-
1
-
-
85061644076
-
SEER stat fact sheets: kidney and renal pelvis cancer
-
Bethesda: National Cancer Institute
-
Surveillance, Epidemiology, and End Results Program. SEER stat fact sheets: kidney and renal pelvis cancer. Bethesda: National Cancer Institute; 2017. at http://seer.cancer.gov/statfacts/html/urinb.html.
-
(2017)
-
-
-
3
-
-
84910051486
-
Bladder cancer: ESMO practice guidelines for diagnosis, treatment and follow-up
-
Bellmunt J, Orsola A, Leow JJ, et al. Bladder cancer: ESMO practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(Suppl 3):iii40-8.
-
(2014)
Ann Oncol
, vol.25
, pp. 40-48
-
-
Bellmunt, J.1
Orsola, A.2
Leow, J.J.3
-
4
-
-
84973277821
-
Guideline on muscle-invasive and metastatic bladder cancer (European Association of Urology guideline): American Society of Clinical Oncology clinical practice guideline endorsement
-
Milowsky MI, Rumble RB, Booth CM, et al. Guideline on muscle-invasive and metastatic bladder cancer (European Association of Urology guideline): American Society of Clinical Oncology clinical practice guideline endorsement. J Clin Oncol. 2016;34:1945-52.
-
(2016)
J Clin Oncol
, vol.34
, pp. 1945-1952
-
-
Milowsky, M.I.1
Rumble, R.B.2
Booth, C.M.3
-
6
-
-
85020854314
-
FDA Approval Summary: Atezolizumab for the Treatment of Patients with Progressive Advanced Urothelial Carcinoma after Platinum-Containing Chemotherapy
-
Ning YM, Suzman D, Maher VE, et al. FDA Approval Summary: Atezolizumab for the Treatment of Patients with Progressive Advanced Urothelial Carcinoma after Platinum-Containing Chemotherapy. Oncologist. 2017;22(6):743-9.
-
(2017)
Oncologist
, vol.22
, Issue.6
, pp. 743-749
-
-
Ning, Y.M.1
Suzman, D.2
Maher, V.E.3
-
7
-
-
84923078390
-
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
-
Powles T, Eder JP, Fine GD, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature. 2014;515:558-62.
-
(2014)
Nature
, vol.515
, pp. 558-562
-
-
Powles, T.1
Eder, J.P.2
Fine, G.D.3
-
8
-
-
84959577118
-
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
-
Rosenberg JE, Hoffman-Censits J, Powles T, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet. 2016;387:1909-20.
-
(2016)
Lancet
, vol.387
, pp. 1909-1920
-
-
Rosenberg, J.E.1
Hoffman-Censits, J.2
Powles, T.3
-
9
-
-
85015345322
-
PD-L1 Immunohistochemistry assays for lung cancer: results from phase 1 of the blueprint PD-L1 IHC assay comparison project
-
Hirsch FR, McElhinny A, Stanforth D, et al. PD-L1 Immunohistochemistry assays for lung cancer: results from phase 1 of the blueprint PD-L1 IHC assay comparison project. J Thorac Oncol. 2017;12:208-22.
-
(2017)
J Thorac Oncol
, vol.12
, pp. 208-222
-
-
Hirsch, F.R.1
McElhinny, A.2
Stanforth, D.3
-
10
-
-
85007564166
-
Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial
-
Balar AV, Galsky MD, Rosenberg JE, et al. Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial. Lancet. 2017;389:67-76.
-
(2017)
Lancet
, vol.389
, pp. 67-76
-
-
Balar, A.V.1
Galsky, M.D.2
Rosenberg, J.E.3
-
11
-
-
85010904121
-
Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial
-
Sharma P, Retz M, Siefker-Radtke A, et al. Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial. Lancet Oncol. 2017;18:312-22.
-
(2017)
Lancet Oncol
, vol.18
, pp. 312-322
-
-
Sharma, P.1
Retz, M.2
Siefker-Radtke, A.3
-
12
-
-
84960085003
-
Second-line single-agent versus doublet chemotherapy as salvage therapy for metastatic urothelial cancer: a systematic review and meta-analysis
-
Raggi D, Miceli R, Sonpavde G, et al. Second-line single-agent versus doublet chemotherapy as salvage therapy for metastatic urothelial cancer: a systematic review and meta-analysis. Ann Oncol. 2016;27:49-61.
-
(2016)
Ann Oncol
, vol.27
, pp. 49-61
-
-
Raggi, D.1
Miceli, R.2
Sonpavde, G.3
-
13
-
-
85015755043
-
Pembrolizumab as second-line therapy for advanced Urothelial carcinoma
-
Bellmunt J, de Wit R, Vaughn DJ, et al. Pembrolizumab as second-line therapy for advanced Urothelial carcinoma. N Engl J Med. 2017;376:1015-26.
-
(2017)
N Engl J Med
, vol.376
, pp. 1015-1026
-
-
Bellmunt, J.1
de Wit, R.2
Vaughn, D.J.3
-
14
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
-
Herbst RS, Baas P, Kim DW, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 2016;387:1540-50.
-
(2016)
Lancet
, vol.387
, pp. 1540-1550
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.W.3
-
15
-
-
84946607195
-
Nivolumab versus Everolimus in advanced renal-cell carcinoma
-
Motzer RJ, Escudier B, McDermott DF, et al. Nivolumab versus Everolimus in advanced renal-cell carcinoma. N Engl J Med. 2015;373:1803-13.
-
(2015)
N Engl J Med
, vol.373
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
-
16
-
-
85009701352
-
Pembrolizumab (pembro) as first-line therapy for advanced/unresectable or metastatic urothelial cancer: preliminary results from the phase 2 KEYNOTE-052 study
-
LBA32_PR-LBA_PR.
-
Balar A, Bellmunt J, O'Donnell PH, et al. Pembrolizumab (pembro) as first-line therapy for advanced/unresectable or metastatic urothelial cancer: preliminary results from the phase 2 KEYNOTE-052 study. Ann Oncol. 2016;27:LBA32_PR-LBA_PR.
-
(2016)
Ann Oncol
, vol.27
-
-
Balar, A.1
Bellmunt, J.2
O'Donnell, P.H.3
-
17
-
-
85030481851
-
Biomarker findings and mature clinical results from KEYNOTE-052: first-line pembrolizumab (pembro) in cisplatin-ineligible advanced urothelial cancer (UC)
-
O'Donnell PH, Grivas P, Balar AV, et al. Biomarker findings and mature clinical results from KEYNOTE-052: first-line pembrolizumab (pembro) in cisplatin-ineligible advanced urothelial cancer (UC). J Clin Oncol. 2017;35:4502.
-
(2017)
J Clin Oncol
, vol.35
, pp. 4502
-
-
O'Donnell, P.H.1
Grivas, P.2
Balar, A.V.3
-
18
-
-
85026675148
-
IFN-gamma-related mRNA profile predicts clinical response to PD-1 blockade
-
Ayers M, Lunceford J, Nebozhyn M, et al. IFN-gamma-related mRNA profile predicts clinical response to PD-1 blockade. J Clin Invest. 2017;127(8):2930-40.
-
(2017)
J Clin Invest
, vol.127
, Issue.8
, pp. 2930-2940
-
-
Ayers, M.1
Lunceford, J.2
Nebozhyn, M.3
-
19
-
-
84989918072
-
Safety and efficacy of Durvalumab (MEDI4736), an anti-programmed cell death Ligand-1 immune checkpoint inhibitor, in patients with advanced Urothelial bladder cancer
-
Massard C, Gordon MS, Sharma S, et al. Safety and efficacy of Durvalumab (MEDI4736), an anti-programmed cell death Ligand-1 immune checkpoint inhibitor, in patients with advanced Urothelial bladder cancer. J Clin Oncol. 2016;34:3119-25.
-
(2016)
J Clin Oncol
, vol.34
, pp. 3119-3125
-
-
Massard, C.1
Gordon, M.S.2
Sharma, S.3
-
20
-
-
84989827378
-
Programmed cell death Ligand-1 blockade in Urothelial bladder cancer: to select or not to select
-
Drake CG, Bivalacqua TJ, Hahn NM. Programmed cell death Ligand-1 blockade in Urothelial bladder cancer: to select or not to select. J Clin Oncol. 2016;34:3115-6.
-
(2016)
J Clin Oncol
, vol.34
, pp. 3115-3116
-
-
Drake, C.G.1
Bivalacqua, T.J.2
Hahn, N.M.3
-
21
-
-
85020935413
-
Updated efficacy and tolerability of durvalumab in locally advanced or metastatic urothelial carcinoma (UC)
-
Hahn NM, Powles T, Massard C, et al. Updated efficacy and tolerability of durvalumab in locally advanced or metastatic urothelial carcinoma (UC). J Clin Oncol. 2017;35:4525.
-
(2017)
J Clin Oncol
, vol.35
, pp. 4525
-
-
Hahn, N.M.1
Powles, T.2
Massard, C.3
-
22
-
-
85020609662
-
Avelumab, an anti-programmed death-Ligand 1 antibody, in patients with refractory metastatic Urothelial carcinoma: results from a multicenter, phase Ib study
-
JCO2016716795.
-
Apolo AB, Infante JR, Balmanoukian A, et al. Avelumab, an anti-programmed death-Ligand 1 antibody, in patients with refractory metastatic Urothelial carcinoma: results from a multicenter, phase Ib study. J Clin Oncol. 2017;2017:JCO2016716795.
-
(2017)
J Clin Oncol
, vol.2017
-
-
Apolo, A.B.1
Infante, J.R.2
Balmanoukian, A.3
-
23
-
-
85019031526
-
Avelumab in patients with metastatic urothelial carcinoma: pooled results from two cohorts of the phase 1b JAVELIN solid tumor trial
-
Patel MR, Ellerton JA, Infante JR, et al. Avelumab in patients with metastatic urothelial carcinoma: pooled results from two cohorts of the phase 1b JAVELIN solid tumor trial. J Clin Oncol. 2017;35:330.
-
(2017)
J Clin Oncol
, vol.35
, pp. 330
-
-
Patel, M.R.1
Ellerton, J.A.2
Infante, J.R.3
-
24
-
-
84936147067
-
Combined Nivolumab and Ipilimumab or Monotherapy in untreated melanoma
-
Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined Nivolumab and Ipilimumab or Monotherapy in untreated melanoma. N Engl J Med. 2015;373:23-34.
-
(2015)
N Engl J Med
, vol.373
, pp. 23-34
-
-
Larkin, J.1
Chiarion-Sileni, V.2
Gonzalez, R.3
-
25
-
-
85007425840
-
Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study
-
Hellmann MD, Rizvi NA, Goldman JW, et al. Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study. Lancet Oncol. 2017;18:31-41.
-
(2017)
Lancet Oncol
, vol.18
, pp. 31-41
-
-
Hellmann, M.D.1
Rizvi, N.A.2
Goldman, J.W.3
-
26
-
-
84982152011
-
Efficacy and safety of nivolumab plus ipilimumab in previously treated metastatic urothelial carcinoma: first results from the phase I/II CheckMate 032 study
-
Sharma PCM, Calvo E, et al. Efficacy and safety of nivolumab plus ipilimumab in previously treated metastatic urothelial carcinoma: first results from the phase I/II CheckMate 032 study. J Clin Oncol. 2016;34(15 suppl):2016. 2016 SITC Annual Meeting; National Harbor, MD
-
(2016)
J Clin Oncol
, vol.34
, Issue.15
, pp. 2016
-
-
Sharma, P.C.M.1
Calvo, E.2
-
27
-
-
85034645203
-
Evaluation of the clinical activity of ipilimumab (IPI) plus nivolumab (NIVO) in patients (pts) with NIVO-refractory metastatic urothelial cancer (UC)
-
Callahan MK, Kania BE, Iyer G, et al. Evaluation of the clinical activity of ipilimumab (IPI) plus nivolumab (NIVO) in patients (pts) with NIVO-refractory metastatic urothelial cancer (UC). J Clin Oncol. 2017;35:384.
-
(2017)
J Clin Oncol
, vol.35
, pp. 384
-
-
Callahan, M.K.1
Kania, B.E.2
Iyer, G.3
-
28
-
-
85020917101
-
A phase 3 study of first-line durvalumab (MEDI4736) ± tremelimumab versus standard of care (SoC) chemotherapy (CT) in patients (pts) with unresectable stage IV urothelial bladder cancer (UBC): DANUBE
-
Powles T, Galsky MD, Castellano D, et al. A phase 3 study of first-line durvalumab (MEDI4736) ± tremelimumab versus standard of care (SoC) chemotherapy (CT) in patients (pts) with unresectable stage IV urothelial bladder cancer (UBC): DANUBE. J Clin Oncol. 2016;34:TPS4574-TPS.
-
(2016)
J Clin Oncol
, vol.34
, pp. 4574-4574
-
-
Powles, T.1
Galsky, M.D.2
Castellano, D.3
-
29
-
-
85036497908
-
Phase 3 KEYNOTE-361 trial: Pembrolizumab (pembro) with or without chemotherapy versus chemotherapy alone in advanced urothelial cancer
-
Powles T, Gschwend JE, Loriot Y, et al. Phase 3 KEYNOTE-361 trial: Pembrolizumab (pembro) with or without chemotherapy versus chemotherapy alone in advanced urothelial cancer. J Clin Oncol. 2017;35:TPS4590-TPS.
-
(2017)
J Clin Oncol
, vol.35
, pp. 4590-4594
-
-
Powles, T.1
Gschwend, J.E.2
Loriot, Y.3
-
30
-
-
85027154045
-
Epacadostat plus pembrolizumab in patients with advanced urothelial carcinoma: preliminary phase I/II results of ECHO-202/KEYNOTE-037
-
Smith DC, Gajewski T, Hamid O, et al. Epacadostat plus pembrolizumab in patients with advanced urothelial carcinoma: preliminary phase I/II results of ECHO-202/KEYNOTE-037. J Clin Oncol. 2017;35:4503.
-
(2017)
J Clin Oncol
, vol.35
, pp. 4503
-
-
Smith, D.C.1
Gajewski, T.2
Hamid, O.3
-
31
-
-
85034625581
-
Clinical results with combination of anti-CD27 agonist antibody, varlilumab, with anti-PD1 antibody nivolumab in advanced cancer patients
-
Chicago: ASCO Annual Meeting 2017
-
Rachel E, Sanborn MJP, Harriet M, Kluger, Callahan MK, Weise AM, Lutzky J, Yellin MJ, Rawls T, Vitale L, Halim A, Keler T, Davis T, Naiyer A, Rizvi. Clinical results with combination of anti-CD27 agonist antibody, varlilumab, with anti-PD1 antibody nivolumab in advanced cancer patients. Chicago: ASCO Annual Meeting 2017; 2017.
-
(2017)
-
-
Rachel, E.1
Sanborn, M.J.P.2
Harriet, M.3
Kluger, C.M.K.4
Weise, A.M.5
Lutzky, J.6
Yellin, M.J.7
Rawls, T.8
Vitale, L.9
Halim, A.10
Keler, T.11
Davis, T.12
Rizvi, N.A.13
-
32
-
-
84992103934
-
ENGAGE-1: a first in human study of the OX40 agonist GSK3174998 alone and in combination with pembrolizumab in patients with advanced solid tumors
-
Infante JR, Ahlers CM, Hodi FS, et al. ENGAGE-1: a first in human study of the OX40 agonist GSK3174998 alone and in combination with pembrolizumab in patients with advanced solid tumors. J Clin Oncol. 2016;34:TPS3107-TPS.
-
(2016)
J Clin Oncol
, vol.34
, pp. 3107-3173
-
-
Infante, J.R.1
Ahlers, C.M.2
Hodi, F.S.3
-
33
-
-
84982867393
-
Phase 1/2a study of double immune suppression blockade by combining a CSF1R inhibitor (pexidartinib/PLX3397) with an anti PD-1 antibody (pembrolizumab) to treat advanced melanoma and other solid tumors
-
Wainberg ZA, Eisenberg PD, Sachdev JC, et al. Phase 1/2a study of double immune suppression blockade by combining a CSF1R inhibitor (pexidartinib/PLX3397) with an anti PD-1 antibody (pembrolizumab) to treat advanced melanoma and other solid tumors. J Clin Oncol. 2016;34:TPS465-TPS.
-
(2016)
J Clin Oncol
, vol.34
, pp. 465
-
-
Wainberg, Z.A.1
Eisenberg, P.D.2
Sachdev, J.C.3
-
34
-
-
85034624276
-
A phase I study of cabozantinib plus nivolumab (CaboNivo) and cabonivo plus ipilimumab (CaboNivoIpi) in patients (pts) with refractory metastatic (m) urothelial carcinoma (UC) and other genitourinary (GU) tumors
-
Apolo AB, Mortazavi A, Stein MN, et al. A phase I study of cabozantinib plus nivolumab (CaboNivo) and cabonivo plus ipilimumab (CaboNivoIpi) in patients (pts) with refractory metastatic (m) urothelial carcinoma (UC) and other genitourinary (GU) tumors. J Clin Oncol. 2017;35:4562.
-
(2017)
J Clin Oncol
, vol.35
, pp. 4562
-
-
Apolo, A.B.1
Mortazavi, A.2
Stein, M.N.3
-
35
-
-
85020882236
-
KEYNOTE-057: phase 2 study of pembrolizumab for patients (pts) with bacillus Calmette Guerin (BCG)-unresponsive, high-risk non-muscle-invasive bladder cancer (NMIBC)
-
TPS4576-TPS4TPS.
-
Kamat AM, Bellmunt J, Choueiri TK, et al. KEYNOTE-057: phase 2 study of pembrolizumab for patients (pts) with bacillus Calmette Guerin (BCG)-unresponsive, high-risk non-muscle-invasive bladder cancer (NMIBC). J Clin Oncol. 2016;34:TPS4576-TPS.
-
(2016)
J Clin Oncol
, vol.34
-
-
Kamat, A.M.1
Bellmunt, J.2
Choueiri, T.K.3
-
36
-
-
85034664196
-
S1605: phase II trial of atezolizumab in BCG-unresponsive non-muscle invasive bladder cancer
-
TPS4591-TPS4TPS.
-
Singh P, Catherine T, Lerner SP, et al. S1605: phase II trial of atezolizumab in BCG-unresponsive non-muscle invasive bladder cancer. J Clin Oncol. 2017;35:TPS4591-TPS.
-
(2017)
J Clin Oncol
, vol.35
-
-
Singh, P.1
Catherine, T.2
Lerner, S.P.3
-
37
-
-
51049096135
-
T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival
-
Boorjian SA, Sheinin Y, Crispen PL, et al. T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival. Clin Cancer Res. 2008;14:4800-8.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4800-4808
-
-
Boorjian, S.A.1
Sheinin, Y.2
Crispen, P.L.3
-
38
-
-
85052489122
-
Assessment of tumoral PD-L1 expression and intratumoral CD8+ T cells in urothelial carcinoma
-
Faraj SF, Munari E, Guner G, et al. Assessment of tumoral PD-L1 expression and intratumoral CD8+ T cells in urothelial carcinoma. Urology. 2015;85:703 e1-6.
-
(2015)
Urology
, vol.85
, pp. 703
-
-
Faraj, S.F.1
Munari, E.2
Guner, G.3
-
39
-
-
34247113727
-
PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression
-
Inman BA, Sebo TJ, Frigola X, et al. PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression. Cancer. 2007;109:1499-505.
-
(2007)
Cancer
, vol.109
, pp. 1499-1505
-
-
Inman, B.A.1
Sebo, T.J.2
Frigola, X.3
-
40
-
-
84998854597
-
PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction?
-
Grigg C, Rizvi NA. PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction? J Immunother Cancer. 2016;4:48.
-
(2016)
J Immunother Cancer
, vol.4
, pp. 48
-
-
Grigg, C.1
Rizvi, N.A.2
-
41
-
-
85028949327
-
A prospective, multi-institutional, pathologist-based assessment of 4 Immunohistochemistry assays for PD-L1 expression in non-small cell lung cancer
-
Rimm DL, Han G, Taube JM, et al. A prospective, multi-institutional, pathologist-based assessment of 4 Immunohistochemistry assays for PD-L1 expression in non-small cell lung cancer. JAMA Oncol. 2017;3(8):1051-58.
-
(2017)
JAMA Oncol
, vol.3
, Issue.8
, pp. 1051-1058
-
-
Rimm, D.L.1
Han, G.2
Taube, J.M.3
-
42
-
-
85010777933
-
Quantitative assessment of the heterogeneity of PD-L1 expression in non-small-cell lung cancer
-
McLaughlin J, Han G, Schalper KA, et al. Quantitative assessment of the heterogeneity of PD-L1 expression in non-small-cell lung cancer. JAMA Oncol. 2016;2:46-54.
-
(2016)
JAMA Oncol
, vol.2
, pp. 46-54
-
-
McLaughlin, J.1
Han, G.2
Schalper, K.A.3
-
43
-
-
84897022815
-
Comprehensive molecular characterization of urothelial bladder carcinoma
-
The Cancer Genome Atlas Research N. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014;507:315-22.
-
(2014)
Nature
, vol.507
, pp. 315-322
-
-
-
44
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 2014;371:2189-99.
-
(2014)
N Engl J Med
, vol.371
, pp. 2189-2199
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
-
45
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348:124-8.
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
-
46
-
-
84928770388
-
Neoantigens in cancer immunotherapy
-
Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science. 2015;348:69-74.
-
(2015)
Science
, vol.348
, pp. 69-74
-
-
Schumacher, T.N.1
Schreiber, R.D.2
-
47
-
-
84904472602
-
Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia
-
Rajasagi M, Shukla SA, Fritsch EF, et al. Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia. Blood. 2014;124:453-62.
-
(2014)
Blood
, vol.124
, pp. 453-462
-
-
Rajasagi, M.1
Shukla, S.A.2
Fritsch, E.F.3
-
48
-
-
84962301577
-
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
-
McGranahan N, Furness AJ, Rosenthal R, et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science. 2016;351:1463-9.
-
(2016)
Science
, vol.351
, pp. 1463-1469
-
-
McGranahan, N.1
Furness, A.J.2
Rosenthal, R.3
-
49
-
-
85011421950
-
NSCLC, metastaticCheckMate 026: a phase 3 trial of nivolumab vs investigator's choice (IC) of platinum-based doublet chemotherapy (PT-DC) as first-line therapy for stage iv/recurrent programmed death ligand 1 (PD-L1)-positive NSCLC
-
LBA7_PR-LBA_PR.
-
Socinski M, Creelan B, Horn L, et al. NSCLC, metastaticCheckMate 026: a phase 3 trial of nivolumab vs investigator's choice (IC) of platinum-based doublet chemotherapy (PT-DC) as first-line therapy for stage iv/recurrent programmed death ligand 1 (PD-L1)-positive NSCLC. Ann Oncol. 2016;27:LBA7_PR-LBA_PR.
-
(2016)
Ann Oncol
, vol.27
-
-
Socinski, M.1
Creelan, B.2
Horn, L.3
-
50
-
-
85020964772
-
First-line Nivolumab in stage IV or recurrent non-small-cell lung cancer
-
Carbone DP, Reck M, Paz-Ares L, et al. First-line Nivolumab in stage IV or recurrent non-small-cell lung cancer. N Engl J Med. 2017;376:2415-26.
-
(2017)
N Engl J Med
, vol.376
, pp. 2415-2426
-
-
Carbone, D.P.1
Reck, M.2
Paz-Ares, L.3
-
51
-
-
85034754372
-
Impact of tumor mutation burden on the efficacy of firstline nivolumab in stage iv or recurrent non-small cell lung cancer: an exploratory analysis of CheckMate 026
-
Washington: American Association for Cancer Research Annual Meeting
-
Peters S. Impact of tumor mutation burden on the efficacy of firstline nivolumab in stage iv or recurrent non-small cell lung cancer: an exploratory analysis of CheckMate 026. Washington: American Association for Cancer Research Annual Meeting; 2017.
-
(2017)
-
-
Peters, S.1
-
52
-
-
85034669249
-
Molecular determinants of response and resistance to anti-PD-(L)1 blockade in patients with NSCLC profiled with targeted next-generation sequencing (NGS)
-
Hellmann MD, Sanchez-Vega F, La K, et al. Molecular determinants of response and resistance to anti-PD-(L)1 blockade in patients with NSCLC profiled with targeted next-generation sequencing (NGS). J Clin Oncol. 2017;35:9015.
-
(2017)
J Clin Oncol
, vol.35
, pp. 9015
-
-
Hellmann, M.D.1
Sanchez-Vega, F.2
La, K.3
-
53
-
-
84977575226
-
Burden of nonsynonymous mutations among TCGA cancers and candidate immune checkpoint inhibitor responses
-
Colli LM, Machiela MJ, Myers TA, Jessop L, Yu K, Chanock SJ. Burden of nonsynonymous mutations among TCGA cancers and candidate immune checkpoint inhibitor responses. Cancer Res. 2016;76:3767-72.
-
(2016)
Cancer Res
, vol.76
, pp. 3767-3772
-
-
Colli, L.M.1
Machiela, M.J.2
Myers, T.A.3
Jessop, L.4
Yu, K.5
Chanock, S.J.6
-
54
-
-
84974577346
-
Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer
-
Mehnert JM, Panda A, Zhong H, et al. Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer. J Clin Invest. 2016;126:2334-40.
-
(2016)
J Clin Invest
, vol.126
, pp. 2334-2340
-
-
Mehnert, J.M.1
Panda, A.2
Zhong, H.3
-
55
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le DT, Uram JN, Wang H, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 2015;372:2509-20.
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
56
-
-
84987603333
-
PD-1 blockade in mismatch repair deficient non-colorectal gastrointestinal cancers
-
Le DT, Uram JN, Wang H, et al. PD-1 blockade in mismatch repair deficient non-colorectal gastrointestinal cancers. J Clin Oncol. 2016;34:195.
-
(2016)
J Clin Oncol
, vol.34
, pp. 195
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
57
-
-
85034638218
-
KEYNOTE-177: randomized phase III study of pembrolizumab versus investigator-choice chemotherapy for mismatch repair-deficient or microsatellite instability-high metastatic colorectal carcinoma
-
TPS815-TPS.
-
Diaz LA, Le DT, Yoshino T, et al. KEYNOTE-177: randomized phase III study of pembrolizumab versus investigator-choice chemotherapy for mismatch repair-deficient or microsatellite instability-high metastatic colorectal carcinoma. J Clin Oncol. 2017;35:TPS815-TPS.
-
(2017)
J Clin Oncol
, vol.35
-
-
Diaz, L.A.1
Le, D.T.2
Yoshino, T.3
-
58
-
-
85034663823
-
STK11/LKB1 co-mutations to predict for de novo resistance to PD-1/PD-L1 axis blockade in KRAS-mutant lung adenocarcinoma
-
Skoulidis F, Hellmann MD, Awad MM, et al. STK11/LKB1 co-mutations to predict for de novo resistance to PD-1/PD-L1 axis blockade in KRAS-mutant lung adenocarcinoma. J Clin Oncol. 2017;35:9016.
-
(2017)
J Clin Oncol
, vol.35
, pp. 9016
-
-
Skoulidis, F.1
Hellmann, M.D.2
Awad, M.M.3
-
59
-
-
84998631681
-
Validation of biomarkers to predict response to immunotherapy in cancer: volume I - pre-analytical and analytical validation
-
Masucci GV, Cesano A, Hawtin R, et al. Validation of biomarkers to predict response to immunotherapy in cancer: volume I - pre-analytical and analytical validation. J Immunother Cancer. 2016;4:76.
-
(2016)
J Immunother Cancer
, vol.4
, pp. 76
-
-
Masucci, G.V.1
Cesano, A.2
Hawtin, R.3
-
60
-
-
84998773662
-
Validation of biomarkers to predict response to immunotherapy in cancer: volume II - clinical validation and regulatory considerations
-
Dobbin KK, Cesano A, Alvarez J, et al. Validation of biomarkers to predict response to immunotherapy in cancer: volume II - clinical validation and regulatory considerations. J Immunother Cancer. 2016;4:77.
-
(2016)
J Immunother Cancer
, vol.4
, pp. 77
-
-
Dobbin, K.K.1
Cesano, A.2
Alvarez, J.3
-
61
-
-
84997530136
-
Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers
-
Sweis RF, Galsky MD. Emerging role of immunotherapy in urothelial carcinoma-Immunobiology/biomarkers. Urol Oncol. 2016;34:556-65.
-
(2016)
Urol Oncol
, vol.34
, pp. 556-565
-
-
Sweis, R.F.1
Galsky, M.D.2
-
62
-
-
85048960377
-
Mutational load (ML) and T-cell-inflamed microenvironment as preditors of response to pembrolizumab
-
Cristescu RMR, Ayers M, Albright A, Murphy E, Yearley J, Sher X, Liu X, et al. Mutational load (ML) and T-cell-inflamed microenvironment as preditors of response to pembrolizumab. Orlando: ASCO-SITC Clinical Immuno-Oncology Symposium; 2017.
-
(2017)
Orlando: ASCO-SITC Clinical Immuno-Oncology Symposium
-
-
Cristescu, R.M.R.1
Ayers, M.2
Albright, A.3
Murphy, E.4
Yearley, J.5
Sher, X.6
Liu, X.7
-
63
-
-
85034626501
-
Genomic determinants of response to pembrolizumab in head and neck squamous cell carcinoma (HNSCC)
-
Haddad RI, Seiwert TY, Chow LQM, et al. Genomic determinants of response to pembrolizumab in head and neck squamous cell carcinoma (HNSCC). J Clin Oncol. 2017;35:6009.
-
(2017)
J Clin Oncol
, vol.35
, pp. 6009
-
-
Haddad, R.I.1
Seiwert, T.Y.2
Chow, L.Q.M.3
-
64
-
-
85020087828
-
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: an exploratory multi-omic analysis
-
Snyder A, Nathanson T, Funt SA, et al. Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: an exploratory multi-omic analysis. PLoS Med. 2017;14:e1002309.
-
(2017)
PLoS Med
, vol.14
-
-
Snyder, A.1
Nathanson, T.2
Funt, S.A.3
-
65
-
-
84982946696
-
Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade
-
Chen PL, Roh W, Reuben A, et al. Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade. Cancer Discov. 2016;6:827-37.
-
(2016)
Cancer Discov
, vol.6
, pp. 827-837
-
-
Chen, P.L.1
Roh, W.2
Reuben, A.3
-
66
-
-
84940372582
-
The next hurdle in cancer immunotherapy: overcoming the non-T-cell-inflamed tumor microenvironment
-
Gajewski TF. The next hurdle in cancer immunotherapy: overcoming the non-T-cell-inflamed tumor microenvironment. Semin Oncol. 2015;42:663-71.
-
(2015)
Semin Oncol
, vol.42
, pp. 663-671
-
-
Gajewski, T.F.1
-
67
-
-
84979763259
-
Molecular drivers of the non-T-cell-inflamed tumor microenvironment in Urothelial bladder cancer
-
Sweis RF, Spranger S, Bao R, et al. Molecular drivers of the non-T-cell-inflamed tumor microenvironment in Urothelial bladder cancer. Cancer Immunol Res. 2016;4:563-8.
-
(2016)
Cancer Immunol Res
, vol.4
, pp. 563-568
-
-
Sweis, R.F.1
Spranger, S.2
Bao, R.3
-
68
-
-
84998660014
-
Development and analytical performance of a molecular diagnostic for anti-PD1 response on the nCounter Dx analysis system
-
Wallden B, Pekker I, Popa S, et al. Development and analytical performance of a molecular diagnostic for anti-PD1 response on the nCounter Dx analysis system. J Clin Oncol. 2016;34:3034.
-
(2016)
J Clin Oncol
, vol.34
, pp. 3034
-
-
Wallden, B.1
Pekker, I.2
Popa, S.3
-
69
-
-
85034626603
-
Verification of the analytical performance of a molecular diagnostic for response to anti-PD1 therapy on the nCounter Dx analysis system
-
Wallden BPI, Popa S, Dowidar N, Ngouenet C, Sullivan A, Danaher P, et al. Verification of the analytical performance of a molecular diagnostic for response to anti-PD1 therapy on the nCounter Dx analysis system. Orlando: 2017 ASCO-SITC Clinical Immuno-Oncology Symposium; 2017.
-
(2017)
Orlando: 2017 ASCO-SITC Clinical Immuno-Oncology Symposium
-
-
Wallden, B.P.I.1
Popa, S.2
Dowidar, N.3
Ngouenet, C.4
Sullivan, A.5
Danaher, P.6
-
70
-
-
85021095185
-
Pembrolizumab therapy for microsatellite instability high (MSI-H) colorectal cancer (CRC) and non-CRC
-
Diaz LA, Marabelle A, Delord J-P, et al. Pembrolizumab therapy for microsatellite instability high (MSI-H) colorectal cancer (CRC) and non-CRC. J Clin Oncol. 2017;35:3071.
-
(2017)
J Clin Oncol
, vol.35
, pp. 3071
-
-
Diaz, L.A.1
Marabelle, A.2
Delord, J.-P.3
-
71
-
-
85034662177
-
Pembrolizumab for previously treated metastatic adenocarcinoma or squamous cell carcinoma of the esophagus: phase 2 KEYNOTE-180 study
-
TPS4139-TPS4TPS.
-
Shah MA, Bennouna J, Shen L, et al. Pembrolizumab for previously treated metastatic adenocarcinoma or squamous cell carcinoma of the esophagus: phase 2 KEYNOTE-180 study. J Clin Oncol. 2016;34:TPS4139-TPS.
-
(2016)
J Clin Oncol
, vol.34
-
-
Shah, M.A.1
Bennouna, J.2
Shen, L.3
-
72
-
-
85034624444
-
KEYNOTE-181: phase 3, open-label study of second-line pembrolizumab vs single-agent chemotherapy in patients with advanced/metastatic esophageal adenocarcinoma
-
Doi T, Bennouna J, Shen L, et al. KEYNOTE-181: phase 3, open-label study of second-line pembrolizumab vs single-agent chemotherapy in patients with advanced/metastatic esophageal adenocarcinoma. J Clin Oncol. 2016;34:TPS4140-TPS.
-
(2016)
J Clin Oncol
, vol.34
, pp. 4140-4144
-
-
Doi, T.1
Bennouna, J.2
Shen, L.3
|