An animal model of necrotizing enterocolitis (NEC) in preterm rabbits

Fetal and Pediatric Pathology

Volumn 32, Issue 2, 2013, Pages 113-122

  Bozeman, Andrew P ^a   Dassinger, Melvin S ^a   Birusingh, Rhea J ^a   Burford, Jeffrey M ^a   Smith, Samuel D ^a  

^a ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

Animal model; Intestinal; Mucosal injury; Necrotizing enterocolitis (NEC); Neonatal

Indexed keywords

INDOMETACIN; RANITIDINE; TISSUE ADHESIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; ENTEROBACTER CLOACAE; FEEDING; GASTROINTESTINAL MOTILITY DISORDER; HISTOPATHOLOGY; INTESTINAL DYSMOTILITY; INTESTINE BRUSH BORDER; INTESTINE FUNCTION; NECROTIZING ENTEROCOLITIS; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; RABBIT; SURVIVOR;

EID: 84874146974     PISSN: 15513815     EISSN: 15513823     Source Type: Journal    
DOI: 10.3109/15513815.2012.681426     Document Type: Article

References (24)

1. Tudehope DI.The epidemiology and pathogenesis of neonatal necrotizing enterocolitis. J Paediatr Child Health 41:167-8, 2005
2. Lorenzo A V, Welch K, Conner S. Spontaneous germinal matrix and intraventricular hemorrhage in prematurely born rabbits. J Neurosurg 56:404-10, 1982 (Pubitemid 12045388)
3. Dinsmore J E, Jackson R J, Smith SD.Theprotective role of gastric acidity in neonatal bacterial translocation. J Pediatr Surg 32:1014-6, 1997 (Pubitemid 27349015)
4. DvorakB,HalpernMD,Holubec H, et al. Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol 282:G156-64, 2002 (Pubitemid 34650110)
5. Newell SJ. Enteral feeding of the micropremie. Clin Perinatol 27:221-34, viii, 2000 (Pubitemid 30109073)
6. Sodhi C, Richardson W, Gribar S, Hackam DJ. The development of animal models for the study of necrotizing enterocolitis. DisModelMech 1:94-8, 2008
7. Sangild P T, Siggers R H, Schmidt M, et al. Diet- And colonization-dependent intestinal dysfunction predisposes to necrotizing enterocolitis in pretermpigs. Gastroenterology 130:1776-92, 2006 (Pubitemid 43668865)
8. Mehall J R, Kite C A, Saltzman D A, Wallett T, Jackson R J, Smith SD. Prospective study of the incidence and complications of bacterial contamination of enteral feeding in neonates. J Pediatr Surg 37:1177-82, 2002 (Pubitemid 34824061)
9. Jilling T, Simon D, Lu J, et al. The roles of bacteria and TLR4 in rat andmurine models of necrotizing enterocolitis. J Immunol 177:3273-82, 2006 (Pubitemid 44277847)
10. Mehall J R, Kite C A, Gilliam C H, Jackson R J, Smith SD. Enteral feeding tubes are a reservoir for nosocomial antibiotic-resistant pathogens. J Pediatr Surg 37:1011-2, 2002 (Pubitemid 34742834)
11. Mehall JR,Northrop R, Saltzman D A, JacksonRJ, Smith SD.Acidification of formula reduces bacterial translocation and gut colonization in a neonatal rabbitmodel. J Pediatr Surg 36:56-62, 2001 (Pubitemid 32044315)
12. Grosfeld JL,Chaet M,Molinari F, et al. Increased risk of necrotizing enterocolitis in premature infants with patent ductus arteriosus treated with indomethacin. Ann Surg 224:350-5; discussion 5-7, 1996
13. Crissinger KD. Animal models of necrotizing enterocolitis. J Pediatr Gastroenterol Nutr 20:17-22, 1995
14. Gribar S C, RichardsonWM, Sodhi C P, Hackam DJ. No longer an innocent bystander: Epithelial tolllike receptor signaling in the development ofmucosal inflammation.MolMed 14:645-59, 2008
15. McVay M R, Boneti C, Habib C M, et al. Formula fortified with live probiotic culture reduces pulmonary and gastrointestinal bacterial colonization and translocation in a newborn animal model. J Pediatr Surg 43:25-9; discussion 9, 2008
16. Boneti C, Habib C M, Keller J E, et al. Probiotic acidified formula in an animal model reduces pulmonary and gastric bacterial load. J Pediatr Surg 44:530-3, 2009
17. Copeland DR,McVay M R, Dassinger M S, Jackson R J, Smith SD. Probiotic fortified diet reduces bacterial colonization and translocation in a long-Termneonatal rabbitmodel. J Pediatr Surg 44:1061-4; discussion 54, 2009
18. Caplan M S, Hedlund E, Adler L, Hsueh W. Role of asphyxia and feeding in a neonatal rat model of necrotizing enterocolitis. Pediatr Pathol 14:1017-28, 1994 (Pubitemid 24357149)
19. Crissinger K D, Burney D L, Velasquez O R, Gonzalez E. An animal model of necrotizing enterocolitis induced by infant formula and ischemia in developing piglets. Gastroenterology 106:1215-22, 1994 (Pubitemid 24129237)
20. Cohen I T, Nelson SD,Moxley R A, HirshMP, Counihan TC,Martin RF. Necrotizing enterocolitis in a neonatal piglet model. J Pediatr Surg 26:598-601, 1991
21. BarlowB, Santulli TV. Importance ofmultiple episodes of hypoxia or cold stress on the development of enterocolitis in an animal model. Surgery 77:687-90, 1975
22. Quaedackers J S, Beuk RJ. An evaluation of methods for grading histologic injury following ischemia/reperfusion of the small bowel. Transplantation Proceedings 32, 1307-10, 2000
23. Sodhi C, Richardson W, Gribar S, Hackam DJ. The development of animal models for the study of necrotizing enterocolitis. DiseaseModels &Mechanisms 1, 94-8, 2008
24. Donnelly, T.M. (1997). Basic anatomy, physiology and husbandry. In: Ferrets, Rabbits and Rodents, Clinical Medicine and Surgery (EV Hillyer, KE Quensenberry, eds.), pp 147-59. Philadelphia: WB Saunders