V.2
  • 15
    • 64249145652 scopus 로고    scopus 로고
    • The development of animal models for the study of necrotizing enterocolitis
    • Sodhi, C., Richardson, W., Gribar, S., et al. The development of animal models for the study of necrotizing enterocolitis. Dis Model Mech 1:2-3 (2008), 94–98.
    • (2008) Dis Model Mech , vol.1 , Issue.2-3 , pp. 94-98
    • Sodhi, C.1    Richardson, W.2    Gribar, S.3
  • 16
    • 0034234534 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase and interleukin-12 in experimental necrotizing enterocolitis
    • Nadler, E.P., Dickinson, E., Knisely, A., et al. Expression of inducible nitric oxide synthase and interleukin-12 in experimental necrotizing enterocolitis. J Surg Res 92:1 (2000), 71–77.
    • (2000) J Surg Res , vol.92 , Issue.1 , pp. 71-77
    • Nadler, E.P.1    Dickinson, E.2    Knisely, A.3
  • 17
    • 80053912340 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy in necrotizing enterocolitis: a rat study
    • Tayman, C., Uckan, D., Kilic, E., et al. Mesenchymal stem cell therapy in necrotizing enterocolitis: a rat study. Pediatr Res 70:5 (2011), 489–494.
    • (2011) Pediatr Res , vol.70 , Issue.5 , pp. 489-494
    • Tayman, C.1    Uckan, D.2    Kilic, E.3
  • 18
    • 84872391628 scopus 로고    scopus 로고
    • Enteral intestinal alkaline phosphatase administration in newborns decreases iNOS expression in a neonatal necrotizing enterocolitis rat model
    • Rentea, R.M., Liedel, J.L., Fredrich, K., et al. Enteral intestinal alkaline phosphatase administration in newborns decreases iNOS expression in a neonatal necrotizing enterocolitis rat model. J Pediatr Surg 48:1 (2013), 124–128.
    • (2013) J Pediatr Surg , vol.48 , Issue.1 , pp. 124-128
    • Rentea, R.M.1    Liedel, J.L.2    Fredrich, K.3
  • 19
    • 84863254669 scopus 로고    scopus 로고
    • Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-kappaB signaling in the intestine
    • Liu, Y., Fatheree, N.Y., Mangalat, N., et al. Lactobacillus reuteri strains reduce incidence and severity of experimental necrotizing enterocolitis via modulation of TLR4 and NF-kappaB signaling in the intestine. Am J Physiol Gastrointest Liver Physiol 302:6 (2012), G608–G617.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , Issue.6 , pp. G608-G617
    • Liu, Y.1    Fatheree, N.Y.2    Mangalat, N.3
  • 20
    • 48749129994 scopus 로고    scopus 로고
    • Enterobacter sakazakii enhances epithelial cell injury by inducing apoptosis in a rat model of necrotizing enterocolitis
    • Hunter, C.J., Singamsetty, V.K., Chokshi, N.K., et al. Enterobacter sakazakii enhances epithelial cell injury by inducing apoptosis in a rat model of necrotizing enterocolitis. J Infect Dis 198:4 (2008), 586–593.
    • (2008) J Infect Dis , vol.198 , Issue.4 , pp. 586-593
    • Hunter, C.J.1    Singamsetty, V.K.2    Chokshi, N.K.3
  • 21
    • 0029931503 scopus 로고    scopus 로고
    • The role of luminal nutrients in intestinal injury from mesenteric reperfusion and platelet-activating factor in the developing rat
    • Bhatia, A.M., Feddersen, R.M., Musemeche, C.A., The role of luminal nutrients in intestinal injury from mesenteric reperfusion and platelet-activating factor in the developing rat. J Surg Res 63:1 (1996), 152–156.
    • (1996) J Surg Res , vol.63 , Issue.1 , pp. 152-156
    • Bhatia, A.M.1    Feddersen, R.M.2    Musemeche, C.A.3
  • 22
    • 84866361378 scopus 로고    scopus 로고
    • Heparin-binding epidermal growth factor-like growth factor and mesenchymal stem cells act synergistically to prevent experimental necrotizing enterocolitis
    • Yang, J., Watkins, D., Chen, C.L., et al. Heparin-binding epidermal growth factor-like growth factor and mesenchymal stem cells act synergistically to prevent experimental necrotizing enterocolitis. J Am Coll Surg 215:4 (2012), 534–545.
    • (2012) J Am Coll Surg , vol.215 , Issue.4 , pp. 534-545
    • Yang, J.1    Watkins, D.2    Chen, C.L.3
  • 23
    • 84979240826 scopus 로고    scopus 로고
    • Temporal profile of intestinal tissue expression of intestinal fatty acid-binding protein in a rat model of necrotizing enterocolitis
    • Simoes, A.L., Figueira, R.L., Goncalves, F.L., et al. Temporal profile of intestinal tissue expression of intestinal fatty acid-binding protein in a rat model of necrotizing enterocolitis. Clinics (Sao Paulo) 71:7 (2016), 412–419.
    • (2016) Clinics (Sao Paulo) , vol.71 , Issue.7 , pp. 412-419
    • Simoes, A.L.1    Figueira, R.L.2    Goncalves, F.L.3
  • 24
    • 85009486474 scopus 로고    scopus 로고
    • A role for cAMP and protein kinase A in experimental necrotizing enterocolitis
    • Blackwood, B.P., Wood, D.R., Yuan, C., et al. A role for cAMP and protein kinase A in experimental necrotizing enterocolitis. Am J Pathol 187:2 (2017), 401–417.
    • (2017) Am J Pathol , vol.187 , Issue.2 , pp. 401-417
    • Blackwood, B.P.1    Wood, D.R.2    Yuan, C.3
  • 25
    • 85011620981 scopus 로고    scopus 로고
    • Breast milk-derived exosomes promote intestinal epithelial cell growth
    • Hock, A., Miyake, H., Li, B., et al. Breast milk-derived exosomes promote intestinal epithelial cell growth. J Pediatr Surg 52:5 (2017), 755–759.
    • (2017) J Pediatr Surg , vol.52 , Issue.5 , pp. 755-759
    • Hock, A.1    Miyake, H.2    Li, B.3
  • 26
    • 0022638365 scopus 로고
    • A mouse model for the study of necrotizing enterocolitis
    • Krasna, I.H., Howell, C., Vega, A., et al. A mouse model for the study of necrotizing enterocolitis. J Pediatr Surg 21:1 (1986), 26–29.
    • (1986) J Pediatr Surg , vol.21 , Issue.1 , pp. 26-29
    • Krasna, I.H.1    Howell, C.2    Vega, A.3
  • 27
    • 35348945803 scopus 로고    scopus 로고
    • Activation of individual tumor necrosis factor receptors differentially affects stem cell growth factor and cytokine production
    • Markel, T.A., Crisostomo, P.R., Wang, M., et al. Activation of individual tumor necrosis factor receptors differentially affects stem cell growth factor and cytokine production. Am J Physiol Gastrointest Liver Physiol 293:4 (2007), G657–G662.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293 , Issue.4 , pp. G657-G662
    • Markel, T.A.1    Crisostomo, P.R.2    Wang, M.3
  • 29
    • 68649103962 scopus 로고    scopus 로고
    • 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis
    • Wang, Y., Hoenig, J.D., Malin, K.J., et al. 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis. ISME J 3:8 (2009), 944–954.
    • (2009) ISME J , vol.3 , Issue.8 , pp. 944-954
    • Wang, Y.1    Hoenig, J.D.2    Malin, K.J.3
  • 30
    • 84863521151 scopus 로고    scopus 로고
    • Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: evidence from an animal model
    • MohanKumar, K., Kaza, N., Jagadeeswaran, R., et al. Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: evidence from an animal model. Am J Physiol Gastrointest Liver Physiol 303:1 (2012), G93–G102.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303 , Issue.1 , pp. G93-G102
    • MohanKumar, K.1    Kaza, N.2    Jagadeeswaran, R.3
  • 31
    • 84886633917 scopus 로고    scopus 로고
    • Mapping the new world of necrotizing enterocolitis (NEC): review and opinion
    • Gordon, P., Christensen, R., Weitkamp, J.H., et al. Mapping the new world of necrotizing enterocolitis (NEC): review and opinion. EJ Neonatol Res 2:4 (2012), 145–172.
    • (2012) EJ Neonatol Res , vol.2 , Issue.4 , pp. 145-172
    • Gordon, P.1    Christensen, R.2    Weitkamp, J.H.3
  • 32
    • 85015735207 scopus 로고    scopus 로고
    • Fecal microbiota transplantation (FMT) could reverse the severity of experimental necrotizing enterocolitis (NEC) via oxidative stress modulation
    • Li, X., Li, X., Shang, Q., et al. Fecal microbiota transplantation (FMT) could reverse the severity of experimental necrotizing enterocolitis (NEC) via oxidative stress modulation. Free Radic Biol Med 108 (2017), 32–43.
    • (2017) Free Radic Biol Med , vol.108 , pp. 32-43
    • Li, X.1    Li, X.2    Shang, Q.3
  • 33
    • 84994248949 scopus 로고    scopus 로고
    • Osmolality of enteral formula and severity of experimental necrotizing enterocolitis
    • Miyake, H., Chen, Y., Koike, Y., et al. Osmolality of enteral formula and severity of experimental necrotizing enterocolitis. Pediatr Surg Int 32:12 (2016), 1153–1156.
    • (2016) Pediatr Surg Int , vol.32 , Issue.12 , pp. 1153-1156
    • Miyake, H.1    Chen, Y.2    Koike, Y.3
  • 34
    • 85021715447 scopus 로고    scopus 로고
    • Neonatal mice with necrotizing enterocolitis-like injury develop thrombocytopenia despite increased megakaryopoiesis
    • Namachivayam, K., MohanKumar, K., Garg, L., et al. Neonatal mice with necrotizing enterocolitis-like injury develop thrombocytopenia despite increased megakaryopoiesis. Pediatr Res 81:5 (2017), 817–824.
    • (2017) Pediatr Res , vol.81 , Issue.5 , pp. 817-824
    • Namachivayam, K.1    MohanKumar, K.2    Garg, L.3
  • 35
    • 84995486946 scopus 로고    scopus 로고
    • Inflammation and apoptosis: dual mediator role for toll-like receptor 4 in the development of necrotizing enterocolitis
    • Zhou, Y., Li, Y., Zhou, B., et al. Inflammation and apoptosis: dual mediator role for toll-like receptor 4 in the development of necrotizing enterocolitis. Inflamm Bowel Dis 23:1 (2017), 44–56.
    • (2017) Inflamm Bowel Dis , vol.23 , Issue.1 , pp. 44-56
    • Zhou, Y.1    Li, Y.2    Zhou, B.3
  • 36
    • 84880064390 scopus 로고    scopus 로고
    • Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets
    • Jensen, M.L., Sangild, P.T., Lykke, M., et al. Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets. Am J Physiol-Reg I 305:1 (2013), R4–R12.
    • (2013) Am J Physiol-Reg I , vol.305 , Issue.1 , pp. R4-R12
    • Jensen, M.L.1    Sangild, P.T.2    Lykke, M.3
  • 37
    • 84884796095 scopus 로고    scopus 로고
    • Invited review: the preterm pig as a model in pediatric gastroenterology
    • Sangild, P.T., Thymann, T., Schmidt, M., et al. Invited review: the preterm pig as a model in pediatric gastroenterology. J Anim Sci 91:10 (2013), 4713–4729.
    • (2013) J Anim Sci , vol.91 , Issue.10 , pp. 4713-4729
    • Sangild, P.T.1    Thymann, T.2    Schmidt, M.3
  • 38
    • 80052415948 scopus 로고    scopus 로고
    • Innate Immunity in the small intestine of the preterm infant
    • McElroy, S.J., Weitkamp, J.H., Innate Immunity in the small intestine of the preterm infant. NeoReviews 12:9 (2011), e517–e526.
    • (2011) NeoReviews , vol.12 , Issue.9 , pp. e517-e526
    • McElroy, S.J.1    Weitkamp, J.H.2
  • 39
    • 85026909241 scopus 로고    scopus 로고
    • Elevated levels of circulating cell-free DNA and neutrophil proteins are associated with neonatal sepsis and necrotizing enterocolitis in immature mice, pigs and infants
    • Nguyen, D.N., Stensballe, A., Lai, J.C., et al. Elevated levels of circulating cell-free DNA and neutrophil proteins are associated with neonatal sepsis and necrotizing enterocolitis in immature mice, pigs and infants. Innate Immun 23:6 (2017), 524–536.
    • (2017) Innate Immun , vol.23 , Issue.6 , pp. 524-536
    • Nguyen, D.N.1    Stensballe, A.2    Lai, J.C.3
  • 40
    • 84998886367 scopus 로고    scopus 로고
    • Human milk oligosaccharide effects on intestinal function and inflammation after preterm birth in pigs
    • Rasmussen, S.O., Martin, L., Ostergaard, M.V., et al. Human milk oligosaccharide effects on intestinal function and inflammation after preterm birth in pigs. J Nutr Biochem 40 (2017), 141–154.
    • (2017) J Nutr Biochem , vol.40 , pp. 141-154
    • Rasmussen, S.O.1    Martin, L.2    Ostergaard, M.V.3
  • 41
    • 0024824140 scopus 로고
    • Intestinal post-ischemic reperfusion injury: studies with neonatal necrotizing enterocolitis
    • Cassutto, B.H., Misra, H.P., Pfeiffer, C.J., Intestinal post-ischemic reperfusion injury: studies with neonatal necrotizing enterocolitis. Acta Physiol Hung 73:2-3 (1989), 363–369.
    • (1989) Acta Physiol Hung , vol.73 , Issue.2-3 , pp. 363-369
    • Cassutto, B.H.1    Misra, H.P.2    Pfeiffer, C.J.3
  • 42
    • 84874146974 scopus 로고    scopus 로고
    • An animal model of necrotizing enterocolitis (NEC) in preterm rabbits
    • Bozeman, A.P., Dassinger, M.S., Birusingh, R.J., et al. An animal model of necrotizing enterocolitis (NEC) in preterm rabbits. Fetal Pediatr Pathol 32:2 (2013), 113–122.
    • (2013) Fetal Pediatr Pathol , vol.32 , Issue.2 , pp. 113-122
    • Bozeman, A.P.1    Dassinger, M.S.2    Birusingh, R.J.3
  • 43
    • 67651174325 scopus 로고    scopus 로고
    • Short-chain fatty acids and polyamines in the pathogenesis of necrotizing enterocolitis: kinetics aspects in gnotobiotic quails
    • Waligora-Dupriet, A.J., Dugay, A., Auzeil, N., et al. Short-chain fatty acids and polyamines in the pathogenesis of necrotizing enterocolitis: kinetics aspects in gnotobiotic quails. Anaerobe 15:4 (2009), 138–144.
    • (2009) Anaerobe , vol.15 , Issue.4 , pp. 138-144
    • Waligora-Dupriet, A.J.1    Dugay, A.2    Auzeil, N.3
  • 44
    • 84959357347 scopus 로고    scopus 로고
    • Organoids as an in vitro model of human development and disease
    • Fatehullah, A., Tan, S.H., Barker, N., Organoids as an in vitro model of human development and disease. Nat Cell Biol 18:3 (2016), 246–254.
    • (2016) Nat Cell Biol , vol.18 , Issue.3 , pp. 246-254
    • Fatehullah, A.1    Tan, S.H.2    Barker, N.3
  • 45
    • 79952825184 scopus 로고    scopus 로고
    • The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response
    • Nanthakumar, N., Meng, D., Goldstein, A.M., et al. The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response. PLoS One, 6(3), 2011, e17776.
    • (2011) PLoS One , vol.6 , Issue.3 , pp. e17776
    • Nanthakumar, N.1    Meng, D.2    Goldstein, A.M.3
  • 46
    • 84901700178 scopus 로고    scopus 로고
    • Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges
    • Lu, P., Sodhi, C.P., Jia, H., et al. Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges. Am J Physiol Gastrointest Liver Physiol 306:11 (2014), G917–G928.
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.306 , Issue.11 , pp. G917-G928
    • Lu, P.1    Sodhi, C.P.2    Jia, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.