Enteral intestinal alkaline phosphatase administration in newborns decreases iNOS expression in a neonatal necrotizing enterocolitis rat model

Journal of Pediatric Surgery

Volumn 48, Issue 1, 2013, Pages 124-128

  Rentea, Rebecca M ^a   Liedel, Jennifer L ^a   Fredrich, Katherine ^a   Pritchard, Kirkwood ^a   Oldham, Keith T ^a   Simpson, Pippa M ^a   Gourlay, David M ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Formula; Inflammation; Intestinal alkaline phosphatase; Necrotizing enterocolitis; Prematurity

Indexed keywords

ALKALINE PHOSPHATASE; ALKALINE PHOSPHATASE INTESTINE ISOENZYME; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; GENE EXPRESSION; INTERMITTENT HYPOXIA; INTESTINE INJURY; NECROTIZING ENTEROCOLITIS; NEWBORN; NITROSATIVE STRESS; NONHUMAN; NUCLEOTIDE SEQUENCE; PREMATURITY; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION;

EID: 84872391628     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2012.10.026     Document Type: Article

References (12)

1. J. Neu, and W.A. Walker Necrotizing enterocolitis N Engl J Med 364 2011 255 264
2. T. Jilling, J. Lu, and M. Jackson Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis Pediatr Res 55 2004 622 629
3. N. Nanthakumar, D. Meng, and A.M. Goldstein The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response PLoS One 6 2011 e17776
4. H. Ford, S. Watkins, and K. Reblock The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis J Pediatr Surg 32 1997 275 282
5. D.A. Potoka, E.P. Nadler, and X. Zhou Inhibition of NF-kappaB by IkappaB prevents cytokine-induced NO production and promotes enterocyte apoptosis in vitro Shock 14 2000 366 373
6. R. Sharma, J.J. Tepas III, and M.L. Hudak Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis J Pediatr Surg 42 2007 454 461
7. A. Lodha, E. Asztalos, and A.M. Moore Cytokine levels in neonatal necrotizing enterocolitis and long-term growth and neurodevelopment Acta Paediatr 99 2010 338 343
8. J.S. Whitehouse, K.M. Riggle, and D.P. Purpi The protective role of intestinal alkaline phosphatase in necrotizing enterocolitis J Surg Res 163 2010 79 85
9. J.L. Liedel, Y. Guo, and Y. Yu Mother's milk induced Hsp70 expression preserves intestinal epithelial barrier function in an immature rat pup model Pediatr Res 69 5 Pt 1 2011 395 400
10. E.C. Claud, L. Lu, and P.M. Anton Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation Proc Natl Acad Sci USA 101 2004 7404 7408
11. S. Cetin, C.L. Leaphart, and J. Li Nitric oxide inhibits enterocyte migration through activation of RhoA-GTPase in a SHP-2-dependent manner Am J Physiol Gastrointest Liver Physiol 292 2007 G1347 G1358
12. D.A. Potoka, J.S. Upperman, and E.P. Nadler NF-kappaB inhibition enhances peroxynitrite-induced enterocyte apoptosis J Surg Res 106 2002 7 14